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The map label for this gene is hemH

Identifier: 45656577

GI number: 45656577

Start: 823415

End: 824272

Strand: Direct

Name: hemH

Synonym: LIC10679

Alternate gene names: 45656577

Gene position: 823415-824272 (Clockwise)

Preceding gene: 45656576

Following gene: 45656578

Centisome position: 19.25

GC content: 39.28

Gene sequence:

>858_bases
ATGAATCCTTCTTACAAAGGAAAGGTCAGAGACATTTATGATCTAGGAGATAAATTGATTCTTTCTTCTTCTGATCGTAT
TTCCGCGTTTGACGTTGTGTTTCCACAACTGGTTCCGGACAAAGGAAAAGTTCTCAATCGAATTTCTGTTTCTTGGTTTG
AATTTTTTAAAGACGTTCCCAATCATATTTTAGAAACGGATGTGAAATACTTTCCGATTCCATTTCAAAATCATCCTGAC
TTAGAAGGCAGATCGGTTCTTGTAAAGAAGTGTAAACGAATCGACTATGAGTGCGTTGTGCGCGGTTATATCTCTGGTTC
TGGTTGGAAAGAATATAAAAATGATGGAACTCTTGCAGGAATCAAACTTCCGTCCGGTTTCAAAGAATCTCAAAAACTTC
CAGAACCTGTTTTTACTCCTGCGGTTAAAAATGATCAGGGACACGACGAAAATATTTCGGAAAAAGAGATGGAGAATCGA
ATCGGTAAGGAACTGTTTAATATACTGAAAGAAAAATCGATTTCCATTTTCTTACGCGCCTCTGAAGTGGTAGATAAGGC
GGGAATCATTCTTTGTGATACCAAATTCGAGTTCGGAATTTTGGATGGCCAAGTGATTTTGATCGACGAGCTTTTGACTC
CGGATTCTTCCCGATATTGGTCTACGGATACTTATTCCGTTGGAATTTCTCCTCCTAGTTTGGATAAACAGATTCTTAGA
AATTATCTGGAAACTACGAGCTGGAACAAGATGCCTCCCGCGCCTAATCTCCCAGCGGAGCTTATCCAAGAGTTGAGAGA
AAAATACCAGAAGATAGAGGACCTCATTCTTTCATGTACATCGCAAAAATCCAAGTAG

Upstream 100 bases:

>100_bases
CTATAGGCGGGGACATTTTAGTTTCTATGATGGAATCGATTCTTGCGCATTCCGATAGAGGTACGAATGACGACGATATT
GCTATGATGGTGTTGAAGTT

Downstream 100 bases:

>100_bases
TTCTCAAAGAATCCGTTTTAGATCCGCAAGGAAGTACGGTTAAAAAAGTTCTTTCCGAAGTTGGAGAAAAATCGGTTCAG
GACGTGAGAGTAGGTAAATA

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MNPSYKGKVRDIYDLGDKLILSSSDRISAFDVVFPQLVPDKGKVLNRISVSWFEFFKDVPNHILETDVKYFPIPFQNHPD
LEGRSVLVKKCKRIDYECVVRGYISGSGWKEYKNDGTLAGIKLPSGFKESQKLPEPVFTPAVKNDQGHDENISEKEMENR
IGKELFNILKEKSISIFLRASEVVDKAGIILCDTKFEFGILDGQVILIDELLTPDSSRYWSTDTYSVGISPPSLDKQILR
NYLETTSWNKMPPAPNLPAELIQELREKYQKIEDLILSCTSQKSK

Sequences:

>Translated_285_residues
MNPSYKGKVRDIYDLGDKLILSSSDRISAFDVVFPQLVPDKGKVLNRISVSWFEFFKDVPNHILETDVKYFPIPFQNHPD
LEGRSVLVKKCKRIDYECVVRGYISGSGWKEYKNDGTLAGIKLPSGFKESQKLPEPVFTPAVKNDQGHDENISEKEMENR
IGKELFNILKEKSISIFLRASEVVDKAGIILCDTKFEFGILDGQVILIDELLTPDSSRYWSTDTYSVGISPPSLDKQILR
NYLETTSWNKMPPAPNLPAELIQELREKYQKIEDLILSCTSQKSK
>Mature_285_residues
MNPSYKGKVRDIYDLGDKLILSSSDRISAFDVVFPQLVPDKGKVLNRISVSWFEFFKDVPNHILETDVKYFPIPFQNHPD
LEGRSVLVKKCKRIDYECVVRGYISGSGWKEYKNDGTLAGIKLPSGFKESQKLPEPVFTPAVKNDQGHDENISEKEMENR
IGKELFNILKEKSISIFLRASEVVDKAGIILCDTKFEFGILDGQVILIDELLTPDSSRYWSTDTYSVGISPPSLDKQILR
NYLETTSWNKMPPAPNLPAELIQELREKYQKIEDLILSCTSQKSK

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Escherichia coli, GI1788820, Length=224, Percent_Identity=30.3571428571429, Blast_Score=79, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6319326, Length=277, Percent_Identity=42.5992779783394, Blast_Score=219, Evalue=4e-58,
Organism=Drosophila melanogaster, GI18860083, Length=260, Percent_Identity=24.6153846153846, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR7_LEPIC (Q72UH8)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_000663.1
- ProteinModelPortal:   Q72UH8
- SMR:   Q72UH8
- GeneID:   2772925
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC10679
- HOGENOM:   HBG555040
- OMA:   LTLMDEV
- ProtClustDB:   PRK13961
- BioCyc:   LINT267671:LIC_10679-MONOMER
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 32472; Mature: 32472

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPSYKGKVRDIYDLGDKLILSSSDRISAFDVVFPQLVPDKGKVLNRISVSWFEFFKDVP
CCCCCCCCHHHHHHCCCEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
NHILETDVKYFPIPFQNHPDLEGRSVLVKKCKRIDYECVVRGYISGSGWKEYKNDGTLAG
HHHHHCCCCEECCCCCCCCCCCHHHHHHHHHHHCCHHHEEEEEECCCCCHHHCCCCCEEE
IKLPSGFKESQKLPEPVFTPAVKNDQGHDENISEKEMENRIGKELFNILKEKSISIFLRA
EECCCCCCHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEH
SEVVDKAGIILCDTKFEFGILDGQVILIDELLTPDSSRYWSTDTYSVGISPPSLDKQILR
HHHHHHCCEEEEECCCEEEECCCEEEEEEHHCCCCCCCCCCCCCEEECCCCCCHHHHHHH
NYLETTSWNKMPPAPNLPAELIQELREKYQKIEDLILSCTSQKSK
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNPSYKGKVRDIYDLGDKLILSSSDRISAFDVVFPQLVPDKGKVLNRISVSWFEFFKDVP
CCCCCCCCHHHHHHCCCEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
NHILETDVKYFPIPFQNHPDLEGRSVLVKKCKRIDYECVVRGYISGSGWKEYKNDGTLAG
HHHHHCCCCEECCCCCCCCCCCHHHHHHHHHHHCCHHHEEEEEECCCCCHHHCCCCCEEE
IKLPSGFKESQKLPEPVFTPAVKNDQGHDENISEKEMENRIGKELFNILKEKSISIFLRA
EECCCCCCHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEH
SEVVDKAGIILCDTKFEFGILDGQVILIDELLTPDSSRYWSTDTYSVGISPPSLDKQILR
HHHHHHCCEEEEECCCEEEECCCEEEEEEHHCCCCCCCCCCCCCEEECCCCCCHHHHHHH
NYLETTSWNKMPPAPNLPAELIQELREKYQKIEDLILSCTSQKSK
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA