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The map label for this gene is pyrD [H]

Identifier: 45358002

GI number: 45358002

Start: 438564

End: 439478

Strand: Direct

Name: pyrD [H]

Synonym: MMP0439

Alternate gene names: 45358002

Gene position: 438564-439478 (Clockwise)

Preceding gene: 45358000

Following gene: 45358003

Centisome position: 26.4

GC content: 38.36

Gene sequence:

>915_bases
ATGCTAAAAACTAAACTTTGGGATATTGAATTTAAAAATCCAGTATTTCTTGCAGCCGGAGTCATGGGTGAGACCGGAAG
TGCACTAAAAAGGATGGCAAAAAACGGTGCAGGGGCAGTATGTACTAAATCTGTTGGAATTGAAAAAAAACCGGGACACA
ACAATCCAACAATGGTTGAAGTCGAGGGGGGCTTTTTAAATGCGATGGGACTTCCAAATCCGGGTGCAGATGAATATGCT
GGAGAAATTGAACGAATAAAAGATGAAATGAAAAGAATGAATGTTAAAATTATCGGTTCAATTTACGGTAAAAACGATTC
TGAATTTCAAAAAGCTGCCGAAATAATTGGAAATTACGTGGATGTTTTGGAATTAAACATTTCATGCCCCCATGCAGGTG
GAGGATATGGTTCATCAATCGGTCAGGACCCATATCTATGTAAAAACGTGGTTTCAGCAGTAAAAGACGTTTCAGACATT
CCAGTTATTGCAAAATTAACTCCAAATGTAACTGACATCAAAGAAATTGCAAATGCAGTTGTAAATGCCGGAGCTGATGG
AATTGTTGCAATAAACACGCTTGGTCCGGGAATGGTAATTGATATCGAGTCAGGAGTTCCAATCCTTGGAAATCGGGTTG
GTGGAATGAGCGGAAAAGCAGTAAAACCAATTGCAGTTAAAAATGTTTACGATATATGTTCAGCAGTAGATGTGCCAGTA
ATTGGCGTTGGTGGAATTACTACCGGGGCTGATGCAATAGAATTTATGATGGCAGGAGCATCAGCAGTTCAAGTTGGAAC
TGGAGTTTACTATCGAGGATACGACATATTCCAAAAGATAAACAATGAAATTGAAGAATATCTCCTGAAAAAAGATTTAA
AAATGTCAGATATCATTGGAATTGCCCAGAAATAA

Upstream 100 bases:

>100_bases
TTTCCATAATTTCCACCGATTTATAAACATAATTATCTGATTCTTTAGTTTTTTATATGTCTTATTATAAAATATATTCA
AAAATATCGGGAGATTTCAG

Downstream 100 bases:

>100_bases
TTCTTAATTTTTATCCGATTTTAAGAATTATAAAAACCGTGCGTAGAATTTATATACCAAAAACGAGAATATATATAGTG
AAACTGTTTTATTATTTTAA

Product: dihydroorotate dehydrogenase 1B

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MLKTKLWDIEFKNPVFLAAGVMGETGSALKRMAKNGAGAVCTKSVGIEKKPGHNNPTMVEVEGGFLNAMGLPNPGADEYA
GEIERIKDEMKRMNVKIIGSIYGKNDSEFQKAAEIIGNYVDVLELNISCPHAGGGYGSSIGQDPYLCKNVVSAVKDVSDI
PVIAKLTPNVTDIKEIANAVVNAGADGIVAINTLGPGMVIDIESGVPILGNRVGGMSGKAVKPIAVKNVYDICSAVDVPV
IGVGGITTGADAIEFMMAGASAVQVGTGVYYRGYDIFQKINNEIEEYLLKKDLKMSDIIGIAQK

Sequences:

>Translated_304_residues
MLKTKLWDIEFKNPVFLAAGVMGETGSALKRMAKNGAGAVCTKSVGIEKKPGHNNPTMVEVEGGFLNAMGLPNPGADEYA
GEIERIKDEMKRMNVKIIGSIYGKNDSEFQKAAEIIGNYVDVLELNISCPHAGGGYGSSIGQDPYLCKNVVSAVKDVSDI
PVIAKLTPNVTDIKEIANAVVNAGADGIVAINTLGPGMVIDIESGVPILGNRVGGMSGKAVKPIAVKNVYDICSAVDVPV
IGVGGITTGADAIEFMMAGASAVQVGTGVYYRGYDIFQKINNEIEEYLLKKDLKMSDIIGIAQK
>Mature_304_residues
MLKTKLWDIEFKNPVFLAAGVMGETGSALKRMAKNGAGAVCTKSVGIEKKPGHNNPTMVEVEGGFLNAMGLPNPGADEYA
GEIERIKDEMKRMNVKIIGSIYGKNDSEFQKAAEIIGNYVDVLELNISCPHAGGGYGSSIGQDPYLCKNVVSAVKDVSDI
PVIAKLTPNVTDIKEIANAVVNAGADGIVAINTLGPGMVIDIESGVPILGNRVGGMSGKAVKPIAVKNVYDICSAVDVPV
IGVGGITTGADAIEFMMAGASAVQVGTGVYYRGYDIFQKINNEIEEYLLKKDLKMSDIIGIAQK

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=310, Percent_Identity=31.6129032258064, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI45006951, Length=324, Percent_Identity=25.3086419753086, Blast_Score=92, Evalue=7e-19,
Organism=Escherichia coli, GI87082059, Length=318, Percent_Identity=31.4465408805031, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1787177, Length=297, Percent_Identity=25.5892255892256, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71984108, Length=289, Percent_Identity=32.1799307958478, Blast_Score=138, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17509475, Length=312, Percent_Identity=29.1666666666667, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6322633, Length=294, Percent_Identity=30.952380952381, Blast_Score=119, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24640763, Length=298, Percent_Identity=32.5503355704698, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI18858217, Length=298, Percent_Identity=32.5503355704698, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI281361352, Length=326, Percent_Identity=23.0061349693252, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI17137316, Length=326, Percent_Identity=23.0061349693252, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.3.1 [H]

Molecular weight: Translated: 31984; Mature: 31984

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKTKLWDIEFKNPVFLAAGVMGETGSALKRMAKNGAGAVCTKSVGIEKKPGHNNPTMVE
CCCCEEEEEECCCCEEEEECCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEEE
VEGGFLNAMGLPNPGADEYAGEIERIKDEMKRMNVKIIGSIYGKNDSEFQKAAEIIGNYV
ECCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHE
DVLELNISCPHAGGGYGSSIGQDPYLCKNVVSAVKDVSDIPVIAKLTPNVTDIKEIANAV
EEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHH
VNAGADGIVAINTLGPGMVIDIESGVPILGNRVGGMSGKAVKPIAVKNVYDICSAVDVPV
HHCCCCCEEEEEECCCCEEEEECCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCE
IGVGGITTGADAIEFMMAGASAVQVGTGVYYRGYDIFQKINNEIEEYLLKKDLKMSDIIG
EEECCCCCCHHHHHHHHHCCCCEEECCCEEECCHHHHHHHHHHHHHHHHHHCCCHHHHHH
IAQK
CCCC
>Mature Secondary Structure
MLKTKLWDIEFKNPVFLAAGVMGETGSALKRMAKNGAGAVCTKSVGIEKKPGHNNPTMVE
CCCCEEEEEECCCCEEEEECCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEEE
VEGGFLNAMGLPNPGADEYAGEIERIKDEMKRMNVKIIGSIYGKNDSEFQKAAEIIGNYV
ECCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHE
DVLELNISCPHAGGGYGSSIGQDPYLCKNVVSAVKDVSDIPVIAKLTPNVTDIKEIANAV
EEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHH
VNAGADGIVAINTLGPGMVIDIESGVPILGNRVGGMSGKAVKPIAVKNVYDICSAVDVPV
HHCCCCCEEEEEECCCCEEEEECCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCE
IGVGGITTGADAIEFMMAGASAVQVGTGVYYRGYDIFQKINNEIEEYLLKKDLKMSDIIG
EEECCCCCCHHHHHHHHHCCCCEEECCCEEECCHHHHHHHHHHHHHHHHHHCCCHHHHHH
IAQK
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]