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The map label for this gene is lysS

Identifier: 45657773

GI number: 45657773

Start: 2309760

End: 2311247

Strand: Direct

Name: lysS

Synonym: LIC11913

Alternate gene names: 45657773

Gene position: 2309760-2311247 (Clockwise)

Preceding gene: 45657772

Following gene: 45657776

Centisome position: 54.0

GC content: 38.37

Gene sequence:

>1488_bases
ATGTCAGAATCAAATGAACTCATTGAACAAAGAATTCAGAAAATCGAAGAATTAAAAAAACAGGGAATCAATCCCTACCC
GGTTCGTTTTTTCCCGGATTCCAAATCGAAAGACATAGCCGAAAAGTTCGAAAAAAATCCGACTGGTCCAGAAACCAAAT
TTAAGTTAGGCGGAAGACTACATTCCAAAAGAGTAATGGGGAAAGCGAGTTTTGCTCATCTCAAAGACAACTCCGGAATC
ATACAACTTTATGCTACTAAAGACGATTTAGGTGAAACTCAATACTCCATTTTTAAATCCCTTGATTTGGGAGATATTAT
CGGTTTGGAAGGATATCTTTTTAAAACCCAAAAAGGAGAGATTACGTTACACGTCACATCGGTGGAACTGCTCTCAAAAT
GTATCCGCCCTCTTCCCGTAGTAAAAGAAAAAGACGGGGTTGTCTACGATGCGTTTGCCGACGTAGAACAAAGATATAGA
ATGCGTTATGTGGACTTAATAGTAAACGATCACGTTAGAGATACATTTATTACAAGAAGTAAAATCGTTTCTGAAATTAG
AAGTTTTCTGACTCAAGAAGGATTTTTAGAAGTGGAAACACCTATGATGCAACCGATTGCGGGAGGTGCTGCTGCAAGAC
CGTTTGTCACTCATCATAATACTCTGGATATGCAATTATTTCTAAGAATCGCTCCAGAACTTTATCTCAAACGTTTGATC
GTTGGCGGAATGGATCGAGTTTTTGAACTCAACCGAAATTTTAGAAACGAAGGAATCTCTACAAAACACAATCCTGAATT
TACGATGATGGAAGCTTATATGGCATTTGGAGATATGAGTACGATGCTCGATCTTACGGAAAGACTCATTACTCACCTGG
CCCAAAAAATTTGTGGAACTTTAAAAATTCAATACGGCAAGGATTTAATCGATCTTTCTCCTCCTTGGAAAAGAACTACT
TATGTGGATATTATCAAAGAATACAGTGGAATTGATTTTAGTCAGATTATTTCTCTGGAAGAAGCCAAGAAAAAAGCTTC
GGAATTAAAAGTAGACGTTTCCAAATGCCAAACAATTTGGAAAGTAGCGGATGAAGTTTTTTCCGAAAAAGCAGAACCAA
ATCTGATTCAACCGATCTTTATCACCGATTATCCGAAAGAACTTTCTCCTCTTGCAAAATCTAACCCAGATAAACCTGGT
TATGTGGAAAGATTCGAACCATACGTAGCCGGAAGAGAAATCGGAAACGCCTTTACCGAGTTAAATGATCCTTTTGATCA
AAAAGAAAGATTTGAAGATCAGGTAAAACAAAGAGAGGCTGGAGACGACGAAGCGTTTATGATGGACGAGGATTACATAC
GAGCTTTGGAATATGGAATGCCTCCTACCGGCGGGCTCGGAATTGGAATCGATCGTCTGGTAATGCTTTTGACGAATTCT
CATTCGATTCGAGATACCATTTTATTTCCGTTGATGAGACCAGAATAA

Upstream 100 bases:

>100_bases
GTATCGGAAATTGGTTTTTAAGTGAAGAAGGATTTGAAATTATATTTTTAAATTTAGCCAGAACCTTTTATCAAATACTC
CCAGGAAAATAAAATCGAAA

Downstream 100 bases:

>100_bases
AATTAGAATTGTTGAAAAATTTCATAGTGGGATTGCCAAAACTACCTCAATTTTCCATTTCAATACAATAAAAACAGATG
GAGAATTAATTTTTCAATAA

Product: lysyl-tRNA synthetase

Products: NA

Alternate protein names: Lysine--tRNA ligase; LysRS [H]

Number of amino acids: Translated: 495; Mature: 494

Protein sequence:

>495_residues
MSESNELIEQRIQKIEELKKQGINPYPVRFFPDSKSKDIAEKFEKNPTGPETKFKLGGRLHSKRVMGKASFAHLKDNSGI
IQLYATKDDLGETQYSIFKSLDLGDIIGLEGYLFKTQKGEITLHVTSVELLSKCIRPLPVVKEKDGVVYDAFADVEQRYR
MRYVDLIVNDHVRDTFITRSKIVSEIRSFLTQEGFLEVETPMMQPIAGGAAARPFVTHHNTLDMQLFLRIAPELYLKRLI
VGGMDRVFELNRNFRNEGISTKHNPEFTMMEAYMAFGDMSTMLDLTERLITHLAQKICGTLKIQYGKDLIDLSPPWKRTT
YVDIIKEYSGIDFSQIISLEEAKKKASELKVDVSKCQTIWKVADEVFSEKAEPNLIQPIFITDYPKELSPLAKSNPDKPG
YVERFEPYVAGREIGNAFTELNDPFDQKERFEDQVKQREAGDDEAFMMDEDYIRALEYGMPPTGGLGIGIDRLVMLLTNS
HSIRDTILFPLMRPE

Sequences:

>Translated_495_residues
MSESNELIEQRIQKIEELKKQGINPYPVRFFPDSKSKDIAEKFEKNPTGPETKFKLGGRLHSKRVMGKASFAHLKDNSGI
IQLYATKDDLGETQYSIFKSLDLGDIIGLEGYLFKTQKGEITLHVTSVELLSKCIRPLPVVKEKDGVVYDAFADVEQRYR
MRYVDLIVNDHVRDTFITRSKIVSEIRSFLTQEGFLEVETPMMQPIAGGAAARPFVTHHNTLDMQLFLRIAPELYLKRLI
VGGMDRVFELNRNFRNEGISTKHNPEFTMMEAYMAFGDMSTMLDLTERLITHLAQKICGTLKIQYGKDLIDLSPPWKRTT
YVDIIKEYSGIDFSQIISLEEAKKKASELKVDVSKCQTIWKVADEVFSEKAEPNLIQPIFITDYPKELSPLAKSNPDKPG
YVERFEPYVAGREIGNAFTELNDPFDQKERFEDQVKQREAGDDEAFMMDEDYIRALEYGMPPTGGLGIGIDRLVMLLTNS
HSIRDTILFPLMRPE
>Mature_494_residues
SESNELIEQRIQKIEELKKQGINPYPVRFFPDSKSKDIAEKFEKNPTGPETKFKLGGRLHSKRVMGKASFAHLKDNSGII
QLYATKDDLGETQYSIFKSLDLGDIIGLEGYLFKTQKGEITLHVTSVELLSKCIRPLPVVKEKDGVVYDAFADVEQRYRM
RYVDLIVNDHVRDTFITRSKIVSEIRSFLTQEGFLEVETPMMQPIAGGAAARPFVTHHNTLDMQLFLRIAPELYLKRLIV
GGMDRVFELNRNFRNEGISTKHNPEFTMMEAYMAFGDMSTMLDLTERLITHLAQKICGTLKIQYGKDLIDLSPPWKRTTY
VDIIKEYSGIDFSQIISLEEAKKKASELKVDVSKCQTIWKVADEVFSEKAEPNLIQPIFITDYPKELSPLAKSNPDKPGY
VERFEPYVAGREIGNAFTELNDPFDQKERFEDQVKQREAGDDEAFMMDEDYIRALEYGMPPTGGLGIGIDRLVMLLTNSH
SIRDTILFPLMRPE

Specific function: Also Can Synthesize A Number Of Adenyl Dinucleotides (In Particular Appppa). These Dinucleotides Have Been Proposed To Act As Modulators Of The Heat-Shock Response And Stress Response. [C]

COG id: COG1190

COG function: function code J; Lysyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI194272210, Length=510, Percent_Identity=42.3529411764706, Blast_Score=404, Evalue=1e-112,
Organism=Homo sapiens, GI5031815, Length=510, Percent_Identity=42.3529411764706, Blast_Score=404, Evalue=1e-112,
Organism=Homo sapiens, GI45439306, Length=459, Percent_Identity=22.8758169934641, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI40789249, Length=289, Percent_Identity=24.5674740484429, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI226491502, Length=469, Percent_Identity=22.8144989339019, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1790571, Length=497, Percent_Identity=51.307847082495, Blast_Score=519, Evalue=1e-148,
Organism=Escherichia coli, GI1789256, Length=497, Percent_Identity=51.5090543259557, Blast_Score=507, Evalue=1e-145,
Organism=Escherichia coli, GI87082379, Length=330, Percent_Identity=31.5151515151515, Blast_Score=154, Evalue=9e-39,
Organism=Escherichia coli, GI1788173, Length=288, Percent_Identity=24.6527777777778, Blast_Score=82, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17535925, Length=514, Percent_Identity=42.6070038910506, Blast_Score=392, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17535927, Length=514, Percent_Identity=42.6070038910506, Blast_Score=391, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI71994340, Length=505, Percent_Identity=42.970297029703, Blast_Score=388, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI32566633, Length=290, Percent_Identity=26.2068965517241, Blast_Score=85, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6320242, Length=518, Percent_Identity=43.4362934362934, Blast_Score=410, Evalue=1e-115,
Organism=Saccharomyces cerevisiae, GI6324256, Length=504, Percent_Identity=30.952380952381, Blast_Score=180, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6323011, Length=474, Percent_Identity=24.2616033755274, Blast_Score=87, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6325153, Length=248, Percent_Identity=26.2096774193548, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24640849, Length=512, Percent_Identity=42.96875, Blast_Score=405, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24640851, Length=512, Percent_Identity=42.96875, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI17136276, Length=452, Percent_Identity=21.9026548672566, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24584738, Length=271, Percent_Identity=26.1992619926199, Blast_Score=79, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR002313
- InterPro:   IPR018149
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365 [H]

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti [H]

EC number: =6.1.1.6 [H]

Molecular weight: Translated: 56628; Mature: 56497

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESNELIEQRIQKIEELKKQGINPYPVRFFPDSKSKDIAEKFEKNPTGPETKFKLGGRL
CCCHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHCCCCCCCCEEECCCCH
HSKRVMGKASFAHLKDNSGIIQLYATKDDLGETQYSIFKSLDLGDIIGLEGYLFKTQKGE
HHHHHHCCHHHHEECCCCCEEEEEECCCCCCHHHHHHHHHCCCHHEECCCCEEEEECCCE
ITLHVTSVELLSKCIRPLPVVKEKDGVVYDAFADVEQRYRMRYVDLIVNDHVRDTFITRS
EEEEEEHHHHHHHHCCCCCCEECCCCEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
KIVSEIRSFLTQEGFLEVETPMMQPIAGGAAARPFVTHHNTLDMQLFLRIAPELYLKRLI
HHHHHHHHHHHHCCCEEECCCHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHH
VGGMDRVFELNRNFRNEGISTKHNPEFTMMEAYMAFGDMSTMLDLTERLITHLAQKICGT
HCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKIQYGKDLIDLSPPWKRTTYVDIIKEYSGIDFSQIISLEEAKKKASELKVDVSKCQTIW
EEEECCCCEECCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KVADEVFSEKAEPNLIQPIFITDYPKELSPLAKSNPDKPGYVERFEPYVAGREIGNAFTE
HHHHHHHHCCCCCCCCCEEEEECCCHHHCHHHHCCCCCCCCHHHHCHHHHHHHHHHHHHH
LNDPFDQKERFEDQVKQREAGDDEAFMMDEDYIRALEYGMPPTGGLGIGIDRLVMLLTNS
CCCCHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCC
HSIRDTILFPLMRPE
CCHHHHHCCCCCCCC
>Mature Secondary Structure 
SESNELIEQRIQKIEELKKQGINPYPVRFFPDSKSKDIAEKFEKNPTGPETKFKLGGRL
CCHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHCCCCCCCCEEECCCCH
HSKRVMGKASFAHLKDNSGIIQLYATKDDLGETQYSIFKSLDLGDIIGLEGYLFKTQKGE
HHHHHHCCHHHHEECCCCCEEEEEECCCCCCHHHHHHHHHCCCHHEECCCCEEEEECCCE
ITLHVTSVELLSKCIRPLPVVKEKDGVVYDAFADVEQRYRMRYVDLIVNDHVRDTFITRS
EEEEEEHHHHHHHHCCCCCCEECCCCEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
KIVSEIRSFLTQEGFLEVETPMMQPIAGGAAARPFVTHHNTLDMQLFLRIAPELYLKRLI
HHHHHHHHHHHHCCCEEECCCHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHH
VGGMDRVFELNRNFRNEGISTKHNPEFTMMEAYMAFGDMSTMLDLTERLITHLAQKICGT
HCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKIQYGKDLIDLSPPWKRTTYVDIIKEYSGIDFSQIISLEEAKKKASELKVDVSKCQTIW
EEEECCCCEECCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KVADEVFSEKAEPNLIQPIFITDYPKELSPLAKSNPDKPGYVERFEPYVAGREIGNAFTE
HHHHHHHHCCCCCCCCCEEEEECCCHHHCHHHHCCCCCCCCHHHHCHHHHHHHHHHHHHH
LNDPFDQKERFEDQVKQREAGDDEAFMMDEDYIRALEYGMPPTGGLGIGIDRLVMLLTNS
CCCCHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCC
HSIRDTILFPLMRPE
CCHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA