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The map label for this gene is gcp

Identifier: 45658150

GI number: 45658150

Start: 2776846

End: 2777862

Strand: Reverse

Name: gcp

Synonym: LIC12302

Alternate gene names: 45658150

Gene position: 2777862-2776846 (Counterclockwise)

Preceding gene: 45658151

Following gene: 45658149

Centisome position: 64.95

GC content: 40.71

Gene sequence:

>1017_bases
ATGATCGGAATGGGAATCGAAACCAGTTGTGATGAAACATCGATTGGGATCGTGCGCGATGGTAAGGACTTACTTAGCCT
TAAAATTTTCAGTCAGATCGATTTACATAAACCCTACGGAGGGATTGTTCCAGAAATCGCCTCTAGGGCTCATTTAGAAA
AAATCAATCTTTTACTCGAAGAAGCGATGGAAGAATCTGAGATTCAATTTAAAGATCTTTCTTACGTCGCTGTGACTTCT
TCTCCTGGTTTGACTGGTTCTTTGATGGTAGGAGCCCAGATGGCCCGTTGTATTCACATGGTATACGAAACTCCGATTTT
ACCTGTATGCCATCTTCAGTCTCATTTTGCTGTGTTACATTTGGAGGGAGTTCCCACAGAATTTCCTGTTTTAGGACTTT
TACTTTCCGGAGGGAATTCGGCCATTTACATCTTACATGAATTTGGTAAAATGGAACTGTTAGGAGATACGATGGATGAC
GCTTTAGGGGAGGCCTTTGATAAAGTGGCAGGCCTTTTAGAACTTCCTTATCCTGGCGGACCTCATATAGAAGTGAGGGC
GAAAGAATACAAACCATCTCCAAATGAAAAACCGATCCTTCCAGCACTTTTACGAAATCTTCCACAAGAAGAGGTATCTT
TTTCTTTTAGCGGACTGAAAACCGCTGTGATGGTATTATTGGAAAAGCAAAAAGAACTTTCAAAAGAAAGGATTTGTTGG
AATTTTCAGAATTCTGCGTTTGATCTAGTTGAAAGAAATCTTAAACGGGCAGTTTCGAAAACCGGGATCAAACGTATTTT
TGCCGCGGGAGGGGTGCTTGCAAACTTCACTCTTCAGAATCGGTTGTATACCTGGGCCGAAAAAAATTCCGTGGAACTTT
TTGCTCCCAAGAAAAAAATTTATTGTACTGATAACGGTGCAATGGTAGCGTCGCTGGGATACTATTTGTTTCAAAAAGGT
TATCAAAGAGATATTGATTTTACGGTCAGTCCATCCAGACAGGAGATTTTTTCATGA

Upstream 100 bases:

>100_bases
GGGCAAAATTCGATTTTGGATTTGGAGCTGGATCCACAACTTCGTAAGGCGATTGAAATTCTAAGTCCTAACAAAGACGG
AGAAAAAAAATCTTAAACCC

Downstream 100 bases:

>100_bases
AACTCAAACTTAGTTGGGTTCCTAATACTCTTACGCTCGGAAATCTCACGATGGGATTCAGCGCGATGCTCGTAGCATCG
GAAGCAGGGTCCAGAAATGG

Product: putative DNA-binding/iron metalloprotein/AP endonuclease

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MIGMGIETSCDETSIGIVRDGKDLLSLKIFSQIDLHKPYGGIVPEIASRAHLEKINLLLEEAMEESEIQFKDLSYVAVTS
SPGLTGSLMVGAQMARCIHMVYETPILPVCHLQSHFAVLHLEGVPTEFPVLGLLLSGGNSAIYILHEFGKMELLGDTMDD
ALGEAFDKVAGLLELPYPGGPHIEVRAKEYKPSPNEKPILPALLRNLPQEEVSFSFSGLKTAVMVLLEKQKELSKERICW
NFQNSAFDLVERNLKRAVSKTGIKRIFAAGGVLANFTLQNRLYTWAEKNSVELFAPKKKIYCTDNGAMVASLGYYLFQKG
YQRDIDFTVSPSRQEIFS

Sequences:

>Translated_338_residues
MIGMGIETSCDETSIGIVRDGKDLLSLKIFSQIDLHKPYGGIVPEIASRAHLEKINLLLEEAMEESEIQFKDLSYVAVTS
SPGLTGSLMVGAQMARCIHMVYETPILPVCHLQSHFAVLHLEGVPTEFPVLGLLLSGGNSAIYILHEFGKMELLGDTMDD
ALGEAFDKVAGLLELPYPGGPHIEVRAKEYKPSPNEKPILPALLRNLPQEEVSFSFSGLKTAVMVLLEKQKELSKERICW
NFQNSAFDLVERNLKRAVSKTGIKRIFAAGGVLANFTLQNRLYTWAEKNSVELFAPKKKIYCTDNGAMVASLGYYLFQKG
YQRDIDFTVSPSRQEIFS
>Mature_338_residues
MIGMGIETSCDETSIGIVRDGKDLLSLKIFSQIDLHKPYGGIVPEIASRAHLEKINLLLEEAMEESEIQFKDLSYVAVTS
SPGLTGSLMVGAQMARCIHMVYETPILPVCHLQSHFAVLHLEGVPTEFPVLGLLLSGGNSAIYILHEFGKMELLGDTMDD
ALGEAFDKVAGLLELPYPGGPHIEVRAKEYKPSPNEKPILPALLRNLPQEEVSFSFSGLKTAVMVLLEKQKELSKERICW
NFQNSAFDLVERNLKRAVSKTGIKRIFAAGGVLANFTLQNRLYTWAEKNSVELFAPKKKIYCTDNGAMVASLGYYLFQKG
YQRDIDFTVSPSRQEIFS

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family

Homologues:

Organism=Homo sapiens, GI8923380, Length=325, Percent_Identity=28.9230769230769, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI116812636, Length=344, Percent_Identity=31.1046511627907, Blast_Score=129, Evalue=5e-30,
Organism=Escherichia coli, GI1789445, Length=330, Percent_Identity=40.9090909090909, Blast_Score=248, Evalue=5e-67,
Organism=Caenorhabditis elegans, GI71995670, Length=345, Percent_Identity=28.9855072463768, Blast_Score=131, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17557464, Length=333, Percent_Identity=28.2282282282282, Blast_Score=122, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6320099, Length=364, Percent_Identity=28.2967032967033, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6322891, Length=355, Percent_Identity=23.0985915492958, Blast_Score=90, Evalue=4e-19,
Organism=Drosophila melanogaster, GI20129063, Length=340, Percent_Identity=32.0588235294118, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI21357207, Length=334, Percent_Identity=29.3413173652695, Blast_Score=135, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_LEPIC (Q72Q12)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_002236.1
- ProteinModelPortal:   Q72Q12
- MEROPS:   M22.001
- GeneID:   2772480
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC12302
- HOGENOM:   HBG304663
- OMA:   PAVGVHH
- ProtClustDB:   PRK09604
- BioCyc:   LINT267671:LIC_12302-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_01445
- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017861
- PANTHER:   PTHR11735
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03723
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22

EC number: =3.4.24.57

Molecular weight: Translated: 37520; Mature: 37520

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGMGIETSCDETSIGIVRDGKDLLSLKIFSQIDLHKPYGGIVPEIASRAHLEKINLLLE
CCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
EAMEESEIQFKDLSYVAVTSSPGLTGSLMVGAQMARCIHMVYETPILPVCHLQSHFAVLH
HHHHHCCCEEECCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEE
LEGVPTEFPVLGLLLSGGNSAIYILHEFGKMELLGDTMDDALGEAFDKVAGLLELPYPGG
ECCCCCCCCEEEEEEECCCCEEEEEEECCCEEEECCHHHHHHHHHHHHHHHEEECCCCCC
PHIEVRAKEYKPSPNEKPILPALLRNLPQEEVSFSFSGLKTAVMVLLEKQKELSKERICW
CEEEEEECCCCCCCCCCCCHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCEE
NFQNSAFDLVERNLKRAVSKTGIKRIFAAGGVLANFTLQNRLYTWAEKNSVELFAPKKKI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEECCCEEEEECCCCEEEEECCCEE
YCTDNGAMVASLGYYLFQKGYQRDIDFTVSPSRQEIFS
EECCCCCHHHHHHHHHHHCCCCCCCCEEECCCHHHHCC
>Mature Secondary Structure
MIGMGIETSCDETSIGIVRDGKDLLSLKIFSQIDLHKPYGGIVPEIASRAHLEKINLLLE
CCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
EAMEESEIQFKDLSYVAVTSSPGLTGSLMVGAQMARCIHMVYETPILPVCHLQSHFAVLH
HHHHHCCCEEECCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEE
LEGVPTEFPVLGLLLSGGNSAIYILHEFGKMELLGDTMDDALGEAFDKVAGLLELPYPGG
ECCCCCCCCEEEEEEECCCCEEEEEEECCCEEEECCHHHHHHHHHHHHHHHEEECCCCCC
PHIEVRAKEYKPSPNEKPILPALLRNLPQEEVSFSFSGLKTAVMVLLEKQKELSKERICW
CEEEEEECCCCCCCCCCCCHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCEE
NFQNSAFDLVERNLKRAVSKTGIKRIFAAGGVLANFTLQNRLYTWAEKNSVELFAPKKKI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEECCCEEEEECCCCEEEEECCCEE
YCTDNGAMVASLGYYLFQKGYQRDIDFTVSPSRQEIFS
EECCCCCHHHHHHHHHHHCCCCCCCCEEECCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA