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The map label for this gene is purL

Identifier: 45656579

GI number: 45656579

Start: 824493

End: 825152

Strand: Direct

Name: purL

Synonym: LIC10681

Alternate gene names: 45656579

Gene position: 824493-825152 (Clockwise)

Preceding gene: 45656578

Following gene: 45656580

Centisome position: 19.28

GC content: 38.18

Gene sequence:

>660_bases
ATGAAAATAGCGGTAATTACTTTTCCCGGTTCTAATTGTGATTCGGACATCTATCGAGTTCTAAAAGATCAATATAACGC
CGAAGTGGATCGAATTTGGCATAGAGATGGGCTTGATAAAAAATACGAACTTGTAATATTGCCTGGTGGTTTTTCTTACG
GAGATTATCTTCGTTCCGGTGCTATGGCTGGTTTTTCTCCAGTAATGAAATCTGTTAAGGAACATGTGGATAAGGGCGGC
AAACTTTTTGGAATCTGTAATGGGTTTCAGATTTTGACCGAAGCGGAATATCTTCCGGGCGCACTGATAAGAAATAAAAC
TCTCAAATATATCTGTAAAACTGTAATTTTAACAAAAGGTTCTGCTGGAAATCCTGTGACCGCTTCTATGGATGTTCGTA
AGGAATTGAAAATTCCGATTGCTCACGCGGATGGTTGTTATTATGCGACTTCAGATGTTCTGAAACAACTTGAGGATGAA
GATAGAATCTTATTTCGTTATTCTGGGGAGAATCCAAATGGTTCTTTGGATTCGATTGCTGGGATTACTTCTAAAAATTT
TAAAATTGTGGGGATGATGCCTCACCCAGAAAGAGCAATGAATCCAATTACTGGTGAAATGGATGGTAAAGTAGTTCTGG
ATTTGATCTTAGGATCTTGA

Upstream 100 bases:

>100_bases
CCCCGAGCGAAGAAGTTGCTAGAAAAGACGTAGAAAGACTTTGTGATAAGATTTTAGTCAATCATATTATAGAAACATAT
TCTATGAATATTCAAAAAAT

Downstream 100 bases:

>100_bases
AAATTGTTTTTAGAAAAGACTTTTTATGGATTTGATTTTTCGAAAATTAACTTTGATAGAAAAAATCACGCCGAAATTAC
GACTGTTCACATCGCTTAGG

Product: phosphoribosylformylglycinamidine synthase I

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase I; FGAM synthase I

Number of amino acids: Translated: 219; Mature: 219

Protein sequence:

>219_residues
MKIAVITFPGSNCDSDIYRVLKDQYNAEVDRIWHRDGLDKKYELVILPGGFSYGDYLRSGAMAGFSPVMKSVKEHVDKGG
KLFGICNGFQILTEAEYLPGALIRNKTLKYICKTVILTKGSAGNPVTASMDVRKELKIPIAHADGCYYATSDVLKQLEDE
DRILFRYSGENPNGSLDSIAGITSKNFKIVGMMPHPERAMNPITGEMDGKVVLDLILGS

Sequences:

>Translated_219_residues
MKIAVITFPGSNCDSDIYRVLKDQYNAEVDRIWHRDGLDKKYELVILPGGFSYGDYLRSGAMAGFSPVMKSVKEHVDKGG
KLFGICNGFQILTEAEYLPGALIRNKTLKYICKTVILTKGSAGNPVTASMDVRKELKIPIAHADGCYYATSDVLKQLEDE
DRILFRYSGENPNGSLDSIAGITSKNFKIVGMMPHPERAMNPITGEMDGKVVLDLILGS
>Mature_219_residues
MKIAVITFPGSNCDSDIYRVLKDQYNAEVDRIWHRDGLDKKYELVILPGGFSYGDYLRSGAMAGFSPVMKSVKEHVDKGG
KLFGICNGFQILTEAEYLPGALIRNKTLKYICKTVILTKGSAGNPVTASMDVRKELKIPIAHADGCYYATSDVLKQLEDE
DRILFRYSGENPNGSLDSIAGITSKNFKIVGMMPHPERAMNPITGEMDGKVVLDLILGS

Specific function: Unknown

COG id: COG0047

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Saccharomyces cerevisiae, GI6321498, Length=185, Percent_Identity=31.3513513513514, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24582111, Length=237, Percent_Identity=26.5822784810127, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24582109, Length=237, Percent_Identity=26.5822784810127, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17137292, Length=237, Percent_Identity=26.5822784810127, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURQ_LEPIC (Q72UH6)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_000665.1
- ProteinModelPortal:   Q72UH6
- SMR:   Q72UH6
- GeneID:   2770829
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC10681
- HOGENOM:   HBG302712
- OMA:   HPENHVE
- ProtClustDB:   PRK03619
- BioCyc:   LINT267671:LIC_10681-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00421
- InterPro:   IPR017926
- InterPro:   IPR011698
- InterPro:   IPR010075
- PIRSF:   PIRSF001586
- TIGRFAMs:   TIGR01737

Pfam domain/function: PF07685 GATase_3

EC number: =6.3.5.3

Molecular weight: Translated: 24117; Mature: 24117

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: PS51273 GATASE_TYPE_1

Important sites: ACT_SITE 86-86 ACT_SITE 195-195 ACT_SITE 197-197

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAVITFPGSNCDSDIYRVLKDQYNAEVDRIWHRDGLDKKYELVILPGGFSYGDYLRSG
CEEEEEEECCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHC
AMAGFSPVMKSVKEHVDKGGKLFGICNGFQILTEAEYLPGALIRNKTLKYICKTVILTKG
CCCCHHHHHHHHHHHHCCCCCEEEEECCEEEEECCCCCCCHHHHHHHHHHHHHHHHEECC
SAGNPVTASMDVRKELKIPIAHADGCYYATSDVLKQLEDEDRILFRYSGENPNGSLDSIA
CCCCCEEECCCCHHHCCCEEEECCCCEEHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHH
GITSKNFKIVGMMPHPERAMNPITGEMDGKVVLDLILGS
CCCCCCEEEEEECCCCHHHCCCCCCCCCCEEEEEEEECC
>Mature Secondary Structure
MKIAVITFPGSNCDSDIYRVLKDQYNAEVDRIWHRDGLDKKYELVILPGGFSYGDYLRSG
CEEEEEEECCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHC
AMAGFSPVMKSVKEHVDKGGKLFGICNGFQILTEAEYLPGALIRNKTLKYICKTVILTKG
CCCCHHHHHHHHHHHHCCCCCEEEEECCEEEEECCCCCCCHHHHHHHHHHHHHHHHEECC
SAGNPVTASMDVRKELKIPIAHADGCYYATSDVLKQLEDEDRILFRYSGENPNGSLDSIA
CCCCCEEECCCCHHHCCCEEEECCCCEEHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHH
GITSKNFKIVGMMPHPERAMNPITGEMDGKVVLDLILGS
CCCCCCEEEEEECCCCHHHCCCCCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA