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The map label for this gene is aspS

Identifier: 45657956

GI number: 45657956

Start: 2549569

End: 2551374

Strand: Reverse

Name: aspS

Synonym: LIC12108

Alternate gene names: 45657956

Gene position: 2551374-2549569 (Counterclockwise)

Preceding gene: 45657957

Following gene: 45657955

Centisome position: 59.65

GC content: 38.32

Gene sequence:

>1806_bases
TTGAAACATTGGATTCAGGAAAATTATAAAAATCGTTCTTGGGCTGGAGAATTAAACGAATCTCAAGAAGGTAAACAGAT
CGTTCTTTTTGGCTGGTCTTTTCGTTTTAGAGATCAAGGTGGTGTGATCTTTATCGATCTTAGAGATAGAACCGGTATCA
TTCAAGTTGTGGCTCGTAAAGAACTTCTGGGAGATTCTTTCACTCTTGCAGAAAAGGTTCGTTCTGAATACGTTTTGGCG
GTCAGAGGTACTCTTAAAAAAAGAGATTTAGAATCTATCAATCCTAGAATGCAAACCGGGACGATCGAAGTGGTTCTGGA
TCAATTAGAGATTTTGAATGTTGCCAAAACTCCTCCGTTTTCTTTAGATGAGTTTGATGAAGTTTCCGAAGAATTAAAAT
TAAAATATCGTTATTTGGATTTTAGAAGAGAAGAACTTAAAAACCGGATGATCAAAAGACACGAGTTTATATTCGCAATT
CGTAATTATCTTAACAAACGTAAGTTTGTAGAAATAGAAACTCCTATCTTAAACAAGTCTACTCCAGAAGGTGCGAGGGA
TTTTTTAGTTCCTTCTAGACTCAATCCAAATCAATTTTATGCCCTTCCTCAGTCCCCTCAAATCTTTAAACAAATTTTAA
TGGTCGGAGGTATGGAACGTTATTTTCAGATCGTAAAGTGTTTTAGAGACGAGGATTTACGCGCGGATAGACAACCTGAG
TTTACTCAGTTAGATATGGAGTTTTCTTTTGTTAGCCAGGAAGAAATTCTTTCCGAAATTGAAGGACTTGTTGAGACGAT
TTATAAAGAAGTTTTTAATATTCAACTTTCCATTCCTTTTCCAAGAATGACTTATAATACCGCTATGGAAGAATACGGTT
CTGACAAGCCAGATCTTCGTTTTGGTATGAAACTCGTGGATGTTTCTGAAATTGTAAAAGATTGTGACTTCAATGTTTTT
GCTGGTGCCGTAAAAAACGGTGGAACCGTTAAGGTGGTTTGTGTCCCGGGTGGATCTATCATTTCTAGAAAAGAAATCGA
AGATTATACCGCGTGGTTAAACAGGGACTATAAAGCCAAGGGTCTTGCGTATATGAAACACGGAACCGAAGGTTTGGAAT
CCACCATTACAAAACGTTTTAAAAAAGAAGAATTAGAGGCCATCTCTAAGGCGTGTGGTTCTAAAGAAGGAGATATGCTT
TTTTTCGGGGCGGACGAAAGGGAGATCGTCAATCATTCATTAGGTGCTCTTCGTTTGAAACTTTCAGAACGTTTTGAAAC
TCCTAAAGAAAATGAAATCAACATCACTTGGATTGTGGATTTTCCTATGTTCGAATGGAATAAAGACCATAAACGTTGGG
ATGCACTTCATCATCCGTTTACTTCTCCTTCGGATGAGAGTATTCCATTTTTTGAATCTATGGAAACCTTACAAAAAAAC
GCAGGAAATGCCACGGCAAAAGCGTATGATCTTGTGATGAACGGAGTTGAAATCGGAGGTGGTTCGATTAGGATTCATTC
TAAAGAGATTCAAAACAAAGTGTTTCAGGTTTTGGGGATTAACGAAGAAGAAGCCAAAGAGAAATTTGGGTTTCTGCTGG
AAGCCCTCGAATTTGGTGCCCCACCTCACGGTGGTTTGGCGTTTGGTATCGATCGTATGTTGATGCTTCTCACCGGAGGA
AAATCAATTCGGGACGTGATCGCTTTTCCTAAAACTCAAAAAGGTCTTTGTCTGATGAGTGAATGTCCTTCTCCCGTTGA
AGAGAAACAACTTCAGGAATTGAAGATCAAACTCGCAAAGGTATAA

Upstream 100 bases:

>100_bases
CTGGTCCTATTGGTTCTTTTCATCTTGCTTTTAGGCCCGAGCTTAGCAGATTTGATAATATAGATTAATTTTATAAGTTT
TTGATAGGAAACAGAAATCA

Downstream 100 bases:

>100_bases
ACTTATTTCCACGCGCAAAGAACAGTTTAACTTCGAGAATCAGGATCTGTATCGTAAGGTCTGTGGTATCAACGACGAAG
GTGTCAAAATTCTCGAAAAA

Product: aspartyl-tRNA synthetase

Products: NA

Alternate protein names: Aspartate--tRNA ligase; AspRS

Number of amino acids: Translated: 601; Mature: 601

Protein sequence:

>601_residues
MKHWIQENYKNRSWAGELNESQEGKQIVLFGWSFRFRDQGGVIFIDLRDRTGIIQVVARKELLGDSFTLAEKVRSEYVLA
VRGTLKKRDLESINPRMQTGTIEVVLDQLEILNVAKTPPFSLDEFDEVSEELKLKYRYLDFRREELKNRMIKRHEFIFAI
RNYLNKRKFVEIETPILNKSTPEGARDFLVPSRLNPNQFYALPQSPQIFKQILMVGGMERYFQIVKCFRDEDLRADRQPE
FTQLDMEFSFVSQEEILSEIEGLVETIYKEVFNIQLSIPFPRMTYNTAMEEYGSDKPDLRFGMKLVDVSEIVKDCDFNVF
AGAVKNGGTVKVVCVPGGSIISRKEIEDYTAWLNRDYKAKGLAYMKHGTEGLESTITKRFKKEELEAISKACGSKEGDML
FFGADEREIVNHSLGALRLKLSERFETPKENEINITWIVDFPMFEWNKDHKRWDALHHPFTSPSDESIPFFESMETLQKN
AGNATAKAYDLVMNGVEIGGGSIRIHSKEIQNKVFQVLGINEEEAKEKFGFLLEALEFGAPPHGGLAFGIDRMLMLLTGG
KSIRDVIAFPKTQKGLCLMSECPSPVEEKQLQELKIKLAKV

Sequences:

>Translated_601_residues
MKHWIQENYKNRSWAGELNESQEGKQIVLFGWSFRFRDQGGVIFIDLRDRTGIIQVVARKELLGDSFTLAEKVRSEYVLA
VRGTLKKRDLESINPRMQTGTIEVVLDQLEILNVAKTPPFSLDEFDEVSEELKLKYRYLDFRREELKNRMIKRHEFIFAI
RNYLNKRKFVEIETPILNKSTPEGARDFLVPSRLNPNQFYALPQSPQIFKQILMVGGMERYFQIVKCFRDEDLRADRQPE
FTQLDMEFSFVSQEEILSEIEGLVETIYKEVFNIQLSIPFPRMTYNTAMEEYGSDKPDLRFGMKLVDVSEIVKDCDFNVF
AGAVKNGGTVKVVCVPGGSIISRKEIEDYTAWLNRDYKAKGLAYMKHGTEGLESTITKRFKKEELEAISKACGSKEGDML
FFGADEREIVNHSLGALRLKLSERFETPKENEINITWIVDFPMFEWNKDHKRWDALHHPFTSPSDESIPFFESMETLQKN
AGNATAKAYDLVMNGVEIGGGSIRIHSKEIQNKVFQVLGINEEEAKEKFGFLLEALEFGAPPHGGLAFGIDRMLMLLTGG
KSIRDVIAFPKTQKGLCLMSECPSPVEEKQLQELKIKLAKV
>Mature_601_residues
MKHWIQENYKNRSWAGELNESQEGKQIVLFGWSFRFRDQGGVIFIDLRDRTGIIQVVARKELLGDSFTLAEKVRSEYVLA
VRGTLKKRDLESINPRMQTGTIEVVLDQLEILNVAKTPPFSLDEFDEVSEELKLKYRYLDFRREELKNRMIKRHEFIFAI
RNYLNKRKFVEIETPILNKSTPEGARDFLVPSRLNPNQFYALPQSPQIFKQILMVGGMERYFQIVKCFRDEDLRADRQPE
FTQLDMEFSFVSQEEILSEIEGLVETIYKEVFNIQLSIPFPRMTYNTAMEEYGSDKPDLRFGMKLVDVSEIVKDCDFNVF
AGAVKNGGTVKVVCVPGGSIISRKEIEDYTAWLNRDYKAKGLAYMKHGTEGLESTITKRFKKEELEAISKACGSKEGDML
FFGADEREIVNHSLGALRLKLSERFETPKENEINITWIVDFPMFEWNKDHKRWDALHHPFTSPSDESIPFFESMETLQKN
AGNATAKAYDLVMNGVEIGGGSIRIHSKEIQNKVFQVLGINEEEAKEKFGFLLEALEFGAPPHGGLAFGIDRMLMLLTGG
KSIRDVIAFPKTQKGLCLMSECPSPVEEKQLQELKIKLAKV

Specific function: Unknown

COG id: COG0173

COG function: function code J; Aspartyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI40789249, Length=596, Percent_Identity=39.0939597315436, Blast_Score=414, Evalue=1e-115,
Organism=Homo sapiens, GI194272210, Length=240, Percent_Identity=25, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI5031815, Length=240, Percent_Identity=25, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1788173, Length=593, Percent_Identity=48.397976391231, Blast_Score=561, Evalue=1e-161,
Organism=Escherichia coli, GI1790571, Length=296, Percent_Identity=27.7027027027027, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1789256, Length=314, Percent_Identity=26.7515923566879, Blast_Score=82, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI32566633, Length=597, Percent_Identity=35.8458961474037, Blast_Score=324, Evalue=7e-89,
Organism=Caenorhabditis elegans, GI71994340, Length=309, Percent_Identity=23.3009708737864, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17535927, Length=309, Percent_Identity=23.3009708737864, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17535925, Length=309, Percent_Identity=23.3009708737864, Blast_Score=79, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6325153, Length=653, Percent_Identity=34.1500765696784, Blast_Score=298, Evalue=2e-81,
Organism=Saccharomyces cerevisiae, GI6320242, Length=176, Percent_Identity=26.7045454545455, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323011, Length=280, Percent_Identity=28.9285714285714, Blast_Score=74, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6321807, Length=254, Percent_Identity=25.9842519685039, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24584738, Length=585, Percent_Identity=37.4358974358974, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24640849, Length=260, Percent_Identity=24.2307692307692, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI19921528, Length=251, Percent_Identity=26.6932270916335, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24640851, Length=260, Percent_Identity=24.2307692307692, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: 1320 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYD_LEPIC (Q72QK5)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_002042.1
- ProteinModelPortal:   Q72QK5
- SMR:   Q72QK5
- GeneID:   2772327
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC12108
- NMPDR:   fig|267671.1.peg.2042
- HOGENOM:   HBG396032
- OMA:   AFPKTQQ
- ProtClustDB:   PRK00476
- BioCyc:   LINT267671:LIC_12108-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00044_B
- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR020564
- InterPro:   IPR004524
- InterPro:   IPR018153
- InterPro:   IPR002312
- InterPro:   IPR004115
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365
- Gene3D:   G3DSA:3.30.1360.30
- Gene3D:   G3DSA:2.40.50.140
- PANTHER:   PTHR22594
- PANTHER:   PTHR22594:SF5
- PRINTS:   PR01042
- TIGRFAMs:   TIGR00459

Pfam domain/function: PF02938 GAD; PF00152 tRNA-synt_2; PF01336 tRNA_anti; SSF50249 Nucleic_acid_OB

EC number: =6.1.1.12

Molecular weight: Translated: 69083; Mature: 69083

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHWIQENYKNRSWAGELNESQEGKQIVLFGWSFRFRDQGGVIFIDLRDRTGIIQVVARK
CCCCHHHCCCCCCCCCCCCCCCCCCEEEEEEEEEEEECCCCEEEEEECCCCCHHHHHHHH
ELLGDSFTLAEKVRSEYVLAVRGTLKKRDLESINPRMQTGTIEVVLDQLEILNVAKTPPF
HHHCCCHHHHHHHHHHEEEEEECCHHHCCHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCC
SLDEFDEVSEELKLKYRYLDFRREELKNRMIKRHEFIFAIRNYLNKRKFVEIETPILNKS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCC
TPEGARDFLVPSRLNPNQFYALPQSPQIFKQILMVGGMERYFQIVKCFRDEDLRADRQPE
CCCCHHHCCCCCCCCCCCEEECCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCC
FTQLDMEFSFVSQEEILSEIEGLVETIYKEVFNIQLSIPFPRMTYNTAMEEYGSDKPDLR
CEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHCCCCCCHH
FGMKLVDVSEIVKDCDFNVFAGAVKNGGTVKVVCVPGGSIISRKEIEDYTAWLNRDYKAK
HCCCCCCHHHHHHHCCCCEEEHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCC
GLAYMKHGTEGLESTITKRFKKEELEAISKACGSKEGDMLFFGADEREIVNHSLGALRLK
CEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHCCHHHEEEE
LSERFETPKENEINITWIVDFPMFEWNKDHKRWDALHHPFTSPSDESIPFFESMETLQKN
HHHHCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHC
AGNATAKAYDLVMNGVEIGGGSIRIHSKEIQNKVFQVLGINEEEAKEKFGFLLEALEFGA
CCCCHHHHHHHHHCCEEECCCEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
PPHGGLAFGIDRMLMLLTGGKSIRDVIAFPKTQKGLCLMSECPSPVEEKQLQELKIKLAK
CCCCCHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHCC
V
C
>Mature Secondary Structure
MKHWIQENYKNRSWAGELNESQEGKQIVLFGWSFRFRDQGGVIFIDLRDRTGIIQVVARK
CCCCHHHCCCCCCCCCCCCCCCCCCEEEEEEEEEEEECCCCEEEEEECCCCCHHHHHHHH
ELLGDSFTLAEKVRSEYVLAVRGTLKKRDLESINPRMQTGTIEVVLDQLEILNVAKTPPF
HHHCCCHHHHHHHHHHEEEEEECCHHHCCHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCC
SLDEFDEVSEELKLKYRYLDFRREELKNRMIKRHEFIFAIRNYLNKRKFVEIETPILNKS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCC
TPEGARDFLVPSRLNPNQFYALPQSPQIFKQILMVGGMERYFQIVKCFRDEDLRADRQPE
CCCCHHHCCCCCCCCCCCEEECCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCC
FTQLDMEFSFVSQEEILSEIEGLVETIYKEVFNIQLSIPFPRMTYNTAMEEYGSDKPDLR
CEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHCCCCCCHH
FGMKLVDVSEIVKDCDFNVFAGAVKNGGTVKVVCVPGGSIISRKEIEDYTAWLNRDYKAK
HCCCCCCHHHHHHHCCCCEEEHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCC
GLAYMKHGTEGLESTITKRFKKEELEAISKACGSKEGDMLFFGADEREIVNHSLGALRLK
CEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHCCHHHEEEE
LSERFETPKENEINITWIVDFPMFEWNKDHKRWDALHHPFTSPSDESIPFFESMETLQKN
HHHHCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHC
AGNATAKAYDLVMNGVEIGGGSIRIHSKEIQNKVFQVLGINEEEAKEKFGFLLEALEFGA
CCCCHHHHHHHHHCCEEECCCEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
PPHGGLAFGIDRMLMLLTGGKSIRDVIAFPKTQKGLCLMSECPSPVEEKQLQELKIKLAK
CCCCCHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHCC
V
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA