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The map label for this gene is rnR

Identifier: 45655949

GI number: 45655949

Start: 41921

End: 44176

Strand: Direct

Name: rnR

Synonym: LIC10035

Alternate gene names: 45655949

Gene position: 41921-44176 (Clockwise)

Preceding gene: 45655948

Following gene: 45655950

Centisome position: 0.98

GC content: 32.67

Gene sequence:

>2256_bases
ATGAATATAAAGAAAAAACAAACAACAGAAAATAAATCTGTAAAATCTAACAGAAAAAAGAAAACGTTTGATAAATCCAA
TAAAACTAAAAAAGAAAGAACCGACGGTTTTCGTGAGAATGAAATAGGAAAAAAAATCTTAAAGTATATTCAATCCAGAG
CGGGTTCTGTAATTCAATTTAAAGATTTGAACGCGAAAATTCTAAGAGAAGAAAATCAAAACTCTTACGGTAAAAAAAGA
GAAAAATGGGAGTTTCAAGAAAAAGAAAGGGAGATATTGGAAACATTAAAAATTCTTGAAACAGAAGGATTAATCGAATT
AGAAAAAAAGAATATTATTATCAATTCAAACCAGAAACTTCAAGGAACAATTTCTATTAGTAAAAAAGGAGACGGTTTTG
TAAAACTTTCTTCGGGAGTCGAGATTTTCGTTCCAAATCAATATACACAATCTGCCATTCAAGGTGATTTAGTAGAAGTT
CGTCCTTACGGAGTTGGTAAAAAGAGAAGGTTAGAAGGAGAAGTCACGGAGATTCTCAGAAGAGGGCGCGATCTTTATAG
AATGATCGTCACCGAAAAAGAGCCTAAGTTTATTTTCGGAAAACTTTTGGATATAGACGGAGAGGAAAAGGAAGGTTATC
TTCTTCGTAAAACAATTCTTACGGATCTTCAAGAGGAAATTCAATCCGGAGACGTTTTGATAGTTAAATTAAAAGAAGAA
ACGGAACACGAAAAGAATCTTTATGAGGTCCAGTTTTTACGTTTTGAGTCAGATACCAAAGAAGATTTGGATCTGATGAG
AATGTTGATGAAATACAATTATAATATTCTTTATCCTGAAAATATAATATTAGATCTTCCTGAAGAAGTAAACGAAAGCA
CTGTGGACGATTGGAATGAACGTGTAGATCTTAGGAATCTGAAATGTATTACAATAGACGGAGAGTATTCCAAAGATTTT
GACGACGCGATTAGTTTTATAGAGGAAAAAAATCGAATTCGATTTTACGTACATATCGCGGATGTTTCTTATTATGTAAG
ACCGGGAAACGATTTAGACGAAGAAGCATATAATCGTGCTACTTCTGTATATTTAGGAAGTCGGGTTGTTCCTATGTTAC
CTCCCGAGTTATCCGAAAGTCTTTGTTCCTTGATTGCCGGAAAAAATCGTTTGGCTTTTACCGTGGAAATGGAAGCTGAT
TGGAAAGGAAAAATTACTCACGCAAAATATTATAAAAGCATAATAAATGTAAAAGAAAGATATACTTATAACAAAGCCGA
GTCCGAAATCTTATCTGGGGATTCTGATAATTGGATCTTTAGAATGAATGAATTTGCCAAAATTCTTCGAACAAAAAGAA
TCGAAGATGGAAGAGTGGATTTAAATTTGAAAGAAAATAAAGTGGTCACTGATTCCGAACACAACGTGATTGAAATAGCG
ATTCAAGATAGGCTCCAATCGCATATTCTCATAGAAGAATTTATGCTTTCTGCAAATATTAAAGTTGCTGAATATATTCG
TAAGAAAAAACACCCGACTTTATATAGAGTTCATGAAGCCATGAATGAAGAAAAAATAGAATCCTTAAACGCATTTCTTC
AATTAAATGCCACTAAAATTTTACTCAAAGATTCTAGTTACGAATCTATTCGTTCGGTTCTAAAAGAATTAGAAGCAAAA
CCTGCAGAAAGATTGTTTAATATGTTTTTATTGAGAACATTTATGCAAGCTTATTATTCTGGAGAACATTTAGGACATTG
GGGTTTGGGATTTGAAGACTACTGTCATTTTACGTCTCCGATTCGAAGATATCCTGATCTGGTTTGCCATAGGGTTTTAC
AAAATATTCTTTTAGGTAAAAAGCCTATTTATACTCCGGAAGAAATAGTGACTTTCGGTTTGCATTGTTCACATCAGGAA
CGCAAAGCAAGTGATGCAGAAAGGGATTATTATAAACTTAAGGCATGTCGCTATTTGGAAAAAACTGGAATTAAAGAATT
TTCAGCAACGATCACTGGTTGTAGACCACATTTAATTTTTGTAGATCTGGAAAATCCTGCTGTAGATGCTTGTTTATTTT
CTTCTGAGTTTACGGATGAAGGTGAAATTCGTTTAGAGACGGACTTTTCATTTTACTCTAAAAAGTATTCTAAAATTTAT
ACTCTTGGAGATAAAATTGAAGTAGAACTGGATCGAATCGACTACGAAGAAATTAAAATCTTTGTAAAAATGAAAAAATT
CCAAAAGAAAGTATAG

Upstream 100 bases:

>100_bases
AGGAAGCTCTGGATTTTCCGGATCGATTTCCTTATTGGAAACTTGTACCTAACTACGTGCGCGGAACCTATGTTGATGAT
AGATCAACGATTTAGAAATT

Downstream 100 bases:

>100_bases
ACAAATAAATTCTTTTCTAATATTTCTGCGGAACGGTTTTTCTTAGTTTCGTAAGTCATGCAAAGTATTTTTGAATGTTG
ATACAAAAACATTTTGAAAG

Product: ribonuclease R

Products: NA

Alternate protein names: RNase R; VacB protein homolog [H]

Number of amino acids: Translated: 751; Mature: 751

Protein sequence:

>751_residues
MNIKKKQTTENKSVKSNRKKKTFDKSNKTKKERTDGFRENEIGKKILKYIQSRAGSVIQFKDLNAKILREENQNSYGKKR
EKWEFQEKEREILETLKILETEGLIELEKKNIIINSNQKLQGTISISKKGDGFVKLSSGVEIFVPNQYTQSAIQGDLVEV
RPYGVGKKRRLEGEVTEILRRGRDLYRMIVTEKEPKFIFGKLLDIDGEEKEGYLLRKTILTDLQEEIQSGDVLIVKLKEE
TEHEKNLYEVQFLRFESDTKEDLDLMRMLMKYNYNILYPENIILDLPEEVNESTVDDWNERVDLRNLKCITIDGEYSKDF
DDAISFIEEKNRIRFYVHIADVSYYVRPGNDLDEEAYNRATSVYLGSRVVPMLPPELSESLCSLIAGKNRLAFTVEMEAD
WKGKITHAKYYKSIINVKERYTYNKAESEILSGDSDNWIFRMNEFAKILRTKRIEDGRVDLNLKENKVVTDSEHNVIEIA
IQDRLQSHILIEEFMLSANIKVAEYIRKKKHPTLYRVHEAMNEEKIESLNAFLQLNATKILLKDSSYESIRSVLKELEAK
PAERLFNMFLLRTFMQAYYSGEHLGHWGLGFEDYCHFTSPIRRYPDLVCHRVLQNILLGKKPIYTPEEIVTFGLHCSHQE
RKASDAERDYYKLKACRYLEKTGIKEFSATITGCRPHLIFVDLENPAVDACLFSSEFTDEGEIRLETDFSFYSKKYSKIY
TLGDKIEVELDRIDYEEIKIFVKMKKFQKKV

Sequences:

>Translated_751_residues
MNIKKKQTTENKSVKSNRKKKTFDKSNKTKKERTDGFRENEIGKKILKYIQSRAGSVIQFKDLNAKILREENQNSYGKKR
EKWEFQEKEREILETLKILETEGLIELEKKNIIINSNQKLQGTISISKKGDGFVKLSSGVEIFVPNQYTQSAIQGDLVEV
RPYGVGKKRRLEGEVTEILRRGRDLYRMIVTEKEPKFIFGKLLDIDGEEKEGYLLRKTILTDLQEEIQSGDVLIVKLKEE
TEHEKNLYEVQFLRFESDTKEDLDLMRMLMKYNYNILYPENIILDLPEEVNESTVDDWNERVDLRNLKCITIDGEYSKDF
DDAISFIEEKNRIRFYVHIADVSYYVRPGNDLDEEAYNRATSVYLGSRVVPMLPPELSESLCSLIAGKNRLAFTVEMEAD
WKGKITHAKYYKSIINVKERYTYNKAESEILSGDSDNWIFRMNEFAKILRTKRIEDGRVDLNLKENKVVTDSEHNVIEIA
IQDRLQSHILIEEFMLSANIKVAEYIRKKKHPTLYRVHEAMNEEKIESLNAFLQLNATKILLKDSSYESIRSVLKELEAK
PAERLFNMFLLRTFMQAYYSGEHLGHWGLGFEDYCHFTSPIRRYPDLVCHRVLQNILLGKKPIYTPEEIVTFGLHCSHQE
RKASDAERDYYKLKACRYLEKTGIKEFSATITGCRPHLIFVDLENPAVDACLFSSEFTDEGEIRLETDFSFYSKKYSKIY
TLGDKIEVELDRIDYEEIKIFVKMKKFQKKV
>Mature_751_residues
MNIKKKQTTENKSVKSNRKKKTFDKSNKTKKERTDGFRENEIGKKILKYIQSRAGSVIQFKDLNAKILREENQNSYGKKR
EKWEFQEKEREILETLKILETEGLIELEKKNIIINSNQKLQGTISISKKGDGFVKLSSGVEIFVPNQYTQSAIQGDLVEV
RPYGVGKKRRLEGEVTEILRRGRDLYRMIVTEKEPKFIFGKLLDIDGEEKEGYLLRKTILTDLQEEIQSGDVLIVKLKEE
TEHEKNLYEVQFLRFESDTKEDLDLMRMLMKYNYNILYPENIILDLPEEVNESTVDDWNERVDLRNLKCITIDGEYSKDF
DDAISFIEEKNRIRFYVHIADVSYYVRPGNDLDEEAYNRATSVYLGSRVVPMLPPELSESLCSLIAGKNRLAFTVEMEAD
WKGKITHAKYYKSIINVKERYTYNKAESEILSGDSDNWIFRMNEFAKILRTKRIEDGRVDLNLKENKVVTDSEHNVIEIA
IQDRLQSHILIEEFMLSANIKVAEYIRKKKHPTLYRVHEAMNEEKIESLNAFLQLNATKILLKDSSYESIRSVLKELEAK
PAERLFNMFLLRTFMQAYYSGEHLGHWGLGFEDYCHFTSPIRRYPDLVCHRVLQNILLGKKPIYTPEEIVTFGLHCSHQE
RKASDAERDYYKLKACRYLEKTGIKEFSATITGCRPHLIFVDLENPAVDACLFSSEFTDEGEIRLETDFSFYSKKYSKIY
TLGDKIEVELDRIDYEEIKIFVKMKKFQKKV

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014623, Length=493, Percent_Identity=30.8316430020284, Blast_Score=180, Evalue=5e-45,
Organism=Homo sapiens, GI190014625, Length=493, Percent_Identity=30.8316430020284, Blast_Score=179, Evalue=9e-45,
Organism=Homo sapiens, GI134288890, Length=420, Percent_Identity=29.5238095238095, Blast_Score=140, Evalue=4e-33,
Organism=Homo sapiens, GI19115966, Length=420, Percent_Identity=27.8571428571429, Blast_Score=126, Evalue=6e-29,
Organism=Homo sapiens, GI219521928, Length=420, Percent_Identity=27.8571428571429, Blast_Score=126, Evalue=9e-29,
Organism=Escherichia coli, GI87082383, Length=653, Percent_Identity=30.4747320061256, Blast_Score=273, Evalue=3e-74,
Organism=Escherichia coli, GI1787542, Length=589, Percent_Identity=24.7877758913413, Blast_Score=126, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI212645896, Length=394, Percent_Identity=30.7106598984772, Blast_Score=149, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17553506, Length=416, Percent_Identity=28.3653846153846, Blast_Score=144, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6324552, Length=480, Percent_Identity=32.9166666666667, Blast_Score=163, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6323943, Length=378, Percent_Identity=25.3968253968254, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6320499, Length=348, Percent_Identity=22.9885057471264, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24649634, Length=351, Percent_Identity=34.1880341880342, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI19922976, Length=415, Percent_Identity=28.9156626506024, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24654597, Length=415, Percent_Identity=28.9156626506024, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24654592, Length=412, Percent_Identity=29.3689320388349, Blast_Score=140, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805
- InterPro:   IPR011991 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 88050; Mature: 88050

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIKKKQTTENKSVKSNRKKKTFDKSNKTKKERTDGFRENEIGKKILKYIQSRAGSVIQF
CCCCCCCCCCCHHHHHCCHHHHCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEE
KDLNAKILREENQNSYGKKREKWEFQEKEREILETLKILETEGLIELEKKNIIINSNQKL
ECCCHHHHHCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHCCCCEEEECCEEEECCCCCE
QGTISISKKGDGFVKLSSGVEIFVPNQYTQSAIQGDLVEVRPYGVGKKRRLEGEVTEILR
EEEEEEECCCCCEEEEECCEEEEECCHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHH
RGRDLYRMIVTEKEPKFIFGKLLDIDGEEKEGYLLRKTILTDLQEEIQSGDVLIVKLKEE
CCHHHHHHHHCCCCCCEEEHEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCC
TEHEKNLYEVQFLRFESDTKEDLDLMRMLMKYNYNILYPENIILDLPEEVNESTVDDWNE
CCCCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCEECCCCEEEECCHHCCCCHHHHHHH
RVDLRNLKCITIDGEYSKDFDDAISFIEEKNRIRFYVHIADVSYYVRPGNDLDEEAYNRA
CCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCEEEEEEEEEEEEEECCCCCCCHHHHHHH
TSVYLGSRVVPMLPPELSESLCSLIAGKNRLAFTVEMEADWKGKITHAKYYKSIINVKER
HHEEECCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHH
YTYNKAESEILSGDSDNWIFRMNEFAKILRTKRIEDGRVDLNLKENKVVTDSEHNVIEIA
HCCCHHHHHHHCCCCCCEEEEHHHHHHHHHHHCCCCCCEEEEECCCEEEECCCCCEEEEE
IQDRLQSHILIEEFMLSANIKVAEYIRKKKHPTLYRVHEAMNEEKIESLNAFLQLNATKI
EHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHCHHHHHHHHHHEEECCEEE
LLKDSSYESIRSVLKELEAKPAERLFNMFLLRTFMQAYYSGEHLGHWGLGFEDYCHFTSP
EEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
IRRYPDLVCHRVLQNILLGKKPIYTPEEIVTFGLHCSHQERKASDAERDYYKLKACRYLE
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHEECCCCCCHHHHCCCHHHHHHHHHHHHHHH
KTGIKEFSATITGCRPHLIFVDLENPAVDACLFSSEFTDEGEIRLETDFSFYSKKYSKIY
HCCCHHHHHHEECCCCEEEEEECCCCCCHHEEECCCCCCCCCEEEEECHHHHHHHHHHEE
TLGDKIEVELDRIDYEEIKIFVKMKKFQKKV
EECCEEEEEEECCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNIKKKQTTENKSVKSNRKKKTFDKSNKTKKERTDGFRENEIGKKILKYIQSRAGSVIQF
CCCCCCCCCCCHHHHHCCHHHHCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEE
KDLNAKILREENQNSYGKKREKWEFQEKEREILETLKILETEGLIELEKKNIIINSNQKL
ECCCHHHHHCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHCCCCEEEECCEEEECCCCCE
QGTISISKKGDGFVKLSSGVEIFVPNQYTQSAIQGDLVEVRPYGVGKKRRLEGEVTEILR
EEEEEEECCCCCEEEEECCEEEEECCHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHH
RGRDLYRMIVTEKEPKFIFGKLLDIDGEEKEGYLLRKTILTDLQEEIQSGDVLIVKLKEE
CCHHHHHHHHCCCCCCEEEHEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCC
TEHEKNLYEVQFLRFESDTKEDLDLMRMLMKYNYNILYPENIILDLPEEVNESTVDDWNE
CCCCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCEECCCCEEEECCHHCCCCHHHHHHH
RVDLRNLKCITIDGEYSKDFDDAISFIEEKNRIRFYVHIADVSYYVRPGNDLDEEAYNRA
CCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCEEEEEEEEEEEEEECCCCCCCHHHHHHH
TSVYLGSRVVPMLPPELSESLCSLIAGKNRLAFTVEMEADWKGKITHAKYYKSIINVKER
HHEEECCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHH
YTYNKAESEILSGDSDNWIFRMNEFAKILRTKRIEDGRVDLNLKENKVVTDSEHNVIEIA
HCCCHHHHHHHCCCCCCEEEEHHHHHHHHHHHCCCCCCEEEEECCCEEEECCCCCEEEEE
IQDRLQSHILIEEFMLSANIKVAEYIRKKKHPTLYRVHEAMNEEKIESLNAFLQLNATKI
EHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHCHHHHHHHHHHEEECCEEE
LLKDSSYESIRSVLKELEAKPAERLFNMFLLRTFMQAYYSGEHLGHWGLGFEDYCHFTSP
EEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
IRRYPDLVCHRVLQNILLGKKPIYTPEEIVTFGLHCSHQERKASDAERDYYKLKACRYLE
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHEECCCCCCHHHHCCCHHHHHHHHHHHHHHH
KTGIKEFSATITGCRPHLIFVDLENPAVDACLFSSEFTDEGEIRLETDFSFYSKKYSKIY
HCCCHHHHHHEECCCCEEEEEECCCCCCHHEEECCCCCCCCCEEEEECHHHHHHHHHHEE
TLGDKIEVELDRIDYEEIKIFVKMKKFQKKV
EECCEEEEEEECCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]