Click here to switch to the map view.

The map label for this gene is dsbD

Identifier: 45658250

GI number: 45658250

Start: 2913321

End: 2914697

Strand: Reverse

Name: dsbD

Synonym: LIC12404

Alternate gene names: 45658250

Gene position: 2914697-2913321 (Counterclockwise)

Preceding gene: 45658252

Following gene: 45658249

Centisome position: 68.15

GC content: 36.96

Gene sequence:

>1377_bases
TTGGTCTTTTCATTTGTGTTATCTAAAATTTTAATATATAAGAATTTTATAATACGTTTTTCGATCTTGAGCATCAGCTT
ATTCGGATGTGTTCTTCCTATTTCCGCAGAAGCTGTATCTGAATCTCTGAGAAAAATAGTTGTAGAAGGTATTTCCGGCG
ACGGTCCAACAACCGGGTTGATCCTGGTCATGGGTGGAATTTTGGCAAGTTTATTGCCCTGTGTTTATCCTTTGTATCCG
ATTACAGTAGGAATTATAAGAGCCAGAGGAGAAGGTTCTCCAAAAATTCTTCACCCTGCTATTTATTATCTTGGTTTGGT
TGTAACTTATTCTTGTTTTGGGCTGATTGCGGGTTTTAGTGGGGGGGCGTTTAACGTTATCCTACGTTATCCTATCGTAA
ACCTGGGGCTTTCTATTTTTATTTTTTTATTGGCACTGGGATCATTGGATCTAATTCATCTTCCTTTTTTTAGATCTAAA
GAAGTAAAAACAGGACAAGGTTGTGGCGGAACATTTTTACTAGGGATGGGAGCGGGACTTCTTTCGTCTCCTTGTGTAGG
ACCGGTTGTGGTAGCGATTCTTTTGCAGATCACTGCGGGGGCTGGTGTAATATCGATCGGTTCTGTATTTCTTGCTTCTT
TTAAGATGTTTTTGTTTGGGGTCGGTTTAGGTTTTCCTTTTTTAATGATAGGCGTTTTTGGTTTGAGTTTACCAAAATCA
GGAAAATGGATGCGTTGGATTCAGTGGATTTTAGGAATATTTGTATTATACTTTTCTTATACGTATTTTCAAAAATCTCT
TTCGGGTTGGGGGATTCCAGATTCTTCTATTCCTTTGGCGGCGTTTGGAATTTTGTTTTTACTTTTTTGTCTCTATTTTT
TTCTTCCAGATGAATGGAATCGTTATGTGAAAATGAAAAAAACTCTCCTTTTAGGAGGAATTATATTATCCGCTGTAGGA
CTTGTAGTTTTACTGATGTATAATTTGGAAAGAACCAATTCCATCTCCGTTGTAGAGATGGAAACGAAGGGAAACCTTTC
TTGGCATCGAATTCCTTCTAAGGCTTATGCGGAAGGAACAGAGACCGGAAAAAAAGTGTTCATCGATTTTTATGCTGATT
GGTGTACAAATTGTAAAACGTTCGAGGAACTTACTCAAAGTGACTCCGCTTTGAACGATGCTTTGCAAGGTGCTGTTCTT
TTGAAAATCAAAGACCAAGATCCTATTTTTGAAACGTATGCAAAAGATCCTCGTTTTGAGGAATTAAAAATAGGTCTCCC
GTTTTTTGTGATCTTGGACGCTGATGGAAATCTTTTATATAAAAATACAGATTATCAAGATACTTCTACTATGATCCAAA
TTTTAAAACAACTTTGA

Upstream 100 bases:

>100_bases
TCTGAGTCTAAACTTACGAGTTCTGAAATTACTTTGATGGGAATGAGGTTGACCTCAGGTTTTTTAATTGAAGCATAGTT
CTCGGAACCAAATTTCTTTT

Downstream 100 bases:

>100_bases
AAATCTAAATTTATAACAGTAAATTTGTTTTGTAGGTTTTAAACAGAAGTATTTTAAAAATAGAACTTTAATAATTTATG
TTTTTAGAATATTCATAAAA

Product: disulfide interchange transmembrane protein

Products: NA

Alternate protein names: Protein-disulfide reductase; Disulfide reductase [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MVFSFVLSKILIYKNFIIRFSILSISLFGCVLPISAEAVSESLRKIVVEGISGDGPTTGLILVMGGILASLLPCVYPLYP
ITVGIIRARGEGSPKILHPAIYYLGLVVTYSCFGLIAGFSGGAFNVILRYPIVNLGLSIFIFLLALGSLDLIHLPFFRSK
EVKTGQGCGGTFLLGMGAGLLSSPCVGPVVVAILLQITAGAGVISIGSVFLASFKMFLFGVGLGFPFLMIGVFGLSLPKS
GKWMRWIQWILGIFVLYFSYTYFQKSLSGWGIPDSSIPLAAFGILFLLFCLYFFLPDEWNRYVKMKKTLLLGGIILSAVG
LVVLLMYNLERTNSISVVEMETKGNLSWHRIPSKAYAEGTETGKKVFIDFYADWCTNCKTFEELTQSDSALNDALQGAVL
LKIKDQDPIFETYAKDPRFEELKIGLPFFVILDADGNLLYKNTDYQDTSTMIQILKQL

Sequences:

>Translated_458_residues
MVFSFVLSKILIYKNFIIRFSILSISLFGCVLPISAEAVSESLRKIVVEGISGDGPTTGLILVMGGILASLLPCVYPLYP
ITVGIIRARGEGSPKILHPAIYYLGLVVTYSCFGLIAGFSGGAFNVILRYPIVNLGLSIFIFLLALGSLDLIHLPFFRSK
EVKTGQGCGGTFLLGMGAGLLSSPCVGPVVVAILLQITAGAGVISIGSVFLASFKMFLFGVGLGFPFLMIGVFGLSLPKS
GKWMRWIQWILGIFVLYFSYTYFQKSLSGWGIPDSSIPLAAFGILFLLFCLYFFLPDEWNRYVKMKKTLLLGGIILSAVG
LVVLLMYNLERTNSISVVEMETKGNLSWHRIPSKAYAEGTETGKKVFIDFYADWCTNCKTFEELTQSDSALNDALQGAVL
LKIKDQDPIFETYAKDPRFEELKIGLPFFVILDADGNLLYKNTDYQDTSTMIQILKQL
>Mature_458_residues
MVFSFVLSKILIYKNFIIRFSILSISLFGCVLPISAEAVSESLRKIVVEGISGDGPTTGLILVMGGILASLLPCVYPLYP
ITVGIIRARGEGSPKILHPAIYYLGLVVTYSCFGLIAGFSGGAFNVILRYPIVNLGLSIFIFLLALGSLDLIHLPFFRSK
EVKTGQGCGGTFLLGMGAGLLSSPCVGPVVVAILLQITAGAGVISIGSVFLASFKMFLFGVGLGFPFLMIGVFGLSLPKS
GKWMRWIQWILGIFVLYFSYTYFQKSLSGWGIPDSSIPLAAFGILFLLFCLYFFLPDEWNRYVKMKKTLLLGGIILSAVG
LVVLLMYNLERTNSISVVEMETKGNLSWHRIPSKAYAEGTETGKKVFIDFYADWCTNCKTFEELTQSDSALNDALQGAVL
LKIKDQDPIFETYAKDPRFEELKIGLPFFVILDADGNLLYKNTDYQDTSTMIQILKQL

Specific function: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a

COG id: COG4232

COG function: function code OC; Thiol:disulfide interchange protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1790578, Length=422, Percent_Identity=28.6729857819905, Blast_Score=139, Evalue=4e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003834
- InterPro:   IPR022910
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF02683 DsbD; PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 50301; Mature: 50301

Theoretical pI: Translated: 8.34; Mature: 8.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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EEEECCCEEEEEECCCCEEEECCCCCHHHHHHHHHHHC
>Mature Secondary Structure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EEEECCCEEEEEECCCCEEEECCCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA