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The map label for this gene is typA [H]

Identifier: 45658203

GI number: 45658203

Start: 2853940

End: 2855760

Strand: Reverse

Name: typA [H]

Synonym: LIC12357

Alternate gene names: 45658203

Gene position: 2855760-2853940 (Counterclockwise)

Preceding gene: 45658206

Following gene: 45658202

Centisome position: 66.77

GC content: 43.05

Gene sequence:

>1821_bases
ATGGAAATCCGCAATATAGCAATCATTGCCCACGTAGACCACGGGAAAACCACACTTCTGGACGGAATTCTCCGTCAAAC
CGGCGCCGTCACAGCCAAAGAGGACGGAGAAAGAATCATGGATTCCAATGACTTGGAAAAGGAAAAAGGAATCACGATCA
AAGCAAAAAATACAGCGGTGGTTTATAAAGGGACTAGAATCAACGTAGTAGATACTCCCGGTCACGCGGATTTCGGCGGA
GAAGTGGAACGCGTTCTTGCAACTGCGGATTCTTGTCTTCTTCTTGTGGACGCTTTTGACGGACCGATGCCTCAGACTCG
TTTCGTATTAGGAAAATCTCTTCAACTCGGACACAGACCTATTTTAGTAATTAATAAAATAGACCGTCCAGGCGCGAGAC
CAGAAGCGGTTGTAGATATGGCGTTTGATCTATTTTCCGATTTAGGAGCCACAGACGAACAGTTAGATTTTCCAATCGTA
TATGCATCTGCAAAACAAGGTTGGGCGGTTCACAATCTGAGCGAATCTCCGGGTACAAACCTGGATCCTCTTTTGGACAC
CGTTCTTAAACACGTTCCGCCTGTTCAAGCGGACACGGAAGCCCCGCTTCAATTCCAAGTGACTTCCTTGGATTATAACG
ACTATGTAGGAAGAATTGCAGTCGGAAAAATTTATGCGGGAAAAATGGCGCTCGGAATGAACGTTATACAACTTGCGGCA
AAAAAAACCGAAACGGCTCCATCAGCGGATACTGCATTATTTAGGATTACAAAATTATACAATTTTGAAGGACTCAAAAG
AAACGAAGTCAATACGGCGGAAGCAGGAGACATCGTGGCGATTGCGGGTCTTCCGGATGTGTTTATCGGAGATACAATTT
GTGAACCTGGAAAACCGGCCCCCAGACCAGCGATCGAGGTAGAAGAACCGACCGTATCTATGTTTTTTATGGTAAACAAT
TCTCCGTTTGCCGGAAAAGAAGGAAAGTTCGTAACGACCCGAAATATTCGAGAACGTTTGGATCGAGAACTAGAAACTAA
CGTAGCGATGAGACTCGAAGAAACCGAAGATAAGGATCGTTTTAAGGTGTTAGGGCGTGGAGAACTTCATTTGTCGGTTC
TTATCGAAACAATGAGAAGAGAAGGATTTGAAATCCAAGTCTCTCGTCCTGAAGTCATTTTAAAAACTAACGAGCAAGGG
CAAAAACTCGAACCTTACGAATATTTGGTAATGGATGTTCCTGATCAATTTACAGGAGCGATCATTGCCGAGTTAAACCG
TAGAAAGGGAGAACTACAATTGATGGACGCACATCCGTCCGGAATGACCCGAGTAGAATTTGTAATACCTACAAGGGGAA
TTATAGGTTTTAGAGGATTTTTTATTTCAGAAACCAGAGGAGAAGGAGTGATGTCTTCTCGTTTTCTTAGGTTCGATGTA
TATAAAGGGGATATTCCTGGTCGTAAGAACGGCGCATTGATTTCAATGGACTCAGGAGAATCCACTGCATATGCTCTTTG
GAAGATTCAAGAAAGAGGGGAATTGGTGATCGGGCCGAATACCTCTGTTTATCCCGGAATGATCATCGGAATTCATTCTC
GTGATAATGATCTAGAAGTGAATCCTGTAAAGGAAAAGAAACTGAGTAACGTTCGTTCTTCTGGAGCGGATGAGGCGATA
CGTCTGGTTCCTCCTAGAAAATTTTCTTTAGAACAAAACATAGAATTTTTAGATGATGACGAACTTTTGGAAGTAACTCC
CACGAGTTTACGTCTTCGTAAAAAGTTTTTAGACGCAAATATGCGTAAACGTAACAAATAA

Upstream 100 bases:

>100_bases
TCATCAAATCAAAAAGATCAGAGATTCTCATAGAGGATCCTGGATTCGATGATAAAATAAGTATTTACACCAGGAGGCTT
CCGAAATTTTTGGTTTTAGA

Downstream 100 bases:

>100_bases
ATATTAGAATTGTTGAAAAATTAATTCTCCATCTGTTTCTATTTTATGGAAACCGGCAATTGAAGTAGTTTTGTTAATCG
TCACTATGGAATTTTTCAAC

Product: elongation factor EF-G

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 606; Mature: 606

Protein sequence:

>606_residues
MEIRNIAIIAHVDHGKTTLLDGILRQTGAVTAKEDGERIMDSNDLEKEKGITIKAKNTAVVYKGTRINVVDTPGHADFGG
EVERVLATADSCLLLVDAFDGPMPQTRFVLGKSLQLGHRPILVINKIDRPGARPEAVVDMAFDLFSDLGATDEQLDFPIV
YASAKQGWAVHNLSESPGTNLDPLLDTVLKHVPPVQADTEAPLQFQVTSLDYNDYVGRIAVGKIYAGKMALGMNVIQLAA
KKTETAPSADTALFRITKLYNFEGLKRNEVNTAEAGDIVAIAGLPDVFIGDTICEPGKPAPRPAIEVEEPTVSMFFMVNN
SPFAGKEGKFVTTRNIRERLDRELETNVAMRLEETEDKDRFKVLGRGELHLSVLIETMRREGFEIQVSRPEVILKTNEQG
QKLEPYEYLVMDVPDQFTGAIIAELNRRKGELQLMDAHPSGMTRVEFVIPTRGIIGFRGFFISETRGEGVMSSRFLRFDV
YKGDIPGRKNGALISMDSGESTAYALWKIQERGELVIGPNTSVYPGMIIGIHSRDNDLEVNPVKEKKLSNVRSSGADEAI
RLVPPRKFSLEQNIEFLDDDELLEVTPTSLRLRKKFLDANMRKRNK

Sequences:

>Translated_606_residues
MEIRNIAIIAHVDHGKTTLLDGILRQTGAVTAKEDGERIMDSNDLEKEKGITIKAKNTAVVYKGTRINVVDTPGHADFGG
EVERVLATADSCLLLVDAFDGPMPQTRFVLGKSLQLGHRPILVINKIDRPGARPEAVVDMAFDLFSDLGATDEQLDFPIV
YASAKQGWAVHNLSESPGTNLDPLLDTVLKHVPPVQADTEAPLQFQVTSLDYNDYVGRIAVGKIYAGKMALGMNVIQLAA
KKTETAPSADTALFRITKLYNFEGLKRNEVNTAEAGDIVAIAGLPDVFIGDTICEPGKPAPRPAIEVEEPTVSMFFMVNN
SPFAGKEGKFVTTRNIRERLDRELETNVAMRLEETEDKDRFKVLGRGELHLSVLIETMRREGFEIQVSRPEVILKTNEQG
QKLEPYEYLVMDVPDQFTGAIIAELNRRKGELQLMDAHPSGMTRVEFVIPTRGIIGFRGFFISETRGEGVMSSRFLRFDV
YKGDIPGRKNGALISMDSGESTAYALWKIQERGELVIGPNTSVYPGMIIGIHSRDNDLEVNPVKEKKLSNVRSSGADEAI
RLVPPRKFSLEQNIEFLDDDELLEVTPTSLRLRKKFLDANMRKRNK
>Mature_606_residues
MEIRNIAIIAHVDHGKTTLLDGILRQTGAVTAKEDGERIMDSNDLEKEKGITIKAKNTAVVYKGTRINVVDTPGHADFGG
EVERVLATADSCLLLVDAFDGPMPQTRFVLGKSLQLGHRPILVINKIDRPGARPEAVVDMAFDLFSDLGATDEQLDFPIV
YASAKQGWAVHNLSESPGTNLDPLLDTVLKHVPPVQADTEAPLQFQVTSLDYNDYVGRIAVGKIYAGKMALGMNVIQLAA
KKTETAPSADTALFRITKLYNFEGLKRNEVNTAEAGDIVAIAGLPDVFIGDTICEPGKPAPRPAIEVEEPTVSMFFMVNN
SPFAGKEGKFVTTRNIRERLDRELETNVAMRLEETEDKDRFKVLGRGELHLSVLIETMRREGFEIQVSRPEVILKTNEQG
QKLEPYEYLVMDVPDQFTGAIIAELNRRKGELQLMDAHPSGMTRVEFVIPTRGIIGFRGFFISETRGEGVMSSRFLRFDV
YKGDIPGRKNGALISMDSGESTAYALWKIQERGELVIGPNTSVYPGMIIGIHSRDNDLEVNPVKEKKLSNVRSSGADEAI
RLVPPRKFSLEQNIEFLDDDELLEVTPTSLRLRKKFLDANMRKRNK

Specific function: Not known; probably interacts with the ribosomes in a GTP dependent manner [H]

COG id: COG1217

COG function: function code T; Predicted membrane GTPase involved in stress response

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TypA subfamily [H]

Homologues:

Organism=Homo sapiens, GI157426893, Length=535, Percent_Identity=27.1028037383178, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI94966754, Length=162, Percent_Identity=39.5061728395062, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI18390331, Length=140, Percent_Identity=41.4285714285714, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI4503483, Length=144, Percent_Identity=36.8055555555556, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI310132016, Length=110, Percent_Identity=40, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI310110807, Length=110, Percent_Identity=40, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI310123363, Length=110, Percent_Identity=40, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI25306287, Length=468, Percent_Identity=25.8547008547009, Blast_Score=87, Evalue=7e-17,
Organism=Homo sapiens, GI25306283, Length=169, Percent_Identity=35.5029585798817, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI19923640, Length=169, Percent_Identity=35.5029585798817, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI34147630, Length=332, Percent_Identity=28.0120481927711, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI217272894, Length=134, Percent_Identity=33.5820895522388, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI217272892, Length=134, Percent_Identity=33.5820895522388, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI94966752, Length=157, Percent_Identity=30.5732484076433, Blast_Score=76, Evalue=1e-13,
Organism=Escherichia coli, GI48994988, Length=606, Percent_Identity=55.1155115511551, Blast_Score=653, Evalue=0.0,
Organism=Escherichia coli, GI1788922, Length=509, Percent_Identity=27.5049115913556, Blast_Score=142, Evalue=6e-35,
Organism=Escherichia coli, GI1789738, Length=501, Percent_Identity=25.748502994012, Blast_Score=123, Evalue=4e-29,
Organism=Escherichia coli, GI1790835, Length=144, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1789737, Length=304, Percent_Identity=28.2894736842105, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1790412, Length=304, Percent_Identity=28.2894736842105, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1789108, Length=355, Percent_Identity=24.7887323943662, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1789559, Length=186, Percent_Identity=32.258064516129, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17557151, Length=231, Percent_Identity=34.1991341991342, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71988811, Length=128, Percent_Identity=40.625, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71988819, Length=128, Percent_Identity=40.625, Blast_Score=109, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17533571, Length=144, Percent_Identity=43.0555555555556, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17556745, Length=141, Percent_Identity=39.0070921985816, Blast_Score=101, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI17506493, Length=156, Percent_Identity=33.974358974359, Blast_Score=94, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17552882, Length=134, Percent_Identity=35.0746268656716, Blast_Score=86, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17556456, Length=170, Percent_Identity=31.7647058823529, Blast_Score=72, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323320, Length=504, Percent_Identity=26.984126984127, Blast_Score=129, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6324707, Length=202, Percent_Identity=32.1782178217822, Blast_Score=101, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6320593, Length=202, Percent_Identity=32.1782178217822, Blast_Score=101, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6322359, Length=152, Percent_Identity=38.8157894736842, Blast_Score=90, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6323098, Length=143, Percent_Identity=39.1608391608392, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324166, Length=142, Percent_Identity=36.6197183098592, Blast_Score=84, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6324761, Length=283, Percent_Identity=28.9752650176678, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324550, Length=178, Percent_Identity=34.2696629213483, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI78706572, Length=530, Percent_Identity=26.2264150943396, Blast_Score=127, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24582462, Length=143, Percent_Identity=42.6573426573427, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI28574573, Length=138, Percent_Identity=37.6811594202899, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24585711, Length=148, Percent_Identity=36.4864864864865, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24585713, Length=148, Percent_Identity=36.4864864864865, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24585709, Length=148, Percent_Identity=36.4864864864865, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI21357743, Length=134, Percent_Identity=35.8208955223881, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI221458488, Length=161, Percent_Identity=34.7826086956522, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19921738, Length=254, Percent_Identity=28.740157480315, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI281363316, Length=304, Percent_Identity=26.3157894736842, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI17864358, Length=304, Percent_Identity=26.3157894736842, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI28572034, Length=181, Percent_Identity=34.2541436464088, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR006298 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 67251; Mature: 67251

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIRNIAIIAHVDHGKTTLLDGILRQTGAVTAKEDGERIMDSNDLEKEKGITIKAKNTAV
CCCCEEEEEEEECCCCHHHHHHHHHHHCCEEECCCCCHHCCCCCCHHHCCEEEEECCEEE
VYKGTRINVVDTPGHADFGGEVERVLATADSCLLLVDAFDGPMPQTRFVLGKSLQLGHRP
EEECCEEEEEECCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCC
ILVINKIDRPGARPEAVVDMAFDLFSDLGATDEQLDFPIVYASAKQGWAVHNLSESPGTN
EEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCEEEEECCCCCCCC
LDPLLDTVLKHVPPVQADTEAPLQFQVTSLDYNDYVGRIAVGKIYAGKMALGMNVIQLAA
HHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCEEEEEEEEECHHHHHHHHHHHHH
KKTETAPSADTALFRITKLYNFEGLKRNEVNTAEAGDIVAIAGLPDVFIGDTICEPGKPA
HHCCCCCCCCHHHEEEEHHHCCCCCCCCCCCCCCCCCEEEEECCCCHHCCCCCCCCCCCC
PRPAIEVEEPTVSMFFMVNNSPFAGKEGKFVTTRNIRERLDRELETNVAMRLEETEDKDR
CCCCEEECCCCEEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHCCEEEEEECCCCCCE
FKVLGRGELHLSVLIETMRREGFEIQVSRPEVILKTNEQGQKLEPYEYLVMDVPDQFTGA
EEEECCCCEEHHHHHHHHHHCCCEEEECCCEEEEEECCCCCCCCCEEEEEEECCCHHHHH
IIAELNRRKGELQLMDAHPSGMTRVEFVIPTRGIIGFRGFFISETRGEGVMSSRFLRFDV
HHHHHHCCCCCEEEEECCCCCCEEEEEEECCCCCEEEEEEEEECCCCCCCHHCCEEEEEE
YKGDIPGRKNGALISMDSGESTAYALWKIQERGELVIGPNTSVYPGMIIGIHSRDNDLEV
EECCCCCCCCCEEEEECCCCCEEEEEEEEECCCCEEECCCCCCCCCEEEEEECCCCCEEE
NPVKEKKLSNVRSSGADEAIRLVPPRKFSLEQNIEFLDDDELLEVTPTSLRLRKKFLDAN
CCCHHHHHHHHHCCCCCCEEEECCCCCCCHHCCCCCCCCCCEEEECCHHHHHHHHHHCCC
MRKRNK
HHHCCC
>Mature Secondary Structure
MEIRNIAIIAHVDHGKTTLLDGILRQTGAVTAKEDGERIMDSNDLEKEKGITIKAKNTAV
CCCCEEEEEEEECCCCHHHHHHHHHHHCCEEECCCCCHHCCCCCCHHHCCEEEEECCEEE
VYKGTRINVVDTPGHADFGGEVERVLATADSCLLLVDAFDGPMPQTRFVLGKSLQLGHRP
EEECCEEEEEECCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCC
ILVINKIDRPGARPEAVVDMAFDLFSDLGATDEQLDFPIVYASAKQGWAVHNLSESPGTN
EEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCEEEEECCCCCCCC
LDPLLDTVLKHVPPVQADTEAPLQFQVTSLDYNDYVGRIAVGKIYAGKMALGMNVIQLAA
HHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCEEEEEEEEECHHHHHHHHHHHHH
KKTETAPSADTALFRITKLYNFEGLKRNEVNTAEAGDIVAIAGLPDVFIGDTICEPGKPA
HHCCCCCCCCHHHEEEEHHHCCCCCCCCCCCCCCCCCEEEEECCCCHHCCCCCCCCCCCC
PRPAIEVEEPTVSMFFMVNNSPFAGKEGKFVTTRNIRERLDRELETNVAMRLEETEDKDR
CCCCEEECCCCEEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHCCEEEEEECCCCCCE
FKVLGRGELHLSVLIETMRREGFEIQVSRPEVILKTNEQGQKLEPYEYLVMDVPDQFTGA
EEEECCCCEEHHHHHHHHHHCCCEEEECCCEEEEEECCCCCCCCCEEEEEEECCCHHHHH
IIAELNRRKGELQLMDAHPSGMTRVEFVIPTRGIIGFRGFFISETRGEGVMSSRFLRFDV
HHHHHHCCCCCEEEEECCCCCCEEEEEEECCCCCEEEEEEEEECCCCCCCHHCCEEEEEE
YKGDIPGRKNGALISMDSGESTAYALWKIQERGELVIGPNTSVYPGMIIGIHSRDNDLEV
EECCCCCCCCCEEEEECCCCCEEEEEEEEECCCCEEECCCCCCCCCEEEEEECCCCCEEE
NPVKEKKLSNVRSSGADEAIRLVPPRKFSLEQNIEFLDDDELLEVTPTSLRLRKKFLDAN
CCCHHHHHHHHHCCCCCCEEEECCCCCCCHHCCCCCCCCCCEEEECCHHHHHHHHHHCCC
MRKRNK
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]