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The map label for this gene is eif

Identifier: 45657059

GI number: 45657059

Start: 1444815

End: 1445909

Strand: Reverse

Name: eif

Synonym: LIC11175

Alternate gene names: 45657059

Gene position: 1445909-1444815 (Counterclockwise)

Preceding gene: 45657062

Following gene: 45657058

Centisome position: 33.81

GC content: 39.82

Gene sequence:

>1095_bases
ATGCAGGAATCAGGACTAAAACCAATTCTTTGGAAAAACAAAGAACTTATACTTTTAGATCAAAGAGTTCTTCCGGGGAC
TACTTCATACATCACGGCAAAAACCTTAGAAGATTGTATCTTTGCGATTCGAGAAATGGTCGTTAGGGGAGCCCCTGCAA
TTGCAATCACAGGAGCTTTTGGCATCACTCTGTATTGGAATAGTCTTGTTTCAAAACCGTCTTTTTCCGAACTCAAGTTA
AAACTTTCAGAACTTTTAGAATCCAGACCTACCGCAGTCAATCTAAGACTCGCCATTGAGGAATTTTCTTCCCGTTTTCC
AGAATCTAATTATTCTTCCTTTAGTTTGGAAGAGATACAAAAAGGTGCAGAAGAATTGGCGCTATTTATGCTCAGTGAAG
ATTTAGAAAACAATCTGACACTTTCTAAATACGCCCTTTCTCTTTTTCCAAAACAACCCTCTTCTTTGAACATAATCACC
CATTGTAATACGGGAGCCCTGGCTACTGCAGGACACGGAACCGCGTTAGGTGTTATACGATCTCTTAGAGACGCGGGACA
CTCTCTTACCGTTTTTGCAGACGAAACCAGACCTTACTTACAAGGAGCTCGCCTAACTGCTTGGGAATTACAAGAAGAAA
AAATTCAATCTTTTTTGATCACGGACAATATGGCCGGTTGGGTAATGTCTTCTAGAAAGATAGACGCCGTTATTGTAGGC
GCGGATAGAATCGCTTCTAACGGAGATACTGCCAATAAAATCGGAACCTATCCTTTAGCAATTGTAGCCAAACACCATGG
GGTTCCTTTTTACGTAGCTGCTACCGCCAAAAGTATGGATTTTAGAATTCCAAATGGTAGTTATATTCCGATTGAAATGA
GAAAGGAAGAAGAAATCACTTCATTCGGTTTTTTAAAAGACTCTGATGGAAAACCACTTTTAAAAGAAGGTGTGATCGCA
CCCAAAGGAATGAAAGCTCTCAATCCATCCTTTGACGTAACCCCAGCTTCTCTCATTACTGGTATCATCACAGAAAAAGG
AATTGTTTCTCCAGTTACGGAAGAAAATCTAAAGAAGATTTTTCAATCAATCTGA

Upstream 100 bases:

>100_bases
CCCGGGTTTCCACATTCTCCGGGAGAAGGAGAATGATTTTTCAATCACATTCTTTAAATCGAAAAATCGTGTCTCAACCT
TTAGAGTCGGAAAGAAAAAA

Downstream 100 bases:

>100_bases
GTTTTGTATTTACTCTTTTATAAAAATCCAGCAAATCGAACTTATGTTCCTCTGTAAAATTTCAGAATTTTACTGCAACA
AAAGACAATTTGATTTTTTA

Product: translation initiation factor

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MQESGLKPILWKNKELILLDQRVLPGTTSYITAKTLEDCIFAIREMVVRGAPAIAITGAFGITLYWNSLVSKPSFSELKL
KLSELLESRPTAVNLRLAIEEFSSRFPESNYSSFSLEEIQKGAEELALFMLSEDLENNLTLSKYALSLFPKQPSSLNIIT
HCNTGALATAGHGTALGVIRSLRDAGHSLTVFADETRPYLQGARLTAWELQEEKIQSFLITDNMAGWVMSSRKIDAVIVG
ADRIASNGDTANKIGTYPLAIVAKHHGVPFYVAATAKSMDFRIPNGSYIPIEMRKEEEITSFGFLKDSDGKPLLKEGVIA
PKGMKALNPSFDVTPASLITGIITEKGIVSPVTEENLKKIFQSI

Sequences:

>Translated_364_residues
MQESGLKPILWKNKELILLDQRVLPGTTSYITAKTLEDCIFAIREMVVRGAPAIAITGAFGITLYWNSLVSKPSFSELKL
KLSELLESRPTAVNLRLAIEEFSSRFPESNYSSFSLEEIQKGAEELALFMLSEDLENNLTLSKYALSLFPKQPSSLNIIT
HCNTGALATAGHGTALGVIRSLRDAGHSLTVFADETRPYLQGARLTAWELQEEKIQSFLITDNMAGWVMSSRKIDAVIVG
ADRIASNGDTANKIGTYPLAIVAKHHGVPFYVAATAKSMDFRIPNGSYIPIEMRKEEEITSFGFLKDSDGKPLLKEGVIA
PKGMKALNPSFDVTPASLITGIITEKGIVSPVTEENLKKIFQSI
>Mature_364_residues
MQESGLKPILWKNKELILLDQRVLPGTTSYITAKTLEDCIFAIREMVVRGAPAIAITGAFGITLYWNSLVSKPSFSELKL
KLSELLESRPTAVNLRLAIEEFSSRFPESNYSSFSLEEIQKGAEELALFMLSEDLENNLTLSKYALSLFPKQPSSLNIIT
HCNTGALATAGHGTALGVIRSLRDAGHSLTVFADETRPYLQGARLTAWELQEEKIQSFLITDNMAGWVMSSRKIDAVIVG
ADRIASNGDTANKIGTYPLAIVAKHHGVPFYVAATAKSMDFRIPNGSYIPIEMRKEEEITSFGFLKDSDGKPLLKEGVIA
PKGMKALNPSFDVTPASLITGIITEKGIVSPVTEENLKKIFQSI

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily

Homologues:

Organism=Homo sapiens, GI72534748, Length=356, Percent_Identity=42.4157303370786, Blast_Score=256, Evalue=3e-68,
Organism=Homo sapiens, GI23943880, Length=351, Percent_Identity=37.3219373219373, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17557462, Length=336, Percent_Identity=39.8809523809524, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17557123, Length=221, Percent_Identity=28.9592760180996, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6325375, Length=394, Percent_Identity=37.5634517766497, Blast_Score=210, Evalue=4e-55,
Organism=Drosophila melanogaster, GI21357667, Length=374, Percent_Identity=42.2459893048128, Blast_Score=276, Evalue=1e-74,
Organism=Drosophila melanogaster, GI24651647, Length=374, Percent_Identity=42.2459893048128, Blast_Score=276, Evalue=1e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNA_LEPIC (Q72T46)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_001145.1
- ProteinModelPortal:   Q72T46
- SMR:   Q72T46
- GeneID:   2771777
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC11175
- NMPDR:   fig|267671.1.peg.1145
- HOGENOM:   HBG682649
- OMA:   RPRNQGA
- ProtClustDB:   CLSK574624
- BioCyc:   LINT-130-01:LINT-130-01-001145-MONOMER
- BioCyc:   LINT267671:LIC_11175-MONOMER
- HAMAP:   MF_01678
- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559
- PANTHER:   PTHR10233
- TIGRFAMs:   TIGR00524
- TIGRFAMs:   TIGR00512

Pfam domain/function: PF01008 IF-2B

EC number: =5.3.1.23

Molecular weight: Translated: 39886; Mature: 39886

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: NA

Important sites: ACT_SITE 242-242 BINDING 89-89 BINDING 201-201

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQESGLKPILWKNKELILLDQRVLPGTTSYITAKTLEDCIFAIREMVVRGAPAIAITGAF
CCCCCCCCEEECCCCEEEEECCCCCCCCHHEEHHHHHHHHHHHHHHHHCCCCEEEEECCC
GITLYWNSLVSKPSFSELKLKLSELLESRPTAVNLRLAIEEFSSRFPESNYSSFSLEEIQ
EEEEEEHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEEEEHHHHHHCCCCCCCCCCHHHHH
KGAEELALFMLSEDLENNLTLSKYALSLFPKQPSSLNIITHCNTGALATAGHGTALGVIR
CCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCEEEEEECCCCCEEECCCCHHHHHHH
SLRDAGHSLTVFADETRPYLQGARLTAWELQEEKIQSFLITDNMAGWVMSSRKIDAVIVG
HHHHCCCEEEEEECCCCHHHCCCCEEEEHHHHHHHHHEEEECCCCHHEECCCCCCEEEEE
ADRIASNGDTANKIGTYPLAIVAKHHGVPFYVAATAKSMDFRIPNGSYIPIEMRKEEEIT
CHHHCCCCCCCHHCCCCEEEEEEECCCCCEEEEEECCCCEEECCCCCEEEEEECCCCCHH
SFGFLKDSDGKPLLKEGVIAPKGMKALNPSFDVTPASLITGIITEKGIVSPVTEENLKKI
HCCCEECCCCCCHHHHCCCCCCCCHHCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHH
FQSI
HHHC
>Mature Secondary Structure
MQESGLKPILWKNKELILLDQRVLPGTTSYITAKTLEDCIFAIREMVVRGAPAIAITGAF
CCCCCCCCEEECCCCEEEEECCCCCCCCHHEEHHHHHHHHHHHHHHHHCCCCEEEEECCC
GITLYWNSLVSKPSFSELKLKLSELLESRPTAVNLRLAIEEFSSRFPESNYSSFSLEEIQ
EEEEEEHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEEEEHHHHHHCCCCCCCCCCHHHHH
KGAEELALFMLSEDLENNLTLSKYALSLFPKQPSSLNIITHCNTGALATAGHGTALGVIR
CCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCEEEEEECCCCCEEECCCCHHHHHHH
SLRDAGHSLTVFADETRPYLQGARLTAWELQEEKIQSFLITDNMAGWVMSSRKIDAVIVG
HHHHCCCEEEEEECCCCHHHCCCCEEEEHHHHHHHHHEEEECCCCHHEECCCCCCEEEEE
ADRIASNGDTANKIGTYPLAIVAKHHGVPFYVAATAKSMDFRIPNGSYIPIEMRKEEEIT
CHHHCCCCCCCHHCCCCEEEEEEECCCCCEEEEEECCCCEEECCCCCEEEEEECCCCCHH
SFGFLKDSDGKPLLKEGVIAPKGMKALNPSFDVTPASLITGIITEKGIVSPVTEENLKKI
HCCCEECCCCCCHHHHCCCCCCCCHHCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHH
FQSI
HHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA