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The map label for this gene is cysK

Identifier: 45657930

GI number: 45657930

Start: 2521078

End: 2522007

Strand: Reverse

Name: cysK

Synonym: LIC12082

Alternate gene names: 45657930

Gene position: 2522007-2521078 (Counterclockwise)

Preceding gene: 45657931

Following gene: 45657929

Centisome position: 58.96

GC content: 40.86

Gene sequence:

>930_bases
ATGAAAGCTAAGAACATTTTAGAAACGATCGGAAATACACCTCATGTAAAAATTAACCGTTTGTTTAATACGAAAAGCGA
GGTTTATGCAAAATTAGAAAGATCCAATCCAGGCGGGTCCATTAAGGATCGCATTGCACTTTCCATGATCGAAGACGCGG
AAAAAACAGGTAAACTTACTAAAGACAGCATCATTGTAGAACCTACTTCTGGAAATACTGGAATTGGTTTAGCACTCGTT
GCAGCGGTTAAAGGTTATAAGTTACTTTTAGTTATGCCTGAATCTATGAGTATCGAGAGAAGAAGAATTATGGCGGCGTA
CGGAGCGGAGTTTGAACTGACTCCAAGAGAAAAAGGAATGCCGGGGGCGATCGAAAAGGCAAAACAAATTGTCGCAGAAA
ATCCAAAAGCGTGGATGCCTCAACAATTTGAAAACGAAGCAAATATTAAGATTCACGTAGAAACAACCGCTCAAGAGATT
GCAAAAGATTTTCCAGATGGGCTGGACTACGTAATTACAGGTGTCGGCACTGGGGGACATATCACGGGTGTGGCGCAGGT
CCTAAAACAAAAATTTCCTAAATTGAAAGTGTTTGCCGTGGAACCAGAAGCATCTCCAGTAATCTCCGGAGGAAAACCGG
GACCACATCCGATTCAAGGAATTGGTGCGGGATTTATTCCTAAAAATTTACATACAAATCTTTTAGACGGAACTATACAA
ATTAGTAAAGACGAAGCGTTTGAGTATGCACAAAGAGCGGCAAAAGAAGAAGGACTTTTTATAGGAGTTTCATCCGGAGC
GGCACTTGCAGCGGTTGCAAAAAAATTGCCTGAAATTCCGGAAGGTTCAAGAATATTAACTTTTTCTTATGACACTGGAG
AAAGGTATCTTTCTATCGAAGGGCTTTTCCCTGTTCCATCTAACGCATAA

Upstream 100 bases:

>100_bases
AAAAGGTTTTTTTCTTGAATTCATTTGTTATATTGAAATAAATGTCTAATATAACAACATAGAAACCAAAAGAACGCTTG
TAAAAGGCAGGAAAACAGAA

Downstream 100 bases:

>100_bases
CAGATTTTTTAGATCTAAATTTTCTTTATTGGAAACCTCGGAGTATATAATTCCGGGGTTTCTTTTTTTCATTTGAATTT
ATAGATATAACTTAGTCTTT

Product: cysteine synthase

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MKAKNILETIGNTPHVKINRLFNTKSEVYAKLERSNPGGSIKDRIALSMIEDAEKTGKLTKDSIIVEPTSGNTGIGLALV
AAVKGYKLLLVMPESMSIERRRIMAAYGAEFELTPREKGMPGAIEKAKQIVAENPKAWMPQQFENEANIKIHVETTAQEI
AKDFPDGLDYVITGVGTGGHITGVAQVLKQKFPKLKVFAVEPEASPVISGGKPGPHPIQGIGAGFIPKNLHTNLLDGTIQ
ISKDEAFEYAQRAAKEEGLFIGVSSGAALAAVAKKLPEIPEGSRILTFSYDTGERYLSIEGLFPVPSNA

Sequences:

>Translated_309_residues
MKAKNILETIGNTPHVKINRLFNTKSEVYAKLERSNPGGSIKDRIALSMIEDAEKTGKLTKDSIIVEPTSGNTGIGLALV
AAVKGYKLLLVMPESMSIERRRIMAAYGAEFELTPREKGMPGAIEKAKQIVAENPKAWMPQQFENEANIKIHVETTAQEI
AKDFPDGLDYVITGVGTGGHITGVAQVLKQKFPKLKVFAVEPEASPVISGGKPGPHPIQGIGAGFIPKNLHTNLLDGTIQ
ISKDEAFEYAQRAAKEEGLFIGVSSGAALAAVAKKLPEIPEGSRILTFSYDTGERYLSIEGLFPVPSNA
>Mature_309_residues
MKAKNILETIGNTPHVKINRLFNTKSEVYAKLERSNPGGSIKDRIALSMIEDAEKTGKLTKDSIIVEPTSGNTGIGLALV
AAVKGYKLLLVMPESMSIERRRIMAAYGAEFELTPREKGMPGAIEKAKQIVAENPKAWMPQQFENEANIKIHVETTAQEI
AKDFPDGLDYVITGVGTGGHITGVAQVLKQKFPKLKVFAVEPEASPVISGGKPGPHPIQGIGAGFIPKNLHTNLLDGTIQ
ISKDEAFEYAQRAAKEEGLFIGVSSGAALAAVAKKLPEIPEGSRILTFSYDTGERYLSIEGLFPVPSNA

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=305, Percent_Identity=40, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI295821200, Length=305, Percent_Identity=40, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI4557415, Length=305, Percent_Identity=40, Blast_Score=217, Evalue=1e-56,
Organism=Escherichia coli, GI1788754, Length=300, Percent_Identity=50.6666666666667, Blast_Score=233, Evalue=1e-62,
Organism=Escherichia coli, GI2367138, Length=300, Percent_Identity=39, Blast_Score=193, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17535051, Length=295, Percent_Identity=43.728813559322, Blast_Score=227, Evalue=6e-60,
Organism=Caenorhabditis elegans, GI115535073, Length=299, Percent_Identity=47.8260869565217, Blast_Score=223, Evalue=8e-59,
Organism=Caenorhabditis elegans, GI17562970, Length=297, Percent_Identity=42.0875420875421, Blast_Score=221, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI32566674, Length=294, Percent_Identity=42.5170068027211, Blast_Score=221, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI17561720, Length=297, Percent_Identity=41.7508417508418, Blast_Score=194, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI17534315, Length=312, Percent_Identity=38.4615384615385, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI32566672, Length=211, Percent_Identity=41.2322274881517, Blast_Score=154, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI25147552, Length=277, Percent_Identity=38.6281588447653, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17561716, Length=117, Percent_Identity=38.4615384615385, Blast_Score=71, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6321594, Length=314, Percent_Identity=36.3057324840764, Blast_Score=189, Evalue=5e-49,
Organism=Saccharomyces cerevisiae, GI6321449, Length=328, Percent_Identity=35.0609756097561, Blast_Score=140, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24643623, Length=308, Percent_Identity=36.038961038961, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI20129101, Length=308, Percent_Identity=36.038961038961, Blast_Score=173, Evalue=1e-43,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 33249; Mature: 33249

Theoretical pI: Translated: 8.70; Mature: 8.70

Prosite motif: PS00901 CYS_SYNTHASE ; PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAKNILETIGNTPHVKINRLFNTKSEVYAKLERSNPGGSIKDRIALSMIEDAEKTGKLT
CCHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCC
KDSIIVEPTSGNTGIGLALVAAVKGYKLLLVMPESMSIERRRIMAAYGAEFELTPREKGM
CCCEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHCCCEEECCCCCCC
PGAIEKAKQIVAENPKAWMPQQFENEANIKIHVETTAQEIAKDFPDGLDYVITGVGTGGH
CHHHHHHHHHHHCCCCCCCCHHHCCCCCEEEEEECHHHHHHHHCCCCCEEEEEECCCCCH
ITGVAQVLKQKFPKLKVFAVEPEASPVISGGKPGPHPIQGIGAGFIPKNLHTNLLDGTIQ
HHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
ISKDEAFEYAQRAAKEEGLFIGVSSGAALAAVAKKLPEIPEGSRILTFSYDTGERYLSIE
ECHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHCCCCCCCCEEEEEEECCCCEEEEEE
GLFPVPSNA
EECCCCCCC
>Mature Secondary Structure
MKAKNILETIGNTPHVKINRLFNTKSEVYAKLERSNPGGSIKDRIALSMIEDAEKTGKLT
CCHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCC
KDSIIVEPTSGNTGIGLALVAAVKGYKLLLVMPESMSIERRRIMAAYGAEFELTPREKGM
CCCEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHCCCEEECCCCCCC
PGAIEKAKQIVAENPKAWMPQQFENEANIKIHVETTAQEIAKDFPDGLDYVITGVGTGGH
CHHHHHHHHHHHCCCCCCCCHHHCCCCCEEEEEECHHHHHHHHCCCCCEEEEEECCCCCH
ITGVAQVLKQKFPKLKVFAVEPEASPVISGGKPGPHPIQGIGAGFIPKNLHTNLLDGTIQ
HHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
ISKDEAFEYAQRAAKEEGLFIGVSSGAALAAVAKKLPEIPEGSRILTFSYDTGERYLSIE
ECHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHCCCCCCCCEEEEEEECCCCEEEEEE
GLFPVPSNA
EECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8867384 [H]