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The map label for this gene is trm1 [H]

Identifier: 45357791

GI number: 45357791

Start: 236852

End: 237973

Strand: Direct

Name: trm1 [H]

Synonym: MMP0228

Alternate gene names: 45357791

Gene position: 236852-237973 (Clockwise)

Preceding gene: 45357787

Following gene: 45357794

Centisome position: 14.26

GC content: 34.05

Gene sequence:

>1122_bases
ATGAAAATAATTAGTGAAGGCGAGACAAAATTAATGGTTCCAGAAGAATCAACTTTATCAAAGAAAGATACTGTATTTTA
TAATCCGGTAATGGAAACAAATCGGGATATTTCTGTTTCAGTTGTTCAATCATTTTTAGACGATTTCAAAAGAGATGAAT
TTTTAATGTGCGATCCTCTCGGGGGCAGTGGTGCAAGAGGGATCAGGTACGCAAAAGAATTGAAATTTAACGGAGATTTG
AAAGTTTCGATTGGAGATATTAATCCAAGCGCTGTAAAAATGATAAAAGAGAATTTAAAATTAAATGAACTTGAAAACGT
CGAAGTATTTCACGAAGATGCAAATGTACTTCTTTCAAAAAACTTTAAAGTATTTAATGTAGTTGATTTAGACCCATTTG
GATCTCCGGTTCCTTATTTGGACAGTGGAATCAGGGCAAGTCTCACAAAAGGGGGACTTTTGTGCATGACTGCAACAGAT
ACGGCAGTATTATGCGGAGCATACCGAAAAACATGCATTAGAAAATACAATGCGGTGCCTTTAAAAGGCGATAAGGAACT
TGCAGTACGTTTAATGATTGGATATGCTGTAAAAATGGCTTCAAAATATGATATTGGATTAAAACCAATATTTTCACATG
TAACGGATCACTATGCAAGAACTTTCATGGTTACAGAACGGGGAGCCGGAAAAGCAGATTCTGCAATTGAAAATTTAGGG
TATATCCGGCAGGATAGTGAGCAAAAATCATTTAAAACGTTTGAAGAAGGGTCTGAAAAAGGATATGCAGGTCCATTCTA
TTTAGGTGAAATTTCAGATAAAAATATCGTTCAAAATGCATTAAATACTGCTAAAACTAGAAATTATTCAAAAAGGGCAG
TAAATATTTTGGAAATGATTTCAAGAGAATCAGAAATCAATCAGGTAGGCTGTTTTGATATTCACGAGCTCTGCAGTTTT
ATAAAAAAGCTGGTTCCGCCGGTAAACGATATCATGGAAAACTTAAAAGAAAATGGATTTAAAGTTACAAGGGTTCACTA
CAATCCTTATGGTTTAAAAACAGATGCAGAACTTTCAGATCTGGTCGTTTTAATATCTGAATACCATTCAAAAAAATATT
AA

Upstream 100 bases:

>100_bases
AAGTAAGATTAATATATATCATTATCGATACGAAGTTCGAGCTTTAATTATATAAATAAGCTTAAAAACGGATATTTATG
GATGTTTACTGGTGAAGCAG

Downstream 100 bases:

>100_bases
TTTATTTTTATGTTATATCTATTTTTAAAATTATTAGTTGTGCGAAAGAATTTTTCCAAAGAAGTTTTTCGTTCTTTCAT
TTTTAGGATTACTAAATACA

Product: N(2),N(2)-dimethylguanosine tRNA methyltransferase

Products: NA

Alternate protein names: tRNA 2,2-dimethylguanosine-26 methyltransferase; tRNA(guanine-26,N(2)-N(2)) methyltransferase; tRNA(m(2,2)G26)dimethyltransferase [H]

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MKIISEGETKLMVPEESTLSKKDTVFYNPVMETNRDISVSVVQSFLDDFKRDEFLMCDPLGGSGARGIRYAKELKFNGDL
KVSIGDINPSAVKMIKENLKLNELENVEVFHEDANVLLSKNFKVFNVVDLDPFGSPVPYLDSGIRASLTKGGLLCMTATD
TAVLCGAYRKTCIRKYNAVPLKGDKELAVRLMIGYAVKMASKYDIGLKPIFSHVTDHYARTFMVTERGAGKADSAIENLG
YIRQDSEQKSFKTFEEGSEKGYAGPFYLGEISDKNIVQNALNTAKTRNYSKRAVNILEMISRESEINQVGCFDIHELCSF
IKKLVPPVNDIMENLKENGFKVTRVHYNPYGLKTDAELSDLVVLISEYHSKKY

Sequences:

>Translated_373_residues
MKIISEGETKLMVPEESTLSKKDTVFYNPVMETNRDISVSVVQSFLDDFKRDEFLMCDPLGGSGARGIRYAKELKFNGDL
KVSIGDINPSAVKMIKENLKLNELENVEVFHEDANVLLSKNFKVFNVVDLDPFGSPVPYLDSGIRASLTKGGLLCMTATD
TAVLCGAYRKTCIRKYNAVPLKGDKELAVRLMIGYAVKMASKYDIGLKPIFSHVTDHYARTFMVTERGAGKADSAIENLG
YIRQDSEQKSFKTFEEGSEKGYAGPFYLGEISDKNIVQNALNTAKTRNYSKRAVNILEMISRESEINQVGCFDIHELCSF
IKKLVPPVNDIMENLKENGFKVTRVHYNPYGLKTDAELSDLVVLISEYHSKKY
>Mature_373_residues
MKIISEGETKLMVPEESTLSKKDTVFYNPVMETNRDISVSVVQSFLDDFKRDEFLMCDPLGGSGARGIRYAKELKFNGDL
KVSIGDINPSAVKMIKENLKLNELENVEVFHEDANVLLSKNFKVFNVVDLDPFGSPVPYLDSGIRASLTKGGLLCMTATD
TAVLCGAYRKTCIRKYNAVPLKGDKELAVRLMIGYAVKMASKYDIGLKPIFSHVTDHYARTFMVTERGAGKADSAIENLG
YIRQDSEQKSFKTFEEGSEKGYAGPFYLGEISDKNIVQNALNTAKTRNYSKRAVNILEMISRESEINQVGCFDIHELCSF
IKKLVPPVNDIMENLKENGFKVTRVHYNPYGLKTDAELSDLVVLISEYHSKKY

Specific function: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups [H]

COG id: COG1867

COG function: function code J; N2,N2-dimethylguanosine tRNA methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TRM1 family [H]

Homologues:

Organism=Homo sapiens, GI216548445, Length=313, Percent_Identity=29.7124600638978, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI8923219, Length=341, Percent_Identity=28.1524926686217, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI209862871, Length=341, Percent_Identity=28.1524926686217, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI163792194, Length=278, Percent_Identity=27.6978417266187, Blast_Score=96, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17564890, Length=425, Percent_Identity=26.8235294117647, Blast_Score=132, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6320325, Length=464, Percent_Identity=27.5862068965517, Blast_Score=137, Evalue=3e-33,
Organism=Drosophila melanogaster, GI19921190, Length=455, Percent_Identity=25.0549450549451, Blast_Score=122, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022923
- InterPro:   IPR002905 [H]

Pfam domain/function: PF02005 TRM [H]

EC number: =2.1.1.32 [H]

Molecular weight: Translated: 41820; Mature: 41820

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIISEGETKLMVPEESTLSKKDTVFYNPVMETNRDISVSVVQSFLDDFKRDEFLMCDPL
CCCCCCCCEEEECCCHHCCCCCCCEEECCHHHCCCCCHHHHHHHHHHHHCCCCEEEECCC
GGSGARGIRYAKELKFNGDLKVSIGDINPSAVKMIKENLKLNELENVEVFHEDANVLLSK
CCCCCCHHHHHHHEECCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCEEEECCCCEEEEC
NFKVFNVVDLDPFGSPVPYLDSGIRASLTKGGLLCMTATDTAVLCGAYRKTCIRKYNAVP
CCEEEEEEECCCCCCCCCHHCCCCEEECCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCC
LKGDKELAVRLMIGYAVKMASKYDIGLKPIFSHVTDHYARTFMVTERGAGKADSAIENLG
CCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHH
YIRQDSEQKSFKTFEEGSEKGYAGPFYLGEISDKNIVQNALNTAKTRNYSKRAVNILEMI
HHHCCCHHHHHHHHHCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHH
SRESEINQVGCFDIHELCSFIKKLVPPVNDIMENLKENGFKVTRVHYNPYGLKTDAELSD
HCHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCEEEEEEEECCCCCCCCCCHHH
LVVLISEYHSKKY
HHHHHHHHHCCCC
>Mature Secondary Structure
MKIISEGETKLMVPEESTLSKKDTVFYNPVMETNRDISVSVVQSFLDDFKRDEFLMCDPL
CCCCCCCCEEEECCCHHCCCCCCCEEECCHHHCCCCCHHHHHHHHHHHHCCCCEEEECCC
GGSGARGIRYAKELKFNGDLKVSIGDINPSAVKMIKENLKLNELENVEVFHEDANVLLSK
CCCCCCHHHHHHHEECCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCEEEECCCCEEEEC
NFKVFNVVDLDPFGSPVPYLDSGIRASLTKGGLLCMTATDTAVLCGAYRKTCIRKYNAVP
CCEEEEEEECCCCCCCCCHHCCCCEEECCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCC
LKGDKELAVRLMIGYAVKMASKYDIGLKPIFSHVTDHYARTFMVTERGAGKADSAIENLG
CCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHH
YIRQDSEQKSFKTFEEGSEKGYAGPFYLGEISDKNIVQNALNTAKTRNYSKRAVNILEMI
HHHCCCHHHHHHHHHCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHH
SRESEINQVGCFDIHELCSFIKKLVPPVNDIMENLKENGFKVTRVHYNPYGLKTDAELSD
HCHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCEEEEEEEECCCCCCCCCCHHH
LVVLISEYHSKKY
HHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA