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The map label for this gene is hemC [H]

Identifier: 45358435

GI number: 45358435

Start: 863940

End: 864854

Strand: Direct

Name: hemC [H]

Synonym: MMP0872

Alternate gene names: 45358435

Gene position: 863940-864854 (Clockwise)

Preceding gene: 45358434

Following gene: 45358436

Centisome position: 52.01

GC content: 36.28

Gene sequence:

>915_bases
TTGAAGTTAAGAATAGGAACAAGAGGAAGTACACTTGCAATGGTCCAGACAGAGTATATTGCAGGTCTTTTAAATGATTT
AGATATTGAGACTGAAATAATCATAGTTAAAACTACTGGCGACAAAGATCAGAATAAAAAACTCGCTGATCTTGGAATCG
GTGTTTTCACAAAAGAACTCGATAATAAAATGCTTGAAAATGAAATTGATATTGCAGTGCACAGTTTAAAAGACGTTCCA
ACCCTTTGGAGTGATGAATTACAAATTACTGCAACACCTAAGCGAGAAAGTCCTGATGACATTATAATCTGGAGAAAAGA
CTGCGATTTTGATATTGAACACGATGAATTAAATGTAGGAACTTCAAGCATTAGAAGAACCTCATTTTTACAGTTCACCA
ACCCAAATCTCACCCCAAAACTACTCAGGGGTAATGTTGCAACAAGAATTAATAAATTAAGAAATGGGGAATACGATACG
ATTGTAATGGCAAAAGCGGGACTCATAAGGCAGGGTATTGATTTATCCGAATTTAATTACAAAAAGCTAGATATACTTCC
TGCACCGGCACAAGGCGTAATTGGTGTTGCTTCAAGAAAGGCAGATGCGAAAATAAACCAGATTTTAGAAAAAATATGTG
ATAAAAAGACATATATTGAAGCTACTGCTGAAAGATGGGCCTTAAAAGAATACGGTGGTGGATGTCAGGCGCCTTTCGGG
GCGTTTGCCATTTATGATACTGAAGAAGGAATTTTAAATTTAAGATGCGAACTTGTAGACGAACAGGGTACAATAAAGCG
AGTAAAATCAAACGAAGGATTTGTAATATGTACTACTGACGATGTCGAACTTTCAAAGGAACTTGGTGCAAGGGTCGGTG
CATCATTTAAAGAAATCGAAACTTTTACGTATTAG

Upstream 100 bases:

>100_bases
CAAAAGTAATAAGAATAAAATATTTAAAAATAATAACAGACTTTATTCAAATTATTCGATTTTAATATTTTTCATATTTT
AGTTATTTAGCGGTGAAATT

Downstream 100 bases:

>100_bases
TTCTTTTTTCTTTTTTTAAAATATTTAGAGAAAGTTTTAAATTATTTAAAGTTTAATTTTATTTTAATTGTTATCATCGA
GGGATTTTTATGGCAGATTA

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MKLRIGTRGSTLAMVQTEYIAGLLNDLDIETEIIIVKTTGDKDQNKKLADLGIGVFTKELDNKMLENEIDIAVHSLKDVP
TLWSDELQITATPKRESPDDIIIWRKDCDFDIEHDELNVGTSSIRRTSFLQFTNPNLTPKLLRGNVATRINKLRNGEYDT
IVMAKAGLIRQGIDLSEFNYKKLDILPAPAQGVIGVASRKADAKINQILEKICDKKTYIEATAERWALKEYGGGCQAPFG
AFAIYDTEEGILNLRCELVDEQGTIKRVKSNEGFVICTTDDVELSKELGARVGASFKEIETFTY

Sequences:

>Translated_304_residues
MKLRIGTRGSTLAMVQTEYIAGLLNDLDIETEIIIVKTTGDKDQNKKLADLGIGVFTKELDNKMLENEIDIAVHSLKDVP
TLWSDELQITATPKRESPDDIIIWRKDCDFDIEHDELNVGTSSIRRTSFLQFTNPNLTPKLLRGNVATRINKLRNGEYDT
IVMAKAGLIRQGIDLSEFNYKKLDILPAPAQGVIGVASRKADAKINQILEKICDKKTYIEATAERWALKEYGGGCQAPFG
AFAIYDTEEGILNLRCELVDEQGTIKRVKSNEGFVICTTDDVELSKELGARVGASFKEIETFTY
>Mature_304_residues
MKLRIGTRGSTLAMVQTEYIAGLLNDLDIETEIIIVKTTGDKDQNKKLADLGIGVFTKELDNKMLENEIDIAVHSLKDVP
TLWSDELQITATPKRESPDDIIIWRKDCDFDIEHDELNVGTSSIRRTSFLQFTNPNLTPKLLRGNVATRINKLRNGEYDT
IVMAKAGLIRQGIDLSEFNYKKLDILPAPAQGVIGVASRKADAKINQILEKICDKKTYIEATAERWALKEYGGGCQAPFG
AFAIYDTEEGILNLRCELVDEQGTIKRVKSNEGFVICTTDDVELSKELGARVGASFKEIETFTY

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI66933009, Length=245, Percent_Identity=35.5102040816327, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI20149500, Length=245, Percent_Identity=35.5102040816327, Blast_Score=134, Evalue=1e-31,
Organism=Escherichia coli, GI48994974, Length=245, Percent_Identity=38.7755102040816, Blast_Score=150, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6319996, Length=277, Percent_Identity=33.2129963898917, Blast_Score=140, Evalue=3e-34,
Organism=Drosophila melanogaster, GI20130425, Length=252, Percent_Identity=33.3333333333333, Blast_Score=123, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 33953; Mature: 33953

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLRIGTRGSTLAMVQTEYIAGLLNDLDIETEIIIVKTTGDKDQNKKLADLGIGVFTKEL
CEEEECCCCCEEEEEHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCHHHHCCHHHHHHH
DNKMLENEIDIAVHSLKDVPTLWSDELQITATPKRESPDDIIIWRKDCDFDIEHDELNVG
HHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCC
TSSIRRTSFLQFTNPNLTPKLLRGNVATRINKLRNGEYDTIVMAKAGLIRQGIDLSEFNY
HHHHHHEEEEEECCCCCCHHHHCCCHHHHHHHHCCCCCCEEEEECCCHHHCCCCCCCCCC
KKLDILPAPAQGVIGVASRKADAKINQILEKICDKKTYIEATAERWALKEYGGGCQAPFG
EEEEEECCCCCCEEEECCCCCHHHHHHHHHHHHCCHHEEHHHHHHHHHHHCCCCCCCCCC
AFAIYDTEEGILNLRCELVDEQGTIKRVKSNEGFVICTTDDVELSKELGARVGASFKEIE
EEEEEECCCCEEEEEEEEECCCCCEEEEECCCCEEEEECCCCHHHHHHHHHHCCCHHHHH
TFTY
CCCC
>Mature Secondary Structure
MKLRIGTRGSTLAMVQTEYIAGLLNDLDIETEIIIVKTTGDKDQNKKLADLGIGVFTKEL
CEEEECCCCCEEEEEHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCHHHHCCHHHHHHH
DNKMLENEIDIAVHSLKDVPTLWSDELQITATPKRESPDDIIIWRKDCDFDIEHDELNVG
HHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCC
TSSIRRTSFLQFTNPNLTPKLLRGNVATRINKLRNGEYDTIVMAKAGLIRQGIDLSEFNY
HHHHHHEEEEEECCCCCCHHHHCCCHHHHHHHHCCCCCCEEEEECCCHHHCCCCCCCCCC
KKLDILPAPAQGVIGVASRKADAKINQILEKICDKKTYIEATAERWALKEYGGGCQAPFG
EEEEEECCCCCCEEEECCCCCHHHHHHHHHHHHCCHHEEHHHHHHHHHHHCCCCCCCCCC
AFAIYDTEEGILNLRCELVDEQGTIKRVKSNEGFVICTTDDVELSKELGARVGASFKEIE
EEEEEECCCCEEEEEEEEECCCCCEEEEECCCCEEEEECCCCHHHHHHHHHHCCCHHHHH
TFTY
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]