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The map label for this gene is sch1

Identifier: 45658165

GI number: 45658165

Start: 2794944

End: 2796239

Strand: Direct

Name: sch1

Synonym: LIC12317

Alternate gene names: 45658165

Gene position: 2794944-2796239 (Clockwise)

Preceding gene: 45658164

Following gene: 45658166

Centisome position: 65.35

GC content: 41.82

Gene sequence:

>1296_bases
ATGAGCATGGACAAACCAAAAACCAATCACAATTCAAGAGTTGCTATTACTGGGATAGGAGTTATCCTTCCGAATACGTA
TTCTGTGGACACTTTTTGGAAAAATCTTTCCGAAGGAAATTCCCAAATAGATACGATTACCAGATTTCCAACCGACGATA
TGCCCGTAAAAGTTGCGGCGGAAATGAACGATTTCGATTGGAAAAAGTTCTTACCCGATTTAGACGAAAAACATTCAAAA
CACTATAACCGAGAAACCTTCGCAATTATGTCTGCAATGGAAGAAGCGCGAAGAGACGCCAAATTAGAAAAGGATTCCGT
TGATCCATCTAAAGTAGGTTTTATAGATTCTTCCTCTAGAGCTTCTCTCGCTTGGTGGGAACACGCTTGGAAACTTTATC
ACGAAGAAAAAGATCCTAACGTTTTTGATCGTTATTCGGTTCTTACTTCTATGGCTTCCAATCCTACAAATCTTACCGCA
ATCTACGCGAACGTGCAAGGTTTTGTAACCACAATCACAGCCGCCTGTGTAGGAGGACATCACGCAATTAGTCTTTGTTA
CCAAGCAATCCGAAAAGGAAGAGCGGAAGTAATGTATGCCGGAGGTCATGAGTTTCCTTTGATCAAACCTCTCATGATGA
TGTATTCCGATCCGGTAAGTTCCGTTATGTCTTCCGAAAAAGACAATCCTAAATCTGCAATCAAACCTTACGATCGAAAT
CGAGATGGTTTTATCTTAGGAGAAGGTGCCGCCGTTCTTTGTATGGAAAGAATGGATCACGCCATCGCAAGAGGTGCCAG
AATTTATGCGGAAGTTTTAGGAACCTTTAGCTACAACGAAGCGGATCACGCGATGAGAATGGATCTTACCGGCAAAAAGG
CTGCGAATGGTTTAAACCGACTTCTAAAAATCAGCGGACTCAATTTAGGAGATATTGATTATTTCTGCGGACATGGAACG
GCAACGATCAACAACGATATGGCAGAAAGTAGGGCTCTCAAAATTTTATACAACGGCCTTGCTCGGAATAAATGGGCTCC
TCTTGGTTCTATCAAGCCAATTTTTGGTCATACTTTTGGAGCTGCAGGGATTATCAACGTTGCGGCAACAGCCCTCATGC
TTGAAAAACAAATTCTTTGCCCTACCATCAATCTAAAAGACGTAGACCCAGAATGCGATCATGATCATATTACAGATGGT
GCCAGAAAGGTTCGACTTAGAAATGCAATTTCAATGGCTTTTGCAATTGGAAGTCAATCTTCCTTCGTAAGTCTTACCGC
ACCGGATCTTCTTTAA

Upstream 100 bases:

>100_bases
TCAAATACACGTTATGCATGTTTGATATCAAAAGAATATAAAATTTAACGTTCTAAAATACAAAGTTTTTAATTACTTTT
GGGACAAGCAGCAAAATCAG

Downstream 100 bases:

>100_bases
GGAAATTAGGATGGAATTCGACAGATTGTATAGACAATACGATTATTTGAAAAAATTAAAATCGGTTCTCTATTATCAAG
GTGCAGTAACCCATGAAGTT

Product: beta-ketoacyl synthase

Products: 3-oxoacyl-[acyl-carrier protein]; CO2; [acyl-carrier protein]

Alternate protein names: KS; Polyketide condensing enzyme [H]

Number of amino acids: Translated: 431; Mature: 430

Protein sequence:

>431_residues
MSMDKPKTNHNSRVAITGIGVILPNTYSVDTFWKNLSEGNSQIDTITRFPTDDMPVKVAAEMNDFDWKKFLPDLDEKHSK
HYNRETFAIMSAMEEARRDAKLEKDSVDPSKVGFIDSSSRASLAWWEHAWKLYHEEKDPNVFDRYSVLTSMASNPTNLTA
IYANVQGFVTTITAACVGGHHAISLCYQAIRKGRAEVMYAGGHEFPLIKPLMMMYSDPVSSVMSSEKDNPKSAIKPYDRN
RDGFILGEGAAVLCMERMDHAIARGARIYAEVLGTFSYNEADHAMRMDLTGKKAANGLNRLLKISGLNLGDIDYFCGHGT
ATINNDMAESRALKILYNGLARNKWAPLGSIKPIFGHTFGAAGIINVAATALMLEKQILCPTINLKDVDPECDHDHITDG
ARKVRLRNAISMAFAIGSQSSFVSLTAPDLL

Sequences:

>Translated_431_residues
MSMDKPKTNHNSRVAITGIGVILPNTYSVDTFWKNLSEGNSQIDTITRFPTDDMPVKVAAEMNDFDWKKFLPDLDEKHSK
HYNRETFAIMSAMEEARRDAKLEKDSVDPSKVGFIDSSSRASLAWWEHAWKLYHEEKDPNVFDRYSVLTSMASNPTNLTA
IYANVQGFVTTITAACVGGHHAISLCYQAIRKGRAEVMYAGGHEFPLIKPLMMMYSDPVSSVMSSEKDNPKSAIKPYDRN
RDGFILGEGAAVLCMERMDHAIARGARIYAEVLGTFSYNEADHAMRMDLTGKKAANGLNRLLKISGLNLGDIDYFCGHGT
ATINNDMAESRALKILYNGLARNKWAPLGSIKPIFGHTFGAAGIINVAATALMLEKQILCPTINLKDVDPECDHDHITDG
ARKVRLRNAISMAFAIGSQSSFVSLTAPDLL
>Mature_430_residues
SMDKPKTNHNSRVAITGIGVILPNTYSVDTFWKNLSEGNSQIDTITRFPTDDMPVKVAAEMNDFDWKKFLPDLDEKHSKH
YNRETFAIMSAMEEARRDAKLEKDSVDPSKVGFIDSSSRASLAWWEHAWKLYHEEKDPNVFDRYSVLTSMASNPTNLTAI
YANVQGFVTTITAACVGGHHAISLCYQAIRKGRAEVMYAGGHEFPLIKPLMMMYSDPVSSVMSSEKDNPKSAIKPYDRNR
DGFILGEGAAVLCMERMDHAIARGARIYAEVLGTFSYNEADHAMRMDLTGKKAANGLNRLLKISGLNLGDIDYFCGHGTA
TINNDMAESRALKILYNGLARNKWAPLGSIKPIFGHTFGAAGIINVAATALMLEKQILCPTINLKDVDPECDHDHITDGA
RKVRLRNAISMAFAIGSQSSFVSLTAPDLL

Specific function: Involved in developmentally regulated synthesis of a compound biosynthetically related to polyketide antibiotics which is essential for spore color in Streptomyces halstedii [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=399, Percent_Identity=30.5764411027569, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI41872631, Length=397, Percent_Identity=22.4181360201511, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1787337, Length=394, Percent_Identity=31.2182741116751, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1788663, Length=412, Percent_Identity=25.9708737864078, Blast_Score=130, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI71983541, Length=381, Percent_Identity=26.509186351706, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71983535, Length=225, Percent_Identity=29.7777777777778, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI212642053, Length=399, Percent_Identity=22.8070175438596, Blast_Score=75, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6320904, Length=400, Percent_Identity=25, Blast_Score=112, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24644341, Length=414, Percent_Identity=27.0531400966184, Blast_Score=134, Evalue=9e-32,
Organism=Drosophila melanogaster, GI221330659, Length=418, Percent_Identity=22.488038277512, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI19920632, Length=418, Percent_Identity=22.7272727272727, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: 2.3.1.41

Molecular weight: Translated: 47667; Mature: 47536

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMDKPKTNHNSRVAITGIGVILPNTYSVDTFWKNLSEGNSQIDTITRFPTDDMPVKVAA
CCCCCCCCCCCCEEEEEEEEEEECCCCCHHHHHHHHHCCCCHHHHHEECCCCCCCEEEEE
EMNDFDWKKFLPDLDEKHSKHYNRETFAIMSAMEEARRDAKLEKDSVDPSKVGFIDSSSR
CCCCCCHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHEEEECCCCC
ASLAWWEHAWKLYHEEKDPNVFDRYSVLTSMASNPTNLTAIYANVQGFVTTITAACVGGH
CHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEHHHHHHHHHHHHHCCH
HAISLCYQAIRKGRAEVMYAGGHEFPLIKPLMMMYSDPVSSVMSSEKDNPKSAIKPYDRN
HHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCHHHHHHHCCCCCCHHHCCCCCCC
RDGFILGEGAAVLCMERMDHAIARGARIYAEVLGTFSYNEADHAMRMDLTGKKAANGLNR
CCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHH
LLKISGLNLGDIDYFCGHGTATINNDMAESRALKILYNGLARNKWAPLGSIKPIFGHTFG
HHHHCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCC
AAGIINVAATALMLEKQILCPTINLKDVDPECDHDHITDGARKVRLRNAISMAFAIGSQS
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHEECCCC
SFVSLTAPDLL
CEEEECCCCCC
>Mature Secondary Structure 
SMDKPKTNHNSRVAITGIGVILPNTYSVDTFWKNLSEGNSQIDTITRFPTDDMPVKVAA
CCCCCCCCCCCEEEEEEEEEEECCCCCHHHHHHHHHCCCCHHHHHEECCCCCCCEEEEE
EMNDFDWKKFLPDLDEKHSKHYNRETFAIMSAMEEARRDAKLEKDSVDPSKVGFIDSSSR
CCCCCCHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHEEEECCCCC
ASLAWWEHAWKLYHEEKDPNVFDRYSVLTSMASNPTNLTAIYANVQGFVTTITAACVGGH
CHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEHHHHHHHHHHHHHCCH
HAISLCYQAIRKGRAEVMYAGGHEFPLIKPLMMMYSDPVSSVMSSEKDNPKSAIKPYDRN
HHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCHHHHHHHCCCCCCHHHCCCCCCC
RDGFILGEGAAVLCMERMDHAIARGARIYAEVLGTFSYNEADHAMRMDLTGKKAANGLNR
CCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHH
LLKISGLNLGDIDYFCGHGTATINNDMAESRALKILYNGLARNKWAPLGSIKPIFGHTFG
HHHHCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCC
AAGIINVAATALMLEKQILCPTINLKDVDPECDHDHITDGARKVRLRNAISMAFAIGSQS
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHEECCCC
SFVSLTAPDLL
CEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: None [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.04 {acetyl-ACP}} 0.031 {acetyl-ACP}} 0.138 {cis-9-hexadecenoyl-ACP}} 0.017 {cis-9-hexadecenoyl-ACP}} 0.012 {cis-3-decenoyl-ACP}} [C]

Substrates: acyl-[acyl-carrier protein]; malonyl-[acyl-carrier protein]

Specific reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

General reaction: Acyl group transfer [C]

Inhibitor: Acetyl-CoA; Acyl-CoA; Iodoacetamide; N-Ethyl maleimide acyl -ACP-derivatives protect, malonyl-ACP-decarboxylation, Cerulenin [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8344517 [H]