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The map label for this gene is serA [H]

Identifier: 45658002

GI number: 45658002

Start: 2603811

End: 2604809

Strand: Reverse

Name: serA [H]

Synonym: LIC12153

Alternate gene names: 45658002

Gene position: 2604809-2603811 (Counterclockwise)

Preceding gene: 45658003

Following gene: 45658001

Centisome position: 60.9

GC content: 39.74

Gene sequence:

>999_bases
ATGAAATTTTACAAAATATTTATATCCACGTATCCTTTTGGATATTATAACTCCGAACCAATGGAAATCTTGAATCAATC
AGGTTGGGAGATTGTTACCAATCCTTTAAAACGCAAGCTTACCCCCTTAGAGGTTTCAGAATTTGCAAAAGAGGTCGATG
GAATTATTGCAGGTACCGAAGATTTGACTCCTCTCATTCATAAAAATCGGAATTTAAAAATCATTTCGAGAGTCGGGATC
GGTTTAGATTCGGTTCCTTTAAATCTTTGCAAAGAAAGAGGTATCGCAGTGGCGTACACGCCAGATGCGGTGACCATGGC
CGTGGCGGAATTGACGATTGGTCTTATGATTTCTTCCACGCGAAAAGTATTTCTCGCTCATCAAGAATTGAAAACAGGGG
GTTGGTCCAGATTTACTGGAAAACGACTGGGTGAATCCACGATCGGTATTGTCGGTGTCGGAAGAGTCGGTTTGAACGTG
ATTCGAATTTTGTCGGAGTTTAGACCTAAGATGATTTTAATCAACGATCTTAAGGATAAAAAAAAGGAAGTTTCCGAAAT
CCTGGATTTTAAAAATGTTCCCTATCGATTCACGGAAAAGGAGGAGATTTATTCCTCTTCGGATATTGTTTCTTTACATA
TCCCTCTGTCCCACAAAACCAAAAACTTAATCGGAAAAAAAGAATTCGATCTTTTTCCTAAGGACTCCTTTCTGATCAAC
ACCGCGAGAGGTGGTATCGTAAATGAGAACGATTTATATGACGTTTTAAGATCCAATCGGATCGGGGGCGCGGCGATTGA
CGTTTTCGAACAGGAGCCATATAAAGGAAATCTAACAGAATTAGATAATATTATTCTTACTGAACATATGGGATCTTGTT
CTTACGACTGTAGACTTCTGATGGAAAAAGGTGCCGCCGAAGAAGTCACCCGTTTTTTTCGGGGGGAGTCTTTGCTTAAT
CCAGTTCCTGAAGAGGAATATCAAAATCAGATTGTCTAA

Upstream 100 bases:

>100_bases
TCTTTCCTAAAAAAGCACAAACTAAGCTCGCATATTTGGGTTTTCGCAAAAAAATGAGCTTATCGATCGAATTATCAAAA
TATTAGAATAATAAAATATT

Downstream 100 bases:

>100_bases
ATCCAACTTAAATCAAAAATCCATTTTAATTTGGGATCAAATTGGGCATCGTATCCCCGAATTTTCGGGCAGTGTTTATC
TTTGGAAAGAATACTCTGAA

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MKFYKIFISTYPFGYYNSEPMEILNQSGWEIVTNPLKRKLTPLEVSEFAKEVDGIIAGTEDLTPLIHKNRNLKIISRVGI
GLDSVPLNLCKERGIAVAYTPDAVTMAVAELTIGLMISSTRKVFLAHQELKTGGWSRFTGKRLGESTIGIVGVGRVGLNV
IRILSEFRPKMILINDLKDKKKEVSEILDFKNVPYRFTEKEEIYSSSDIVSLHIPLSHKTKNLIGKKEFDLFPKDSFLIN
TARGGIVNENDLYDVLRSNRIGGAAIDVFEQEPYKGNLTELDNIILTEHMGSCSYDCRLLMEKGAAEEVTRFFRGESLLN
PVPEEEYQNQIV

Sequences:

>Translated_332_residues
MKFYKIFISTYPFGYYNSEPMEILNQSGWEIVTNPLKRKLTPLEVSEFAKEVDGIIAGTEDLTPLIHKNRNLKIISRVGI
GLDSVPLNLCKERGIAVAYTPDAVTMAVAELTIGLMISSTRKVFLAHQELKTGGWSRFTGKRLGESTIGIVGVGRVGLNV
IRILSEFRPKMILINDLKDKKKEVSEILDFKNVPYRFTEKEEIYSSSDIVSLHIPLSHKTKNLIGKKEFDLFPKDSFLIN
TARGGIVNENDLYDVLRSNRIGGAAIDVFEQEPYKGNLTELDNIILTEHMGSCSYDCRLLMEKGAAEEVTRFFRGESLLN
PVPEEEYQNQIV
>Mature_332_residues
MKFYKIFISTYPFGYYNSEPMEILNQSGWEIVTNPLKRKLTPLEVSEFAKEVDGIIAGTEDLTPLIHKNRNLKIISRVGI
GLDSVPLNLCKERGIAVAYTPDAVTMAVAELTIGLMISSTRKVFLAHQELKTGGWSRFTGKRLGESTIGIVGVGRVGLNV
IRILSEFRPKMILINDLKDKKKEVSEILDFKNVPYRFTEKEEIYSSSDIVSLHIPLSHKTKNLIGKKEFDLFPKDSFLIN
TARGGIVNENDLYDVLRSNRIGGAAIDVFEQEPYKGNLTELDNIILTEHMGSCSYDCRLLMEKGAAEEVTRFFRGESLLN
PVPEEEYQNQIV

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=294, Percent_Identity=32.6530612244898, Blast_Score=151, Evalue=7e-37,
Organism=Homo sapiens, GI23308577, Length=302, Percent_Identity=30.1324503311258, Blast_Score=137, Evalue=9e-33,
Organism=Homo sapiens, GI145580578, Length=280, Percent_Identity=32.1428571428571, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI4557499, Length=280, Percent_Identity=32.1428571428571, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI145580575, Length=276, Percent_Identity=31.8840579710145, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI61743967, Length=278, Percent_Identity=30.9352517985612, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI4557497, Length=278, Percent_Identity=30.9352517985612, Blast_Score=109, Evalue=4e-24,
Organism=Escherichia coli, GI87082289, Length=296, Percent_Identity=27.3648648648649, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1789279, Length=253, Percent_Identity=33.201581027668, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1787645, Length=207, Percent_Identity=27.536231884058, Blast_Score=98, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17532191, Length=307, Percent_Identity=31.9218241042345, Blast_Score=138, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI25147481, Length=266, Percent_Identity=28.9473684210526, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324055, Length=271, Percent_Identity=28.7822878228782, Blast_Score=111, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6322116, Length=300, Percent_Identity=28, Blast_Score=111, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6320925, Length=300, Percent_Identity=27.6666666666667, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6324964, Length=314, Percent_Identity=25.1592356687898, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324980, Length=139, Percent_Identity=28.0575539568345, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24585514, Length=303, Percent_Identity=30.03300330033, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI28574282, Length=303, Percent_Identity=30.03300330033, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI28574284, Length=303, Percent_Identity=30.03300330033, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI45552429, Length=289, Percent_Identity=30.7958477508651, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI45551003, Length=289, Percent_Identity=30.7958477508651, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI28574286, Length=316, Percent_Identity=29.1139240506329, Blast_Score=134, Evalue=8e-32,
Organism=Drosophila melanogaster, GI28571528, Length=303, Percent_Identity=29.7029702970297, Blast_Score=124, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24585516, Length=259, Percent_Identity=28.5714285714286, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI19921140, Length=300, Percent_Identity=27.3333333333333, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24646446, Length=294, Percent_Identity=29.9319727891156, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24646448, Length=294, Percent_Identity=29.9319727891156, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24646452, Length=294, Percent_Identity=29.9319727891156, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24646450, Length=294, Percent_Identity=29.9319727891156, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI62472511, Length=279, Percent_Identity=30.1075268817204, Blast_Score=102, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 37443; Mature: 37443

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFYKIFISTYPFGYYNSEPMEILNQSGWEIVTNPLKRKLTPLEVSEFAKEVDGIIAGTE
CCEEEEEEECCCCCCCCCCHHHHHHCCCCCEECCHHHHCCCCCCHHHHHHHHHHEEECCH
DLTPLIHKNRNLKIISRVGIGLDSVPLNLCKERGIAVAYTPDAVTMAVAELTIGLMISST
HCCHHHHCCCCEEEEEECCCCCCCCCHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHCC
RKVFLAHQELKTGGWSRFTGKRLGESTIGIVGVGRVGLNVIRILSEFRPKMILINDLKDK
CEEEEEHHHHHCCCCCCCCHHHCCCCCEEEEEECHHHHHHHHHHHHCCCCEEEEECHHHH
KKEVSEILDFKNVPYRFTEKEEIYSSSDIVSLHIPLSHKTKNLIGKKEFDLFPKDSFLIN
HHHHHHHHHCCCCCCCCCCHHHHCCCCCEEEEEECCCCCHHHHCCCCCCCCCCCCCEEEE
TARGGIVNENDLYDVLRSNRIGGAAIDVFEQEPYKGNLTELDNIILTEHMGSCSYDCRLL
CCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHEECCCCCCCHHHHHH
MEKGAAEEVTRFFRGESLLNPVPEEEYQNQIV
HHCCCHHHHHHHHCCCHHCCCCCCHHHHCCCC
>Mature Secondary Structure
MKFYKIFISTYPFGYYNSEPMEILNQSGWEIVTNPLKRKLTPLEVSEFAKEVDGIIAGTE
CCEEEEEEECCCCCCCCCCHHHHHHCCCCCEECCHHHHCCCCCCHHHHHHHHHHEEECCH
DLTPLIHKNRNLKIISRVGIGLDSVPLNLCKERGIAVAYTPDAVTMAVAELTIGLMISST
HCCHHHHCCCCEEEEEECCCCCCCCCHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHCC
RKVFLAHQELKTGGWSRFTGKRLGESTIGIVGVGRVGLNVIRILSEFRPKMILINDLKDK
CEEEEEHHHHHCCCCCCCCHHHCCCCCEEEEEECHHHHHHHHHHHHCCCCEEEEECHHHH
KKEVSEILDFKNVPYRFTEKEEIYSSSDIVSLHIPLSHKTKNLIGKKEFDLFPKDSFLIN
HHHHHHHHHCCCCCCCCCCHHHHCCCCCEEEEEECCCCCHHHHCCCCCCCCCCCCCEEEE
TARGGIVNENDLYDVLRSNRIGGAAIDVFEQEPYKGNLTELDNIILTEHMGSCSYDCRLL
CCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHEECCCCCCCHHHHHH
MEKGAAEEVTRFFRGESLLNPVPEEEYQNQIV
HHCCCHHHHHHHHCCCHHCCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]