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The map label for this gene is mcrA [H]

Identifier: 45359122

GI number: 45359122

Start: 1512964

End: 1514625

Strand: Direct

Name: mcrA [H]

Synonym: MMP1559

Alternate gene names: 45359122

Gene position: 1512964-1514625 (Clockwise)

Preceding gene: 45359121

Following gene: 45359123

Centisome position: 91.08

GC content: 42.18

Gene sequence:

>1662_bases
ATGGAAGCTGAAAAAAGATTATTTTTGAAAGCCTTAAAGGAAAAATTCGAAGAAGACCCTAAAGAAAAGTACACAAAATT
CTATACCTTTGGCGGTTGGGAACAATCTGCTAGAAAAAGAGAATTTGTTGAAGCTAATGAAAAAATAGTATCTGAAAAAA
GACAAGGAATCCCACTCTACAACCCAGACATTGGTGTTCCTCTAGGACAGAGAAAATTAATGCCTTACAAATTGTCAAAC
ACTGACGATTACTGTGAAGGTGACGATTTACACTTCTTAAACAACGCTGCTATCCAACAATTATGGGACGATATCAGAAG
AACTGTTATTGTAGGTATGGACACTGCTCACTCAGTTTTAGAAAAAAGATTGGGTGTAGAAGTAACTCCTGAAACAATCA
ACGAATACATGCACACAATCAACCACTCCCTTCCAGGAGGAGCTGTTGTTCAGGAACACATGGTTGAAGTTCACCCTTCC
CTTGCATGGGACTGTTACGCTAGAATCTTCACCGGTGACGATGAATTAGCTGACGAATTAGACAGCAGATTCTTAATCGA
CATCAACAAATTATTCCCTGAAGAACAAGCTGAAACATTAAAAGCTGCAATTGGTAAAAAAACATACCAAGTATCAAGAG
TTCCATCACTCGTAGGTAGAGTATGTGACGGCGGTACAATCTCAAGATGGTCTGCAATGCAGATCGGAATGTCATTCATT
ACCGCATACAAACTTTGTGCAGGGGAAGCTGCAACAGCTGACTTCTCATACGCTTCAAAACACGCTGATGTAATTCAGAT
GGGTAATGCTTTACCAGGAAGAAGAGCAAGAGGTCCAAACGAACCAGGAGGAATCAGATTCGGTATTCTCTCCGATGTTG
TACAAACAACAAGAGTTTCAGAAGACCCAGTTGAACAATCATTAGAAGTAGTAGCAACAGGTGCTGCTTTATATGACCAG
ATCTGGCTCGGTGCATACATGTCTGGTGGTGTAGGATTCACTCAATACGCTACCGCATCATACACCGACGATATCTTAGA
TGACTTCTCATACTACGCACTCGACTACGTTGAGAAAAAATACGGTAGAATGGGAACAAAAGCTACAATGGATGTAGTAG
AAGATGTTGCTGGAGAAGTTACACTCTACGCATTAGAACAGTACGATGACTACCCAGCATTATTAGAAGACCACTTCGGT
GGATCACAAAGAGCTGCAGTTGCTGCTGCTGCATCAGGTATTGGTGTATGTATGGCAACAGGAAACTCAAACGCTGGTGT
AAACGGCTGGTACTTATCACAAATCTTACACAAAGAATACCACAGCAGACTCGGATTCTACGGTTACGACTTGCAGGACC
AGTGTGGTGCTTCAAACTCACTCGCAATCAGAAACGACGAAGCTGCACCTCTTGAATTAAGAGGACCTAACTACCCTAAC
TACGCGATGAACGTAGGTCACCAGGGAGAATACGCAGGTATTGCACAAGCTGCACACTCCGCAAGAGGAGACGCATTTGC
ACTTAGCCCATTGGTAAAAGTTGCATTTGCTGACCCAATGCTCGTATTCGATTTCTCCAAACCTAGAAAAGAAATGGCTA
GGGGAGCATTAAGAGAATTCGAAGCTGCAGGAGAAAGAGACGTTATCTTACCTGCTAAATAA

Upstream 100 bases:

>100_bases
CAAGAACACTCGGTGGATACATCCCTACAAACGAAACATTCAAAGGATTATAACTAAATTTTAAATTAAAAAAAACCTCT
TAAACCATTGAGGTGAACTT

Downstream 100 bases:

>100_bases
ATTCTATAATTTAAGGGAGCCACTTGGCTTCCTTTTTTTATACTTATTATATATTGTTTCATAATCGTTAACAATATAGA
TTAATTAAAATATACTTTAA

Product: methyl-coenzyme M reductase I subunit alpha

Products: NA

Alternate protein names: Coenzyme-B sulfoethylthiotransferase alpha [H]

Number of amino acids: Translated: 553; Mature: 553

Protein sequence:

>553_residues
MEAEKRLFLKALKEKFEEDPKEKYTKFYTFGGWEQSARKREFVEANEKIVSEKRQGIPLYNPDIGVPLGQRKLMPYKLSN
TDDYCEGDDLHFLNNAAIQQLWDDIRRTVIVGMDTAHSVLEKRLGVEVTPETINEYMHTINHSLPGGAVVQEHMVEVHPS
LAWDCYARIFTGDDELADELDSRFLIDINKLFPEEQAETLKAAIGKKTYQVSRVPSLVGRVCDGGTISRWSAMQIGMSFI
TAYKLCAGEAATADFSYASKHADVIQMGNALPGRRARGPNEPGGIRFGILSDVVQTTRVSEDPVEQSLEVVATGAALYDQ
IWLGAYMSGGVGFTQYATASYTDDILDDFSYYALDYVEKKYGRMGTKATMDVVEDVAGEVTLYALEQYDDYPALLEDHFG
GSQRAAVAAAASGIGVCMATGNSNAGVNGWYLSQILHKEYHSRLGFYGYDLQDQCGASNSLAIRNDEAAPLELRGPNYPN
YAMNVGHQGEYAGIAQAAHSARGDAFALSPLVKVAFADPMLVFDFSKPRKEMARGALREFEAAGERDVILPAK

Sequences:

>Translated_553_residues
MEAEKRLFLKALKEKFEEDPKEKYTKFYTFGGWEQSARKREFVEANEKIVSEKRQGIPLYNPDIGVPLGQRKLMPYKLSN
TDDYCEGDDLHFLNNAAIQQLWDDIRRTVIVGMDTAHSVLEKRLGVEVTPETINEYMHTINHSLPGGAVVQEHMVEVHPS
LAWDCYARIFTGDDELADELDSRFLIDINKLFPEEQAETLKAAIGKKTYQVSRVPSLVGRVCDGGTISRWSAMQIGMSFI
TAYKLCAGEAATADFSYASKHADVIQMGNALPGRRARGPNEPGGIRFGILSDVVQTTRVSEDPVEQSLEVVATGAALYDQ
IWLGAYMSGGVGFTQYATASYTDDILDDFSYYALDYVEKKYGRMGTKATMDVVEDVAGEVTLYALEQYDDYPALLEDHFG
GSQRAAVAAAASGIGVCMATGNSNAGVNGWYLSQILHKEYHSRLGFYGYDLQDQCGASNSLAIRNDEAAPLELRGPNYPN
YAMNVGHQGEYAGIAQAAHSARGDAFALSPLVKVAFADPMLVFDFSKPRKEMARGALREFEAAGERDVILPAK
>Mature_553_residues
MEAEKRLFLKALKEKFEEDPKEKYTKFYTFGGWEQSARKREFVEANEKIVSEKRQGIPLYNPDIGVPLGQRKLMPYKLSN
TDDYCEGDDLHFLNNAAIQQLWDDIRRTVIVGMDTAHSVLEKRLGVEVTPETINEYMHTINHSLPGGAVVQEHMVEVHPS
LAWDCYARIFTGDDELADELDSRFLIDINKLFPEEQAETLKAAIGKKTYQVSRVPSLVGRVCDGGTISRWSAMQIGMSFI
TAYKLCAGEAATADFSYASKHADVIQMGNALPGRRARGPNEPGGIRFGILSDVVQTTRVSEDPVEQSLEVVATGAALYDQ
IWLGAYMSGGVGFTQYATASYTDDILDDFSYYALDYVEKKYGRMGTKATMDVVEDVAGEVTLYALEQYDDYPALLEDHFG
GSQRAAVAAAASGIGVCMATGNSNAGVNGWYLSQILHKEYHSRLGFYGYDLQDQCGASNSLAIRNDEAAPLELRGPNYPN
YAMNVGHQGEYAGIAQAAHSARGDAFALSPLVKVAFADPMLVFDFSKPRKEMARGALREFEAAGERDVILPAK

Specific function: Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and an heterodisulfide [H]

COG id: COG4058

COG function: function code H; Methyl coenzyme M reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022681
- InterPro:   IPR016212
- InterPro:   IPR008924
- InterPro:   IPR009047
- InterPro:   IPR003183
- InterPro:   IPR015811
- InterPro:   IPR015823
- InterPro:   IPR009024 [H]

Pfam domain/function: PF02249 MCR_alpha; PF02745 MCR_alpha_N [H]

EC number: =2.8.4.1 [H]

Molecular weight: Translated: 61070; Mature: 61070

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAEKRLFLKALKEKFEEDPKEKYTKFYTFGGWEQSARKREFVEANEKIVSEKRQGIPLY
CCHHHHHHHHHHHHHHHCCHHHHHHEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
NPDIGVPLGQRKLMPYKLSNTDDYCEGDDLHFLNNAAIQQLWDDIRRTVIVGMDTAHSVL
CCCCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCHHHHHH
EKRLGVEVTPETINEYMHTINHSLPGGAVVQEHMVEVHPSLAWDCYARIFTGDDELADEL
HHHCCCEECHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHEECCCHHHHHHH
DSRFLIDINKLFPEEQAETLKAAIGKKTYQVSRVPSLVGRVCDGGTISRWSAMQIGMSFI
CCEEEEEHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
TAYKLCAGEAATADFSYASKHADVIQMGNALPGRRARGPNEPGGIRFGILSDVVQTTRVS
HHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHCCC
EDPVEQSLEVVATGAALYDQIWLGAYMSGGVGFTQYATASYTDDILDDFSYYALDYVEKK
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHH
YGRMGTKATMDVVEDVAGEVTLYALEQYDDYPALLEDHFGGSQRAAVAAAASGIGVCMAT
HHCCCCHHHHHHHHHHCCCEEEEEHHHCCCCHHHHHHCCCCCHHHHHHHHHCCCEEEEEE
GNSNAGVNGWYLSQILHKEYHSRLGFYGYDLQDQCGASNSLAIRNDEAAPLELRGPNYPN
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCEEEECCCCCCEEECCCCCCC
YAMNVGHQGEYAGIAQAAHSARGDAFALSPLVKVAFADPMLVFDFSKPRKEMARGALREF
HHCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHH
EAAGERDVILPAK
HCCCCCCEECCCC
>Mature Secondary Structure
MEAEKRLFLKALKEKFEEDPKEKYTKFYTFGGWEQSARKREFVEANEKIVSEKRQGIPLY
CCHHHHHHHHHHHHHHHCCHHHHHHEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
NPDIGVPLGQRKLMPYKLSNTDDYCEGDDLHFLNNAAIQQLWDDIRRTVIVGMDTAHSVL
CCCCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCHHHHHH
EKRLGVEVTPETINEYMHTINHSLPGGAVVQEHMVEVHPSLAWDCYARIFTGDDELADEL
HHHCCCEECHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHEECCCHHHHHHH
DSRFLIDINKLFPEEQAETLKAAIGKKTYQVSRVPSLVGRVCDGGTISRWSAMQIGMSFI
CCEEEEEHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
TAYKLCAGEAATADFSYASKHADVIQMGNALPGRRARGPNEPGGIRFGILSDVVQTTRVS
HHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHCCC
EDPVEQSLEVVATGAALYDQIWLGAYMSGGVGFTQYATASYTDDILDDFSYYALDYVEKK
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHH
YGRMGTKATMDVVEDVAGEVTLYALEQYDDYPALLEDHFGGSQRAAVAAAASGIGVCMAT
HHCCCCHHHHHHHHHHCCCEEEEEHHHCCCCHHHHHHCCCCCHHHHHHHHHCCCEEEEEE
GNSNAGVNGWYLSQILHKEYHSRLGFYGYDLQDQCGASNSLAIRNDEAAPLELRGPNYPN
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCEEEECCCCCCEEECCCCCCC
YAMNVGHQGEYAGIAQAAHSARGDAFALSPLVKVAFADPMLVFDFSKPRKEMARGALREF
HHCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHH
EAAGERDVILPAK
HCCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3185509 [H]