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The map label for this gene is sdhA

Identifier: 45657855

GI number: 45657855

Start: 2411697

End: 2413610

Strand: Direct

Name: sdhA

Synonym: LIC12002

Alternate gene names: 45657855

Gene position: 2411697-2413610 (Clockwise)

Preceding gene: 45657854

Following gene: 45657856

Centisome position: 56.39

GC content: 43.57

Gene sequence:

>1914_bases
ATGAGTTTAGATTCTAAAATTCCAAACGGCTCGATTGATAAAAAATGGTCCAATCACAAGGCTAATATTAAGTTAGTCAA
TCCGGCTAACAAAAGAAAATTCAATATCATCGTGGTAGGTTCCGGTCTTGCAGGGGCTTCCGCATCGGCAACGTTAGCCG
AACTAGGTTATAACGTTAAAACATTCTGTTTTCAAGACAGCCCTCGTCGTGCTCACAGTATCGCGGCTCAGGGTGGGATT
AACGCAGCTAAAAATTATCAAAATGACGGAGATTCCGTCTATCGTCTGTTCTACGACACTGTAAAAGGTGGAGACTTTCG
CGCAAGAGAAGCGAATGTTCACCGTTTGGCGGAAGTTTCGGTGAACATCATCGATCAGTGTGTGGCACAAGGTGTTCCAT
TTGCAAGAGAATATGGTGGGCATCTTTCTAACCGTTCTTTTGGCGGAGCTCAGGTTTCCAGAACCTTTTATGCAAAAGGT
CAAACAGGACAACAGCTTTTACTAGGAGCCTATTCCGCTCTTTCTCGTCAAATTGGCCTAGGTTCTGTAAAGATGTATCC
TAGAACCGAGATGGTGGAATTGATCGTAGTAGACGGTCACGCGAAAGGAATCGTGGTTCGAGATCTTGTAACCGGAAAAC
TTTCCACTCATATGGCGGACGCAGTAGTTCTCGGAACCGGAGGATATGGAAACGTATTCTTTCTTTCTACAAACGCAAAA
GGTTGTAATGTAACTGCTACCTGGAAGGCTCACAAAAAAGGGGCATTCTTTGCTAACCCTTGTTATACGCAAATTCATCC
TACATGTATTCCTGTTTCGGGAGATCATCAATCTAAACTGACTCTGATGTCCGAATCTCTCCGTAACGACGGTAGGATTT
GGGTTCCGAAAAACAAAGGGGATAAACGAAATCCAGCAGACATTCCTGAATCGGAAAGAGACTATTATCTCGAAAGAAAA
TATCCAAGCTACGGAAACCTTTCTCCACGTGATATCGCATCTCGCGCGGCCAAAGAAGCCTGCGACGCAGGGTTAGGCGT
GGGAGAATCCGGTCAGGGTGTATATTTAGATTTTGCAGACTCGATCAAACGTCTGGGAGAACCTAAAATTCGAGACCGTT
ACGAAAACCTATTCCAAATGTATGAACAAATCACAGGAGAAAATCCATACAAACAACCGATGAGAATTTATCCTGCGGTT
CATTACACAATGGGAGGTCTTTGGGTAGATTATAATTTAATGAGTAACCTACCTGGTTTATTTGTAATTGGAGAAGCGAA
CTTCTCCGATCATGGTGCTAACCGACTTGGAGCTTCGGCTCTAATGCAAGGTCTTGCAGATGGATATTTTATTCTTCCTT
ACACGATCGGAAACTATCTCGCAGGAGTTGGATTTAATTCTCATCCGAAAGAAGATCATCCAGAAGCGAAGAAAGCGCTG
AACGACGCGGAAGAAACCACAAAAAAACTTCTCTCCATCAAAGGAAAAAGAACCGTAGATTCTTTCCATAGACAACTCGG
CAAACTAATGTGGGATAAATGCGGAATGGCTCGCAATGATAAAGGACTCAAAGAAGCATTATCCGAAATTCCTAAAATTC
GTGAAGAATTCTGGCAAAACGTAAACGTCCCAGGAAGTGGAACAGAGCTCAACCAATCTCTTGAAAAAGCGGGAAGAGTG
GCAGATTTCTTGGAGTTTGGAGAGCTTCTCTGCCTCGACGCTCTTACAAGAGAAGAATCCTGTGGAGGTCATTTCCGAGA
AGAATACCAGGAAGAAGGAGAAGCAAAACGCAACGACGATAAGTTCTGTCATGCCACAGCTTGGGAATTTAACGGAGTCG
GTAAAAAGCCAACCGAACACAGAGAAAAATTGGAGTTCGAAAACGTTCACCTCGCCACAAGGAGTTATAAATAA

Upstream 100 bases:

>100_bases
AGCGATTTTATTCGCGCTTTTGATCTTTATAGGCAATACTTCTATCCCACTTTCGATTTTGCTGGGATACGTTCATCCGT
AATTCTTTGGAGAAACTTTT

Downstream 100 bases:

>100_bases
TGGATCTGAAACTCAAAGTCTGGAGACAAAAAAGCGGAGAAACCAAGGGAAAAATCGTAGATTACAACGCGAAAGATATT
TCCCCCAATATGTCGTTCTT

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 637; Mature: 636

Protein sequence:

>637_residues
MSLDSKIPNGSIDKKWSNHKANIKLVNPANKRKFNIIVVGSGLAGASASATLAELGYNVKTFCFQDSPRRAHSIAAQGGI
NAAKNYQNDGDSVYRLFYDTVKGGDFRAREANVHRLAEVSVNIIDQCVAQGVPFAREYGGHLSNRSFGGAQVSRTFYAKG
QTGQQLLLGAYSALSRQIGLGSVKMYPRTEMVELIVVDGHAKGIVVRDLVTGKLSTHMADAVVLGTGGYGNVFFLSTNAK
GCNVTATWKAHKKGAFFANPCYTQIHPTCIPVSGDHQSKLTLMSESLRNDGRIWVPKNKGDKRNPADIPESERDYYLERK
YPSYGNLSPRDIASRAAKEACDAGLGVGESGQGVYLDFADSIKRLGEPKIRDRYENLFQMYEQITGENPYKQPMRIYPAV
HYTMGGLWVDYNLMSNLPGLFVIGEANFSDHGANRLGASALMQGLADGYFILPYTIGNYLAGVGFNSHPKEDHPEAKKAL
NDAEETTKKLLSIKGKRTVDSFHRQLGKLMWDKCGMARNDKGLKEALSEIPKIREEFWQNVNVPGSGTELNQSLEKAGRV
ADFLEFGELLCLDALTREESCGGHFREEYQEEGEAKRNDDKFCHATAWEFNGVGKKPTEHREKLEFENVHLATRSYK

Sequences:

>Translated_637_residues
MSLDSKIPNGSIDKKWSNHKANIKLVNPANKRKFNIIVVGSGLAGASASATLAELGYNVKTFCFQDSPRRAHSIAAQGGI
NAAKNYQNDGDSVYRLFYDTVKGGDFRAREANVHRLAEVSVNIIDQCVAQGVPFAREYGGHLSNRSFGGAQVSRTFYAKG
QTGQQLLLGAYSALSRQIGLGSVKMYPRTEMVELIVVDGHAKGIVVRDLVTGKLSTHMADAVVLGTGGYGNVFFLSTNAK
GCNVTATWKAHKKGAFFANPCYTQIHPTCIPVSGDHQSKLTLMSESLRNDGRIWVPKNKGDKRNPADIPESERDYYLERK
YPSYGNLSPRDIASRAAKEACDAGLGVGESGQGVYLDFADSIKRLGEPKIRDRYENLFQMYEQITGENPYKQPMRIYPAV
HYTMGGLWVDYNLMSNLPGLFVIGEANFSDHGANRLGASALMQGLADGYFILPYTIGNYLAGVGFNSHPKEDHPEAKKAL
NDAEETTKKLLSIKGKRTVDSFHRQLGKLMWDKCGMARNDKGLKEALSEIPKIREEFWQNVNVPGSGTELNQSLEKAGRV
ADFLEFGELLCLDALTREESCGGHFREEYQEEGEAKRNDDKFCHATAWEFNGVGKKPTEHREKLEFENVHLATRSYK
>Mature_636_residues
SLDSKIPNGSIDKKWSNHKANIKLVNPANKRKFNIIVVGSGLAGASASATLAELGYNVKTFCFQDSPRRAHSIAAQGGIN
AAKNYQNDGDSVYRLFYDTVKGGDFRAREANVHRLAEVSVNIIDQCVAQGVPFAREYGGHLSNRSFGGAQVSRTFYAKGQ
TGQQLLLGAYSALSRQIGLGSVKMYPRTEMVELIVVDGHAKGIVVRDLVTGKLSTHMADAVVLGTGGYGNVFFLSTNAKG
CNVTATWKAHKKGAFFANPCYTQIHPTCIPVSGDHQSKLTLMSESLRNDGRIWVPKNKGDKRNPADIPESERDYYLERKY
PSYGNLSPRDIASRAAKEACDAGLGVGESGQGVYLDFADSIKRLGEPKIRDRYENLFQMYEQITGENPYKQPMRIYPAVH
YTMGGLWVDYNLMSNLPGLFVIGEANFSDHGANRLGASALMQGLADGYFILPYTIGNYLAGVGFNSHPKEDHPEAKKALN
DAEETTKKLLSIKGKRTVDSFHRQLGKLMWDKCGMARNDKGLKEALSEIPKIREEFWQNVNVPGSGTELNQSLEKAGRVA
DFLEFGELLCLDALTREESCGGHFREEYQEEGEAKRNDDKFCHATAWEFNGVGKKPTEHREKLEFENVHLATRSYK

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=561, Percent_Identity=26.0249554367201, Blast_Score=151, Evalue=2e-36,
Organism=Escherichia coli, GI1790597, Length=571, Percent_Identity=28.1961471103327, Blast_Score=196, Evalue=6e-51,
Organism=Escherichia coli, GI1788928, Length=591, Percent_Identity=25.5499153976311, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1786942, Length=603, Percent_Identity=25.2072968490879, Blast_Score=120, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17550100, Length=543, Percent_Identity=28.5451197053407, Blast_Score=173, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17505833, Length=546, Percent_Identity=28.5714285714286, Blast_Score=172, Evalue=5e-43,
Organism=Saccharomyces cerevisiae, GI6322701, Length=600, Percent_Identity=27.1666666666667, Blast_Score=180, Evalue=6e-46,
Organism=Saccharomyces cerevisiae, GI6322416, Length=620, Percent_Identity=26.7741935483871, Blast_Score=174, Evalue=3e-44,
Organism=Drosophila melanogaster, GI17137288, Length=651, Percent_Identity=26.7281105990783, Blast_Score=169, Evalue=5e-42,
Organism=Drosophila melanogaster, GI24655642, Length=651, Percent_Identity=26.7281105990783, Blast_Score=169, Evalue=5e-42,
Organism=Drosophila melanogaster, GI24655647, Length=651, Percent_Identity=26.7281105990783, Blast_Score=169, Evalue=5e-42,
Organism=Drosophila melanogaster, GI24663005, Length=578, Percent_Identity=25.6055363321799, Blast_Score=154, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011280 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 70443; Mature: 70312

Theoretical pI: Translated: 8.60; Mature: 8.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLDSKIPNGSIDKKWSNHKANIKLVNPANKRKFNIIVVGSGLAGASASATLAELGYNVK
CCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCEEEEEEEECCCCCCCCHHHHHHHCCCEE
TFCFQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRLFYDTVKGGDFRAREANVHRLAEVS
EEEECCCCHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
VNIIDQCVAQGVPFAREYGGHLSNRSFGGAQVSRTFYAKGQTGQQLLLGAYSALSRQIGL
HHHHHHHHHCCCCHHHHHCCCCCCCCCCCCHHEEEEEECCCCCHHHHHHHHHHHHHHCCC
GSVKMYPRTEMVELIVVDGHAKGIVVRDLVTGKLSTHMADAVVLGTGGYGNVFFLSTNAK
CCEEECCCCCEEEEEEECCCCCCEEEEHHHHHHHHHHHCCEEEEECCCCCCEEEEECCCC
GCNVTATWKAHKKGAFFANPCYTQIHPTCIPVSGDHQSKLTLMSESLRNDGRIWVPKNKG
CCEEEEEECCCCCCCEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCEEEEECCCC
DKRNPADIPESERDYYLERKYPSYGNLSPRDIASRAAKEACDAGLGVGESGQGVYLDFAD
CCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHH
SIKRLGEPKIRDRYENLFQMYEQITGENPYKQPMRIYPAVHYTMGGLWVDYNLMSNLPGL
HHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCEEECCCEEEEEEHHHCCCCE
FVIGEANFSDHGANRLGASALMQGLADGYFILPYTIGNYLAGVGFNSHPKEDHPEAKKAL
EEEECCCCCCCCCHHHHHHHHHHHHCCCEEEEEEHHHHHHHCCCCCCCCCCCCCHHHHHH
NDAEETTKKLLSIKGKRTVDSFHRQLGKLMWDKCGMARNDKGLKEALSEIPKIREEFWQN
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHC
VNVPGSGTELNQSLEKAGRVADFLEFGELLCLDALTREESCGGHFREEYQEEGEAKRNDD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCC
KFCHATAWEFNGVGKKPTEHREKLEFENVHLATRSYK
CEEEEEEEECCCCCCCCHHHHHHCCCCCEEEEECCCC
>Mature Secondary Structure 
SLDSKIPNGSIDKKWSNHKANIKLVNPANKRKFNIIVVGSGLAGASASATLAELGYNVK
CCCCCCCCCCCCCCCCCCCCCEEEECCCCCCEEEEEEEECCCCCCCCHHHHHHHCCCEE
TFCFQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRLFYDTVKGGDFRAREANVHRLAEVS
EEEECCCCHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
VNIIDQCVAQGVPFAREYGGHLSNRSFGGAQVSRTFYAKGQTGQQLLLGAYSALSRQIGL
HHHHHHHHHCCCCHHHHHCCCCCCCCCCCCHHEEEEEECCCCCHHHHHHHHHHHHHHCCC
GSVKMYPRTEMVELIVVDGHAKGIVVRDLVTGKLSTHMADAVVLGTGGYGNVFFLSTNAK
CCEEECCCCCEEEEEEECCCCCCEEEEHHHHHHHHHHHCCEEEEECCCCCCEEEEECCCC
GCNVTATWKAHKKGAFFANPCYTQIHPTCIPVSGDHQSKLTLMSESLRNDGRIWVPKNKG
CCEEEEEECCCCCCCEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCEEEEECCCC
DKRNPADIPESERDYYLERKYPSYGNLSPRDIASRAAKEACDAGLGVGESGQGVYLDFAD
CCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHH
SIKRLGEPKIRDRYENLFQMYEQITGENPYKQPMRIYPAVHYTMGGLWVDYNLMSNLPGL
HHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCEEECCCEEEEEEHHHCCCCE
FVIGEANFSDHGANRLGASALMQGLADGYFILPYTIGNYLAGVGFNSHPKEDHPEAKKAL
EEEECCCCCCCCCHHHHHHHHHHHHCCCEEEEEEHHHHHHHCCCCCCCCCCCCCHHHHHH
NDAEETTKKLLSIKGKRTVDSFHRQLGKLMWDKCGMARNDKGLKEALSEIPKIREEFWQN
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHC
VNVPGSGTELNQSLEKAGRVADFLEFGELLCLDALTREESCGGHFREEYQEEGEAKRNDD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCC
KFCHATAWEFNGVGKKPTEHREKLEFENVHLATRSYK
CEEEEEEEECCCCCCCCHHHHHHCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3027051; 8969504; 9384377; 3086287; 3021212 [H]