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The map label for this gene is prsA [H]

Identifier: 45357973

GI number: 45357973

Start: 408933

End: 409796

Strand: Direct

Name: prsA [H]

Synonym: MMP0410

Alternate gene names: 45357973

Gene position: 408933-409796 (Clockwise)

Preceding gene: 45357971

Following gene: 45357975

Centisome position: 24.62

GC content: 36.69

Gene sequence:

>864_bases
ATGATTATTATTCCTGGCTTAAATTCACAAAATCTGGCCAAAGAAGTTGCAAAACTAACAAATTCGGAACTTGCAAGAGT
GGAATCAAAGCAATTTCCTGATGGCGAAATATATGTTAGAGTTCACAATGAACTAAAAGGAAAAGATGCAGTTATAATTC
AGACCCAAAACACGCAGAATGATTCAATTGTTGAAGCAATTTTAATGTGCGAAGCTTTAAGGGACGAAGGAGTAAAAAGC
ATAACTTTAGTTGCACCATACCTTGCATACGCAAGACAGGATAAAAAATTCAATGCTGGAGAGCCAATCAGCATAAAAGC
GCTTGCAAAAGTATATTCAAACATTTGTGATAGAATTATCACGATAAACCCCCACGAAACACATATCAAAGAGTTTTTTG
ATATACCATTTATTTACGGGGATGCAATACCAAAATTAGCAGAACATGCAGGGGTAAAACTTGTAAAACCGCTCGTACTA
TCCCCCGACAAAGGAGCAGTTGCGCTTGCAAAAAGAGCAGCTGAAGAGTTAAACTGTGAATGCGACTATTTAGAAAAAAC
AAGAATTTCTCCAACAGAAATTAAAATTGCGCCAAAAAATCTTGATGTATCTGGAAAAGACGTTTTAATTGTTGATGATA
TCATTTCAACAGGCGGAACAATGGCAACAGCAATTTCAATGTTAATTGAACAAGGAGCAAGAACAGTTATTGCGGCATGC
GTTCACCCGGTTTTAATTGGGGATGCATTAAACAAACTCCACCTCGGAGGAGCTTCTGAAATTGTTGGAACAAACACGTA
CCCTTCAGAAGTTTCAAAAGTATGTGTATCAACAATAATTGCAGACATTTTAAATGGGGAATAA

Upstream 100 bases:

>100_bases
AATTATAATATAAAATACTCTTTTGATAGATTTTTTAAGATTCATAAAACACATTAACTTTTCGGTAAATATTATTTTAT
AAGAGAAATATGGTGACACC

Downstream 100 bases:

>100_bases
TTAAAATAAAATAATTTTAACTATTTTTTAATTAAAATTAGAAAAAAGGAAAAGATATACTAAATTTCGATTATTTGTCG
TGTTCCCAGTAAAGTGCATC

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MIIIPGLNSQNLAKEVAKLTNSELARVESKQFPDGEIYVRVHNELKGKDAVIIQTQNTQNDSIVEAILMCEALRDEGVKS
ITLVAPYLAYARQDKKFNAGEPISIKALAKVYSNICDRIITINPHETHIKEFFDIPFIYGDAIPKLAEHAGVKLVKPLVL
SPDKGAVALAKRAAEELNCECDYLEKTRISPTEIKIAPKNLDVSGKDVLIVDDIISTGGTMATAISMLIEQGARTVIAAC
VHPVLIGDALNKLHLGGASEIVGTNTYPSEVSKVCVSTIIADILNGE

Sequences:

>Translated_287_residues
MIIIPGLNSQNLAKEVAKLTNSELARVESKQFPDGEIYVRVHNELKGKDAVIIQTQNTQNDSIVEAILMCEALRDEGVKS
ITLVAPYLAYARQDKKFNAGEPISIKALAKVYSNICDRIITINPHETHIKEFFDIPFIYGDAIPKLAEHAGVKLVKPLVL
SPDKGAVALAKRAAEELNCECDYLEKTRISPTEIKIAPKNLDVSGKDVLIVDDIISTGGTMATAISMLIEQGARTVIAAC
VHPVLIGDALNKLHLGGASEIVGTNTYPSEVSKVCVSTIIADILNGE
>Mature_287_residues
MIIIPGLNSQNLAKEVAKLTNSELARVESKQFPDGEIYVRVHNELKGKDAVIIQTQNTQNDSIVEAILMCEALRDEGVKS
ITLVAPYLAYARQDKKFNAGEPISIKALAKVYSNICDRIITINPHETHIKEFFDIPFIYGDAIPKLAEHAGVKLVKPLVL
SPDKGAVALAKRAAEELNCECDYLEKTRISPTEIKIAPKNLDVSGKDVLIVDDIISTGGTMATAISMLIEQGARTVIAAC
VHPVLIGDALNKLHLGGASEIVGTNTYPSEVSKVCVSTIIADILNGE

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506129, Length=289, Percent_Identity=30.7958477508651, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI84875539, Length=292, Percent_Identity=31.1643835616438, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI4506127, Length=273, Percent_Identity=30.7692307692308, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI28557709, Length=287, Percent_Identity=30.3135888501742, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI4506133, Length=303, Percent_Identity=28.3828382838284, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI194018537, Length=301, Percent_Identity=25.9136212624585, Blast_Score=72, Evalue=7e-13,
Organism=Escherichia coli, GI1787458, Length=274, Percent_Identity=34.3065693430657, Blast_Score=152, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17554704, Length=302, Percent_Identity=30.1324503311258, Blast_Score=124, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI25149168, Length=302, Percent_Identity=30.1324503311258, Blast_Score=124, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI17554702, Length=302, Percent_Identity=30.1324503311258, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71989924, Length=302, Percent_Identity=30.1324503311258, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17570245, Length=310, Percent_Identity=24.8387096774194, Blast_Score=74, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6321776, Length=266, Percent_Identity=31.203007518797, Blast_Score=127, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6320946, Length=302, Percent_Identity=30.794701986755, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6319403, Length=276, Percent_Identity=30.4347826086957, Blast_Score=120, Evalue=2e-28,
Organism=Drosophila melanogaster, GI21355239, Length=273, Percent_Identity=30.4029304029304, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI45551540, Length=296, Percent_Identity=28.3783783783784, Blast_Score=114, Evalue=8e-26,
Organism=Drosophila melanogaster, GI24651458, Length=322, Percent_Identity=27.9503105590062, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24651456, Length=322, Percent_Identity=27.9503105590062, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI281362873, Length=322, Percent_Identity=27.9503105590062, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24651454, Length=322, Percent_Identity=27.9503105590062, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 31026; Mature: 31026

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIIPGLNSQNLAKEVAKLTNSELARVESKQFPDGEIYVRVHNELKGKDAVIIQTQNTQN
CEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCEEEEEECCCCC
DSIVEAILMCEALRDEGVKSITLVAPYLAYARQDKKFNAGEPISIKALAKVYSNICDRII
HHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHEE
TINPHETHIKEFFDIPFIYGDAIPKLAEHAGVKLVKPLVLSPDKGAVALAKRAAEELNCE
ECCCCHHHHHHHHCCCHHEHHHHHHHHHHCCCEEEHHEEECCCCCHHHHHHHHHHHCCCC
CDYLEKTRISPTEIKIAPKNLDVSGKDVLIVDDIISTGGTMATAISMLIEQGARTVIAAC
CCHHHHCCCCCCEEEEECCCCCCCCCCEEEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
VHPVLIGDALNKLHLGGASEIVGTNTYPSEVSKVCVSTIIADILNGE
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIIIPGLNSQNLAKEVAKLTNSELARVESKQFPDGEIYVRVHNELKGKDAVIIQTQNTQN
CEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCEEEEEECCCCC
DSIVEAILMCEALRDEGVKSITLVAPYLAYARQDKKFNAGEPISIKALAKVYSNICDRII
HHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHEE
TINPHETHIKEFFDIPFIYGDAIPKLAEHAGVKLVKPLVLSPDKGAVALAKRAAEELNCE
ECCCCHHHHHHHHCCCHHEHHHHHHHHHHCCCEEEHHEEECCCCCHHHHHHHHHHHCCCC
CDYLEKTRISPTEIKIAPKNLDVSGKDVLIVDDIISTGGTMATAISMLIEQGARTVIAAC
CCHHHHCCCCCCEEEEECCCCCCCCCCEEEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
VHPVLIGDALNKLHLGGASEIVGTNTYPSEVSKVCVSTIIADILNGE
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]