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The map label for this gene is gch3 [H]

Identifier: 45357968

GI number: 45357968

Start: 404516

End: 405316

Strand: Direct

Name: gch3 [H]

Synonym: MMP0405

Alternate gene names: 45357968

Gene position: 404516-405316 (Clockwise)

Preceding gene: 45357967

Following gene: 45357969

Centisome position: 24.35

GC content: 36.08

Gene sequence:

>801_bases
ATGATTCAAATAACCGTTGTACAAATTGATAATTACGGTCCATGGACAGTTACCCCCAATCCAAGAAGAGAAAGTGACTT
ACAGGCACTTCAATCAAGACTTTACTGCGATATGAACTTGCAATTTGGAGCACACAAAGGTCTTGCATTTTACACAAGAT
TTGACAATATTATTGCAATTACAAATGGGATTGATTTAGAAACCCACAAAAGAATTCAAAATAGTGTAAAAAATAGGTAT
CCATTTACTGTCAGCATGGCGGTAGCTTCTGCAGAAACTGCATACGAAGCTCAAAAACTTGCAACAAAAACAATTCAGGA
ATACGGAAGTGCACAAGACGATGTTAGAAAAGAAGTCTTAGATGTAGCTAACGAATTTGTATCAAATGGCTACGTGCAAC
TTGCACACGTAGATATAAACGATATAACGGGCAAATTAACCGATCTTGAAACGGCATACGATACTTATCTTTCAGTGCAA
AAAACAAAGCTTAAATTGATGGAAGAACTTAAAAAATACGATTCATTGGGCTTTTTCATTGGTGGGGACAACTTCATGTG
TCCATGTAATGGAATGAACGAAAAAGATTTCCTCTGTATGTTTGAAGACATAAAAGATTCCTGCGGTATTGAATTAAAAG
CAGGTATTGGAATTGGAAAAACTGCAGAAGATGCATCAAACCTTGCAGATATCGGCTTAGAAGTTATTCGGGAAGGAAAA
ACTGATTCCCAGGTTTACACCTTGAAACAGGAAATTGATGAACAAAAAAATGTACCTTACAACTACATGTGCCCAATTTA
A

Upstream 100 bases:

>100_bases
TTAATAATATTATTGAGTAATATATTTATTAAGTGTTATATTAAAGTCAAATTATTGCTTCGTAAACTGAAAAGTTAGCG
GATTAATAAAGGAGATAATA

Downstream 100 bases:

>100_bases
ACTAATTCTTTTTTTATTCGGGATTTTATGAAAAAATTAGATAAAATTTACACGATTCCAAAAAAAATAGTCCTTGCTCC
AATGGCTGGGATTACTGATG

Product: GTP cyclohydrolase III

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 266; Mature: 266

Protein sequence:

>266_residues
MIQITVVQIDNYGPWTVTPNPRRESDLQALQSRLYCDMNLQFGAHKGLAFYTRFDNIIAITNGIDLETHKRIQNSVKNRY
PFTVSMAVASAETAYEAQKLATKTIQEYGSAQDDVRKEVLDVANEFVSNGYVQLAHVDINDITGKLTDLETAYDTYLSVQ
KTKLKLMEELKKYDSLGFFIGGDNFMCPCNGMNEKDFLCMFEDIKDSCGIELKAGIGIGKTAEDASNLADIGLEVIREGK
TDSQVYTLKQEIDEQKNVPYNYMCPI

Sequences:

>Translated_266_residues
MIQITVVQIDNYGPWTVTPNPRRESDLQALQSRLYCDMNLQFGAHKGLAFYTRFDNIIAITNGIDLETHKRIQNSVKNRY
PFTVSMAVASAETAYEAQKLATKTIQEYGSAQDDVRKEVLDVANEFVSNGYVQLAHVDINDITGKLTDLETAYDTYLSVQ
KTKLKLMEELKKYDSLGFFIGGDNFMCPCNGMNEKDFLCMFEDIKDSCGIELKAGIGIGKTAEDASNLADIGLEVIREGK
TDSQVYTLKQEIDEQKNVPYNYMCPI
>Mature_266_residues
MIQITVVQIDNYGPWTVTPNPRRESDLQALQSRLYCDMNLQFGAHKGLAFYTRFDNIIAITNGIDLETHKRIQNSVKNRY
PFTVSMAVASAETAYEAQKLATKTIQEYGSAQDDVRKEVLDVANEFVSNGYVQLAHVDINDITGKLTDLETAYDTYLSVQ
KTKLKLMEELKKYDSLGFFIGGDNFMCPCNGMNEKDFLCMFEDIKDSCGIELKAGIGIGKTAEDASNLADIGLEVIREGK
TDSQVYTLKQEIDEQKNVPYNYMCPI

Specific function: Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity [H]

COG id: COG2429

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the archaeal-type GTP cyclohydrolase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007839
- ProDom:   PD313320 [H]

Pfam domain/function: PF05165 GGDN [H]

EC number: =3.5.4.29 [H]

Molecular weight: Translated: 29942; Mature: 29942

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQITVVQIDNYGPWTVTPNPRRESDLQALQSRLYCDMNLQFGAHKGLAFYTRFDNIIAI
CEEEEEEEECCCCCEECCCCCCCHHHHHHHHHHHEEEEECCCCCCCCEEEEEECCCEEEE
TNGIDLETHKRIQNSVKNRYPFTVSMAVASAETAYEAQKLATKTIQEYGSAQDDVRKEVL
ECCCCHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
DVANEFVSNGYVQLAHVDINDITGKLTDLETAYDTYLSVQKTKLKLMEELKKYDSLGFFI
HHHHHHHCCCEEEEEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
GGDNFMCPCNGMNEKDFLCMFEDIKDSCGIELKAGIGIGKTAEDASNLADIGLEVIREGK
CCCCEEECCCCCCCCCCEEEEHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCC
TDSQVYTLKQEIDEQKNVPYNYMCPI
CCCCEEHHHHHHHHHHCCCCEEECCC
>Mature Secondary Structure
MIQITVVQIDNYGPWTVTPNPRRESDLQALQSRLYCDMNLQFGAHKGLAFYTRFDNIIAI
CEEEEEEEECCCCCEECCCCCCCHHHHHHHHHHHEEEEECCCCCCCCEEEEEECCCEEEE
TNGIDLETHKRIQNSVKNRYPFTVSMAVASAETAYEAQKLATKTIQEYGSAQDDVRKEVL
ECCCCHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
DVANEFVSNGYVQLAHVDINDITGKLTDLETAYDTYLSVQKTKLKLMEELKKYDSLGFFI
HHHHHHHCCCEEEEEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
GGDNFMCPCNGMNEKDFLCMFEDIKDSCGIELKAGIGIGKTAEDASNLADIGLEVIREGK
CCCCEEECCCCCCCCCCEEEEHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCC
TDSQVYTLKQEIDEQKNVPYNYMCPI
CCCCEEHHHHHHHHHHCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA