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The map label for this gene is aroE

Identifier: 45358499

GI number: 45358499

Start: 923937

End: 924773

Strand: Direct

Name: aroE

Synonym: MMP0936

Alternate gene names: 45358499

Gene position: 923937-924773 (Clockwise)

Preceding gene: 45358498

Following gene: 45358500

Centisome position: 55.62

GC content: 31.66

Gene sequence:

>837_bases
TTGATAAACTCTAAAACAAAACTAGTTGGACTTATTGGACACCCGGTAGATCATTCATTTTCACCGATAATGCATAACGC
TGCAATAAAAGACCTTAAAATAAATTACAGATACTTTGCATTTGACGTTTCAGAAGAAAATTTAAAAGACGTTGTAGCAG
GTGCAAAAGCATTTAATTTTAGGGGATTTAACATTACAATTCCTCACAAAATGAATATCATGAAATATCTTGATGAAATT
GATTGTGATGCAGAGGCTATCGGTGCAGTCAACACAGTAAAAATTGAAAACGGAAAAGCAATAGGATATAACACTGACGG
AATTGGTGTAAAAAAAGCACTTGAAGAAAAAACAGGCATTTTAATCAATAAAAACATTTTAATTATAGGCTCAGGAGGTG
CCTCAAGAGCTGTTTCTTTCGAACTTGCAAAGGATAATAATTTAACAATTGTAAATAGAAATATTGAAAAAGCAGAAAAT
CTCTCAAAAGAAATTTCTAGAAAGTTGAAAAAAGAAAATCCTCTAAATTACGGCGGCCTTGATATAAACATTGAAAATTT
TGATATAATAATAAATACAACACCTGTTGGAATGTACCCGCATACTGAAGTGGAGCCAGTTATACCATTAAATAACATTA
AAAAAGATGCTGTCGTAATGGACTTGATATACAACCCCCTTGAACCTGTTTTTTTAAAAGAAGCAAAAAAATATGGCGCA
AAAACCATTAATGGCATTGGAATGTTAGTATACCAGGGTGCAGTTTCCTTTGAGATATGGACAGGAATAAAACCAGACAT
ATTCGTGATGAAGAAAAGTATTATTTCAAAAATTTAA

Upstream 100 bases:

>100_bases
AAGGACAGAACATAATTAAAAGACAGGAAAGTGGAATAGAAAAAGCATATAATACGTTTATTGATATTTTAAAAAAAGAA
TACAATTTAAAGTGATAATC

Downstream 100 bases:

>100_bases
AAAATCGTGGGAAAAAATGATAAAAGAAAGAGTAAAAATGGAAGTAATAGGCCTTGAAATTCCATTAATCAGTGGAAATG
AAGATTATACGTTAGCAGAG

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MINSKTKLVGLIGHPVDHSFSPIMHNAAIKDLKINYRYFAFDVSEENLKDVVAGAKAFNFRGFNITIPHKMNIMKYLDEI
DCDAEAIGAVNTVKIENGKAIGYNTDGIGVKKALEEKTGILINKNILIIGSGGASRAVSFELAKDNNLTIVNRNIEKAEN
LSKEISRKLKKENPLNYGGLDINIENFDIIINTTPVGMYPHTEVEPVIPLNNIKKDAVVMDLIYNPLEPVFLKEAKKYGA
KTINGIGMLVYQGAVSFEIWTGIKPDIFVMKKSIISKI

Sequences:

>Translated_278_residues
MINSKTKLVGLIGHPVDHSFSPIMHNAAIKDLKINYRYFAFDVSEENLKDVVAGAKAFNFRGFNITIPHKMNIMKYLDEI
DCDAEAIGAVNTVKIENGKAIGYNTDGIGVKKALEEKTGILINKNILIIGSGGASRAVSFELAKDNNLTIVNRNIEKAEN
LSKEISRKLKKENPLNYGGLDINIENFDIIINTTPVGMYPHTEVEPVIPLNNIKKDAVVMDLIYNPLEPVFLKEAKKYGA
KTINGIGMLVYQGAVSFEIWTGIKPDIFVMKKSIISKI
>Mature_278_residues
MINSKTKLVGLIGHPVDHSFSPIMHNAAIKDLKINYRYFAFDVSEENLKDVVAGAKAFNFRGFNITIPHKMNIMKYLDEI
DCDAEAIGAVNTVKIENGKAIGYNTDGIGVKKALEEKTGILINKNILIIGSGGASRAVSFELAKDNNLTIVNRNIEKAEN
LSKEISRKLKKENPLNYGGLDINIENFDIIINTTPVGMYPHTEVEPVIPLNNIKKDAVVMDLIYNPLEPVFLKEAKKYGA
KTINGIGMLVYQGAVSFEIWTGIKPDIFVMKKSIISKI

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1787983, Length=270, Percent_Identity=31.1111111111111, Blast_Score=149, Evalue=1e-37,
Organism=Escherichia coli, GI1789675, Length=261, Percent_Identity=32.183908045977, Blast_Score=124, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6320332, Length=274, Percent_Identity=29.5620437956204, Blast_Score=100, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_METMP (Q6LYQ2)

Other databases:

- EMBL:   BX950229
- RefSeq:   NP_988056.1
- HSSP:   Q58484
- ProteinModelPortal:   Q6LYQ2
- SMR:   Q6LYQ2
- GeneID:   2762259
- GenomeReviews:   BX950229_GR
- KEGG:   mmp:MMP0936
- NMPDR:   fig|267377.1.peg.936
- HOGENOM:   HBG553408
- OMA:   AVAFKIW
- ProtClustDB:   PRK00258
- BioCyc:   MMAR267377:MMP0936-MONOMER
- BRENDA:   1.1.1.25
- GO:   GO:0005737
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 30781; Mature: 30781

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: NA

Important sites: ACT_SITE 70-70

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINSKTKLVGLIGHPVDHSFSPIMHNAAIKDLKINYRYFAFDVSEENLKDVVAGAKAFNF
CCCCCCEEEEEECCCCCCCCCHHHHCCEEEEEEEEEEEEEEECCHHHHHHHHHCCCEEEE
RGFNITIPHKMNIMKYLDEIDCDAEAIGAVNTVKIENGKAIGYNTDGIGVKKALEEKTGI
CCEEEECCCCHHHHHHHHHCCCCHHHHCCEEEEEEECCEEEEECCCCCCHHHHHHHHCCE
LINKNILIIGSGGASRAVSFELAKDNNLTIVNRNIEKAENLSKEISRKLKKENPLNYGGL
EEECCEEEEECCCCCCEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCE
DINIENFDIIINTTPVGMYPHTEVEPVIPLNNIKKDAVVMDLIYNPLEPVFLKEAKKYGA
EEEEECEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCC
KTINGIGMLVYQGAVSFEIWTGIKPDIFVMKKSIISKI
CCCCCEEEEEEECCEEEEEECCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MINSKTKLVGLIGHPVDHSFSPIMHNAAIKDLKINYRYFAFDVSEENLKDVVAGAKAFNF
CCCCCCEEEEEECCCCCCCCCHHHHCCEEEEEEEEEEEEEEECCHHHHHHHHHCCCEEEE
RGFNITIPHKMNIMKYLDEIDCDAEAIGAVNTVKIENGKAIGYNTDGIGVKKALEEKTGI
CCEEEECCCCHHHHHHHHHCCCCHHHHCCEEEEEEECCEEEEECCCCCCHHHHHHHHCCE
LINKNILIIGSGGASRAVSFELAKDNNLTIVNRNIEKAENLSKEISRKLKKENPLNYGGL
EEECCEEEEECCCCCCEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCE
DINIENFDIIINTTPVGMYPHTEVEPVIPLNNIKKDAVVMDLIYNPLEPVFLKEAKKYGA
EEEEECEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCC
KTINGIGMLVYQGAVSFEIWTGIKPDIFVMKKSIISKI
CCCCCEEEEEEECCEEEEEECCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA