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The map label for this gene is yogA [H]

Identifier: 45656158

GI number: 45656158

Start: 289714

End: 290967

Strand: Direct

Name: yogA [H]

Synonym: LIC10253

Alternate gene names: 45656158

Gene position: 289714-290967 (Clockwise)

Preceding gene: 45656155

Following gene: 45656161

Centisome position: 6.77

GC content: 47.61

Gene sequence:

>1254_bases
GTGCACATGAGCCAAATTGAATCCGTTCCAATCGGAACCCTCCCACCCCTGGGACAGGTTCCTAAAAAAATGTATGCACA
GGTCGTTCGTCCCGAGCGTTACGGCGATCCGATCACAGCAATTCAGGAAGAACTCATCGATGTTCCAGAAATAGCTCCGG
ACGAGGTTCTCGTCGCGGTAATGGCAGCCGGTGTAAATTATAACAACGTTTGGGCCGCACTCGGATTTCCCGTAGATGTA
ATCGGCGCCAGAAACAAAAAAGGTGAACCCGAGAAGTTTCACATCGGCGGGTCCGACGCATCTGGGATCGTTTATAAAGT
CGGCGCGGATGTTAAGAACGTAAAAGTCGGAGACGAAGTCGTTCTTCACTGTGGAATCTGGGATAAGAACGATCCTTGGG
TCAAAGCGGGAAAAGATCCGATGTTTGCCCCTTCTCAGCTGATCTGGGCTTATGAAACCAACTGGGGATCCTTTGCACAA
TTCTGCAAGGTTCAAGATCATCAGTGTCTTCCAAAACCGAAACATCTCACTTGGGAAGAATCCGCCGCTTACATGTTAGT
GGGCGCTACCGCTTATAGAATGCTTCACCATTGGAAACCAAACGATGTACAAAAAGACGACGTGGTTCTAATTTGGGGAG
GCGCAGGCGGACTGGGTGCAATGGCGATTCAGATCGTAAAAGCTGCCGGTGGAATTCCCATCGCCGTCGTTTCCGAAGAC
GATAAAATCGACTTCTGTAAAAAACTCGGTGCCGCAGGCGTAATCAATCGTAAGAAATTCAACCACTGGGGAGCTTTGAC
TTCCGAGATCAATAAGACCGAAAAATTCATAGAATGGACAAAGGCCGCTCGTGAATTTGGAAAGGCTATCTGGGACATCG
CGGGTAAAGGAAATAATCCTAGGATCGTGTTCGAACATCCGGGTGAAACCACAATTCCTACTTCTATGTTCGTTTGTGAA
ACGGGCGGAATGGTAGTGATCTGCGCGGGAACCACAGGATACAACGCAACCGTGGATTTGCGTTATCTTTGGATGAGACA
AAAACGTCTGCAAGGTTCTCACTTTGCGAACGACGAAAACTCAAAAGGTCTGAACGATTTAGTCATCGATAAAAAAGTCG
ATCCTTGTCTTTCTAAAACCTTCGCTTGGAACGAGACGGCGCATTCTCATCAATTGATGAAGGAAAACAAACACCCGGCG
GGAAACATGTCTATCCTGGTCGGAGCTGAAAAAACAGGATTAGGAAAGAAATAA

Upstream 100 bases:

>100_bases
AACGTGTTGAAATAGGAATCAAACTTTATCAAAAACCGATCTCAATTCATCACGAATTTCTTGAAATTGGTGTAGATCAA
ATACCAAAGTTCAGAAATCT

Downstream 100 bases:

>100_bases
TTTCTTTTTCTAATTCGGTTTCAAACCCCGAAGGCGGTTTTGCTTTCGGGGTTTTTTATTTTTAAAGGGACCCTTGGATA
CTTTAACTTTATTACGTAGT

Product: alcohol dehydrogenase

Products: aldehyde; ketone; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MHMSQIESVPIGTLPPLGQVPKKMYAQVVRPERYGDPITAIQEELIDVPEIAPDEVLVAVMAAGVNYNNVWAALGFPVDV
IGARNKKGEPEKFHIGGSDASGIVYKVGADVKNVKVGDEVVLHCGIWDKNDPWVKAGKDPMFAPSQLIWAYETNWGSFAQ
FCKVQDHQCLPKPKHLTWEESAAYMLVGATAYRMLHHWKPNDVQKDDVVLIWGGAGGLGAMAIQIVKAAGGIPIAVVSED
DKIDFCKKLGAAGVINRKKFNHWGALTSEINKTEKFIEWTKAAREFGKAIWDIAGKGNNPRIVFEHPGETTIPTSMFVCE
TGGMVVICAGTTGYNATVDLRYLWMRQKRLQGSHFANDENSKGLNDLVIDKKVDPCLSKTFAWNETAHSHQLMKENKHPA
GNMSILVGAEKTGLGKK

Sequences:

>Translated_417_residues
MHMSQIESVPIGTLPPLGQVPKKMYAQVVRPERYGDPITAIQEELIDVPEIAPDEVLVAVMAAGVNYNNVWAALGFPVDV
IGARNKKGEPEKFHIGGSDASGIVYKVGADVKNVKVGDEVVLHCGIWDKNDPWVKAGKDPMFAPSQLIWAYETNWGSFAQ
FCKVQDHQCLPKPKHLTWEESAAYMLVGATAYRMLHHWKPNDVQKDDVVLIWGGAGGLGAMAIQIVKAAGGIPIAVVSED
DKIDFCKKLGAAGVINRKKFNHWGALTSEINKTEKFIEWTKAAREFGKAIWDIAGKGNNPRIVFEHPGETTIPTSMFVCE
TGGMVVICAGTTGYNATVDLRYLWMRQKRLQGSHFANDENSKGLNDLVIDKKVDPCLSKTFAWNETAHSHQLMKENKHPA
GNMSILVGAEKTGLGKK
>Mature_417_residues
MHMSQIESVPIGTLPPLGQVPKKMYAQVVRPERYGDPITAIQEELIDVPEIAPDEVLVAVMAAGVNYNNVWAALGFPVDV
IGARNKKGEPEKFHIGGSDASGIVYKVGADVKNVKVGDEVVLHCGIWDKNDPWVKAGKDPMFAPSQLIWAYETNWGSFAQ
FCKVQDHQCLPKPKHLTWEESAAYMLVGATAYRMLHHWKPNDVQKDDVVLIWGGAGGLGAMAIQIVKAAGGIPIAVVSED
DKIDFCKKLGAAGVINRKKFNHWGALTSEINKTEKFIEWTKAAREFGKAIWDIAGKGNNPRIVFEHPGETTIPTSMFVCE
TGGMVVICAGTTGYNATVDLRYLWMRQKRLQGSHFANDENSKGLNDLVIDKKVDPCLSKTFAWNETAHSHQLMKENKHPA
GNMSILVGAEKTGLGKK

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=236, Percent_Identity=30.5084745762712, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI22538446, Length=104, Percent_Identity=37.5, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI22538444, Length=104, Percent_Identity=37.5, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1790485, Length=369, Percent_Identity=24.1192411924119, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71988145, Length=248, Percent_Identity=29.0322580645161, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17562876, Length=262, Percent_Identity=28.6259541984733, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323729, Length=236, Percent_Identity=29.2372881355932, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17137530, Length=216, Percent_Identity=29.1666666666667, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.1

Molecular weight: Translated: 45785; Mature: 45785

Theoretical pI: Translated: 7.61; Mature: 7.61

Prosite motif: PS01162 QOR_ZETA_CRYSTAL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHMSQIESVPIGTLPPLGQVPKKMYAQVVRPERYGDPITAIQEELIDVPEIAPDEVLVAV
CCHHHHCCCCCCCCCCCHHHHHHHHHHHHCCHHCCCHHHHHHHHHCCCCCCCHHHHHHHH
MAAGVNYNNVWAALGFPVDVIGARNKKGEPEKFHIGGSDASGIVYKVGADVKNVKVGDEV
HHCCCCCCCEEEECCCCEEEEECCCCCCCCCEEEECCCCCCCEEEEECCCCCEEECCCEE
VLHCGIWDKNDPWVKAGKDPMFAPSQLIWAYETNWGSFAQFCKVQDHQCLPKPKHLTWEE
EEEECCCCCCCCCEECCCCCCCCCCEEEEEEECCCHHHHHHHHCCCCCCCCCCCCCCCCC
SAAYMLVGATAYRMLHHWKPNDVQKDDVVLIWGGAGGLGAMAIQIVKAAGGIPIAVVSED
CCCEEEEHHHHHHHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCC
DKIDFCKKLGAAGVINRKKFNHWGALTSEINKTEKFIEWTKAAREFGKAIWDIAGKGNNP
CCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
RIVFEHPGETTIPTSMFVCETGGMVVICAGTTGYNATVDLRYLWMRQKRLQGSHFANDEN
EEEEECCCCCCCCCEEEEEECCCEEEEEECCCCCCCEEEEHHHHHHHHHHCCCCCCCCCC
SKGLNDLVIDKKVDPCLSKTFAWNETAHSHQLMKENKHPAGNMSILVGAEKTGLGKK
CCCCCCEEECCCCCHHHHHHCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCC
>Mature Secondary Structure
MHMSQIESVPIGTLPPLGQVPKKMYAQVVRPERYGDPITAIQEELIDVPEIAPDEVLVAV
CCHHHHCCCCCCCCCCCHHHHHHHHHHHHCCHHCCCHHHHHHHHHCCCCCCCHHHHHHHH
MAAGVNYNNVWAALGFPVDVIGARNKKGEPEKFHIGGSDASGIVYKVGADVKNVKVGDEV
HHCCCCCCCEEEECCCCEEEEECCCCCCCCCEEEECCCCCCCEEEEECCCCCEEECCCEE
VLHCGIWDKNDPWVKAGKDPMFAPSQLIWAYETNWGSFAQFCKVQDHQCLPKPKHLTWEE
EEEECCCCCCCCCEECCCCCCCCCCEEEEEEECCCHHHHHHHHCCCCCCCCCCCCCCCCC
SAAYMLVGATAYRMLHHWKPNDVQKDDVVLIWGGAGGLGAMAIQIVKAAGGIPIAVVSED
CCCEEEEHHHHHHHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCC
DKIDFCKKLGAAGVINRKKFNHWGALTSEINKTEKFIEWTKAAREFGKAIWDIAGKGNNP
CCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
RIVFEHPGETTIPTSMFVCETGGMVVICAGTTGYNATVDLRYLWMRQKRLQGSHFANDEN
EEEEECCCCCCCCCEEEEEECCCEEEEEECCCCCCCEEEEHHHHHHHHHHCCCCCCCCCC
SKGLNDLVIDKKVDPCLSKTFAWNETAHSHQLMKENKHPAGNMSILVGAEKTGLGKK
CCCCCCEEECCCCCHHHHHHCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: alcohol; NAD+

Specific reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]