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The map label for this gene is met-7

Identifier: 45656012

GI number: 45656012

Start: 120143

End: 121645

Strand: Reverse

Name: met-7

Synonym: LIC10101

Alternate gene names: 45656012

Gene position: 121645-120143 (Counterclockwise)

Preceding gene: 45656013

Following gene: 45656011

Centisome position: 2.84

GC content: 34.26

Gene sequence:

>1503_bases
ATGTTAAAAGAAATCAACGAACCACACCGAACACTTTGCGGAGAAAGAATTCCATTTGAGAACATCCACGCGGTTTCTGT
AAGTCTTCCACAACTGTCAGATGTGATTGGTTACGAAGAAAAAAGAACGGAAACTCTTTCTAGATTGAAGTCTGGTTATC
CCAGATTTGTCGCACATTCTTATATAGCCAGAATTTTAGACTACAACAGGGATACAAAAAAAATCAACACGCCCCAATTT
ATCATTTCTTCCAAAAAAGCTGCAAACTGGATCGTACAAAAATTCTCCATTCAAAATTTTGAAATTATCGAAGACGAAGG
AATTACAACCTTAGTCATTCCAGATTTAAAAGATTTAGAAAAAGAAATTCTTTCTTTCATTCAACACACCGGATGTCTTG
CTTCTTCTAGAATGGCAGAGGACTTCCTTTTAAAAAAAGGAATCCTACAAGAAATTTTTAGGGAGAAAGTTGAAAAAGAA
AATCCGGTCGATAAAATTCTTTCTACTCTATCTTCTTTCTATGGAGATCTAAATCCTGAAATACTTCTTTCCGCTTCTGG
AATGAACGGTGTCTATTCTGCTTTTGAATCCTTAAGCTTAATTCAACAAAAGAAAGGAAAAACTATTTGGGTTCGTTTGG
GTTGGCTATATGTTGATAATATTAGAATATTAGAAAAATATACAGAAAGTTCTTACGTAATTCACAACGCTACTGACCTA
GAAGAACTGGAAATATTTTTAAAACAAAATTCGGAGCAAGTCGCTGGAATTATCACGGAATGCCCTACTAATCCACTTCT
TTTGGTTCCGGATTACGAAAAACTTAAATCCATCGTAGACCATTACAAAATTCCTTTGATTGTAGATATTTCCGTGGCAG
GATCAGCGATAATCAACATTCTCCCCTACGTAGATGTAATCGTGGAAAGTTTAACCAAATTCGCCTGTGGAAACGGTGAC
CTTATGATGGGTGCTGTAATATTAAATAAAAATTCAAATTGGTTCTCCGAAATTCTTCCGCTATGTAAAGAATGGATTGA
AAAACCATATTTTAGAGATTGTGAAAGACTAGCTTATGAAATCAAAGATTATGAAAAAAGAGTTTTTAAAATCAGCGAGA
ACGTCAAAAAACTCGCAGATTTTTTTTCAAAACAACCCGGTATTAGAAAAGTTTTTTGGACAGGGGCAATAGATTCTTTT
CAAAACTTCCAAAAAGTTACCAGACTTCCAAATATACATTCTGGAGTTTTATCGATTGAACTTTCAACTTCATTAGAAAA
GTTTTATGATCGACTTACTTTATTAAAAGGACCAAGTTTTGGCACCGAGTTTACTCTCAATATGCTTTATGTCTATCTGG
CTCATTACGACTTAGTGATTCAAGATGAAGGAAGAAAATTTTTAAAAGAAAACGGACTCGATCCAAACTTGATCCGAATT
TCCGTTGGCATTGAAGATCCGGAACTTTTAATTGAGGAATATAAAAAGGCTCTAGAAGTTTAA

Upstream 100 bases:

>100_bases
AGGATAGAGTTCGAAAAATTTCCGAGACTCAAACACATTAGAATTTTAATAAATTTACATATTAAAAAATTCCCAATGAA
CAACCACTGGAATCCATAAA

Downstream 100 bases:

>100_bases
TTAATTTTAATATACTAATTTAATGTATAAAATTTATTTATAGAAATCTAGATAAAATCCAAAAAAGAACCATAGTCTTA
ATTAAACTTTTGTATAAAAT

Product: cystathionine gamma-synthase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MLKEINEPHRTLCGERIPFENIHAVSVSLPQLSDVIGYEEKRTETLSRLKSGYPRFVAHSYIARILDYNRDTKKINTPQF
IISSKKAANWIVQKFSIQNFEIIEDEGITTLVIPDLKDLEKEILSFIQHTGCLASSRMAEDFLLKKGILQEIFREKVEKE
NPVDKILSTLSSFYGDLNPEILLSASGMNGVYSAFESLSLIQQKKGKTIWVRLGWLYVDNIRILEKYTESSYVIHNATDL
EELEIFLKQNSEQVAGIITECPTNPLLLVPDYEKLKSIVDHYKIPLIVDISVAGSAIINILPYVDVIVESLTKFACGNGD
LMMGAVILNKNSNWFSEILPLCKEWIEKPYFRDCERLAYEIKDYEKRVFKISENVKKLADFFSKQPGIRKVFWTGAIDSF
QNFQKVTRLPNIHSGVLSIELSTSLEKFYDRLTLLKGPSFGTEFTLNMLYVYLAHYDLVIQDEGRKFLKENGLDPNLIRI
SVGIEDPELLIEEYKKALEV

Sequences:

>Translated_500_residues
MLKEINEPHRTLCGERIPFENIHAVSVSLPQLSDVIGYEEKRTETLSRLKSGYPRFVAHSYIARILDYNRDTKKINTPQF
IISSKKAANWIVQKFSIQNFEIIEDEGITTLVIPDLKDLEKEILSFIQHTGCLASSRMAEDFLLKKGILQEIFREKVEKE
NPVDKILSTLSSFYGDLNPEILLSASGMNGVYSAFESLSLIQQKKGKTIWVRLGWLYVDNIRILEKYTESSYVIHNATDL
EELEIFLKQNSEQVAGIITECPTNPLLLVPDYEKLKSIVDHYKIPLIVDISVAGSAIINILPYVDVIVESLTKFACGNGD
LMMGAVILNKNSNWFSEILPLCKEWIEKPYFRDCERLAYEIKDYEKRVFKISENVKKLADFFSKQPGIRKVFWTGAIDSF
QNFQKVTRLPNIHSGVLSIELSTSLEKFYDRLTLLKGPSFGTEFTLNMLYVYLAHYDLVIQDEGRKFLKENGLDPNLIRI
SVGIEDPELLIEEYKKALEV
>Mature_500_residues
MLKEINEPHRTLCGERIPFENIHAVSVSLPQLSDVIGYEEKRTETLSRLKSGYPRFVAHSYIARILDYNRDTKKINTPQF
IISSKKAANWIVQKFSIQNFEIIEDEGITTLVIPDLKDLEKEILSFIQHTGCLASSRMAEDFLLKKGILQEIFREKVEKE
NPVDKILSTLSSFYGDLNPEILLSASGMNGVYSAFESLSLIQQKKGKTIWVRLGWLYVDNIRILEKYTESSYVIHNATDL
EELEIFLKQNSEQVAGIITECPTNPLLLVPDYEKLKSIVDHYKIPLIVDISVAGSAIINILPYVDVIVESLTKFACGNGD
LMMGAVILNKNSNWFSEILPLCKEWIEKPYFRDCERLAYEIKDYEKRVFKISENVKKLADFFSKQPGIRKVFWTGAIDSF
QNFQKVTRLPNIHSGVLSIELSTSLEKFYDRLTLLKGPSFGTEFTLNMLYVYLAHYDLVIQDEGRKFLKENGLDPNLIRI
SVGIEDPELLIEEYKKALEV

Specific function: The enzymatic degradation of amino acids in cheese is believed to generate aroma compounds and therefore to be essential for flavor development. Cystathionine beta-lyase (CBL) can convert cystathionine to homocysteine but is also able to catalyze an alpha

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Caenorhabditis elegans, GI71980708, Length=247, Percent_Identity=27.1255060728745, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322970, Length=581, Percent_Identity=25.473321858864, Blast_Score=159, Evalue=8e-40,
Organism=Saccharomyces cerevisiae, GI6322590, Length=359, Percent_Identity=27.5766016713092, Blast_Score=130, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6323557, Length=349, Percent_Identity=26.3610315186246, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI19922554, Length=249, Percent_Identity=28.1124497991968, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 57351; Mature: 57351

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKEINEPHRTLCGERIPFENIHAVSVSLPQLSDVIGYEEKRTETLSRLKSGYPRFVAHS
CCCCCCCCHHHHCCCCCCCCCCEEEEEECHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHH
YIARILDYNRDTKKINTPQFIISSKKAANWIVQKFSIQNFEIIEDEGITTLVIPDLKDLE
HHHHHHHCCCCCCCCCCCHHEEECHHHHHHHHHHHCCCCCEEEECCCCEEEECCCHHHHH
KEILSFIQHTGCLASSRMAEDFLLKKGILQEIFREKVEKENPVDKILSTLSSFYGDLNPE
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCE
ILLSASGMNGVYSAFESLSLIQQKKGKTIWVRLGWLYVDNIRILEKYTESSYVIHNATDL
EEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCHHHHHHHCCCCEEEECCCCH
EELEIFLKQNSEQVAGIITECPTNPLLLVPDYEKLKSIVDHYKIPLIVDISVAGSAIINI
HHHHHHHHCCCHHHHHHHHHCCCCCEEECCCHHHHHHHHHHCCCCEEEEEEHHHHHHHHH
LPYVDVIVESLTKFACGNGDLMMGAVILNKNSNWFSEILPLCKEWIEKPYFRDCERLAYE
HHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHCHHHHHHHHHHHH
IKDYEKRVFKISENVKKLADFFSKQPGIRKVFWTGAIDSFQNFQKVTRLPNIHSGVLSIE
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEE
LSTSLEKFYDRLTLLKGPSFGTEFTLNMLYVYLAHYDLVIQDEGRKFLKENGLDPNLIRI
EHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHEEEEECCCHHHHHHCCCCCCEEEE
SVGIEDPELLIEEYKKALEV
EECCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MLKEINEPHRTLCGERIPFENIHAVSVSLPQLSDVIGYEEKRTETLSRLKSGYPRFVAHS
CCCCCCCCHHHHCCCCCCCCCCEEEEEECHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHH
YIARILDYNRDTKKINTPQFIISSKKAANWIVQKFSIQNFEIIEDEGITTLVIPDLKDLE
HHHHHHHCCCCCCCCCCCHHEEECHHHHHHHHHHHCCCCCEEEECCCCEEEECCCHHHHH
KEILSFIQHTGCLASSRMAEDFLLKKGILQEIFREKVEKENPVDKILSTLSSFYGDLNPE
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCE
ILLSASGMNGVYSAFESLSLIQQKKGKTIWVRLGWLYVDNIRILEKYTESSYVIHNATDL
EEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCHHHHHHHCCCCEEEECCCCH
EELEIFLKQNSEQVAGIITECPTNPLLLVPDYEKLKSIVDHYKIPLIVDISVAGSAIINI
HHHHHHHHCCCHHHHHHHHHCCCCCEEECCCHHHHHHHHHHCCCCEEEEEEHHHHHHHHH
LPYVDVIVESLTKFACGNGDLMMGAVILNKNSNWFSEILPLCKEWIEKPYFRDCERLAYE
HHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHCHHHHHHHHHHHH
IKDYEKRVFKISENVKKLADFFSKQPGIRKVFWTGAIDSFQNFQKVTRLPNIHSGVLSIE
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEE
LSTSLEKFYDRLTLLKGPSFGTEFTLNMLYVYLAHYDLVIQDEGRKFLKENGLDPNLIRI
EHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHEEEEECCCHHHHHHCCCCCCEEEE
SVGIEDPELLIEEYKKALEV
EECCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]