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The map label for this gene is ubiB [C]

Identifier: 45658236

GI number: 45658236

Start: 2894653

End: 2896365

Strand: Reverse

Name: ubiB [C]

Synonym: LIC12390

Alternate gene names: 45658236

Gene position: 2896365-2894653 (Counterclockwise)

Preceding gene: 45658237

Following gene: 45658235

Centisome position: 67.72

GC content: 36.95

Gene sequence:

>1713_bases
ATGCTCGTAACCGGAACAAGCGGACCTCAGGAAACCCTGTCCTACAAGTTACACAGTAGTTCTTGGAGATTTTGGAACGC
TAATTCTTTTGTTTGGAAAAAAATTTGGAGTATATTCTGGTTTTTTAAATTAGGAAAAATTTTTTTTCCTTCTTATAGAG
ATACGGATGCTCACGAAAAATTCTTTCGTACGTTAGGTGAAGATTGTCGTAATTTCTTTTTATCTATGGGTGGAGTTTAT
ATCAAACTCGGTCAATACTTAGGGAATCTTTCTCATATTTTTCCAGACTCGTTTACGGAATCTTTGCAAGATCTTCAAGA
CAGAGTTCCTCCTCATCCGTTTTCGGAAATAGAAGAAAGGTTTCGATCTGAGTTTGGAAAAGAAATTATAAAAGTTTTTC
CGGATATTTCCAACGTTCCAGAAGCAAGCGCTTCCACGGCTCAGGTTCACGTGGCTTCGATCGGAGGCCAAAAAGTTGCG
GTTAAAGTTTTGTATCCTGGAATTGAAACGTTAATCGCAAACGATCTCAAAAACATTCGTTCTTTTTTAAAAAGAATCAA
TCGTTATCTATTTCGTTTTGAATATAAAAAAATTCACGATGAGATTACTCGGTTGGTTACGAGGGAAACTGATCTGAAAC
TGGAAGCGGATTCTTACGATAGGATGAGACAATTTTTTGTAGAAGAACCCGATTATATCTTTCCAAAAGTCATTCGTCAA
TTTTCTGGAAAAAGTGTTTTAGTAACTGAATTTATAGAAGGTGTCAAGATCACAAGAGCGACTCCGGTCTTAAAAGGTCA
GGCAAAGTCTAGACCGGTGGAACTTTTAGTACGCGCTTATGTTTTGATGATCTTTCAATATCGTTTTTATCACGCAGACC
CTCATCCAGGAAATCTAATTTACACACCGGAAGAAAAACTTTGTTTTTTAGATTTCGGAGCAGTGGGGGAGATCAATTCT
GGAGGAGCATACGCACTTAAAAAAATATTTCTATGTGCGATTGCCAAAGATTACTTTGGGGTAGTAGACGGTTTGGAAGA
AATGGGGGCTTTGTCTGCTTCTGCAGATAGAGATAAATTAGAAGAAGTGGTTCGTTATTCTTTGGAGAAATTGGGAAGGT
TTGTAGCGGATACGGACTACTTCCGAAATCTTTCTCTGGGTCAAATTCATACTCGAGAAGATCAACTTTTTTTAAAAGAG
ATCAATTCCAGTTTGAAAGAAATTTTTAGAATGATTCAGATTCCTGAAAATTTCATTTTCTTAGAACGTGTCCTGGGTTT
ATTGGTAGGGATTACTTCGATTTTGGATCCTTATAGAACCGTTTTAGACTACGGAGAAAAACCGTTCCGGACCGTCGCCT
CCGGAAAAGAAGGCGGACTGGAGTTTCTTTTGTTAAACGAAGATAAAAATCTTTTAGGTAATACACTTTCCATTCCGGGA
GAATTTTATAAAGTACTCCAGAACATCAATCGAGGAAAACAGGGAATTCAACTTCGGGAAGTCGAAAGACACACTCGGAA
GATGTATATTCTGGGACATCAGATTTTATATTCTGGATTCTTGATTGCAGGAATTCATTTTGGAAATGATTATCTCGAAA
AAGGAATGGAGATTCAAAGTTGGGGATTTTTTACGTCTTCTGTGATTTTCGGATTTATACTTATCTATTCATTTTGGAAA
AATAAACTTAAAAAGAAAGGAACCTCTTTGTGA

Upstream 100 bases:

>100_bases
TTACAGGGGATATAGAAGAGAATCTTCAAATTCTCACCCTGTTGGATACGATCCGGAGAAAAGCCGAAAAAAGAATCCTA
GAGGTTTAGAAGTTTTATCC

Downstream 100 bases:

>100_bases
AATATTTTGAAAAAAGATTTTTAGACGTCTATCGCCCTATTTATTTGGGAGTTATTTTTTTAGGAATCGTATTGGATCTT
GTGACTAAGTTTTTAGTCAT

Product: hypothetical protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 570; Mature: 570

Protein sequence:

>570_residues
MLVTGTSGPQETLSYKLHSSSWRFWNANSFVWKKIWSIFWFFKLGKIFFPSYRDTDAHEKFFRTLGEDCRNFFLSMGGVY
IKLGQYLGNLSHIFPDSFTESLQDLQDRVPPHPFSEIEERFRSEFGKEIIKVFPDISNVPEASASTAQVHVASIGGQKVA
VKVLYPGIETLIANDLKNIRSFLKRINRYLFRFEYKKIHDEITRLVTRETDLKLEADSYDRMRQFFVEEPDYIFPKVIRQ
FSGKSVLVTEFIEGVKITRATPVLKGQAKSRPVELLVRAYVLMIFQYRFYHADPHPGNLIYTPEEKLCFLDFGAVGEINS
GGAYALKKIFLCAIAKDYFGVVDGLEEMGALSASADRDKLEEVVRYSLEKLGRFVADTDYFRNLSLGQIHTREDQLFLKE
INSSLKEIFRMIQIPENFIFLERVLGLLVGITSILDPYRTVLDYGEKPFRTVASGKEGGLEFLLLNEDKNLLGNTLSIPG
EFYKVLQNINRGKQGIQLREVERHTRKMYILGHQILYSGFLIAGIHFGNDYLEKGMEIQSWGFFTSSVIFGFILIYSFWK
NKLKKKGTSL

Sequences:

>Translated_570_residues
MLVTGTSGPQETLSYKLHSSSWRFWNANSFVWKKIWSIFWFFKLGKIFFPSYRDTDAHEKFFRTLGEDCRNFFLSMGGVY
IKLGQYLGNLSHIFPDSFTESLQDLQDRVPPHPFSEIEERFRSEFGKEIIKVFPDISNVPEASASTAQVHVASIGGQKVA
VKVLYPGIETLIANDLKNIRSFLKRINRYLFRFEYKKIHDEITRLVTRETDLKLEADSYDRMRQFFVEEPDYIFPKVIRQ
FSGKSVLVTEFIEGVKITRATPVLKGQAKSRPVELLVRAYVLMIFQYRFYHADPHPGNLIYTPEEKLCFLDFGAVGEINS
GGAYALKKIFLCAIAKDYFGVVDGLEEMGALSASADRDKLEEVVRYSLEKLGRFVADTDYFRNLSLGQIHTREDQLFLKE
INSSLKEIFRMIQIPENFIFLERVLGLLVGITSILDPYRTVLDYGEKPFRTVASGKEGGLEFLLLNEDKNLLGNTLSIPG
EFYKVLQNINRGKQGIQLREVERHTRKMYILGHQILYSGFLIAGIHFGNDYLEKGMEIQSWGFFTSSVIFGFILIYSFWK
NKLKKKGTSL
>Mature_570_residues
MLVTGTSGPQETLSYKLHSSSWRFWNANSFVWKKIWSIFWFFKLGKIFFPSYRDTDAHEKFFRTLGEDCRNFFLSMGGVY
IKLGQYLGNLSHIFPDSFTESLQDLQDRVPPHPFSEIEERFRSEFGKEIIKVFPDISNVPEASASTAQVHVASIGGQKVA
VKVLYPGIETLIANDLKNIRSFLKRINRYLFRFEYKKIHDEITRLVTRETDLKLEADSYDRMRQFFVEEPDYIFPKVIRQ
FSGKSVLVTEFIEGVKITRATPVLKGQAKSRPVELLVRAYVLMIFQYRFYHADPHPGNLIYTPEEKLCFLDFGAVGEINS
GGAYALKKIFLCAIAKDYFGVVDGLEEMGALSASADRDKLEEVVRYSLEKLGRFVADTDYFRNLSLGQIHTREDQLFLKE
INSSLKEIFRMIQIPENFIFLERVLGLLVGITSILDPYRTVLDYGEKPFRTVASGKEGGLEFLLLNEDKNLLGNTLSIPG
EFYKVLQNINRGKQGIQLREVERHTRKMYILGHQILYSGFLIAGIHFGNDYLEKGMEIQSWGFFTSSVIFGFILIYSFWK
NKLKKKGTSL

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=266, Percent_Identity=27.8195488721804, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI41393593, Length=270, Percent_Identity=29.6296296296296, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI34147522, Length=271, Percent_Identity=26.9372693726937, Blast_Score=83, Evalue=7e-16,
Organism=Homo sapiens, GI27363457, Length=257, Percent_Identity=25.6809338521401, Blast_Score=80, Evalue=7e-15,
Organism=Homo sapiens, GI217416386, Length=202, Percent_Identity=27.2277227722772, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI217035081, Length=197, Percent_Identity=25.3807106598985, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI2367309, Length=320, Percent_Identity=27.8125, Blast_Score=114, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17559152, Length=281, Percent_Identity=27.4021352313167, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI32565180, Length=247, Percent_Identity=27.5303643724696, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323282, Length=235, Percent_Identity=29.7872340425532, Blast_Score=109, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6321319, Length=287, Percent_Identity=26.1324041811847, Blast_Score=91, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6325148, Length=437, Percent_Identity=23.1121281464531, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI22024280, Length=278, Percent_Identity=27.3381294964029, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24662575, Length=270, Percent_Identity=30.3703703703704, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI18859849, Length=282, Percent_Identity=24.113475177305, Blast_Score=90, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 65750; Mature: 65750

Theoretical pI: Translated: 9.08; Mature: 9.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVTGTSGPQETLSYKLHSSSWRFWNANSFVWKKIWSIFWFFKLGKIFFPSYRDTDAHEK
CEECCCCCCHHHHHEEEECCCCCEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
FFRTLGEDCRNFFLSMGGVYIKLGQYLGNLSHIFPDSFTESLQDLQDRVPPHPFSEIEER
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHH
FRSEFGKEIIKVFPDISNVPEASASTAQVHVASIGGQKVAVKVLYPGIETLIANDLKNIR
HHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCEEEEEEECCCHHHHHHHHHHHHH
SFLKRINRYLFRFEYKKIHDEITRLVTRETDLKLEADSYDRMRQFFVEEPDYIFPKVIRQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHCCCCHHHHHHHHH
FSGKSVLVTEFIEGVKITRATPVLKGQAKSRPVELLVRAYVLMIFQYRFYHADPHPGNLI
HCCCEEEHHHHHCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEE
YTPEEKLCFLDFGAVGEINSGGAYALKKIFLCAIAKDYFGVVDGLEEMGALSASADRDKL
ECCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
EEVVRYSLEKLGRFVADTDYFRNLSLGQIHTREDQLFLKEINSSLKEIFRMIQIPENFIF
HHHHHHHHHHHHHHHHCHHHHHCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHCCCHHHH
LERVLGLLVGITSILDPYRTVLDYGEKPFRTVASGKEGGLEFLLLNEDKNLLGNTLSIPG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCEEEEEECCCCHHHCCCCCCCH
EFYKVLQNINRGKQGIQLREVERHTRKMYILGHQILYSGFLIAGIHFGNDYLEKGMEIQS
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHCCCCCCC
WGFFTSSVIFGFILIYSFWKNKLKKKGTSL
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLVTGTSGPQETLSYKLHSSSWRFWNANSFVWKKIWSIFWFFKLGKIFFPSYRDTDAHEK
CEECCCCCCHHHHHEEEECCCCCEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
FFRTLGEDCRNFFLSMGGVYIKLGQYLGNLSHIFPDSFTESLQDLQDRVPPHPFSEIEER
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHH
FRSEFGKEIIKVFPDISNVPEASASTAQVHVASIGGQKVAVKVLYPGIETLIANDLKNIR
HHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCEEEEEEECCCHHHHHHHHHHHHH
SFLKRINRYLFRFEYKKIHDEITRLVTRETDLKLEADSYDRMRQFFVEEPDYIFPKVIRQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHCCCCHHHHHHHHH
FSGKSVLVTEFIEGVKITRATPVLKGQAKSRPVELLVRAYVLMIFQYRFYHADPHPGNLI
HCCCEEEHHHHHCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEE
YTPEEKLCFLDFGAVGEINSGGAYALKKIFLCAIAKDYFGVVDGLEEMGALSASADRDKL
ECCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
EEVVRYSLEKLGRFVADTDYFRNLSLGQIHTREDQLFLKEINSSLKEIFRMIQIPENFIF
HHHHHHHHHHHHHHHHCHHHHHCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHCCCHHHH
LERVLGLLVGITSILDPYRTVLDYGEKPFRTVASGKEGGLEFLLLNEDKNLLGNTLSIPG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCEEEEEECCCCHHHCCCCCCCH
EFYKVLQNINRGKQGIQLREVERHTRKMYILGHQILYSGFLIAGIHFGNDYLEKGMEIQS
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHCCCCCCC
WGFFTSSVIFGFILIYSFWKNKLKKKGTSL
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]