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The map label for this gene is hisI

Identifier: 45357843

GI number: 45357843

Start: 281057

End: 281446

Strand: Direct

Name: hisI

Synonym: MMP0280

Alternate gene names: 45357843

Gene position: 281057-281446 (Clockwise)

Preceding gene: 45357842

Following gene: 45357844

Centisome position: 16.92

GC content: 33.85

Gene sequence:

>390_bases
ATGGACAAAAATATAAAAGAAATTATAAAAAACATGGATTTGAAATTTAGAAATATCGACGGAAAGAAGCTGTTACTGGC
AATTTCGACAGATAAACAAAAAAATGTTTTAATGACTGCATTTATGAGCGAAGAATCTTTGGAAAAATCAATTGAAACAG
GATATATGCACTACTACTCCACAAGCAGGGATAAAATCTGGAAAAAGGGCGAAGAAAGCAAAAACGTCCAAAAAATAATA
GATGTATATCGGGATTGTGACGGAGATGCACTTCTTTTCACGGTTGAACAGACCGGATGGGCCTGTCATGAAGGATATAT
GTCGTGTTTTCACAACAAGATTGATTTAAATACTGGAGATTCTACCGTTATTGGGACTAAATTAGATTAA

Upstream 100 bases:

>100_bases
AATTTTTCGATAAATTTGGAATCGAAGGCGAGATTATATCTACAAAAGCAAATAATTCAGGATATGAAATAATAAAATAG
TTAAAACATCTGTGGAAAAA

Downstream 100 bases:

>100_bases
TATTTAATTTAACTTATTTTTTAAATTTTAAATATTTTTTATCGTTTTTATGGTGAGACTATGTCTATCGAAGAGATTAA
TCAAAATTTAAATGAAAATA

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH

Number of amino acids: Translated: 129; Mature: 129

Protein sequence:

>129_residues
MDKNIKEIIKNMDLKFRNIDGKKLLLAISTDKQKNVLMTAFMSEESLEKSIETGYMHYYSTSRDKIWKKGEESKNVQKII
DVYRDCDGDALLFTVEQTGWACHEGYMSCFHNKIDLNTGDSTVIGTKLD

Sequences:

>Translated_129_residues
MDKNIKEIIKNMDLKFRNIDGKKLLLAISTDKQKNVLMTAFMSEESLEKSIETGYMHYYSTSRDKIWKKGEESKNVQKII
DVYRDCDGDALLFTVEQTGWACHEGYMSCFHNKIDLNTGDSTVIGTKLD
>Mature_129_residues
MDKNIKEIIKNMDLKFRNIDGKKLLLAISTDKQKNVLMTAFMSEESLEKSIETGYMHYYSTSRDKIWKKGEESKNVQKII
DVYRDCDGDALLFTVEQTGWACHEGYMSCFHNKIDLNTGDSTVIGTKLD

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=75, Percent_Identity=38.6666666666667, Blast_Score=74, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319819, Length=113, Percent_Identity=38.9380530973451, Blast_Score=73, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS3_METMP (P62391)

Other databases:

- EMBL:   BX950229
- RefSeq:   NP_987400.1
- ProteinModelPortal:   P62391
- SMR:   P62391
- GeneID:   2762204
- GenomeReviews:   BX950229_GR
- KEGG:   mmp:MMP0280
- NMPDR:   fig|267377.1.peg.280
- HOGENOM:   HBG294308
- OMA:   MHYYSTS
- ProtClustDB:   PRK00051
- BioCyc:   MMAR267377:MMP0280-MONOMER
- BRENDA:   3.5.4.19
- GO:   GO:0005737
- HAMAP:   MF_01021
- InterPro:   IPR002496
- ProDom:   PD002610

Pfam domain/function: PF01502 PRA-CH

EC number: =3.5.4.19

Molecular weight: Translated: 14855; Mature: 14855

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKNIKEIIKNMDLKFRNIDGKKLLLAISTDKQKNVLMTAFMSEESLEKSIETGYMHYYS
CCCHHHHHHHCCCCEEEECCCCEEEEEEECCCCCCEEEHHHHCHHHHHHHHHHCEEEEEE
TSRDKIWKKGEESKNVQKIIDVYRDCDGDALLFTVEQTGWACHEGYMSCFHNKIDLNTGD
CCHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCC
STVIGTKLD
CEEEEEECC
>Mature Secondary Structure
MDKNIKEIIKNMDLKFRNIDGKKLLLAISTDKQKNVLMTAFMSEESLEKSIETGYMHYYS
CCCHHHHHHHCCCCEEEECCCCEEEEEEECCCCCCEEEHHHHCHHHHHHHHHHCEEEEEE
TSRDKIWKKGEESKNVQKIIDVYRDCDGDALLFTVEQTGWACHEGYMSCFHNKIDLNTGD
CCHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCC
STVIGTKLD
CEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA