| Definition | Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 chromosome chromosome I, complete sequence. |
|---|---|
| Accession | NC_005823 |
| Length | 4,277,185 |
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The map label for this gene is pbp2
Identifier: 45657604
GI number: 45657604
Start: 2116575
End: 2118704
Strand: Reverse
Name: pbp2
Synonym: LIC11738
Alternate gene names: 45657604
Gene position: 2118704-2116575 (Counterclockwise)
Preceding gene: 45657605
Following gene: 45657603
Centisome position: 49.54
GC content: 34.51
Gene sequence:
>2130_bases ATGATTCAAAGAACTTTTATTAAAATAAGAATTATGCCTAAAATGATACGATTGATTTTATGGTTATTGAGTATATTCTT ATATACAAATTTACTTTTTTCAGAAGAAGAAAAAAATACAGAAATTCCTTCTTATAAAGAAATTAGAAATTCGTACCGGC CATCCGACGGAGTAATTTTAGATCATCACGGAAGAATTTTACAAACCATACGATGGAATGTTAGAGAAAGAAAACTTTCT TGGACGGAAGAAGGAGAAATTCCAGAAACTTTTCTACTCGCCTTATTTTTACAAGAAGACAAACGTTTTTTTGAACATTC AGGAGTAGATCGGATTGCAATTTTAGGTTCTATTAAGGACCGACTTTTTGGAAATTCAAGACGGGGTGCAAGTACTCTTT CTATGCAACTCGCTGGAATTTTTTTAGGAACGAAACCGGGACAAAGAAACATTTTTGACAAATGGGAGCAAATGCGAACT GCTCAAAAAATAGAAAAAACCTGGACTAAAAATGAAATTCTTACCGCGTATTTGAACCTAACACAATTTAGAGGAGAACT GAGAGGGCTTAGAGCCGCGAGCCGTGGCCTCTTTCAAAAGGAACCTTCTACGTTAAGCGACACAGAGTCTATTCTATTAG TTGCAATGCTGCCCTATCCTGGAGCGAGTTATAAAGTACTAGCAAAACGAAGTTGTATTTTAGCAAAAAAAATCCAAAAA GAAGAACTCTGCGATTATTTTGAAAGTGTAGCAAAAAAAGCCACTTCCAAAATAAACAATTTACCTTCCACCGAAGGAAT TGCATATCACGTCGCACTGAAAATTTTCAGAGAAAATCCGGAAATTTTTTCTATAGACGGAAAAATTAAAACGACAATCG ATTTTGATCTTCAATGGAAAATTACAGAAATTGCAAAAAATAATTTATACGGATTAAAAAAACAAAACGTCTCAGAAACT GGAATTTTAGTTTTAGATAATATATCTGGGGCCGTCTTAGCTTATATAGGAAATTTAGAAGATAGTAACTCCTTTTATGT GGACGCGATCCAGTCAAAACGACAAGCAGGTTCTACTTTAAAACCTTTTTTATATGGACTTGCGTTTGAAAAAGAAATAT TAAAACCAAATTCTATTTTAGAAGACAGTCCTGCAGAATGGAATGCGGTTTCCGGAATTTATAAACCTTCAAATTATAGC GATACATATCATGGAAATGTACAGGCCAAATATGCTTTGGCATCCTCTTTGAATATACCAGCAATTCGAGTATTAGATCT TGTGAATGTTCCAGATTTTGTAGATAAATTAAAAGAACTAGGCTTAAATGGTCTAAAGAGAGCTGATTTTTACGGATCTT CTCTGGCTTTAGGGACCGCAGATGTTACTCTTTTTGAATTAACGAATGCCTATAGAACTCTTGCAAATGGGGGAATCAGT TCAAAACCAACCTTTTTTCCATTCGAAGCCAAACGTACAGTTCAAGAAAATTTTAAAGAAGGAAATTTTTGGAATCGGGT TTATACTAAAAAATCTGCAGACACGTTAAGCGAAATTTTATCTGATCGAGAATACCGCTCCTTATCTTTTGGATTAAACA ACTATCTTAGTACAAGATTTTTTACTGCGGTTAAAACTGGAACTTCTCAAGATATGAGAGACAATTGGTGTATAGGGTAT TCTAAAAAGTATACAGTAGGGGTTTGGGTAGGAAACATGAACGGCAAACCGATGTGGGACGTAAGTGGAGTTACCGGGGC CGCCCCAATTTGGAATACAGTCATCAATCTACTTCAAGAAAGAGAAGAACAGTCAAACAATCTAACTTTAAAGAATTCTT ATATTCCTCCAGCTCGTCAACTTACAGAATTGTCAAAGATTCCTAAAATTTTAATTCCTGGAAACGAAACCATTTATGCT CTCGATCCGGATATACCAGAAGGAAGACAGAAATTACATTTTTATGCTTCTCAATTTGATTCTGGATTTAAATGGATTTT AGACGGAAAGTCAATTCAAGAAGCAAAAGAAAAAGAAGTATTTTGGAAACCGGAAAAAGGATTTCACATACTTTCTTTAC AAGATCAAAACGGAAAAATCATAGACAGTGTCGTTTTTGAAGTGAGATAG
Upstream 100 bases:
>100_bases TGAGTATCATCAATTTTCATCAGAAAACATCACTTTGATAATAAATTTTAGATACTCTTCTATATGGTTCTTGAGCAAAT AGAGTTTTTAAAATTCAGAA
Downstream 100 bases:
>100_bases TTTTTATCTTGCAGCAAACCAGCTTCCGGTTAAAATCAATATTGGAATTCTTATGAAACTATCAACTGAAACGTATCTTT TATCTCCTGCATTAGAAGAG
Product: penicillin binding protein
Products: NA
Alternate protein names: PBP-1c; PBP1c; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Transpeptidase-like module [H]
Number of amino acids: Translated: 709; Mature: 709
Protein sequence:
>709_residues MIQRTFIKIRIMPKMIRLILWLLSIFLYTNLLFSEEEKNTEIPSYKEIRNSYRPSDGVILDHHGRILQTIRWNVRERKLS WTEEGEIPETFLLALFLQEDKRFFEHSGVDRIAILGSIKDRLFGNSRRGASTLSMQLAGIFLGTKPGQRNIFDKWEQMRT AQKIEKTWTKNEILTAYLNLTQFRGELRGLRAASRGLFQKEPSTLSDTESILLVAMLPYPGASYKVLAKRSCILAKKIQK EELCDYFESVAKKATSKINNLPSTEGIAYHVALKIFRENPEIFSIDGKIKTTIDFDLQWKITEIAKNNLYGLKKQNVSET GILVLDNISGAVLAYIGNLEDSNSFYVDAIQSKRQAGSTLKPFLYGLAFEKEILKPNSILEDSPAEWNAVSGIYKPSNYS DTYHGNVQAKYALASSLNIPAIRVLDLVNVPDFVDKLKELGLNGLKRADFYGSSLALGTADVTLFELTNAYRTLANGGIS SKPTFFPFEAKRTVQENFKEGNFWNRVYTKKSADTLSEILSDREYRSLSFGLNNYLSTRFFTAVKTGTSQDMRDNWCIGY SKKYTVGVWVGNMNGKPMWDVSGVTGAAPIWNTVINLLQEREEQSNNLTLKNSYIPPARQLTELSKIPKILIPGNETIYA LDPDIPEGRQKLHFYASQFDSGFKWILDGKSIQEAKEKEVFWKPEKGFHILSLQDQNGKIIDSVVFEVR
Sequences:
>Translated_709_residues MIQRTFIKIRIMPKMIRLILWLLSIFLYTNLLFSEEEKNTEIPSYKEIRNSYRPSDGVILDHHGRILQTIRWNVRERKLS WTEEGEIPETFLLALFLQEDKRFFEHSGVDRIAILGSIKDRLFGNSRRGASTLSMQLAGIFLGTKPGQRNIFDKWEQMRT AQKIEKTWTKNEILTAYLNLTQFRGELRGLRAASRGLFQKEPSTLSDTESILLVAMLPYPGASYKVLAKRSCILAKKIQK EELCDYFESVAKKATSKINNLPSTEGIAYHVALKIFRENPEIFSIDGKIKTTIDFDLQWKITEIAKNNLYGLKKQNVSET GILVLDNISGAVLAYIGNLEDSNSFYVDAIQSKRQAGSTLKPFLYGLAFEKEILKPNSILEDSPAEWNAVSGIYKPSNYS DTYHGNVQAKYALASSLNIPAIRVLDLVNVPDFVDKLKELGLNGLKRADFYGSSLALGTADVTLFELTNAYRTLANGGIS SKPTFFPFEAKRTVQENFKEGNFWNRVYTKKSADTLSEILSDREYRSLSFGLNNYLSTRFFTAVKTGTSQDMRDNWCIGY SKKYTVGVWVGNMNGKPMWDVSGVTGAAPIWNTVINLLQEREEQSNNLTLKNSYIPPARQLTELSKIPKILIPGNETIYA LDPDIPEGRQKLHFYASQFDSGFKWILDGKSIQEAKEKEVFWKPEKGFHILSLQDQNGKIIDSVVFEVR >Mature_709_residues MIQRTFIKIRIMPKMIRLILWLLSIFLYTNLLFSEEEKNTEIPSYKEIRNSYRPSDGVILDHHGRILQTIRWNVRERKLS WTEEGEIPETFLLALFLQEDKRFFEHSGVDRIAILGSIKDRLFGNSRRGASTLSMQLAGIFLGTKPGQRNIFDKWEQMRT AQKIEKTWTKNEILTAYLNLTQFRGELRGLRAASRGLFQKEPSTLSDTESILLVAMLPYPGASYKVLAKRSCILAKKIQK EELCDYFESVAKKATSKINNLPSTEGIAYHVALKIFRENPEIFSIDGKIKTTIDFDLQWKITEIAKNNLYGLKKQNVSET GILVLDNISGAVLAYIGNLEDSNSFYVDAIQSKRQAGSTLKPFLYGLAFEKEILKPNSILEDSPAEWNAVSGIYKPSNYS DTYHGNVQAKYALASSLNIPAIRVLDLVNVPDFVDKLKELGLNGLKRADFYGSSLALGTADVTLFELTNAYRTLANGGIS SKPTFFPFEAKRTVQENFKEGNFWNRVYTKKSADTLSEILSDREYRSLSFGLNNYLSTRFFTAVKTGTSQDMRDNWCIGY SKKYTVGVWVGNMNGKPMWDVSGVTGAAPIWNTVINLLQEREEQSNNLTLKNSYIPPARQLTELSKIPKILIPGNETIYA LDPDIPEGRQKLHFYASQFDSGFKWILDGKSIQEAKEKEVFWKPEKGFHILSLQDQNGKIIDSVVFEVR
Specific function: Cell wall formation. The enzyme has a penicillin- insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a transpeptidase C-terminal domain which may not be functional [H]
COG id: COG4953
COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein PbpC
Gene ontology:
Cell location: Cell inner membrane; Single-pass type II membrane protein [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the transpeptidase family [H]
Homologues:
Organism=Escherichia coli, GI1788867, Length=625, Percent_Identity=28, Blast_Score=193, Evalue=3e-50, Organism=Escherichia coli, GI1786343, Length=545, Percent_Identity=25.6880733944954, Blast_Score=108, Evalue=2e-24, Organism=Escherichia coli, GI87082258, Length=319, Percent_Identity=25.0783699059561, Blast_Score=82, Evalue=1e-16, Organism=Escherichia coli, GI1789601, Length=146, Percent_Identity=36.3013698630137, Blast_Score=72, Evalue=1e-13,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR012338 - InterPro: IPR001264 - InterPro: IPR011815 - InterPro: IPR009647 - InterPro: IPR001460 [H]
Pfam domain/function: PF06832 BiPBP_C; PF00912 Transgly; PF00905 Transpeptidase [H]
EC number: 2.4.2.-
Molecular weight: Translated: 80669; Mature: 80669
Theoretical pI: Translated: 9.52; Mature: 9.52
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.4 %Cys (Translated Protein) 1.3 %Met (Translated Protein) 1.7 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 1.3 %Met (Mature Protein) 1.7 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MIQRTFIKIRIMPKMIRLILWLLSIFLYTNLLFSEEEKNTEIPSYKEIRNSYRPSDGVIL CCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCEEE DHHGRILQTIRWNVRERKLSWTEEGEIPETFLLALFLQEDKRFFEHSGVDRIAILGSIKD CCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHH RLFGNSRRGASTLSMQLAGIFLGTKPGQRNIFDKWEQMRTAQKIEKTWTKNEILTAYLNL HHCCCCCCCCHHHHEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH TQFRGELRGLRAASRGLFQKEPSTLSDTESILLVAMLPYPGASYKVLAKRSCILAKKIQK HHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCCEEHHHHHHHHHHHHHHH EELCDYFESVAKKATSKINNLPSTEGIAYHVALKIFRENPEIFSIDGKIKTTIDFDLQWK HHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEECCCCCEEEECCEEEEEEEEEEEEE ITEIAKNNLYGLKKQNVSETGILVLDNISGAVLAYIGNLEDSNSFYVDAIQSKRQAGSTL EHHHHCCCCCCCCCCCCCCCCEEEEECCCCEEEEEECCCCCCCCEEEHHHHHHHHCCCCH KPFLYGLAFEKEILKPNSILEDSPAEWNAVSGIYKPSNYSDTYHGNVQAKYALASSLNIP HHHHHHHHHHHHHCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCC AIRVLDLVNVPDFVDKLKELGLNGLKRADFYGSSLALGTADVTLFELTNAYRTLANGGIS CEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCEEHHHHHHHHHHHHCCCCC SKPTFFPFEAKRTVQENFKEGNFWNRVYTKKSADTLSEILSDREYRSLSFGLNNYLSTRF CCCCCCCCHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHCCCCHHHHHHCHHHHHHHHH FTAVKTGTSQDMRDNWCIGYSKKYTVGVWVGNMNGKPMWDVSGVTGAAPIWNTVINLLQE HHHEECCCCCCCCCCEEECCCCEEEEEEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHH REEQSNNLTLKNSYIPPARQLTELSKIPKILIPGNETIYALDPDIPEGRQKLHFYASQFD HHHHCCCEEEECCCCCCHHHHHHHHHCCEEEECCCCEEEEECCCCCCCHHHHHHHHHHCC SGFKWILDGKSIQEAKEKEVFWKPEKGFHILSLQDQNGKIIDSVVFEVR CCCEEEECCCHHHHHHHCCCEECCCCCEEEEEEECCCCCEEEHHHEECC >Mature Secondary Structure MIQRTFIKIRIMPKMIRLILWLLSIFLYTNLLFSEEEKNTEIPSYKEIRNSYRPSDGVIL CCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCEEE DHHGRILQTIRWNVRERKLSWTEEGEIPETFLLALFLQEDKRFFEHSGVDRIAILGSIKD CCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHH RLFGNSRRGASTLSMQLAGIFLGTKPGQRNIFDKWEQMRTAQKIEKTWTKNEILTAYLNL HHCCCCCCCCHHHHEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH TQFRGELRGLRAASRGLFQKEPSTLSDTESILLVAMLPYPGASYKVLAKRSCILAKKIQK HHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCCEEHHHHHHHHHHHHHHH EELCDYFESVAKKATSKINNLPSTEGIAYHVALKIFRENPEIFSIDGKIKTTIDFDLQWK HHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEECCCCCEEEECCEEEEEEEEEEEEE ITEIAKNNLYGLKKQNVSETGILVLDNISGAVLAYIGNLEDSNSFYVDAIQSKRQAGSTL EHHHHCCCCCCCCCCCCCCCCEEEEECCCCEEEEEECCCCCCCCEEEHHHHHHHHCCCCH KPFLYGLAFEKEILKPNSILEDSPAEWNAVSGIYKPSNYSDTYHGNVQAKYALASSLNIP HHHHHHHHHHHHHCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCC AIRVLDLVNVPDFVDKLKELGLNGLKRADFYGSSLALGTADVTLFELTNAYRTLANGGIS CEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCEEHHHHHHHHHHHHCCCCC SKPTFFPFEAKRTVQENFKEGNFWNRVYTKKSADTLSEILSDREYRSLSFGLNNYLSTRF CCCCCCCCHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHCCCCHHHHHHCHHHHHHHHH FTAVKTGTSQDMRDNWCIGYSKKYTVGVWVGNMNGKPMWDVSGVTGAAPIWNTVINLLQE HHHEECCCCCCCCCCEEECCCCEEEEEEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHH REEQSNNLTLKNSYIPPARQLTELSKIPKILIPGNETIYALDPDIPEGRQKLHFYASQFD HHHHCCCEEEECCCCCCHHHHHHHHHCCEEEECCCCEEEEECCCCCCCHHHHHHHHHHCC SGFKWILDGKSIQEAKEKEVFWKPEKGFHILSLQDQNGKIIDSVVFEVR CCCEEEECCCHHHHHHHCCCEECCCCCEEEEEEECCCCCEEEHHHEECC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 10542235; 9205837; 9278503; 9841666 [H]