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The map label for this gene is coaBC [H]

Identifier: 45359169

GI number: 45359169

Start: 1553771

End: 1554961

Strand: Direct

Name: coaBC [H]

Synonym: MMP1606

Alternate gene names: 45359169

Gene position: 1553771-1554961 (Clockwise)

Preceding gene: 45359168

Following gene: 45359170

Centisome position: 93.54

GC content: 31.99

Gene sequence:

>1191_bases
ATGCACCCTACAAAAACACTTCACGGAGCAAAATCAAAATTACTGGATGGTAAAAAACTCGTTGTAGCAGTTACTTCATC
GATTGCAGCAATTGAAGCGCCAAGATTGATGAGAGAATTAATCAGACACGGTGCTGAAGTTTACTGCATAATGACGGAAG
AAACAAAAGATATCGTTGGGAAATACTCGCTTGAATTTGGATGCGGAAACGAAGTAATGGATAAAATTACTGGAAAAATT
GAACATGTCGATTTATACAATAAATGCGATGGAATGATAGTTTTTCCAGCAACTGCAAACATAATATCCAAAATTTCGCT
GAATATTGCAGATAACATTGTAAACACGACTGCAATGATGTTTTTAGAAAAAAAACCAATCATAATTGCTCCATCAATGC
ACCAGAACATGCTCGATACCGTTAGGGATCACATAAAAAACCTTTCTGAAAAAAATAACGTCTTTGTAATGGGTTCAAAA
ATGGAAGAAGAAAAAGCAAAAGCAATTTCAATTGATGAAGTTTCAAAGCTTGCGATTGATGTGTTTTCCGATAGAAAAGA
AGAAAGAAAAAAAGTGCTTATATTATCAGGCGGAACTGCTGAACCAATTGATAAAGTCAGAGTAATTACAAATCTTTCTT
CTGGAAAAACCGGTGTTTCACTTGCAGAAGAATTTTGTAGGCAGAATTATGATGTTGATGTGATAAAAGGACTTGGAAAA
GATGTTCCATATTATATAAACTCGGAAAACGTGATCACATCACAAGAAATGCTTAAAAAAGCTCTTGAACTTGGGGAATC
TGCAGATATAATAATTTCGTGCGCTGCAATTTCAGATTATGCTCCTGAAACGAATTTTGAAGGAAAATTAAGTTCAGATA
TCAAAACACAAGTTATAAAATTAAAACAAACTCCGAAAGTTTTGGAAGAATTAAGGAAAAAATTCCCTAAAAAAATTATT
GTAGGATACAAGGCAGAATACGGAATAAATTTAGATGAATTAAAAGAAAAGGCAATTTCAAGACTTGAAAAATATAATTT
AGATGTAATAATTGCAAATGATCTTTCGAAACACTATTTTGGTGATGATTTAAACGAAGTTTTGATTATCGATAAAGAAA
AGGCTTTGAAAGTTTCGGGAAGTAAAGATGAAATATCTAAAAAAATTGTTGAAATTGTAAATAATCTCTAA

Upstream 100 bases:

>100_bases
TACGTTGTAACGCTCGGGCACCCAAAAGGCGAGAAAAAAACAAACGTTATAAAAGTTGAGAGCATATAATCAAATAACAG
CTTGAAAAAAGGAGATTTAA

Downstream 100 bases:

>100_bases
AAGGGATACTTTGGGATACAAAGATGAAATCGGAGTTATTGGAATTGATGATGCGCCATTTAATAAATTTGATAAAGAAG
CGCTGATTGTTGGAACTTAC

Product: flavoprotein:DNA/pantothenate metabolism flavoprotein

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MHPTKTLHGAKSKLLDGKKLVVAVTSSIAAIEAPRLMRELIRHGAEVYCIMTEETKDIVGKYSLEFGCGNEVMDKITGKI
EHVDLYNKCDGMIVFPATANIISKISLNIADNIVNTTAMMFLEKKPIIIAPSMHQNMLDTVRDHIKNLSEKNNVFVMGSK
MEEEKAKAISIDEVSKLAIDVFSDRKEERKKVLILSGGTAEPIDKVRVITNLSSGKTGVSLAEEFCRQNYDVDVIKGLGK
DVPYYINSENVITSQEMLKKALELGESADIIISCAAISDYAPETNFEGKLSSDIKTQVIKLKQTPKVLEELRKKFPKKII
VGYKAEYGINLDELKEKAISRLEKYNLDVIIANDLSKHYFGDDLNEVLIIDKEKALKVSGSKDEISKKIVEIVNNL

Sequences:

>Translated_396_residues
MHPTKTLHGAKSKLLDGKKLVVAVTSSIAAIEAPRLMRELIRHGAEVYCIMTEETKDIVGKYSLEFGCGNEVMDKITGKI
EHVDLYNKCDGMIVFPATANIISKISLNIADNIVNTTAMMFLEKKPIIIAPSMHQNMLDTVRDHIKNLSEKNNVFVMGSK
MEEEKAKAISIDEVSKLAIDVFSDRKEERKKVLILSGGTAEPIDKVRVITNLSSGKTGVSLAEEFCRQNYDVDVIKGLGK
DVPYYINSENVITSQEMLKKALELGESADIIISCAAISDYAPETNFEGKLSSDIKTQVIKLKQTPKVLEELRKKFPKKII
VGYKAEYGINLDELKEKAISRLEKYNLDVIIANDLSKHYFGDDLNEVLIIDKEKALKVSGSKDEISKKIVEIVNNL
>Mature_396_residues
MHPTKTLHGAKSKLLDGKKLVVAVTSSIAAIEAPRLMRELIRHGAEVYCIMTEETKDIVGKYSLEFGCGNEVMDKITGKI
EHVDLYNKCDGMIVFPATANIISKISLNIADNIVNTTAMMFLEKKPIIIAPSMHQNMLDTVRDHIKNLSEKNNVFVMGSK
MEEEKAKAISIDEVSKLAIDVFSDRKEERKKVLILSGGTAEPIDKVRVITNLSSGKTGVSLAEEFCRQNYDVDVIKGLGK
DVPYYINSENVITSQEMLKKALELGESADIIISCAAISDYAPETNFEGKLSSDIKTQVIKLKQTPKVLEELRKKFPKKII
VGYKAEYGINLDELKEKAISRLEKYNLDVIIANDLSKHYFGDDLNEVLIIDKEKALKVSGSKDEISKKIVEIVNNL

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Escherichia coli, GI87082301, Length=394, Percent_Identity=27.6649746192893, Blast_Score=128, Evalue=6e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 44126; Mature: 44126

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHPTKTLHGAKSKLLDGKKLVVAVTSSIAAIEAPRLMRELIRHGAEVYCIMTEETKDIVG
CCCCCCCCCHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHH
KYSLEFGCGNEVMDKITGKIEHVDLYNKCDGMIVFPATANIISKISLNIADNIVNTTAMM
CEEEECCCCHHHHHHHCCCEEEEEHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHH
FLEKKPIIIAPSMHQNMLDTVRDHIKNLSEKNNVFVMGSKMEEEKAKAISIDEVSKLAID
EEECCCEEECCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHCCCHHHHHHHHHH
VFSDRKEERKKVLILSGGTAEPIDKVRVITNLSSGKTGVSLAEEFCRQNYDVDVIKGLGK
HHHCCHHCCCEEEEEECCCCCCHHHEEHEEECCCCCCHHHHHHHHHHCCCCCHHHHHCCC
DVPYYINSENVITSQEMLKKALELGESADIIISCAAISDYAPETNFEGKLSSDIKTQVIK
CCCEEECCCCEECHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHH
LKQTPKVLEELRKKFPKKIIVGYKAEYGINLDELKEKAISRLEKYNLDVIIANDLSKHYF
HCCCHHHHHHHHHHCCHHEEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCHHHHC
GDDLNEVLIIDKEKALKVSGSKDEISKKIVEIVNNL
CCCCCCEEEEECCCCEEECCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHPTKTLHGAKSKLLDGKKLVVAVTSSIAAIEAPRLMRELIRHGAEVYCIMTEETKDIVG
CCCCCCCCCHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHH
KYSLEFGCGNEVMDKITGKIEHVDLYNKCDGMIVFPATANIISKISLNIADNIVNTTAMM
CEEEECCCCHHHHHHHCCCEEEEEHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHH
FLEKKPIIIAPSMHQNMLDTVRDHIKNLSEKNNVFVMGSKMEEEKAKAISIDEVSKLAID
EEECCCEEECCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHCCCHHHHHHHHHH
VFSDRKEERKKVLILSGGTAEPIDKVRVITNLSSGKTGVSLAEEFCRQNYDVDVIKGLGK
HHHCCHHCCCEEEEEECCCCCCHHHEEHEEECCCCCCHHHHHHHHHHCCCCCHHHHHCCC
DVPYYINSENVITSQEMLKKALELGESADIIISCAAISDYAPETNFEGKLSSDIKTQVIK
CCCEEECCCCEECHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHH
LKQTPKVLEELRKKFPKKIIVGYKAEYGINLDELKEKAISRLEKYNLDVIIANDLSKHYF
HCCCHHHHHHHHHHCCHHEEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCHHHHC
GDDLNEVLIIDKEKALKVSGSKDEISKKIVEIVNNL
CCCCCCEEEEECCCCEEECCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]