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The map label for this gene is msrA [H]

Identifier: 45656443

GI number: 45656443

Start: 667284

End: 667847

Strand: Direct

Name: msrA [H]

Synonym: LIC10545

Alternate gene names: 45656443

Gene position: 667284-667847 (Clockwise)

Preceding gene: 45656442

Following gene: 45656444

Centisome position: 15.6

GC content: 36.7

Gene sequence:

>564_bases
TTGCAACCTTTGGATTCTAAGCTTGAATCGTCCCCTATGGAACAAGCAACATTAGGCGGCGGTTGTTTTTGGTGTCTCGA
AGCGGTATATCAAATGGTGGAAGGAGTGGAATCAGTAACTTCTGGTTATGCGGCAGGAAGGACAAAAAATCCGGATTATC
GTTCCGTATGTTCCGGTACTACTGGACACGCGGAAGTGATTCAAATTTCTTTTGATCCCAAAATTATCAGTTACTCTGAA
ATTCTAGAAGTTTTTTGGATTAGCCATGATCCTACTACACTCAATCGACAAGGAAATGATATAGGAACCCAATACCGATC
TATTATTCTTTGTCATTCTAAAGAACAAAAAATACAAGCCGAAGAATCCATCCGAAAAACAGAAGGACATTTTTTAGATC
CAATTATAACTCAAGTAGAAGAACTGAAAGAATTTTATCCGGCCGAAAATTATCATCAAAATTACTTCAGAACCAACCCA
GAACAGTCTTACTGTCATTATGTGATTAAACCTAAAATAGAAAAATATCTCAAAACCGGTTTTAAAGTCAAAAGCACAAA
TTAA

Upstream 100 bases:

>100_bases
CTGTAAAATGATGTGGGAACTATTACAAAATGATAAACGGTTTTTAAGCAACGGTTTTTGTGGGAACTACCACTTTTAAA
AAAACATTTCTCAAAACTAC

Downstream 100 bases:

>100_bases
AAGCCGTTTTAAAAAATATTTTACTCAGAACTATAAATAGAGTATCTAAAAGTTTATTTCTTAATTTAAATTTGTCTCAA
AACTTGTAATACTCTATTTT

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 187; Mature: 187

Protein sequence:

>187_residues
MQPLDSKLESSPMEQATLGGGCFWCLEAVYQMVEGVESVTSGYAAGRTKNPDYRSVCSGTTGHAEVIQISFDPKIISYSE
ILEVFWISHDPTTLNRQGNDIGTQYRSIILCHSKEQKIQAEESIRKTEGHFLDPIITQVEELKEFYPAENYHQNYFRTNP
EQSYCHYVIKPKIEKYLKTGFKVKSTN

Sequences:

>Translated_187_residues
MQPLDSKLESSPMEQATLGGGCFWCLEAVYQMVEGVESVTSGYAAGRTKNPDYRSVCSGTTGHAEVIQISFDPKIISYSE
ILEVFWISHDPTTLNRQGNDIGTQYRSIILCHSKEQKIQAEESIRKTEGHFLDPIITQVEELKEFYPAENYHQNYFRTNP
EQSYCHYVIKPKIEKYLKTGFKVKSTN
>Mature_187_residues
MQPLDSKLESSPMEQATLGGGCFWCLEAVYQMVEGVESVTSGYAAGRTKNPDYRSVCSGTTGHAEVIQISFDPKIISYSE
ILEVFWISHDPTTLNRQGNDIGTQYRSIILCHSKEQKIQAEESIRKTEGHFLDPIITQVEELKEFYPAENYHQNYFRTNP
EQSYCHYVIKPKIEKYLKTGFKVKSTN

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=156, Percent_Identity=44.8717948717949, Blast_Score=137, Evalue=6e-33,
Organism=Homo sapiens, GI208609995, Length=156, Percent_Identity=44.8717948717949, Blast_Score=137, Evalue=8e-33,
Organism=Homo sapiens, GI208609993, Length=109, Percent_Identity=45.8715596330275, Blast_Score=96, Evalue=2e-20,
Organism=Escherichia coli, GI1790665, Length=153, Percent_Identity=45.0980392156863, Blast_Score=142, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17533973, Length=144, Percent_Identity=36.8055555555556, Blast_Score=97, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6320881, Length=162, Percent_Identity=38.2716049382716, Blast_Score=112, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24664627, Length=144, Percent_Identity=39.5833333333333, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24664631, Length=144, Percent_Identity=38.8888888888889, Blast_Score=97, Evalue=6e-21,
Organism=Drosophila melanogaster, GI45553131, Length=136, Percent_Identity=38.9705882352941, Blast_Score=97, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 21358; Mature: 21358

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPLDSKLESSPMEQATLGGGCFWCLEAVYQMVEGVESVTSGYAAGRTKNPDYRSVCSGT
CCCCCHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCC
TGHAEVIQISFDPKIISYSEILEVFWISHDPTTLNRQGNDIGTQYRSIILCHSKEQKIQA
CCCEEEEEEECCCCEECHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHEEEECCCHHHHHH
EESIRKTEGHFLDPIITQVEELKEFYPAENYHQNYFRTNPEQSYCHYVIKPKIEKYLKTG
HHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCHHEEEECHHHHHHHHCC
FKVKSTN
CEEECCC
>Mature Secondary Structure
MQPLDSKLESSPMEQATLGGGCFWCLEAVYQMVEGVESVTSGYAAGRTKNPDYRSVCSGT
CCCCCHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCC
TGHAEVIQISFDPKIISYSEILEVFWISHDPTTLNRQGNDIGTQYRSIILCHSKEQKIQA
CCCEEEEEEECCCCEECHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHEEEECCCHHHHHH
EESIRKTEGHFLDPIITQVEELKEFYPAENYHQNYFRTNPEQSYCHYVIKPKIEKYLKTG
HHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCHHEEEECHHHHHHHHCC
FKVKSTN
CEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA