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The map label for this gene is pth [H]

Identifier: 45656330

GI number: 45656330

Start: 491408

End: 491971

Strand: Direct

Name: pth [H]

Synonym: LIC10431

Alternate gene names: 45656330

Gene position: 491408-491971 (Clockwise)

Preceding gene: 45656329

Following gene: 45656331

Centisome position: 11.49

GC content: 36.35

Gene sequence:

>564_bases
ATGAAGCTGATCGTCGGACTTGGAAATCCAGGGGATAGGTACAACAATAACCGTTCAAATATTGGTTTCAAAATTTTAGA
TGTTATCGCGAATAACATCAATGTTGAAATCAAGACTAAAAAGAAAAAGTCTTTGATCGGTCGGGGTGATTTTGAGGGAG
AAGAGGTTGTACTTTTAAAACCTCAGACTTTTAGCGATCTTTCGGGAGAATCCGTTTTATATATCGCTTCGTTTCTTAAA
ATCCAAGTGGGAGAAATTTTAGTCATTCAAGAAGACTGGACTCTTCCTCTTGGTAGAATTGTAGTCGATAAAGGAACTCA
AGAGACGGATCATCCAGGTGTAAAATCCATTGTTCAATCTCTTCGTTCTCCAAATTTCATTCGAATTCGAATTGGTATTC
AGAATGACGGATTTAATCTGAAAAATAGGGAATCTTTTTTAAAGGAAGATTTCGAACCGATGGAAAATTTAAGTTTGATT
CAAATCATCAATGATGCAGAAGCTGCGATTCGTTCTATCTCGCTCGGAGATATAGACGACGTAATCGAAAAATATCATCT
TTGA

Upstream 100 bases:

>100_bases
GAAGCTAAAGGCTCTGCTGCAGATGACGCTAAAGCTAAAAAAGGTAAGAAGTAATACAAAATTTTCATCAGATCAAATCT
GATAAACAGAATAGGTATTC

Downstream 100 bases:

>100_bases
TGTAAAAAAATCTGACCGATTTTTGTTCTCTTCTGAATGCCTTTTAATGGTTTCTACCAATTCTTCCTTGCCTTTTTGAA
GAAACGTGAAATTCTATCGG

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 187; Mature: 187

Protein sequence:

>187_residues
MKLIVGLGNPGDRYNNNRSNIGFKILDVIANNINVEIKTKKKKSLIGRGDFEGEEVVLLKPQTFSDLSGESVLYIASFLK
IQVGEILVIQEDWTLPLGRIVVDKGTQETDHPGVKSIVQSLRSPNFIRIRIGIQNDGFNLKNRESFLKEDFEPMENLSLI
QIINDAEAAIRSISLGDIDDVIEKYHL

Sequences:

>Translated_187_residues
MKLIVGLGNPGDRYNNNRSNIGFKILDVIANNINVEIKTKKKKSLIGRGDFEGEEVVLLKPQTFSDLSGESVLYIASFLK
IQVGEILVIQEDWTLPLGRIVVDKGTQETDHPGVKSIVQSLRSPNFIRIRIGIQNDGFNLKNRESFLKEDFEPMENLSLI
QIINDAEAAIRSISLGDIDDVIEKYHL
>Mature_187_residues
MKLIVGLGNPGDRYNNNRSNIGFKILDVIANNINVEIKTKKKKSLIGRGDFEGEEVVLLKPQTFSDLSGESVLYIASFLK
IQVGEILVIQEDWTLPLGRIVVDKGTQETDHPGVKSIVQSLRSPNFIRIRIGIQNDGFNLKNRESFLKEDFEPMENLSLI
QIINDAEAAIRSISLGDIDDVIEKYHL

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Escherichia coli, GI1787455, Length=139, Percent_Identity=39.568345323741, Blast_Score=84, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 20992; Mature: 20992

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLIVGLGNPGDRYNNNRSNIGFKILDVIANNINVEIKTKKKKSLIGRGDFEGEEVVLLK
CEEEEECCCCCCCCCCCCCCCCCEEEEEHHCCCEEEEEECHHHHCCCCCCCCCCEEEEEC
PQTFSDLSGESVLYIASFLKIQVGEILVIQEDWTLPLGRIVVDKGTQETDHPGVKSIVQS
CCCCCCCCCCCHHHHHHHHHEEECEEEEEECCCCCCCCEEEEECCCCCCCCCCHHHHHHH
LRSPNFIRIRIGIQNDGFNLKNRESFLKEDFEPMENLSLIQIINDAEAAIRSISLGDIDD
HCCCCEEEEEEEEECCCCCCCHHHHHHHHHCCHHHCCEEEEEECHHHHHHHHCCCCCHHH
VIEKYHL
HHHHHCC
>Mature Secondary Structure
MKLIVGLGNPGDRYNNNRSNIGFKILDVIANNINVEIKTKKKKSLIGRGDFEGEEVVLLK
CEEEEECCCCCCCCCCCCCCCCCEEEEEHHCCCEEEEEECHHHHCCCCCCCCCCEEEEEC
PQTFSDLSGESVLYIASFLKIQVGEILVIQEDWTLPLGRIVVDKGTQETDHPGVKSIVQS
CCCCCCCCCCCHHHHHHHHHEEECEEEEEECCCCCCCCEEEEECCCCCCCCCCHHHHHHH
LRSPNFIRIRIGIQNDGFNLKNRESFLKEDFEPMENLSLIQIINDAEAAIRSISLGDIDD
HCCCCEEEEEEEEECCCCCCCHHHHHHHHHCCHHHCCEEEEEECHHHHHHHHCCCCCHHH
VIEKYHL
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA