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The map label for this gene is aqpM [H]

Identifier: 45358526

GI number: 45358526

Start: 951358

End: 952077

Strand: Direct

Name: aqpM [H]

Synonym: MMP0963

Alternate gene names: 45358526

Gene position: 951358-952077 (Clockwise)

Preceding gene: 45358525

Following gene: 45358527

Centisome position: 57.27

GC content: 41.25

Gene sequence:

>720_bases
ATGAGCATGATCAAAAAATTAATTGCAGAATGCCTTGGAACGGGTATTTTAGTGTTTTTTGGTCCAGGTGCGGCTGCAAT
GACTTTAATGATTGCCAATAATACGGGAACTGCAGGAATTGGATTATTAGGTGGACTTGGAGACTGGTTTGCAATTGGTT
TTTCATTTGCAATCGCTATTGCTGCAGTAATTTATACAATGGGACGTATTTCTGGAGCCCATATTAATCCTGCAGTTACC
ATTGGACTATGGGCCGTTAAAAAATTCCCTACAAAAGATACAGTTCTATATATTATCGCCCAGTTAATCGGTGCTGCAAT
TGGTTCTCTACTGTTCTTTGCATGCATTGGAATTGATTCTGTAACAATTGGAGGACTTGGGGCTACTGCACCATTTGCAG
GAATAAGCTATTTCCAGGCAATACTCGCAGAATTTATTGGAACATTCCTACTAATGTTCGTTATAATGGGTGTTGCGGTA
GACAAACGCGCTCCCGATGGCTTTGCAGGACTGGTTATCGGTTTGACAGTTGGCGCAATAATTACGACTACTGGAAATAT
TGCGGGAGCCTCACTAAACCCTGCAAGGACTTTTGGGCCGTATTTGATAGATAGTATTTACGGGTTAAATCTGTGGTACT
ATTTCCCGATATATATTATCGGCCCGGTTCTTGGAGCAATAGTTGCCGCATTTACTTACGAGTACCTAAATCGCGAATAA

Upstream 100 bases:

>100_bases
ACTGGGAAGGAGGATACCCATTTCCAGCAACGAAATTAAAAAAGACAATTCCACGAATGCTCTGCAAACCCTGCTATAAT
GCACTTATGGAGGGTAAAAA

Downstream 100 bases:

>100_bases
TTAAAAAATCTTTTTTATTTTTTGAAAAATACCATATTTAAAAAATTATTAAACCTATTAACTCATCTGAAAAGTATTAA
TATTTTAAAACACCATATAG

Product: MIP family channel protein

Products: glycerol [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 239; Mature: 238

Protein sequence:

>239_residues
MSMIKKLIAECLGTGILVFFGPGAAAMTLMIANNTGTAGIGLLGGLGDWFAIGFSFAIAIAAVIYTMGRISGAHINPAVT
IGLWAVKKFPTKDTVLYIIAQLIGAAIGSLLFFACIGIDSVTIGGLGATAPFAGISYFQAILAEFIGTFLLMFVIMGVAV
DKRAPDGFAGLVIGLTVGAIITTTGNIAGASLNPARTFGPYLIDSIYGLNLWYYFPIYIIGPVLGAIVAAFTYEYLNRE

Sequences:

>Translated_239_residues
MSMIKKLIAECLGTGILVFFGPGAAAMTLMIANNTGTAGIGLLGGLGDWFAIGFSFAIAIAAVIYTMGRISGAHINPAVT
IGLWAVKKFPTKDTVLYIIAQLIGAAIGSLLFFACIGIDSVTIGGLGATAPFAGISYFQAILAEFIGTFLLMFVIMGVAV
DKRAPDGFAGLVIGLTVGAIITTTGNIAGASLNPARTFGPYLIDSIYGLNLWYYFPIYIIGPVLGAIVAAFTYEYLNRE
>Mature_238_residues
SMIKKLIAECLGTGILVFFGPGAAAMTLMIANNTGTAGIGLLGGLGDWFAIGFSFAIAIAAVIYTMGRISGAHINPAVTI
GLWAVKKFPTKDTVLYIIAQLIGAAIGSLLFFACIGIDSVTIGGLGATAPFAGISYFQAILAEFIGTFLLMFVIMGVAVD
KRAPDGFAGLVIGLTVGAIITTTGNIAGASLNPARTFGPYLIDSIYGLNLWYYFPIYIIGPVLGAIVAAFTYEYLNRE

Specific function: Channel that permits osmotically driven movement of water in both directions [H]

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI4502181, Length=190, Percent_Identity=36.3157894736842, Blast_Score=104, Evalue=6e-23,
Organism=Homo sapiens, GI4755125, Length=190, Percent_Identity=36.3157894736842, Blast_Score=104, Evalue=6e-23,
Organism=Homo sapiens, GI4826645, Length=259, Percent_Identity=28.957528957529, Blast_Score=98, Evalue=6e-21,
Organism=Homo sapiens, GI37694062, Length=234, Percent_Identity=30.7692307692308, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI4502183, Length=242, Percent_Identity=30.5785123966942, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI22538420, Length=258, Percent_Identity=26.7441860465116, Blast_Score=81, Evalue=8e-16,
Organism=Homo sapiens, GI157266307, Length=257, Percent_Identity=28.4046692607004, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI4502179, Length=233, Percent_Identity=28.3261802575107, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI86792455, Length=234, Percent_Identity=29.4871794871795, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI4502187, Length=255, Percent_Identity=25.0980392156863, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI6912506, Length=186, Percent_Identity=26.3440860215054, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI45446752, Length=221, Percent_Identity=27.6018099547511, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1790362, Length=257, Percent_Identity=32.6848249027237, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1787101, Length=222, Percent_Identity=35.1351351351351, Blast_Score=104, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI71993722, Length=243, Percent_Identity=34.156378600823, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71994009, Length=254, Percent_Identity=34.251968503937, Blast_Score=100, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17558372, Length=189, Percent_Identity=34.3915343915344, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71992966, Length=256, Percent_Identity=30.078125, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17544068, Length=259, Percent_Identity=27.027027027027, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17531429, Length=255, Percent_Identity=27.0588235294118, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17531431, Length=255, Percent_Identity=27.0588235294118, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI32564052, Length=254, Percent_Identity=27.9527559055118, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17533613, Length=254, Percent_Identity=27.9527559055118, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321054, Length=218, Percent_Identity=33.4862385321101, Blast_Score=89, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24652747, Length=235, Percent_Identity=30.6382978723404, Blast_Score=100, Evalue=6e-22,
Organism=Drosophila melanogaster, GI45551084, Length=235, Percent_Identity=30.6382978723404, Blast_Score=100, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24762346, Length=241, Percent_Identity=30.2904564315353, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24762348, Length=241, Percent_Identity=30.2904564315353, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI20130305, Length=241, Percent_Identity=30.2904564315353, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24762344, Length=241, Percent_Identity=30.2904564315353, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24762342, Length=232, Percent_Identity=30.1724137931034, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI45550503, Length=246, Percent_Identity=25.609756097561, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI19922038, Length=235, Percent_Identity=31.9148936170213, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24652751, Length=235, Percent_Identity=31.9148936170213, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI17136672, Length=193, Percent_Identity=30.5699481865285, Blast_Score=64, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 24885; Mature: 24754

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMIKKLIAECLGTGILVFFGPGAAAMTLMIANNTGTAGIGLLGGLGDWFAIGFSFAIAI
CHHHHHHHHHHHCCCEEEEECCCHHHEEEEEECCCCCCHHHHHHCHHHHHHHHHHHHHHH
AAVIYTMGRISGAHINPAVTIGLWAVKKFPTKDTVLYIIAQLIGAAIGSLLFFACIGIDS
HHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VTIGGLGATAPFAGISYFQAILAEFIGTFLLMFVIMGVAVDKRAPDGFAGLVIGLTVGAI
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
ITTTGNIAGASLNPARTFGPYLIDSIYGLNLWYYFPIYIIGPVLGAIVAAFTYEYLNRE
HEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SMIKKLIAECLGTGILVFFGPGAAAMTLMIANNTGTAGIGLLGGLGDWFAIGFSFAIAI
HHHHHHHHHHHCCCEEEEECCCHHHEEEEEECCCCCCHHHHHHCHHHHHHHHHHHHHHH
AAVIYTMGRISGAHINPAVTIGLWAVKKFPTKDTVLYIIAQLIGAAIGSLLFFACIGIDS
HHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VTIGGLGATAPFAGISYFQAILAEFIGTFLLMFVIMGVAVDKRAPDGFAGLVIGLTVGAI
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
ITTTGNIAGASLNPARTFGPYLIDSIYGLNLWYYFPIYIIGPVLGAIVAAFTYEYLNRE
HEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glycerol [Periplasm] [C]

Specific reaction: glycerol [Periplasm] = glycerol [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]