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The map label for this gene is ubiB

Identifier: 45657281

GI number: 45657281

Start: 1725042

End: 1726370

Strand: Reverse

Name: ubiB

Synonym: LIC11404

Alternate gene names: 45657281

Gene position: 1726370-1725042 (Counterclockwise)

Preceding gene: 45657283

Following gene: 45657280

Centisome position: 40.36

GC content: 38.0

Gene sequence:

>1329_bases
TTGTATTTTGAATCTAAGCCCAAAATATTTGTGATTATGGCCGGTTTTTTTGATTCCTTGAAAATTGGTTTTGGCGGCGC
CTCTCGAATTCTAAACAGCAGTTTTGTATTCTCCACAAAAACCATTCTTCTTTTAAAAGATCTTGCATTGGGTGACGATA
CGTTTCCGATCCGACTTCGAGAGGCATTTGAAGAGTTAGGCGCCACCTATATCAAGTTAGGTCAATTGATTGCCTCCGCT
CCTTCTCTTTTTCCAGACAAGTTCGTTACCGAAATGCAAAAGTGTTTGGATCAGGTTCGTCCAATTCCCTATTCTATGAT
AACAACTATCATCCAAAAAGAATTAGGCGGAACACTCTCAGATCATTTCCTAAGTGTGGAGCCGATTCCGATCGCCTCTG
CGTCTATCGCACAAGTACATTCTGCGGTCACCAAAGACGGATTAGACGTAGTGATCAAAGTGCAAAGACCGGATATAGAA
TCTACGTTATCCGCCGATTTAAACCTAATCTACTTTGTTTCGGTTCTTTTTGAAAAATTTGCTCCTGGCCTAAGTAAGTC
CGGCATTGCGGACATGGTAGAACAATTCCAAACTTCTATATTAGAAGAAATTGATTTTTATAAAGAAGCAGATAATATAG
AAGAGTTCGAAAAAGAACTTCTTTCTATGGGAGAAACTAGAGCCAGAGTTCCCAAAGTTTACAGAGAATTATCTACGAAA
AAAATTCTTACTCTAGAACGTTTTTACGGAGCCCCGATCACAGATGAAAGTTCAGTCCGTAGATATTCTTCCGATCCTCA
AAAGACTCTGACAGGTGCTCTTGAAATCTGGTTTTCTACACTTTCTAGAAGTGGTTTTTTTCACGCAGATGTACATGCAG
GAAATTTAATGATTCTTAGAGACGGTACCGTTGGTTTTATAGACTTTGGTATCGTAGGTAGAATTTCTCCACGCGTTTGG
GAAGGTTTGATGATCTTTTTAGAAGGCCTTAGTTTAAATCGAACCGAAAAAATCGCTAAGGGTTTGATCCAGATGGATTC
TACGGCCAAAGGTGTGGACGAAAAAAAACTTTCAAAAGATTTAGAGATCGTCTTTTCTAAAATGACCGAAATGGTCTTAA
AGGTTCAGATGGGAGATTTAGAATCTTTGGACGATAAAAAATTAAACGCGATCCTTTTTGAGTTTCGAGAAATTTCAATT
CAAAACGGTTTAAAAATTCCAAAAGAATTCGGGCTTTTAATCAAACAAATTTTATATTTCGACAAATACGTAAAAACGAT
GGCTCCCGATATAGACCTGATCCGAGATCGTGATAAATTTCTAATATGA

Upstream 100 bases:

>100_bases
GCCATAATCAGAATTTGCTCTCGTTCGTAAACAAAAAAGCGGGTTTGACTCGCATACATTCGAGTGAATTCACCCATTTT
TTCAGACTTCTTTTCTGTAG

Downstream 100 bases:

>100_bases
TGTTAAACGAATTAGAAAAAGGGCAAGAAGCCCCTATCATCTTCTTACTTTCTAAACCGGGTAAAGAAGAACTATTCCGA
AACATTTTGGACATCGGCTT

Product: ubiquinone biosynthesis protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MYFESKPKIFVIMAGFFDSLKIGFGGASRILNSSFVFSTKTILLLKDLALGDDTFPIRLREAFEELGATYIKLGQLIASA
PSLFPDKFVTEMQKCLDQVRPIPYSMITTIIQKELGGTLSDHFLSVEPIPIASASIAQVHSAVTKDGLDVVIKVQRPDIE
STLSADLNLIYFVSVLFEKFAPGLSKSGIADMVEQFQTSILEEIDFYKEADNIEEFEKELLSMGETRARVPKVYRELSTK
KILTLERFYGAPITDESSVRRYSSDPQKTLTGALEIWFSTLSRSGFFHADVHAGNLMILRDGTVGFIDFGIVGRISPRVW
EGLMIFLEGLSLNRTEKIAKGLIQMDSTAKGVDEKKLSKDLEIVFSKMTEMVLKVQMGDLESLDDKKLNAILFEFREISI
QNGLKIPKEFGLLIKQILYFDKYVKTMAPDIDLIRDRDKFLI

Sequences:

>Translated_442_residues
MYFESKPKIFVIMAGFFDSLKIGFGGASRILNSSFVFSTKTILLLKDLALGDDTFPIRLREAFEELGATYIKLGQLIASA
PSLFPDKFVTEMQKCLDQVRPIPYSMITTIIQKELGGTLSDHFLSVEPIPIASASIAQVHSAVTKDGLDVVIKVQRPDIE
STLSADLNLIYFVSVLFEKFAPGLSKSGIADMVEQFQTSILEEIDFYKEADNIEEFEKELLSMGETRARVPKVYRELSTK
KILTLERFYGAPITDESSVRRYSSDPQKTLTGALEIWFSTLSRSGFFHADVHAGNLMILRDGTVGFIDFGIVGRISPRVW
EGLMIFLEGLSLNRTEKIAKGLIQMDSTAKGVDEKKLSKDLEIVFSKMTEMVLKVQMGDLESLDDKKLNAILFEFREISI
QNGLKIPKEFGLLIKQILYFDKYVKTMAPDIDLIRDRDKFLI
>Mature_442_residues
MYFESKPKIFVIMAGFFDSLKIGFGGASRILNSSFVFSTKTILLLKDLALGDDTFPIRLREAFEELGATYIKLGQLIASA
PSLFPDKFVTEMQKCLDQVRPIPYSMITTIIQKELGGTLSDHFLSVEPIPIASASIAQVHSAVTKDGLDVVIKVQRPDIE
STLSADLNLIYFVSVLFEKFAPGLSKSGIADMVEQFQTSILEEIDFYKEADNIEEFEKELLSMGETRARVPKVYRELSTK
KILTLERFYGAPITDESSVRRYSSDPQKTLTGALEIWFSTLSRSGFFHADVHAGNLMILRDGTVGFIDFGIVGRISPRVW
EGLMIFLEGLSLNRTEKIAKGLIQMDSTAKGVDEKKLSKDLEIVFSKMTEMVLKVQMGDLESLDDKKLNAILFEFREISI
QNGLKIPKEFGLLIKQILYFDKYVKTMAPDIDLIRDRDKFLI

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=319, Percent_Identity=24.4514106583072, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI41393593, Length=314, Percent_Identity=24.203821656051, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI217035081, Length=221, Percent_Identity=25.3393665158371, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI27363457, Length=188, Percent_Identity=27.6595744680851, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI217416386, Length=173, Percent_Identity=27.7456647398844, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI34147522, Length=188, Percent_Identity=28.1914893617021, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI2367309, Length=408, Percent_Identity=26.2254901960784, Blast_Score=143, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17559152, Length=258, Percent_Identity=24.8062015503876, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI32565180, Length=187, Percent_Identity=29.4117647058824, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323282, Length=264, Percent_Identity=29.1666666666667, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6321319, Length=209, Percent_Identity=26.7942583732057, Blast_Score=84, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6325148, Length=259, Percent_Identity=25.0965250965251, Blast_Score=73, Evalue=9e-14,
Organism=Drosophila melanogaster, GI22024280, Length=233, Percent_Identity=28.755364806867, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24662575, Length=317, Percent_Identity=24.6056782334385, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI18859849, Length=187, Percent_Identity=27.807486631016, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 49765; Mature: 49765

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYFESKPKIFVIMAGFFDSLKIGFGGASRILNSSFVFSTKTILLLKDLALGDDTFPIRLR
CCCCCCCCEEEEEECCHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHH
EAFEELGATYIKLGQLIASAPSLFPDKFVTEMQKCLDQVRPIPYSMITTIIQKELGGTLS
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHH
DHFLSVEPIPIASASIAQVHSAVTKDGLDVVIKVQRPDIESTLSADLNLIYFVSVLFEKF
HHCEECCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHCHHHHHHHHHHHHHH
APGLSKSGIADMVEQFQTSILEEIDFYKEADNIEEFEKELLSMGETRARVPKVYRELSTK
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHH
KILTLERFYGAPITDESSVRRYSSDPQKTLTGALEIWFSTLSRSGFFHADVHAGNLMILR
HHHHHHHHCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEE
DGTVGFIDFGIVGRISPRVWEGLMIFLEGLSLNRTEKIAKGLIQMDSTAKGVDEKKLSKD
CCCEEEEECCHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHH
LEIVFSKMTEMVLKVQMGDLESLDDKKLNAILFEFREISIQNGLKIPKEFGLLIKQILYF
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
DKYVKTMAPDIDLIRDRDKFLI
HHHHHHHCCCHHHHCCCCCCCC
>Mature Secondary Structure
MYFESKPKIFVIMAGFFDSLKIGFGGASRILNSSFVFSTKTILLLKDLALGDDTFPIRLR
CCCCCCCCEEEEEECCHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHH
EAFEELGATYIKLGQLIASAPSLFPDKFVTEMQKCLDQVRPIPYSMITTIIQKELGGTLS
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHH
DHFLSVEPIPIASASIAQVHSAVTKDGLDVVIKVQRPDIESTLSADLNLIYFVSVLFEKF
HHCEECCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHCHHHHHHHHHHHHHH
APGLSKSGIADMVEQFQTSILEEIDFYKEADNIEEFEKELLSMGETRARVPKVYRELSTK
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHH
KILTLERFYGAPITDESSVRRYSSDPQKTLTGALEIWFSTLSRSGFFHADVHAGNLMILR
HHHHHHHHCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEE
DGTVGFIDFGIVGRISPRVWEGLMIFLEGLSLNRTEKIAKGLIQMDSTAKGVDEKKLSKD
CCCEEEEECCHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHH
LEIVFSKMTEMVLKVQMGDLESLDDKKLNAILFEFREISIQNGLKIPKEFGLLIKQILYF
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
DKYVKTMAPDIDLIRDRDKFLI
HHHHHHHCCCHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]