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The map label for this gene is thiM [H]

Identifier: 45358701

GI number: 45358701

Start: 1128004

End: 1128864

Strand: Direct

Name: thiM [H]

Synonym: MMP1138

Alternate gene names: 45358701

Gene position: 1128004-1128864 (Clockwise)

Preceding gene: 45358699

Following gene: 45358702

Centisome position: 67.91

GC content: 36.7

Gene sequence:

>861_bases
ATGTTTTTAAATATATGGATGTTTTTATTAAATGATAATTTGGCGAAAATCGGTGAAAAAATGGACTTTGTAGCAAAAAA
TCTTACAAAATTAAGGGAAACAAACCCGCTCGTTCAAAACATTACAAATTACGTGGTAATGAACTCTACCGCAAACTCGC
TTTTAGCTCTTGGTGCTTCTCCTGTAATGGCTCATGCAATGGATGAATTAGAAGAAATGGTTTCAATTGCAAGCGCATTA
GTGGTAAACATCGGAACTCTTGACGAATACTGGATTCCGTCAATGGAAAAAGCTGCAAAAATTGCAAGTGACCTCAAAAA
ACCAATAGTTCTCGATCCAGTAGGTGCAGGAGCTACTAAATTAAGAACAAAAACTGCTTTAAAAATACTCGACTTTGCAG
ATATTTCAGTTTTAAGAGGAAATTTTGGTGAAATTGCCGCAGTTTTAGGAGAACACGGGAAAACAAGAGGGGTAGATAGT
GCTGCATATGACAGCAATGAAGCTATCGAACTTTCAAAAAATGCTGCAAAAGAATTCAACACAGTTTCAGCAGTAACTGG
CCCCGTTGATCATGTAAGCAATGGAAAAGAAATTTACTCAATTTCAAATGGGCATTCCATGCTTTCAAAAGTTACAGGAA
CGGGCTGTGCAACTACATCAATTATTGGTGCATTTTCCGCGGTTGATGATCCATTGAAAGCTGCCGTAAGTGGACTTGTA
GTTTACGGAATTTCTGCTGAAATGGCATTTACTGAAGCACCGTATCCTGGAACATTTCAGGCAAAAGTATACGACTGGTT
ATACAGAATCGATGAAAAATTAGTTTTAGAAAAAGCTAAGGTGAATAAATTTGAAATTTAA

Upstream 100 bases:

>100_bases
TTTTTTATATTGATATCAACCTATATATATACGTTATACATTATTTAGTATAATGGATATCTGACAAATTTAGAATTTTT
TCGGAAACTTTTTTACCGGC

Downstream 100 bases:

>100_bases
GGATAAATTAAAATTTTACGTAATAACTGACAGTAATTATTCAGATGAAGTTATATCTGTTGAAGAATCCCTAAAAGGAG
GAGCTACATCAATCCAACTT

Product: hydroxyethylthiazole kinase

Products: NA

Alternate protein names: 4-methyl-5-beta-hydroxyethylthiazole kinase; TH kinase; Thz kinase [H]

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MFLNIWMFLLNDNLAKIGEKMDFVAKNLTKLRETNPLVQNITNYVVMNSTANSLLALGASPVMAHAMDELEEMVSIASAL
VVNIGTLDEYWIPSMEKAAKIASDLKKPIVLDPVGAGATKLRTKTALKILDFADISVLRGNFGEIAAVLGEHGKTRGVDS
AAYDSNEAIELSKNAAKEFNTVSAVTGPVDHVSNGKEIYSISNGHSMLSKVTGTGCATTSIIGAFSAVDDPLKAAVSGLV
VYGISAEMAFTEAPYPGTFQAKVYDWLYRIDEKLVLEKAKVNKFEI

Sequences:

>Translated_286_residues
MFLNIWMFLLNDNLAKIGEKMDFVAKNLTKLRETNPLVQNITNYVVMNSTANSLLALGASPVMAHAMDELEEMVSIASAL
VVNIGTLDEYWIPSMEKAAKIASDLKKPIVLDPVGAGATKLRTKTALKILDFADISVLRGNFGEIAAVLGEHGKTRGVDS
AAYDSNEAIELSKNAAKEFNTVSAVTGPVDHVSNGKEIYSISNGHSMLSKVTGTGCATTSIIGAFSAVDDPLKAAVSGLV
VYGISAEMAFTEAPYPGTFQAKVYDWLYRIDEKLVLEKAKVNKFEI
>Mature_286_residues
MFLNIWMFLLNDNLAKIGEKMDFVAKNLTKLRETNPLVQNITNYVVMNSTANSLLALGASPVMAHAMDELEEMVSIASAL
VVNIGTLDEYWIPSMEKAAKIASDLKKPIVLDPVGAGATKLRTKTALKILDFADISVLRGNFGEIAAVLGEHGKTRGVDS
AAYDSNEAIELSKNAAKEFNTVSAVTGPVDHVSNGKEIYSISNGHSMLSKVTGTGCATTSIIGAFSAVDDPLKAAVSGLV
VYGISAEMAFTEAPYPGTFQAKVYDWLYRIDEKLVLEKAKVNKFEI

Specific function: Thiamine biosynthesis. [C]

COG id: COG2145

COG function: function code H; Hydroxyethylthiazole kinase, sugar kinase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Thz kinase family [H]

Homologues:

Organism=Escherichia coli, GI1788421, Length=251, Percent_Identity=34.6613545816733, Blast_Score=135, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6325042, Length=289, Percent_Identity=28.0276816608997, Blast_Score=103, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000417 [H]

Pfam domain/function: PF02110 HK [H]

EC number: =2.7.1.50 [H]

Molecular weight: Translated: 30771; Mature: 30771

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLNIWMFLLNDNLAKIGEKMDFVAKNLTKLRETNPLVQNITNYVVMNSTANSLLALGAS
CCCEEEEHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHEEECCCHHHHHHHCCC
PVMAHAMDELEEMVSIASALVVNIGTLDEYWIPSMEKAAKIASDLKKPIVLDPVGAGATK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCHHHHHHHHHHHCCCEEECCCCCCHHH
LRTKTALKILDFADISVLRGNFGEIAAVLGEHGKTRGVDSAAYDSNEAIELSKNAAKEFN
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHCCCCCCEEHHHHHHHHHH
TVSAVTGPVDHVSNGKEIYSISNGHSMLSKVTGTGCATTSIIGAFSAVDDPLKAAVSGLV
HHHHHCCCHHHCCCCCEEEEECCCHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHE
VYGISAEMAFTEAPYPGTFQAKVYDWLYRIDEKLVLEKAKVNKFEI
EEECCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MFLNIWMFLLNDNLAKIGEKMDFVAKNLTKLRETNPLVQNITNYVVMNSTANSLLALGAS
CCCEEEEHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHEEECCCHHHHHHHCCC
PVMAHAMDELEEMVSIASALVVNIGTLDEYWIPSMEKAAKIASDLKKPIVLDPVGAGATK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCHHHHHHHHHHHCCCEEECCCCCCHHH
LRTKTALKILDFADISVLRGNFGEIAAVLGEHGKTRGVDSAAYDSNEAIELSKNAAKEFN
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHCCCCCCEEHHHHHHHHHH
TVSAVTGPVDHVSNGKEIYSISNGHSMLSKVTGTGCATTSIIGAFSAVDDPLKAAVSGLV
HHHHHCCCHHHCCCCCEEEEECCCHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHE
VYGISAEMAFTEAPYPGTFQAKVYDWLYRIDEKLVLEKAKVNKFEI
EEECCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA