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The map label for this gene is gcp

Identifier: 45357978

GI number: 45357978

Start: 416131

End: 417777

Strand: Direct

Name: gcp

Synonym: MMP0415

Alternate gene names: 45357978

Gene position: 416131-417777 (Clockwise)

Preceding gene: 45357976

Following gene: 45357979

Centisome position: 25.05

GC content: 35.34

Gene sequence:

>1647_bases
ATGGATAATTCTAAAGACGACTTAATATGTATTGGATTTGAGGGAACTGCTGAAAAATCAGGTGTTGGAATAATTACCTC
AAAGGGCGAAGTTTTGTTTAACAAAACAATAATTTATACTCCGCCTGTACAGGGAATACACCCTAGAGAAGCCGCAGATC
ACCACGCAGAAACTTTTGTGAAACTTTTAAAAGAAGCATTAAACGAAGTTCCGCTTGAAAAAATTGATCTTGTTTCATTT
TCACTCGGTCCTGGACTCGGTCCAAGTTTGAGGGTTACTGCAACAACTGCAAGAGCACTTTCTCTTTCAATAAATAAACC
CATAATCGGGGTAAATCACTGTATCGGCCACGTGGAAATTGGAAAATTAACAACTGATGCAGTGGACCCGCTTACATTAT
ATGTAAGTGGTGGAAATACTCAAGTTTTGGCATACACTGGAAAAAAATACCGGGTAATTGGTGAAACTCTCGATATTGCG
ATAGGAAACTGTCTCGACCAGTTTGCAAGGCACTGTAATTTACCGCATCCGGGTGGGGTATACGTTGAGAAATTTGCAAA
AGATGGAAATAAGTTTATAAAACTCCCATACACCGTTAAAGGAATGGATCTTTCTCTTTCAGGGTTATTAACGTCTGCAA
TGAAAAAATACGATTCAAAAGAAAGAATTGAAGATGTATGCTACTCATTGCAGGAAACTTCATTTTCAATGCTAACAGAA
ATCACCGAAAGAGCGCTTGCACATACTAATAAAGCCGAAGTAATGCTTGTTGGGGGAGTTGCTGCAAATAATCGGTTAAA
AGAAATGCTTAAGGTAATGTGTGAAGAGCAGAATGTTGATTTCTACGTTCCAGAAAAACAGTTTTGTGGCGATAACGGTG
CAATGATTGCATGGCTTGGGATATTGCAGTATTTAAATGGAAAAAGAATGGATTTGAAGGATACAAAACCGATTTCAAAC
TACAGAAGTGACATGGTCGAAGTTAACTGGATTCATGACGAAAGCAAAAACTTGAATGATGGAAATATTAAATCTCGAAA
AATTCCAAAACATTTGATTGGAAAAGGCGCTGAAGCCGATATATCAAAAGGAAGGTATTTAGAATTTGAATCTATTACAA
AAGAGCGAGTTAAAAAAGGATACCGTATTTTAAAACTGGATGAATTGATAAGGACAAGAAGAACAGTAAAAGAAGCAAGA
TTTTTGGCAGCAGTTAAAGAATGTGGAATTCATGCTCCAAGCATTTATGACATCGATAAAGAGAATAAAAAAATTATAAT
GGGCTACATTCACGGAAAAATTGCAAAAGACGAAATTGAAGAAGGAAATATCGAATTTTGTAAAAGTTTAGGGGAAACTA
TTGGAAAAATGCATGGCAGTGGAATTGTGCACAATGATTTAACAACTTCAAACTTTATAATTTCAAAAAATCCATATATA
ATAGATTTTGGGCTTGGAAAATACAGCGATTTAATTGAAGACAAAGCAATTGATTTGATAGTCTTAAAAAAATCGATAAT
GAGCATCCACTATGATAAATTTGATTTGGTCTGGAATAAAATAATAGACGGATACAAAACGTATGAACTGGCTGAATCGG
TTTTGGAATGCATAAAAGAGGTTGAAAAACGGGCAAGATATCTTTAA

Upstream 100 bases:

>100_bases
ACACAATATAAAAAATTAATTACTGTGTTTTACGGTGTTTATTTGTAATTGTCTTTTTTTAAAAACTAATTATTTTACGT
TTTATTAACTGGTGGCTATC

Downstream 100 bases:

>100_bases
TTTTTTTATTTTATGTCGGGGACTAAACTTAATTATATATAATTTAATGTCCAAAAATATTATCATGATACTTTGGAGGT
AGAGTATTATGAAAAGACTA

Product: O-sialoglycoprotein endopeptidase/protein kinase

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 548; Mature: 548

Protein sequence:

>548_residues
MDNSKDDLICIGFEGTAEKSGVGIITSKGEVLFNKTIIYTPPVQGIHPREAADHHAETFVKLLKEALNEVPLEKIDLVSF
SLGPGLGPSLRVTATTARALSLSINKPIIGVNHCIGHVEIGKLTTDAVDPLTLYVSGGNTQVLAYTGKKYRVIGETLDIA
IGNCLDQFARHCNLPHPGGVYVEKFAKDGNKFIKLPYTVKGMDLSLSGLLTSAMKKYDSKERIEDVCYSLQETSFSMLTE
ITERALAHTNKAEVMLVGGVAANNRLKEMLKVMCEEQNVDFYVPEKQFCGDNGAMIAWLGILQYLNGKRMDLKDTKPISN
YRSDMVEVNWIHDESKNLNDGNIKSRKIPKHLIGKGAEADISKGRYLEFESITKERVKKGYRILKLDELIRTRRTVKEAR
FLAAVKECGIHAPSIYDIDKENKKIIMGYIHGKIAKDEIEEGNIEFCKSLGETIGKMHGSGIVHNDLTTSNFIISKNPYI
IDFGLGKYSDLIEDKAIDLIVLKKSIMSIHYDKFDLVWNKIIDGYKTYELAESVLECIKEVEKRARYL

Sequences:

>Translated_548_residues
MDNSKDDLICIGFEGTAEKSGVGIITSKGEVLFNKTIIYTPPVQGIHPREAADHHAETFVKLLKEALNEVPLEKIDLVSF
SLGPGLGPSLRVTATTARALSLSINKPIIGVNHCIGHVEIGKLTTDAVDPLTLYVSGGNTQVLAYTGKKYRVIGETLDIA
IGNCLDQFARHCNLPHPGGVYVEKFAKDGNKFIKLPYTVKGMDLSLSGLLTSAMKKYDSKERIEDVCYSLQETSFSMLTE
ITERALAHTNKAEVMLVGGVAANNRLKEMLKVMCEEQNVDFYVPEKQFCGDNGAMIAWLGILQYLNGKRMDLKDTKPISN
YRSDMVEVNWIHDESKNLNDGNIKSRKIPKHLIGKGAEADISKGRYLEFESITKERVKKGYRILKLDELIRTRRTVKEAR
FLAAVKECGIHAPSIYDIDKENKKIIMGYIHGKIAKDEIEEGNIEFCKSLGETIGKMHGSGIVHNDLTTSNFIISKNPYI
IDFGLGKYSDLIEDKAIDLIVLKKSIMSIHYDKFDLVWNKIIDGYKTYELAESVLECIKEVEKRARYL
>Mature_548_residues
MDNSKDDLICIGFEGTAEKSGVGIITSKGEVLFNKTIIYTPPVQGIHPREAADHHAETFVKLLKEALNEVPLEKIDLVSF
SLGPGLGPSLRVTATTARALSLSINKPIIGVNHCIGHVEIGKLTTDAVDPLTLYVSGGNTQVLAYTGKKYRVIGETLDIA
IGNCLDQFARHCNLPHPGGVYVEKFAKDGNKFIKLPYTVKGMDLSLSGLLTSAMKKYDSKERIEDVCYSLQETSFSMLTE
ITERALAHTNKAEVMLVGGVAANNRLKEMLKVMCEEQNVDFYVPEKQFCGDNGAMIAWLGILQYLNGKRMDLKDTKPISN
YRSDMVEVNWIHDESKNLNDGNIKSRKIPKHLIGKGAEADISKGRYLEFESITKERVKKGYRILKLDELIRTRRTVKEAR
FLAAVKECGIHAPSIYDIDKENKKIIMGYIHGKIAKDEIEEGNIEFCKSLGETIGKMHGSGIVHNDLTTSNFIISKNPYI
IDFGLGKYSDLIEDKAIDLIVLKKSIMSIHYDKFDLVWNKIIDGYKTYELAESVLECIKEVEKRARYL

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain

Homologues:

Organism=Homo sapiens, GI8923380, Length=331, Percent_Identity=48.6404833836858, Blast_Score=313, Evalue=4e-85,
Organism=Homo sapiens, GI41327715, Length=211, Percent_Identity=33.175355450237, Blast_Score=116, Evalue=6e-26,
Organism=Homo sapiens, GI116812636, Length=353, Percent_Identity=28.8951841359773, Blast_Score=111, Evalue=2e-24,
Organism=Escherichia coli, GI1789445, Length=319, Percent_Identity=31.6614420062696, Blast_Score=140, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71995670, Length=336, Percent_Identity=49.702380952381, Blast_Score=324, Evalue=7e-89,
Organism=Caenorhabditis elegans, GI17557464, Length=329, Percent_Identity=27.355623100304, Blast_Score=76, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6322891, Length=374, Percent_Identity=43.3155080213904, Blast_Score=290, Evalue=4e-79,
Organism=Saccharomyces cerevisiae, GI6320099, Length=337, Percent_Identity=28.1899109792285, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6321701, Length=197, Percent_Identity=29.4416243654822, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI21357207, Length=349, Percent_Identity=46.4183381088825, Blast_Score=315, Evalue=7e-86,
Organism=Drosophila melanogaster, GI24658177, Length=217, Percent_Identity=33.6405529953917, Blast_Score=102, Evalue=8e-22,
Organism=Drosophila melanogaster, GI20129063, Length=342, Percent_Identity=24.2690058479532, Blast_Score=93, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_METMP (Q6M056)

Other databases:

- EMBL:   BX950229
- RefSeq:   NP_987535.1
- ProteinModelPortal:   Q6M056
- MEROPS:   M22.003
- GeneID:   2762045
- GenomeReviews:   BX950229_GR
- KEGG:   mmp:MMP0415
- NMPDR:   fig|267377.1.peg.415
- HOGENOM:   HBG304663
- OMA:   GNCLDQF
- ProtClustDB:   PRK09605
- BioCyc:   MMAR267377:MMP0415-MONOMER
- BRENDA:   3.4.24.57
- GO:   GO:0006508
- HAMAP:   MF_01447
- InterPro:   IPR022449
- InterPro:   IPR022495
- InterPro:   IPR011009
- InterPro:   IPR009220
- InterPro:   IPR000905
- InterPro:   IPR017861
- InterPro:   IPR018934
- InterPro:   IPR008266
- PANTHER:   PTHR11735
- PIRSF:   PIRSF036401
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03724
- TIGRFAMs:   TIGR03722
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22; PF01163 RIO1; SSF56112 Kinase_like

EC number: =3.4.24.57

Molecular weight: Translated: 61249; Mature: 61249

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: PS01016 GLYCOPROTEASE; PS50011 PROTEIN_KINASE_DOM; PS00109 PROTEIN_KINASE_TYR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNSKDDLICIGFEGTAEKSGVGIITSKGEVLFNKTIIYTPPVQGIHPREAADHHAETFV
CCCCCCCEEEEECCCCCCCCCCEEEECCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHH
KLLKEALNEVPLEKIDLVSFSLGPGLGPSLRVTATTARALSLSINKPIIGVNHCIGHVEI
HHHHHHHHHCCCCCEEEEEEECCCCCCCCEEEEEEEEEEEEEECCCCEEEHHHCCCCEEE
GKLTTDAVDPLTLYVSGGNTQVLAYTGKKYRVIGETLDIAIGNCLDQFARHCNLPHPGGV
CCEECCCCCCEEEEEECCCEEEEEEECCEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCH
YVEKFAKDGNKFIKLPYTVKGMDLSLSGLLTSAMKKYDSKERIEDVCYSLQETSFSMLTE
HHHHHHCCCCCEEECCEEEECCCEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
ITERALAHTNKAEVMLVGGVAANNRLKEMLKVMCEEQNVDFYVPEKQFCGDNGAMIAWLG
HHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEECCCHHHCCCCCCHHHHHH
ILQYLNGKRMDLKDTKPISNYRSDMVEVNWIHDESKNLNDGNIKSRKIPKHLIGKGAEAD
HHHHHCCCCCCCCCCCCHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCCHHHHCCCCCCC
ISKGRYLEFESITKERVKKGYRILKLDELIRTRRTVKEARFLAAVKECGIHAPSIYDIDK
CCCCCEEEHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCC
ENKKIIMGYIHGKIAKDEIEEGNIEFCKSLGETIGKMHGSGIVHNDLTTSNFIISKNPYI
CCCEEEEEEECCEECHHHHCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCEEEECCCEE
IDFGLGKYSDLIEDKAIDLIVLKKSIMSIHYDKFDLVWNKIIDGYKTYELAESVLECIKE
EEECCCCHHHHHHHHCHHHHEEHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHH
VEKRARYL
HHHHHCCC
>Mature Secondary Structure
MDNSKDDLICIGFEGTAEKSGVGIITSKGEVLFNKTIIYTPPVQGIHPREAADHHAETFV
CCCCCCCEEEEECCCCCCCCCCEEEECCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHH
KLLKEALNEVPLEKIDLVSFSLGPGLGPSLRVTATTARALSLSINKPIIGVNHCIGHVEI
HHHHHHHHHCCCCCEEEEEEECCCCCCCCEEEEEEEEEEEEEECCCCEEEHHHCCCCEEE
GKLTTDAVDPLTLYVSGGNTQVLAYTGKKYRVIGETLDIAIGNCLDQFARHCNLPHPGGV
CCEECCCCCCEEEEEECCCEEEEEEECCEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCH
YVEKFAKDGNKFIKLPYTVKGMDLSLSGLLTSAMKKYDSKERIEDVCYSLQETSFSMLTE
HHHHHHCCCCCEEECCEEEECCCEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
ITERALAHTNKAEVMLVGGVAANNRLKEMLKVMCEEQNVDFYVPEKQFCGDNGAMIAWLG
HHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEECCCHHHCCCCCCHHHHHH
ILQYLNGKRMDLKDTKPISNYRSDMVEVNWIHDESKNLNDGNIKSRKIPKHLIGKGAEAD
HHHHHCCCCCCCCCCCCHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCCHHHHCCCCCCC
ISKGRYLEFESITKERVKKGYRILKLDELIRTRRTVKEARFLAAVKECGIHAPSIYDIDK
CCCCCEEEHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCC
ENKKIIMGYIHGKIAKDEIEEGNIEFCKSLGETIGKMHGSGIVHNDLTTSNFIISKNPYI
CCCEEEEEEECCEECHHHHCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCEEEECCCEE
IDFGLGKYSDLIEDKAIDLIVLKKSIMSIHYDKFDLVWNKIIDGYKTYELAESVLECIKE
EEECCCCHHHHHHHHCHHHHEEHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHH
VEKRARYL
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA