Click here to switch to the map view.

The map label for this gene is apbA

Identifier: 45657601

GI number: 45657601

Start: 2113252

End: 2114049

Strand: Direct

Name: apbA

Synonym: LIC11735

Alternate gene names: 45657601

Gene position: 2113252-2114049 (Clockwise)

Preceding gene: 45657600

Following gene: 45657609

Centisome position: 49.41

GC content: 33.96

Gene sequence:

>798_bases
TTGTTTCGAATTTTAGTTTTAGGTTCCGGTGCTATCGCCGGTCTATACGCCGGTAAACTTGTACAAGCGGGTTGTAAGGT
TGATTTTTGGGTTCGAAAAAATTCTTACGAATTAAAAAGAAATGGCTTTCAAATTGAAAGCGTTCCTTGGGGAAATTTTC
ATTATAAGGTAGAAAAGATTTTTGAAAGTATTCCCAAAAACTTAAAAGAATACGATCTGATTTTAAATTGTTTAAAATGT
CTTCCTGATATTAACCTGAAAAAAATTCTAGGGGAAAAAATCCCTCCGAATCTACCAATTTTACTTTTACAAAATGGAAT
TGGTATCGAAGAACCGGTTTCTATTCTTTATCCCGAAAATGAAATTTTAAGCGGACTTGCTTTTGTATGTGCCAATCGGC
TTGATGCTGGAAAAATTCTTCATTTAGATTATGGAGAATTGACGATTGGATCTTGGAACAGAAATCCTTCTTTTATCTGT
GATCAATTAGTAAATCTTTTTAATAGCGTGGGAGTTCCCACACAAAATACAAATACAATCCGTCAAGCTTGTTGGAAAAA
ACTGATGTGGAACGCGCCCTTCAATCCTATCAGTGTTCTTTGTGGCGGTAAAAATACTTTAGAAATTTTAGAAAACCCAC
ATAGTTGTAAACTCGTAATTGAAATTATGAAAGAGGTACAGACCCTTTCTAAATTAGACGGAGCGGAAGTTCCTTCAACT
CAGATAGATATTTTTTTACAGATGACAAAAACGATGAAACCTTATAAAACTAGTATGCTTTTAGATTTTGAAGCGTAG

Upstream 100 bases:

>100_bases
TCTTTGAATGACTATGACCGTGGAGTTTACGACGGTTACGTGCAAGCTATTACTGAAATTTTAAAAAAGATAGAAAGAAA
ATTTTCACAGGCGGGATGAT

Downstream 100 bases:

>100_bases
GCCTATGGAAATTGAAGCAATTCTTGGAAATACAATTCGGATTGCTGAAAAAAATAATTTAGAAATTCCGCATATTCAAA
CTATCAACTCTCTTTTGAAT

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 265; Mature: 265

Protein sequence:

>265_residues
MFRILVLGSGAIAGLYAGKLVQAGCKVDFWVRKNSYELKRNGFQIESVPWGNFHYKVEKIFESIPKNLKEYDLILNCLKC
LPDINLKKILGEKIPPNLPILLLQNGIGIEEPVSILYPENEILSGLAFVCANRLDAGKILHLDYGELTIGSWNRNPSFIC
DQLVNLFNSVGVPTQNTNTIRQACWKKLMWNAPFNPISVLCGGKNTLEILENPHSCKLVIEIMKEVQTLSKLDGAEVPST
QIDIFLQMTKTMKPYKTSMLLDFEA

Sequences:

>Translated_265_residues
MFRILVLGSGAIAGLYAGKLVQAGCKVDFWVRKNSYELKRNGFQIESVPWGNFHYKVEKIFESIPKNLKEYDLILNCLKC
LPDINLKKILGEKIPPNLPILLLQNGIGIEEPVSILYPENEILSGLAFVCANRLDAGKILHLDYGELTIGSWNRNPSFIC
DQLVNLFNSVGVPTQNTNTIRQACWKKLMWNAPFNPISVLCGGKNTLEILENPHSCKLVIEIMKEVQTLSKLDGAEVPST
QIDIFLQMTKTMKPYKTSMLLDFEA
>Mature_265_residues
MFRILVLGSGAIAGLYAGKLVQAGCKVDFWVRKNSYELKRNGFQIESVPWGNFHYKVEKIFESIPKNLKEYDLILNCLKC
LPDINLKKILGEKIPPNLPILLLQNGIGIEEPVSILYPENEILSGLAFVCANRLDAGKILHLDYGELTIGSWNRNPSFIC
DQLVNLFNSVGVPTQNTNTIRQACWKKLMWNAPFNPISVLCGGKNTLEILENPHSCKLVIEIMKEVQTLSKLDGAEVPST
QIDIFLQMTKTMKPYKTSMLLDFEA

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786627, Length=269, Percent_Identity=27.1375464684015, Blast_Score=70, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320057, Length=299, Percent_Identity=24.7491638795987, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 29816; Mature: 29816

Theoretical pI: Translated: 7.97; Mature: 7.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRILVLGSGAIAGLYAGKLVQAGCKVDFWVRKNSYELKRNGFQIESVPWGNFHYKVEKI
CEEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHCCEEEECCCCCCHHHHHHHH
FESIPKNLKEYDLILNCLKCLPDINLKKILGEKIPPNLPILLLQNGIGIEEPVSILYPEN
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCEEEEECCCCCCCCCEEECCCH
EILSGLAFVCANRLDAGKILHLDYGELTIGSWNRNPSFICDQLVNLFNSVGVPTQNTNTI
HHHHHHHHHHHCCCCCCCEEEEECCCEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCHHH
RQACWKKLMWNAPFNPISVLCGGKNTLEILENPHSCKLVIEIMKEVQTLSKLDGAEVPST
HHHHHHHHHCCCCCCCEEEEECCCCCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCH
QIDIFLQMTKTMKPYKTSMLLDFEA
HHHHHEEEHHCCCCCCCEEEEEECC
>Mature Secondary Structure
MFRILVLGSGAIAGLYAGKLVQAGCKVDFWVRKNSYELKRNGFQIESVPWGNFHYKVEKI
CEEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHCCEEEECCCCCCHHHHHHHH
FESIPKNLKEYDLILNCLKCLPDINLKKILGEKIPPNLPILLLQNGIGIEEPVSILYPEN
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCEEEEECCCCCCCCCEEECCCH
EILSGLAFVCANRLDAGKILHLDYGELTIGSWNRNPSFICDQLVNLFNSVGVPTQNTNTI
HHHHHHHHHHHCCCCCCCEEEEECCCEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCHHH
RQACWKKLMWNAPFNPISVLCGGKNTLEILENPHSCKLVIEIMKEVQTLSKLDGAEVPST
HHHHHHHHHCCCCCCCEEEEECCCCCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCH
QIDIFLQMTKTMKPYKTSMLLDFEA
HHHHHEEEHHCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]