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The map label for this gene is dhaT [H]

Identifier: 45656954

GI number: 45656954

Start: 1322318

End: 1323484

Strand: Reverse

Name: dhaT [H]

Synonym: LIC11070

Alternate gene names: 45656954

Gene position: 1323484-1322318 (Counterclockwise)

Preceding gene: 45656955

Following gene: 45656952

Centisome position: 30.94

GC content: 38.05

Gene sequence:

>1167_bases
ATGCCGATACTCCCCGATTGGGTTCACTATACATTTCCTCCAAAAATCCACTTTGAAGCAGATTGTGGCTACAAAGTGGG
TAACTTCGTTAAAAACATAGGTTCTAGAACCGTCATCTTTTCCACACAACAAGAACTAGAAAACATGGACGAACTTTCCG
TCATCAAAACTAGTTTAGAAAAACATATCGATGGGGTCATCTTATATGACGACATCGCCAAAGAACCCTCCCCCGAAGAA
TTAGATACCGCCGCTTACTTTGCAAAAATCGCAAATGCAGATTGTATTATCGGCTACGGTTCTTATGAATCTATCAGTAT
GGCCAAGTTAATCGCTCTACTGATCACAAACGATATTTTTGCAGAAGACATGATTAACGACAGAAAGTTAAAACTAAAAA
AGCCAATTCCCTTAATTTTGATTCCTACTCATCCTATTTTCGGTTTAGAATGTTCTCCTATTTCTACAATTCTATTAGGG
GATGAAAAGATTACCAGATACTTCTCTCATGAACTTCTTTTTCCTGAACTGATCATAGCAGATCCTAAAATTTCTTCGTT
TATGAGTTCTATGGACATTTCCAAAGTAGGAGTGGGAATTTTGGCCGCCGCCGTAGATACAATTCTTTCTAAATTTTCCA
CAGAACTTACAATTTCTTCGGCGCTCCGTGCAATTGAACTTTTACAAAAGAACCTAATTCCATCCATTCGAGATCCTAAA
AACGTAAACTATAAAAATGGTTTATACGCAGCTAGTCTTTTGACAGGAATTGCACAGTCTTCCAGTTCGCTCGGGCTTTG
TTTTGCTCTTTCATTAGCGAGTTCGAATATTACAAATTTAGATATTTTTCAATCTATGTCCATTCTTCTTCCTCACGTGA
TGGAGTATAATTTAACTTCCTCCGCAGGTAAATACGTAATGATCGCTAGAGCCTTAGACGAGGACATCACCAATATTTCG
GTGATCGAAGCCGCAATTAAAGCTGTTGAAGGTATTCGTAAAATTTTTATCGAGCTAAAAATTCCTCAAAGACTTTCGGA
ATACGAAGTAAGAAAGATGGACCTCCCTTCGATCGCAAATCTTGCGGCTTCATTTCCTTTTTTAGACTCTCTCCCGAGAG
AACTTCCTAAAAACGAAATCGAAACAATTTTAATCGCTGCGTTCTAA

Upstream 100 bases:

>100_bases
TCAGAGACCATGTTGGGACAATAAAAACTGTACCACGAATAACTGATTTTTACCTCTATCTAAATTAGAAAATCGCTATG
GTCTCCGGGAGACGACAACG

Downstream 100 bases:

>100_bases
GGGTTTATACTTTCTTTTGAATTACTTCCAAACCGATTTTTGTTCACTAAGGCCCACATCGAAAAAACAAATATCATGAT
CCCGATACAGAATAAATACA

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: 1,3-propanediol oxidoreductase; 3-hydroxypropionaldehyde reductase [H]

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MPILPDWVHYTFPPKIHFEADCGYKVGNFVKNIGSRTVIFSTQQELENMDELSVIKTSLEKHIDGVILYDDIAKEPSPEE
LDTAAYFAKIANADCIIGYGSYESISMAKLIALLITNDIFAEDMINDRKLKLKKPIPLILIPTHPIFGLECSPISTILLG
DEKITRYFSHELLFPELIIADPKISSFMSSMDISKVGVGILAAAVDTILSKFSTELTISSALRAIELLQKNLIPSIRDPK
NVNYKNGLYAASLLTGIAQSSSSLGLCFALSLASSNITNLDIFQSMSILLPHVMEYNLTSSAGKYVMIARALDEDITNIS
VIEAAIKAVEGIRKIFIELKIPQRLSEYEVRKMDLPSIANLAASFPFLDSLPRELPKNEIETILIAAF

Sequences:

>Translated_388_residues
MPILPDWVHYTFPPKIHFEADCGYKVGNFVKNIGSRTVIFSTQQELENMDELSVIKTSLEKHIDGVILYDDIAKEPSPEE
LDTAAYFAKIANADCIIGYGSYESISMAKLIALLITNDIFAEDMINDRKLKLKKPIPLILIPTHPIFGLECSPISTILLG
DEKITRYFSHELLFPELIIADPKISSFMSSMDISKVGVGILAAAVDTILSKFSTELTISSALRAIELLQKNLIPSIRDPK
NVNYKNGLYAASLLTGIAQSSSSLGLCFALSLASSNITNLDIFQSMSILLPHVMEYNLTSSAGKYVMIARALDEDITNIS
VIEAAIKAVEGIRKIFIELKIPQRLSEYEVRKMDLPSIANLAASFPFLDSLPRELPKNEIETILIAAF
>Mature_387_residues
PILPDWVHYTFPPKIHFEADCGYKVGNFVKNIGSRTVIFSTQQELENMDELSVIKTSLEKHIDGVILYDDIAKEPSPEEL
DTAAYFAKIANADCIIGYGSYESISMAKLIALLITNDIFAEDMINDRKLKLKKPIPLILIPTHPIFGLECSPISTILLGD
EKITRYFSHELLFPELIIADPKISSFMSSMDISKVGVGILAAAVDTILSKFSTELTISSALRAIELLQKNLIPSIRDPKN
VNYKNGLYAASLLTGIAQSSSSLGLCFALSLASSNITNLDIFQSMSILLPHVMEYNLTSSAGKYVMIARALDEDITNISV
IEAAIKAVEGIRKIFIELKIPQRLSEYEVRKMDLPSIANLAASFPFLDSLPRELPKNEIETILIAAF

Specific function: Most active with substrates containing two primary alcohol groups separated by one or two carbon atoms. In the physiological direction, 3-hydroxypropionaldehyde is the preferred substrate [H]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=382, Percent_Identity=20.1570680628272, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1789163, Length=349, Percent_Identity=23.7822349570201, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI87082107, Length=315, Percent_Identity=27.9365079365079, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI48994951, Length=334, Percent_Identity=23.9520958083832, Blast_Score=86, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6321181, Length=381, Percent_Identity=22.5721784776903, Blast_Score=78, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.202 [H]

Molecular weight: Translated: 42894; Mature: 42763

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPILPDWVHYTFPPKIHFEADCGYKVGNFVKNIGSRTVIFSTQQELENMDELSVIKTSLE
CCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHCCCCEEEEECHHHHCCHHHHHHHHHHHH
KHIDGVILYDDIAKEPSPEELDTAAYFAKIANADCIIGYGSYESISMAKLIALLITNDIF
HHCCCEEEEEHHCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHH
AEDMINDRKLKLKKPIPLILIPTHPIFGLECSPISTILLGDEKITRYFSHELLFPELIIA
HHHHCCCCCEEECCCCCEEEECCCCCCCCCCCCCEEEEECCHHHHHHHHHHHCCCHHEEC
DPKISSFMSSMDISKVGVGILAAAVDTILSKFSTELTISSALRAIELLQKNLIPSIRDPK
CCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
NVNYKNGLYAASLLTGIAQSSSSLGLCFALSLASSNITNLDIFQSMSILLPHVMEYNLTS
CCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEHHCCCCCCHHHHHHHHHHHHHHHHCCCCC
SAGKYVMIARALDEDITNISVIEAAIKAVEGIRKIFIELKIPQRLSEYEVRKMDLPSIAN
CCCCEEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHCCCCHHHH
LAASFPFLDSLPRELPKNEIETILIAAF
HHHCCCHHHHHHHHCCHHHHCEEEEEEC
>Mature Secondary Structure 
PILPDWVHYTFPPKIHFEADCGYKVGNFVKNIGSRTVIFSTQQELENMDELSVIKTSLE
CCCCCCCCCCCCCCEEEECCCCCHHHHHHHHCCCCEEEEECHHHHCCHHHHHHHHHHHH
KHIDGVILYDDIAKEPSPEELDTAAYFAKIANADCIIGYGSYESISMAKLIALLITNDIF
HHCCCEEEEEHHCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHH
AEDMINDRKLKLKKPIPLILIPTHPIFGLECSPISTILLGDEKITRYFSHELLFPELIIA
HHHHCCCCCEEECCCCCEEEECCCCCCCCCCCCCEEEEECCHHHHHHHHHHHCCCHHEEC
DPKISSFMSSMDISKVGVGILAAAVDTILSKFSTELTISSALRAIELLQKNLIPSIRDPK
CCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
NVNYKNGLYAASLLTGIAQSSSSLGLCFALSLASSNITNLDIFQSMSILLPHVMEYNLTS
CCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEHHCCCCCCHHHHHHHHHHHHHHHHCCCCC
SAGKYVMIARALDEDITNISVIEAAIKAVEGIRKIFIELKIPQRLSEYEVRKMDLPSIAN
CCCCEEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHCCCCHHHH
LAASFPFLDSLPRELPKNEIETILIAAF
HHHCCCHHHHHHHHCCHHHHCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7721705 [H]