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The map label for this gene is hisG

Identifier: 45658289

GI number: 45658289

Start: 2963090

End: 2963710

Strand: Reverse

Name: hisG

Synonym: LIC12445

Alternate gene names: 45658289

Gene position: 2963710-2963090 (Counterclockwise)

Preceding gene: 45658290

Following gene: 45658288

Centisome position: 69.29

GC content: 40.74

Gene sequence:

>621_bases
TTGATGTTAACTCTGGCTTTGCCTAAAGGAAGATTGGCTGAGGAGAGCATCGATTTGATGATCTCCAAGGGTTGGCTTTC
TTCTAAACCCGATCCTAATTCCAAAGAATTGATTTACAACGACCCAAAGGGAAAAATTCGAATTCTACTTGTACGTTCTC
AAGATGTTGCTACTTATGTGGAACAATGTGCAGCGGATGCAGGAATTAGCGGATGGGATGTTTTAAAAGAAGGTGGTTAT
GATTTAGCGACTCCTTTGGATTTAAAAATCGGGAAGTGTAGGCTTTCTCTTGCAGCCCCGAATGGTTTTACTTTAGAAGC
GCATCACCGTAAGATTCGAGTGGCCACCAAATATCCAAATTTGGCGAGAGAGTTTTTCTTTCTGAAAGGACTTTCCTGTG
AAATTTTTAAACTTTATGGAAGTATAGAACTCGCACCTCTCGTCGGTCTTTCCGATTGTATTGTAGACTTGGTTTCTACT
GGAGGAACTCTCAAGGCAAACGGACTCAAGGAGCTGGACATAATTTTGGAATCCTCTGCTCGTCTTGTTTTCAATCGTTC
TTCTCTTTACGGGAAACGAAAAGAAGCGGTTGAATTTATGGATTCTCTTTCTAAAATCTAA

Upstream 100 bases:

>100_bases
TAAAAAAGGTTTTGGATCAAGAGATTAAAACTCCTGCTACGGATTATAATACTGTAAAACAATACGCTACGTTTTTACTA
ATACAACTCAACCAGAAGGG

Downstream 100 bases:

>100_bases
AAACGGAACCCATAAGAAGTGTTTGTTTGAGTTGTGTTTAAGGCAACCCAGAAGAAATTTAACAAATTGCGGATTGAAGA
CTAACGAATGCTTTTCTCAA

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MMLTLALPKGRLAEESIDLMISKGWLSSKPDPNSKELIYNDPKGKIRILLVRSQDVATYVEQCAADAGISGWDVLKEGGY
DLATPLDLKIGKCRLSLAAPNGFTLEAHHRKIRVATKYPNLAREFFFLKGLSCEIFKLYGSIELAPLVGLSDCIVDLVST
GGTLKANGLKELDIILESSARLVFNRSSLYGKRKEAVEFMDSLSKI

Sequences:

>Translated_206_residues
MMLTLALPKGRLAEESIDLMISKGWLSSKPDPNSKELIYNDPKGKIRILLVRSQDVATYVEQCAADAGISGWDVLKEGGY
DLATPLDLKIGKCRLSLAAPNGFTLEAHHRKIRVATKYPNLAREFFFLKGLSCEIFKLYGSIELAPLVGLSDCIVDLVST
GGTLKANGLKELDIILESSARLVFNRSSLYGKRKEAVEFMDSLSKI
>Mature_206_residues
MMLTLALPKGRLAEESIDLMISKGWLSSKPDPNSKELIYNDPKGKIRILLVRSQDVATYVEQCAADAGISGWDVLKEGGY
DLATPLDLKIGKCRLSLAAPNGFTLEAHHRKIRVATKYPNLAREFFFLKGLSCEIFKLYGSIELAPLVGLSDCIVDLVST
GGTLKANGLKELDIILESSARLVFNRSSLYGKRKEAVEFMDSLSKI

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=208, Percent_Identity=35.5769230769231, Blast_Score=96, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320896, Length=194, Percent_Identity=27.8350515463918, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_LEPIC (P62382)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_002375.1
- ProteinModelPortal:   P62382
- SMR:   P62382
- GeneID:   2769741
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC12445
- HOGENOM:   HBG391868
- OMA:   QVDIIKL
- ProtClustDB:   PRK01686
- BioCyc:   LINT-130-01:LINT-130-01-002375-MONOMER
- BioCyc:   LINT267671:LIC_12445-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01018
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070

Pfam domain/function: PF01634 HisG

EC number: =2.4.2.17

Molecular weight: Translated: 22667; Mature: 22667

Theoretical pI: Translated: 8.60; Mature: 8.60

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMLTLALPKGRLAEESIDLMISKGWLSSKPDPNSKELIYNDPKGKIRILLVRSQDVATYV
CEEEEECCCCCCCHHHHEEEEECCCCCCCCCCCCCCEEEECCCCCEEEEEEECCHHHHHH
EQCAADAGISGWDVLKEGGYDLATPLDLKIGKCRLSLAAPNGFTLEAHHRKIRVATKYPN
HHHHHHCCCCHHHHHHCCCCCCCCCCCEEEEEEEEEEECCCCCEEEECCCEEEEEECCCH
LAREFFFLKGLSCEIFKLYGSIELAPLVGLSDCIVDLVSTGGTLKANGLKELDIILESSA
HHHHHHHHCCCCEEEEEEECCEEEEECCCHHHHHHHHHHCCCEEEECCCHHEEEEECCCC
RLVFNRSSLYGKRKEAVEFMDSLSKI
EEEEECHHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MMLTLALPKGRLAEESIDLMISKGWLSSKPDPNSKELIYNDPKGKIRILLVRSQDVATYV
CEEEEECCCCCCCHHHHEEEEECCCCCCCCCCCCCCEEEECCCCCEEEEEEECCHHHHHH
EQCAADAGISGWDVLKEGGYDLATPLDLKIGKCRLSLAAPNGFTLEAHHRKIRVATKYPN
HHHHHHCCCCHHHHHHCCCCCCCCCCCEEEEEEEEEEECCCCCEEEECCCEEEEEECCCH
LAREFFFLKGLSCEIFKLYGSIELAPLVGLSDCIVDLVSTGGTLKANGLKELDIILESSA
HHHHHHHHCCCCEEEEEEECCEEEEECCCHHHHHHHHHHCCCEEEECCCHHEEEEECCCC
RLVFNRSSLYGKRKEAVEFMDSLSKI
EEEEECHHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA