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The map label for this gene is hprA [H]

Identifier: 45358433

GI number: 45358433

Start: 861628

End: 862584

Strand: Direct

Name: hprA [H]

Synonym: MMP0870

Alternate gene names: 45358433

Gene position: 861628-862584 (Clockwise)

Preceding gene: 45358432

Following gene: 45358434

Centisome position: 51.87

GC content: 31.24

Gene sequence:

>957_bases
ATGAAAATCGTTGTACTTGATGGATACGCCATGAATTCAGGAGATTTATCGTGGGAAGATTTAAAAAAACTTGGTGAACT
TTCCATTTATGATAGAACTCTTGAATCAGAAGTAGTTGAAAGAATTTCCGATTCAGAAATTGTCATTACAAATAAAGTAA
TAATTGGAAAAGAAGTCCTTGAAAAATGTAAAAACATAAAATATGTTGGAGTTACTGCAACAGGCTATAATGTTGTAGAT
ACTACTTTGGCCAAAGATCACGGTGTAATTGTAACAAATGTTCCAGCATATTCAACCGATTCAGTGGCCCAACTTGTATT
TTCATTTATACTTGAACACTGTCAAAATGTGTCTAAATATACGGAAAGTGTAAAATCTGGAGATTGGGTAAATTCAAAAG
ATTTTTCATATCAAAAATTTCCAATTATTGAACTTGCAGGTAAATCTCTTGGAATAATCGGATTTGGAGCAATTGGAAAA
AAAGTTGCAGAAATAGGAAATGCTTTTGGAATGAATGTACTTGTAAACACGAGAACTGTTTCAAAAACAGATGAAATAAA
TGTTAATTTTGTATCAAAAGAAGAAATTTTTAAAAATTCTGATTTTTTAACACTTCACTGCCCATTAAATAACGAAACAG
ACAAAATTGTAAATGAAAAAACATTAAATTTAATGAAAAAGTCTGCAATTTTAATAAATACTGGAAGGGGCGGGCTTGTC
AATGAAAAAGATCTTGCAAATGCATTAAATTTGGAAAAAATTGCAGGAGCAGGGCTTGACGTTCTTTCAACAGAACCTCC
AAAAGAAGATAATCCACTACTTAACGCTAAGAATACATATATAACACCACACGTTGCGTGGGCGTCTTATGAAGCGAGAA
AAAGGCTAATGGATGTAACCATAAATAATGTGAAGTCTTTTATCGATGGAAATCCTATAAATGTTGTAAATAAATAA

Upstream 100 bases:

>100_bases
TGCGTAAAAATGATGAAAGAATTTATAGAAAATAATCCAAAATTGTGGAATGAAGACATCGGAGAATAATTTAAAATAGT
TTTAAAAAATGTGATATTTC

Downstream 100 bases:

>100_bases
TATTTATTTAAGTTTAATTTTTTTAAGTCGGGAGATTTTTTATGAGGATAACTGACGTTGTAAGTTTTGCAGGGCGAAAT
ATAACTCAAAAAAAGACGCA

Product: glycerate dehydrogenase

Products: NA

Alternate protein names: GDH; Glyoxylate reductase; Hydroxypyruvate dehydrogenase; NADH-dependent hydroxypyruvate reductase; HPR; HPR-A [H]

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MKIVVLDGYAMNSGDLSWEDLKKLGELSIYDRTLESEVVERISDSEIVITNKVIIGKEVLEKCKNIKYVGVTATGYNVVD
TTLAKDHGVIVTNVPAYSTDSVAQLVFSFILEHCQNVSKYTESVKSGDWVNSKDFSYQKFPIIELAGKSLGIIGFGAIGK
KVAEIGNAFGMNVLVNTRTVSKTDEINVNFVSKEEIFKNSDFLTLHCPLNNETDKIVNEKTLNLMKKSAILINTGRGGLV
NEKDLANALNLEKIAGAGLDVLSTEPPKEDNPLLNAKNTYITPHVAWASYEARKRLMDVTINNVKSFIDGNPINVVNK

Sequences:

>Translated_318_residues
MKIVVLDGYAMNSGDLSWEDLKKLGELSIYDRTLESEVVERISDSEIVITNKVIIGKEVLEKCKNIKYVGVTATGYNVVD
TTLAKDHGVIVTNVPAYSTDSVAQLVFSFILEHCQNVSKYTESVKSGDWVNSKDFSYQKFPIIELAGKSLGIIGFGAIGK
KVAEIGNAFGMNVLVNTRTVSKTDEINVNFVSKEEIFKNSDFLTLHCPLNNETDKIVNEKTLNLMKKSAILINTGRGGLV
NEKDLANALNLEKIAGAGLDVLSTEPPKEDNPLLNAKNTYITPHVAWASYEARKRLMDVTINNVKSFIDGNPINVVNK
>Mature_318_residues
MKIVVLDGYAMNSGDLSWEDLKKLGELSIYDRTLESEVVERISDSEIVITNKVIIGKEVLEKCKNIKYVGVTATGYNVVD
TTLAKDHGVIVTNVPAYSTDSVAQLVFSFILEHCQNVSKYTESVKSGDWVNSKDFSYQKFPIIELAGKSLGIIGFGAIGK
KVAEIGNAFGMNVLVNTRTVSKTDEINVNFVSKEEIFKNSDFLTLHCPLNNETDKIVNEKTLNLMKKSAILINTGRGGLV
NEKDLANALNLEKIAGAGLDVLSTEPPKEDNPLLNAKNTYITPHVAWASYEARKRLMDVTINNVKSFIDGNPINVVNK

Specific function: Plays a central role in assimilation of carbon. It converts hydroxypyruvate to glycerate as a key step in the serine cycle, and may also play an important role in C2 reactions, by interconverting glyoxylate and glycolate [H]

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557497, Length=298, Percent_Identity=31.5436241610738, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI61743967, Length=298, Percent_Identity=31.5436241610738, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI6912396, Length=252, Percent_Identity=32.1428571428571, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI23308577, Length=264, Percent_Identity=32.1969696969697, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI145580578, Length=298, Percent_Identity=28.8590604026846, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI4557499, Length=298, Percent_Identity=28.8590604026846, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI145580575, Length=303, Percent_Identity=29.3729372937294, Blast_Score=134, Evalue=1e-31,
Organism=Escherichia coli, GI87082289, Length=259, Percent_Identity=30.1158301158301, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1787645, Length=270, Percent_Identity=27.7777777777778, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1789279, Length=291, Percent_Identity=28.1786941580756, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI87081824, Length=236, Percent_Identity=26.271186440678, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1788660, Length=263, Percent_Identity=27.7566539923954, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=280, Percent_Identity=32.5, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI25147481, Length=323, Percent_Identity=28.4829721362229, Blast_Score=110, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6320925, Length=317, Percent_Identity=29.9684542586751, Blast_Score=129, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6322116, Length=307, Percent_Identity=29.6416938110749, Blast_Score=127, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6324055, Length=312, Percent_Identity=25.9615384615385, Blast_Score=121, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6324964, Length=298, Percent_Identity=26.510067114094, Blast_Score=93, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6325144, Length=300, Percent_Identity=24.3333333333333, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6324980, Length=199, Percent_Identity=26.6331658291457, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6321253, Length=282, Percent_Identity=23.4042553191489, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24646446, Length=305, Percent_Identity=28.8524590163934, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24646448, Length=305, Percent_Identity=28.8524590163934, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24646452, Length=305, Percent_Identity=28.8524590163934, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24646450, Length=305, Percent_Identity=28.8524590163934, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI28571528, Length=307, Percent_Identity=30.2931596091205, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI28574286, Length=286, Percent_Identity=29.3706293706294, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI62472511, Length=319, Percent_Identity=29.153605015674, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24585516, Length=252, Percent_Identity=28.5714285714286, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI19921140, Length=274, Percent_Identity=27.7372262773723, Blast_Score=110, Evalue=9e-25,
Organism=Drosophila melanogaster, GI45552429, Length=253, Percent_Identity=26.0869565217391, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24585514, Length=253, Percent_Identity=26.0869565217391, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI28574282, Length=253, Percent_Identity=26.0869565217391, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI45551003, Length=253, Percent_Identity=26.0869565217391, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI28574284, Length=253, Percent_Identity=26.0869565217391, Blast_Score=105, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.29 [H]

Molecular weight: Translated: 34993; Mature: 34993

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIVVLDGYAMNSGDLSWEDLKKLGELSIYDRTLESEVVERISDSEIVITNKVIIGKEVL
CEEEEEECEEECCCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEEEEEECHHHH
EKCKNIKYVGVTATGYNVVDTTLAKDHGVIVTNVPAYSTDSVAQLVFSFILEHCQNVSKY
HHHHCCEEEEEEECCCEEEEHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
TESVKSGDWVNSKDFSYQKFPIIELAGKSLGIIGFGAIGKKVAEIGNAFGMNVLVNTRTV
HHHHHCCCCCCCCCCCCCCCCEEEECCCEECEEEECHHHHHHHHHCCCCCCEEEEEEEEE
SKTDEINVNFVSKEEIFKNSDFLTLHCPLNNETDKIVNEKTLNLMKKSAILINTGRGGLV
CCCCCEEEEEECHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCEEEEECCCCCCC
NEKDLANALNLEKIAGAGLDVLSTEPPKEDNPLLNAKNTYITPHVAWASYEARKRLMDVT
CHHHHHHHHCHHHHHCCCCEECCCCCCCCCCCCCCCCCCEECCEEEECCHHHHHHHHHHH
INNVKSFIDGNPINVVNK
HHHHHHHHCCCCEEECCC
>Mature Secondary Structure
MKIVVLDGYAMNSGDLSWEDLKKLGELSIYDRTLESEVVERISDSEIVITNKVIIGKEVL
CEEEEEECEEECCCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEEEEEECHHHH
EKCKNIKYVGVTATGYNVVDTTLAKDHGVIVTNVPAYSTDSVAQLVFSFILEHCQNVSKY
HHHHCCEEEEEEECCCEEEEHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
TESVKSGDWVNSKDFSYQKFPIIELAGKSLGIIGFGAIGKKVAEIGNAFGMNVLVNTRTV
HHHHHCCCCCCCCCCCCCCCCEEEECCCEECEEEECHHHHHHHHHCCCCCCEEEEEEEEE
SKTDEINVNFVSKEEIFKNSDFLTLHCPLNNETDKIVNEKTLNLMKKSAILINTGRGGLV
CCCCCEEEEEECHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCEEEEECCCCCCC
NEKDLANALNLEKIAGAGLDVLSTEPPKEDNPLLNAKNTYITPHVAWASYEARKRLMDVT
CHHHHHHHHCHHHHHCCCCEECCCCCCCCCCCCCCCCCCEECCEEEECCHHHHHHHHHHH
INNVKSFIDGNPINVVNK
HHHHHHHHCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8144463; 1729225; 1657886 [H]