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The map label for this gene is moeA [C]

Identifier: 45357764

GI number: 45357764

Start: 208252

End: 209379

Strand: Direct

Name: moeA [C]

Synonym: MMP0201

Alternate gene names: 45357764

Gene position: 208252-209379 (Clockwise)

Preceding gene: 45357763

Following gene: 45357765

Centisome position: 12.54

GC content: 33.07

Gene sequence:

>1128_bases
ATGAAAACTGCTGATGAAGTTCAAAATATTTTAAATGGATTTACATGTAATCGTGAAGTTTCTGTTGAAATTTATGAATC
ATACGGGAGAGTGCTTTTTGATGACGTTTATTCTAAGGTTGATGTCCCCCTTTGTGATAAATCAACAGTTGACGGCTACG
CAATAACTAATGAAGGACTTAATAATGATTTTTTAGTAATTTCGGATGAAATTCACGCTGGAGACCCTGCAGACATGCTG
ATAAACCCTGGAAAATGTATATGGGTTGCGACAGGTTCAAATATTCCAAAAAATACGGATAGGATAATTCCTTTTGAAAA
CACGATAAATTCAGAAAACACGATAAGAATAGTCAAAATGACAAAAAATTCAAATATTTTTAAAAAAGGAACAGATATTC
CAAAAAATACAAAAGTTCTCGATAAAAATACCTTGATTGATGAAAAAGCGATTGGAATTTTGGCATCAATTGGAATGGAT
AAAATAAATGTTTATGATACTCCAAAAGTTGCGATACTTTCGGTTGGAAGTGAACTTTCAGAAATTAACGAAGTAAATTC
AAAAACACTAACTGCGATTGTTAGAAAGGCAGGTTGTGAGCCTGTTTTTTTAGGGGTTGTTGAAGACAGTATTGAAAAAA
TAACCTCTGCAATAAAAAACGCTGTTTTACAGTATGATATTGTTGTAACTTCGGGTGGAACATCTAAAGGTAAAAAAGAC
TACATGTTTGAAATTATATCATCTATTGGAGATATTTTATTTCATAAAGTAAAATCAATTCCCGGAATGCCAATATTTGC
TGGAAAAGTTAGTGAAAAACCCATAATATGTCTTCCTGGAAATGTTGCATCGTGTCTTGTATGCGGTTATGCGTATCTTT
TACCAATGTTTTTAAACGCGGCTCATAAAACGTTTAAGCGAGAACTGGTAATTGCCGACCTTTCAGAAGAATTTAATTCA
GAACTTGGAATAAAACACTATTTTCCAGTTAAATTAAAGGACGGGATTGCTTACCCTGCATTTCGGGGTTCAAACATGAT
TACTTCAATTGCGAATGCGGACGGTCTTGTTGATGTTAGTGAAAATGAGGTAAAAGTCAGAAAAAATGTTAAAATCTGGC
TGATTTAA

Upstream 100 bases:

>100_bases
GTGAATCTTTTATTAAAAAAGGCACTGATGATGAAAATATCTGCCCAAATTGTGCAGAAAAATCTGCTGAATAATTTTTG
AGTAATGCTGGTGTATTTTT

Downstream 100 bases:

>100_bases
TATTATTATACATATTTGATTAAAATATCAAAAATACATTTTATTAAAAAGATTAAAAAATAAAAAAAGTATTGGGTCAA
ATTTTTAATTTTAAACACAA

Product: molybdenum cofactor biosynthesis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MKTADEVQNILNGFTCNREVSVEIYESYGRVLFDDVYSKVDVPLCDKSTVDGYAITNEGLNNDFLVISDEIHAGDPADML
INPGKCIWVATGSNIPKNTDRIIPFENTINSENTIRIVKMTKNSNIFKKGTDIPKNTKVLDKNTLIDEKAIGILASIGMD
KINVYDTPKVAILSVGSELSEINEVNSKTLTAIVRKAGCEPVFLGVVEDSIEKITSAIKNAVLQYDIVVTSGGTSKGKKD
YMFEIISSIGDILFHKVKSIPGMPIFAGKVSEKPIICLPGNVASCLVCGYAYLLPMFLNAAHKTFKRELVIADLSEEFNS
ELGIKHYFPVKLKDGIAYPAFRGSNMITSIANADGLVDVSENEVKVRKNVKIWLI

Sequences:

>Translated_375_residues
MKTADEVQNILNGFTCNREVSVEIYESYGRVLFDDVYSKVDVPLCDKSTVDGYAITNEGLNNDFLVISDEIHAGDPADML
INPGKCIWVATGSNIPKNTDRIIPFENTINSENTIRIVKMTKNSNIFKKGTDIPKNTKVLDKNTLIDEKAIGILASIGMD
KINVYDTPKVAILSVGSELSEINEVNSKTLTAIVRKAGCEPVFLGVVEDSIEKITSAIKNAVLQYDIVVTSGGTSKGKKD
YMFEIISSIGDILFHKVKSIPGMPIFAGKVSEKPIICLPGNVASCLVCGYAYLLPMFLNAAHKTFKRELVIADLSEEFNS
ELGIKHYFPVKLKDGIAYPAFRGSNMITSIANADGLVDVSENEVKVRKNVKIWLI
>Mature_375_residues
MKTADEVQNILNGFTCNREVSVEIYESYGRVLFDDVYSKVDVPLCDKSTVDGYAITNEGLNNDFLVISDEIHAGDPADML
INPGKCIWVATGSNIPKNTDRIIPFENTINSENTIRIVKMTKNSNIFKKGTDIPKNTKVLDKNTLIDEKAIGILASIGMD
KINVYDTPKVAILSVGSELSEINEVNSKTLTAIVRKAGCEPVFLGVVEDSIEKITSAIKNAVLQYDIVVTSGGTSKGKKD
YMFEIISSIGDILFHKVKSIPGMPIFAGKVSEKPIICLPGNVASCLVCGYAYLLPMFLNAAHKTFKRELVIADLSEEFNS
ELGIKHYFPVKLKDGIAYPAFRGSNMITSIANADGLVDVSENEVKVRKNVKIWLI

Specific function: Involved In The Biosynthesis Of A Demolybdo-Cofactor (Molybdopterin), Necessary For Molybdo-Enzymes. Seems To Be Involved In A Step Of Activation Of Molybdenum In The Form Of Thiomolybdenum. [C]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=296, Percent_Identity=30.7432432432432, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI10880983, Length=296, Percent_Identity=30.7432432432432, Blast_Score=127, Evalue=1e-29,
Organism=Escherichia coli, GI1787049, Length=295, Percent_Identity=28.8135593220339, Blast_Score=140, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI25147659, Length=302, Percent_Identity=29.4701986754967, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17562606, Length=262, Percent_Identity=24.0458015267176, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17136978, Length=292, Percent_Identity=26.3698630136986, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24638841, Length=292, Percent_Identity=26.3698630136986, Blast_Score=75, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 41128; Mature: 41128

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTADEVQNILNGFTCNREVSVEIYESYGRVLFDDVYSKVDVPLCDKSTVDGYAITNEGL
CCCHHHHHHHHCCCCCCCEEEEEEHHHCCHHHHHHHHHHCCCCCCCCCCCCCEEEECCCC
NNDFLVISDEIHAGDPADMLINPGKCIWVATGSNIPKNTDRIIPFENTINSENTIRIVKM
CCCEEEEECCCCCCCCHHEEECCCCEEEEEECCCCCCCCCCEECCCCCCCCCCEEEEEEE
TKNSNIFKKGTDIPKNTKVLDKNTLIDEKAIGILASIGMDKINVYDTPKVAILSVGSELS
ECCCCCEECCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCEEEECCCCCEEEEECCHHHH
EINEVNSKTLTAIVRKAGCEPVFLGVVEDSIEKITSAIKNAVLQYDIVVTSGGTSKGKKD
HHHHCCHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCHH
YMFEIISSIGDILFHKVKSIPGMPIFAGKVSEKPIICLPGNVASCLVCGYAYLLPMFLNA
HHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHH
AHKTFKRELVIADLSEEFNSELGIKHYFPVKLKDGIAYPAFRGSNMITSIANADGLVDVS
HHHHHHHHEEEEEHHHHHCCCCCCEEECCEEECCCCCCCCCCCCCCEEECCCCCCEEECC
ENEVKVRKNVKIWLI
CCCEEEEECEEEEEC
>Mature Secondary Structure
MKTADEVQNILNGFTCNREVSVEIYESYGRVLFDDVYSKVDVPLCDKSTVDGYAITNEGL
CCCHHHHHHHHCCCCCCCEEEEEEHHHCCHHHHHHHHHHCCCCCCCCCCCCCEEEECCCC
NNDFLVISDEIHAGDPADMLINPGKCIWVATGSNIPKNTDRIIPFENTINSENTIRIVKM
CCCEEEEECCCCCCCCHHEEECCCCEEEEEECCCCCCCCCCEECCCCCCCCCCEEEEEEE
TKNSNIFKKGTDIPKNTKVLDKNTLIDEKAIGILASIGMDKINVYDTPKVAILSVGSELS
ECCCCCEECCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCEEEECCCCCEEEEECCHHHH
EINEVNSKTLTAIVRKAGCEPVFLGVVEDSIEKITSAIKNAVLQYDIVVTSGGTSKGKKD
HHHHCCHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCHH
YMFEIISSIGDILFHKVKSIPGMPIFAGKVSEKPIICLPGNVASCLVCGYAYLLPMFLNA
HHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHH
AHKTFKRELVIADLSEEFNSELGIKHYFPVKLKDGIAYPAFRGSNMITSIANADGLVDVS
HHHHHHHHEEEEEHHHHHCCCCCCEEECCEEECCCCCCCCCCCCCCEEECCCCCCEEECC
ENEVKVRKNVKIWLI
CCCEEEEECEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]