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The map label for this gene is mtaP [C]

Identifier: 45357748

GI number: 45357748

Start: 193763

End: 194524

Strand: Direct

Name: mtaP [C]

Synonym: MMP0185

Alternate gene names: 45357748

Gene position: 193763-194524 (Clockwise)

Preceding gene: 45357738

Following gene: 45357749

Centisome position: 11.66

GC content: 35.3

Gene sequence:

>762_bases
TTGATTGGAATTATCGGCGGAACAGGAATTTCTTCGATATTAAACAAGGGCGAAGAAAGAATCATTGATACAAAATACGG
AAAATCTAAAGTTTTAATTGACAAAGAAAGTGATGTTGTATTACTCTTTAGACACGGGGCTGAACACAACACTCCCCCTC
ACAAAATAAACTATCGTGCAAATATCTGCGCTTTAAAGATGCTCGGTGTTGAAAGGATCTTAGCATTAAGTTCAGTTGGA
TCCCTTCGTGAAGATGTGGTTCCAGGAGACTTTTTAATTCCAAACGACTTTTTAGAATTTACAAAAGCAAGAAAAAGCAC
GTTTTATGATGGGGAAGACGGAAAAGTCGTTCACGTTGATGTAACTGAACCGTACTGTCCAGAATTAAAAGAAGTTGCAA
AAAAAATTCTCAAAAAAAGAGATTACAAGTTTAACGAAGGAGTTTACGTATGTACTGAAGGCCCAAGATTCGAAACAAAA
ACAGAAATTCAAATTTATAAAAATTGGGGCCACGTTGTTGGAATGACTGCTTACCCGGAAGTAGTTTTGGCAAGAGAAAT
GGAAATGTGCTACACTTCAATCTGCAATGTTTCAAATTATGCGGCAGGAATTTCTAAAAATGTTTTAACCGTTGATGAAG
TTTTAGAAACCCTAAAAGAAATGGAAGAAAAGATACTAAATGTTGTTGACGACTTTATTAATTATGAATTTAAGGAAAGA
ACATGCTTTTGTAAATCCGCGCTTGAAAACGCGGTAATGTAA

Upstream 100 bases:

>100_bases
CCGTCACTATATATAATTTGAAACCGTTAGTATTTATTCAAAAATATTATCTAACAATTTTATTTTATCGCATAAATATT
TGGCACATTCGGGTGATTAT

Downstream 100 bases:

>100_bases
AAAAAGGGATATTTATGAAAACTTTCGAGATTTCAGAAAGTAATCTCAAAAATTGTGAAAAAGAGATAGAAACCGCAAAG
AAAATGATATTGGGCGGAAA

Product: 5'-methylthioadenosine phosphorylase

Products: ribose-1-phosphate; xanthine [C]

Alternate protein names: NA

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MIGIIGGTGISSILNKGEERIIDTKYGKSKVLIDKESDVVLLFRHGAEHNTPPHKINYRANICALKMLGVERILALSSVG
SLREDVVPGDFLIPNDFLEFTKARKSTFYDGEDGKVVHVDVTEPYCPELKEVAKKILKKRDYKFNEGVYVCTEGPRFETK
TEIQIYKNWGHVVGMTAYPEVVLAREMEMCYTSICNVSNYAAGISKNVLTVDEVLETLKEMEEKILNVVDDFINYEFKER
TCFCKSALENAVM

Sequences:

>Translated_253_residues
MIGIIGGTGISSILNKGEERIIDTKYGKSKVLIDKESDVVLLFRHGAEHNTPPHKINYRANICALKMLGVERILALSSVG
SLREDVVPGDFLIPNDFLEFTKARKSTFYDGEDGKVVHVDVTEPYCPELKEVAKKILKKRDYKFNEGVYVCTEGPRFETK
TEIQIYKNWGHVVGMTAYPEVVLAREMEMCYTSICNVSNYAAGISKNVLTVDEVLETLKEMEEKILNVVDDFINYEFKER
TCFCKSALENAVM
>Mature_253_residues
MIGIIGGTGISSILNKGEERIIDTKYGKSKVLIDKESDVVLLFRHGAEHNTPPHKINYRANICALKMLGVERILALSSVG
SLREDVVPGDFLIPNDFLEFTKARKSTFYDGEDGKVVHVDVTEPYCPELKEVAKKILKKRDYKFNEGVYVCTEGPRFETK
TEIQIYKNWGHVVGMTAYPEVVLAREMEMCYTSICNVSNYAAGISKNVLTVDEVLETLKEMEEKILNVVDDFINYEFKER
TCFCKSALENAVM

Specific function: The Nucleoside Phosphorylases Catalyze The Phosphorolytic Breakdown Of The N-Glycosidic Bond In The Nucleoside Molecule, With The Formation Of The Corresponding Free Bases And Pentose-1-Phosphate. This Protein Can Degrade All Purine Nucleosides Except Ade

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=254, Percent_Identity=39.7637795275591, Blast_Score=170, Evalue=1e-42,
Organism=Escherichia coli, GI1788746, Length=173, Percent_Identity=26.0115606936416, Blast_Score=75, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71980569, Length=234, Percent_Identity=34.6153846153846, Blast_Score=134, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6323045, Length=223, Percent_Identity=31.390134529148, Blast_Score=115, Evalue=8e-27,
Organism=Drosophila melanogaster, GI20130079, Length=276, Percent_Identity=32.9710144927536, Blast_Score=147, Evalue=8e-36,
Organism=Drosophila melanogaster, GI221459247, Length=240, Percent_Identity=32.0833333333333, Blast_Score=122, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: 2.4.2.- [C]

Molecular weight: Translated: 28610; Mature: 28610

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGIIGGTGISSILNKGEERIIDTKYGKSKVLIDKESDVVLLFRHGAEHNTPPHKINYRA
CEEEECCCCHHHHHCCCHHHEEECCCCCEEEEEECCCCEEEEEECCCCCCCCCCEEEECC
NICALKMLGVERILALSSVGSLREDVVPGDFLIPNDFLEFTKARKSTFYDGEDGKVVHVD
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHCCCCCCCCCEEEEEE
VTEPYCPELKEVAKKILKKRDYKFNEGVYVCTEGPRFETKTEIQIYKNWGHVVGMTAYPE
CCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCEEEEEECCCCEEEECCCHH
VVLAREMEMCYTSICNVSNYAAGISKNVLTVDEVLETLKEMEEKILNVVDDFINYEFKER
HHHHHHHHHHHHHHHCHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
TCFCKSALENAVM
HHHHHHHHHHCCC
>Mature Secondary Structure
MIGIIGGTGISSILNKGEERIIDTKYGKSKVLIDKESDVVLLFRHGAEHNTPPHKINYRA
CEEEECCCCHHHHHCCCHHHEEECCCCCEEEEEECCCCEEEEEECCCCCCCCCCEEEECC
NICALKMLGVERILALSSVGSLREDVVPGDFLIPNDFLEFTKARKSTFYDGEDGKVVHVD
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHCCCCCCCCCEEEEEE
VTEPYCPELKEVAKKILKKRDYKFNEGVYVCTEGPRFETKTEIQIYKNWGHVVGMTAYPE
CCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCEEEEEECCCCEEEECCCHH
VVLAREMEMCYTSICNVSNYAAGISKNVLTVDEVLETLKEMEEKILNVVDDFINYEFKER
HHHHHHHHHHHHHHHCHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
TCFCKSALENAVM
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: xanthosine; phosphate [C]

Specific reaction: xanthosine + phosphate = ribose-1-phosphate + xanthine [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]