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The map label for this gene is dhaT [H]

Identifier: 45358365

GI number: 45358365

Start: 794946

End: 796115

Strand: Direct

Name: dhaT [H]

Synonym: MMP0802

Alternate gene names: 45358365

Gene position: 794946-796115 (Clockwise)

Preceding gene: 45358364

Following gene: 45358366

Centisome position: 47.86

GC content: 38.03

Gene sequence:

>1170_bases
ATGAGTTTTAACATGTATGTGCCAACAAAAGTCTTGTTTGGAGCAGGACAACTAAATAATTTACACGAACAAAAAATGCC
TGGCAAAAAAGCTATGATTGTTATTTCAAATGGAAAATCTACAAGGGAATACGGTTACCTTGCAAGAACTGAAGAACAGT
TAAAATTAGCAGGTGTAGAAACTGTAGTATTTGATAAAGTTGAACCAAACCCATTAAGATCAACCGTTATGGCTGGCGGT
GCTTTTGCAAAAGAAAATGACTGCGATTTCATTGTTGCATTAGGTGGCGGGAGCTGTATCGATGCATCAAAAGCAATGTC
CATAATGGCTACAAATGATGGAGATTACTGGGATTACATTTTTGGCGGAACTGGAAAAGGAATGCCTTTGAAAGCTAAAC
CAATCCCTGTTGTAGCAATTACAACTACAGCAGGAACAGGTTCTGAAACCGATCCTTGGGCAGTTGTAACACATGAAATA
AATCGTGAAAAAATCGGATTTGGTAACGAAGATACGTTTCCAGTTTTAGCAGTAGTTGATCCTGAACTTATGAAATCAGT
ACCTCCAAAATACACGGCATATCAAGGATTTGATGCATTATTCCACAGCGTGGAAGGTTATGTATCTATCGGCGCAAATC
TCATGAGCGACATGTATGCAATCACGGCAATAGAAAATGTTTCAAAAAATCTCTCAAAAGCTGTTGAAGATGGAAATGAT
ATGGATGCACGTGAAAAGGTTGCTTTTGGAAATACGTTATCAGGGGTAGTTGAAACTGTTGGACTTTGTACAAGCCAGCA
CGCATTAGAACACGCAATGTCTGCTTATCACCAAGATCTTCCTCACGGTGCAGGGCTTATAATGATCAGCAAAGCATACT
TTACTCATTTTATCGAAAAACATGTATGTGATGACAGGTTTGTAAAAATGGCGAAAGTAATGGGTATGGAAGATGCAACA
GAACCTATGGATTTCATCAGAATGCTCGTAAAATTACAAGAAGAATGTGGAGTTTCAGATCTTAAAATGTCTGATTATGG
CATTACTCCTGAAGAATTTGAAAAAATGGCGAAAAATGCAGTGGATACAATGGGAATGTTGTTTACCTGTGACAGAGCTC
AGTTAAGTATCGAAGATTGCGTTTCAATTTACAGCGCATCCTATAAATAA

Upstream 100 bases:

>100_bases
ATCTATATATATCACAAAAACAAAGTAGTATTTGACTGAGTAGTCAATCTTAAAAATTCAATTATTATATTCAAAAAAAT
TTCGGATAACGGTGAAAATT

Downstream 100 bases:

>100_bases
GGGGCGAATACATGGACTACAGAAAATTACCGCATGGCAATGAAAAGGTCAGTACTATCGGCATTGGATCAGGAAGCTTG
AAAGAAACCACTTCAAAAGA

Product: Iron-containing alcohol dehydrogenase

Products: NA

Alternate protein names: 1,3-propanediol oxidoreductase; 3-hydroxypropionaldehyde reductase [H]

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MSFNMYVPTKVLFGAGQLNNLHEQKMPGKKAMIVISNGKSTREYGYLARTEEQLKLAGVETVVFDKVEPNPLRSTVMAGG
AFAKENDCDFIVALGGGSCIDASKAMSIMATNDGDYWDYIFGGTGKGMPLKAKPIPVVAITTTAGTGSETDPWAVVTHEI
NREKIGFGNEDTFPVLAVVDPELMKSVPPKYTAYQGFDALFHSVEGYVSIGANLMSDMYAITAIENVSKNLSKAVEDGND
MDAREKVAFGNTLSGVVETVGLCTSQHALEHAMSAYHQDLPHGAGLIMISKAYFTHFIEKHVCDDRFVKMAKVMGMEDAT
EPMDFIRMLVKLQEECGVSDLKMSDYGITPEEFEKMAKNAVDTMGMLFTCDRAQLSIEDCVSIYSASYK

Sequences:

>Translated_389_residues
MSFNMYVPTKVLFGAGQLNNLHEQKMPGKKAMIVISNGKSTREYGYLARTEEQLKLAGVETVVFDKVEPNPLRSTVMAGG
AFAKENDCDFIVALGGGSCIDASKAMSIMATNDGDYWDYIFGGTGKGMPLKAKPIPVVAITTTAGTGSETDPWAVVTHEI
NREKIGFGNEDTFPVLAVVDPELMKSVPPKYTAYQGFDALFHSVEGYVSIGANLMSDMYAITAIENVSKNLSKAVEDGND
MDAREKVAFGNTLSGVVETVGLCTSQHALEHAMSAYHQDLPHGAGLIMISKAYFTHFIEKHVCDDRFVKMAKVMGMEDAT
EPMDFIRMLVKLQEECGVSDLKMSDYGITPEEFEKMAKNAVDTMGMLFTCDRAQLSIEDCVSIYSASYK
>Mature_388_residues
SFNMYVPTKVLFGAGQLNNLHEQKMPGKKAMIVISNGKSTREYGYLARTEEQLKLAGVETVVFDKVEPNPLRSTVMAGGA
FAKENDCDFIVALGGGSCIDASKAMSIMATNDGDYWDYIFGGTGKGMPLKAKPIPVVAITTTAGTGSETDPWAVVTHEIN
REKIGFGNEDTFPVLAVVDPELMKSVPPKYTAYQGFDALFHSVEGYVSIGANLMSDMYAITAIENVSKNLSKAVEDGNDM
DAREKVAFGNTLSGVVETVGLCTSQHALEHAMSAYHQDLPHGAGLIMISKAYFTHFIEKHVCDDRFVKMAKVMGMEDATE
PMDFIRMLVKLQEECGVSDLKMSDYGITPEEFEKMAKNAVDTMGMLFTCDRAQLSIEDCVSIYSASYK

Specific function: Most active with substrates containing two primary alcohol groups separated by one or two carbon atoms. In the physiological direction, 3-hydroxypropionaldehyde is the preferred substrate [H]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=298, Percent_Identity=29.8657718120805, Blast_Score=119, Evalue=3e-27,
Organism=Escherichia coli, GI48994951, Length=396, Percent_Identity=31.3131313131313, Blast_Score=171, Evalue=9e-44,
Organism=Escherichia coli, GI87082107, Length=389, Percent_Identity=28.7917737789203, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1789163, Length=401, Percent_Identity=27.431421446384, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1789386, Length=402, Percent_Identity=27.1144278606965, Blast_Score=128, Evalue=7e-31,
Organism=Escherichia coli, GI1787493, Length=292, Percent_Identity=33.2191780821918, Blast_Score=125, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17537053, Length=325, Percent_Identity=28.3076923076923, Blast_Score=126, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6321181, Length=389, Percent_Identity=29.0488431876607, Blast_Score=160, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24657991, Length=314, Percent_Identity=27.3885350318471, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.202 [H]

Molecular weight: Translated: 42456; Mature: 42325

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
7.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
5.7 %Met     (Mature Protein)
7.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFNMYVPTKVLFGAGQLNNLHEQKMPGKKAMIVISNGKSTREYGYLARTEEQLKLAGVE
CCCCEECCHHHEECCCCCCCHHHHHCCCCEEEEEEECCCCCHHHCCHHCCHHHHHHHCCE
TVVFDKVEPNPLRSTVMAGGAFAKENDCDFIVALGGGSCIDASKAMSIMATNDGDYWDYI
EEEEECCCCCHHHHHHHCCCCCCCCCCCCEEEEECCCCEECCCCCEEEEECCCCCEEEEE
FGGTGKGMPLKAKPIPVVAITTTAGTGSETDPWAVVTHEINREKIGFGNEDTFPVLAVVD
ECCCCCCCCCCCCCCEEEEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEEEC
PELMKSVPPKYTAYQGFDALFHSVEGYVSIGANLMSDMYAITAIENVSKNLSKAVEDGND
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
MDAREKVAFGNTLSGVVETVGLCTSQHALEHAMSAYHQDLPHGAGLIMISKAYFTHFIEK
CCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHH
HVCDDRFVKMAKVMGMEDATEPMDFIRMLVKLQEECGVSDLKMSDYGITPEEFEKMAKNA
HHCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
VDTMGMLFTCDRAQLSIEDCVSIYSASYK
HHHHHHEEEECCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure 
SFNMYVPTKVLFGAGQLNNLHEQKMPGKKAMIVISNGKSTREYGYLARTEEQLKLAGVE
CCCEECCHHHEECCCCCCCHHHHHCCCCEEEEEEECCCCCHHHCCHHCCHHHHHHHCCE
TVVFDKVEPNPLRSTVMAGGAFAKENDCDFIVALGGGSCIDASKAMSIMATNDGDYWDYI
EEEEECCCCCHHHHHHHCCCCCCCCCCCCEEEEECCCCEECCCCCEEEEECCCCCEEEEE
FGGTGKGMPLKAKPIPVVAITTTAGTGSETDPWAVVTHEINREKIGFGNEDTFPVLAVVD
ECCCCCCCCCCCCCCEEEEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEEEC
PELMKSVPPKYTAYQGFDALFHSVEGYVSIGANLMSDMYAITAIENVSKNLSKAVEDGND
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
MDAREKVAFGNTLSGVVETVGLCTSQHALEHAMSAYHQDLPHGAGLIMISKAYFTHFIEK
CCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHH
HVCDDRFVKMAKVMGMEDATEPMDFIRMLVKLQEECGVSDLKMSDYGITPEEFEKMAKNA
HHCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
VDTMGMLFTCDRAQLSIEDCVSIYSASYK
HHHHHHEEEECCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7721705 [H]