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The map label for this gene is hbdA [H]

Identifier: 42523333

GI number: 42523333

Start: 1776533

End: 1777393

Strand: Direct

Name: hbdA [H]

Synonym: Bd1850

Alternate gene names: 42523333

Gene position: 1776533-1777393 (Clockwise)

Preceding gene: 42523331

Following gene: 42523334

Centisome position: 46.96

GC content: 49.01

Gene sequence:

>861_bases
ATGAATATCAAAACGATCGGCGTCGTAGGCGCAGGACAGATGGGTAATGGCATCGCACAAGTGGCGGCAAACTTTGGTTT
TAACGTCATCATGATGGACGTGAGCGGTGCAGCTCTTGAAAAAGGGATCGCTACTATTGCTGGCAGCTGTGATCGTATTA
TCAAAAAAGGCGGCATGACTGAGGCTGACAAGGCCACTTTGTTGGGTCGTATCAAGACCGCTCAGGAAACGGCGGGTCTG
AAAGATTGCGACATCGTGATCGAAGCCGCGACTGAAAACATCGACCTGAAACTCAAGATCTTCAAGGACCTGGACGCGAC
CGTAAAACCGGAAGCATTGTTGGTGTCCAATACATCTTCCATCTCCATCACTAAAATTGCCGGCGTGACCAAACGTCCAA
CAAAAGTGGCGGGCATGCACTTCATGAATCCTGTTCCGTTGATGAAACTTGTGGAAGGCATCCGTGGTCTTCAGACTTCC
GATGAAACTTTCGCCATTGTTAAATCTCTGGCAGAAAAAATGGACAAAGTTTTCGTTGAGTCCGTAAAAGACATGCCAGG
CTTCATCGTGAACCGCGTTCTTATGCCGATGATCAACGAAGCGGTTTACACTCTTCACGAGGGCATCGCTTCCGTGGATG
CTATCGACAACGCGATGAAATTGGGAACGAATCAGCCCATGGGTCCTTTGACTTTGGCTGACTTCATCGGTCTGGATACT
TGCCTTGCGATCATGAACGTTCTGCATGAAGGTCTGGGTGATTCCAAGTACCGTCCGTGTCCATTGCTGGTGAAATACGT
TGAAGCCGGCTGGTTGGGTCGTAAAACAGGTCGTGGTTTCTACGACTACTCTGCAAAGTAA

Upstream 100 bases:

>100_bases
TTTAGGCTCGGTGCTCTCAAGGCCAGAAGTTTTGACCTCTGGCCTAAAGTAAAGTATCTAAATCAGGCTGTTTTAAATAC
ATATTAACGCGGAGTGATAA

Downstream 100 bases:

>100_bases
TTGAGGTCTGATAATGGCAAGCAATTATAAAACAATTCTTCTTGAACAAAAAACACACGGGGTTTGGGTTCTGACGATCA
ACCGTCCAGAATCTTTGAAC

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MNIKTIGVVGAGQMGNGIAQVAANFGFNVIMMDVSGAALEKGIATIAGSCDRIIKKGGMTEADKATLLGRIKTAQETAGL
KDCDIVIEAATENIDLKLKIFKDLDATVKPEALLVSNTSSISITKIAGVTKRPTKVAGMHFMNPVPLMKLVEGIRGLQTS
DETFAIVKSLAEKMDKVFVESVKDMPGFIVNRVLMPMINEAVYTLHEGIASVDAIDNAMKLGTNQPMGPLTLADFIGLDT
CLAIMNVLHEGLGDSKYRPCPLLVKYVEAGWLGRKTGRGFYDYSAK

Sequences:

>Translated_286_residues
MNIKTIGVVGAGQMGNGIAQVAANFGFNVIMMDVSGAALEKGIATIAGSCDRIIKKGGMTEADKATLLGRIKTAQETAGL
KDCDIVIEAATENIDLKLKIFKDLDATVKPEALLVSNTSSISITKIAGVTKRPTKVAGMHFMNPVPLMKLVEGIRGLQTS
DETFAIVKSLAEKMDKVFVESVKDMPGFIVNRVLMPMINEAVYTLHEGIASVDAIDNAMKLGTNQPMGPLTLADFIGLDT
CLAIMNVLHEGLGDSKYRPCPLLVKYVEAGWLGRKTGRGFYDYSAK
>Mature_286_residues
MNIKTIGVVGAGQMGNGIAQVAANFGFNVIMMDVSGAALEKGIATIAGSCDRIIKKGGMTEADKATLLGRIKTAQETAGL
KDCDIVIEAATENIDLKLKIFKDLDATVKPEALLVSNTSSISITKIAGVTKRPTKVAGMHFMNPVPLMKLVEGIRGLQTS
DETFAIVKSLAEKMDKVFVESVKDMPGFIVNRVLMPMINEAVYTLHEGIASVDAIDNAMKLGTNQPMGPLTLADFIGLDT
CLAIMNVLHEGLGDSKYRPCPLLVKYVEAGWLGRKTGRGFYDYSAK

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=289, Percent_Identity=41.8685121107266, Blast_Score=201, Evalue=5e-52,
Organism=Homo sapiens, GI296179427, Length=307, Percent_Identity=40.0651465798046, Blast_Score=191, Evalue=9e-49,
Organism=Homo sapiens, GI20127408, Length=286, Percent_Identity=34.2657342657343, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI261878539, Length=300, Percent_Identity=32.6666666666667, Blast_Score=132, Evalue=3e-31,
Organism=Homo sapiens, GI68989263, Length=300, Percent_Identity=32.6666666666667, Blast_Score=132, Evalue=3e-31,
Organism=Homo sapiens, GI115430219, Length=219, Percent_Identity=25.1141552511416, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1787661, Length=289, Percent_Identity=39.1003460207612, Blast_Score=201, Evalue=5e-53,
Organism=Escherichia coli, GI1790281, Length=261, Percent_Identity=35.2490421455939, Blast_Score=144, Evalue=8e-36,
Organism=Escherichia coli, GI1788682, Length=266, Percent_Identity=33.0827067669173, Blast_Score=135, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17553560, Length=288, Percent_Identity=43.75, Blast_Score=229, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17549919, Length=288, Percent_Identity=43.4027777777778, Blast_Score=227, Evalue=4e-60,
Organism=Caenorhabditis elegans, GI17563036, Length=289, Percent_Identity=38.0622837370242, Blast_Score=194, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI25144276, Length=284, Percent_Identity=36.6197183098592, Blast_Score=167, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17508951, Length=284, Percent_Identity=36.6197183098592, Blast_Score=167, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17508953, Length=284, Percent_Identity=36.6197183098592, Blast_Score=167, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17558304, Length=282, Percent_Identity=36.1702127659575, Blast_Score=165, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI71985923, Length=289, Percent_Identity=31.8339100346021, Blast_Score=128, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI71985930, Length=287, Percent_Identity=26.1324041811847, Blast_Score=104, Evalue=5e-23,
Organism=Drosophila melanogaster, GI19921000, Length=286, Percent_Identity=36.3636363636364, Blast_Score=171, Evalue=3e-43,
Organism=Drosophila melanogaster, GI24583077, Length=286, Percent_Identity=36.3636363636364, Blast_Score=171, Evalue=4e-43,
Organism=Drosophila melanogaster, GI24583079, Length=286, Percent_Identity=36.3636363636364, Blast_Score=171, Evalue=4e-43,
Organism=Drosophila melanogaster, GI45549573, Length=243, Percent_Identity=27.1604938271605, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI20129993, Length=231, Percent_Identity=23.8095238095238, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 30586; Mature: 30586

Theoretical pI: Translated: 7.94; Mature: 7.94

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIKTIGVVGAGQMGNGIAQVAANFGFNVIMMDVSGAALEKGIATIAGSCDRIIKKGGMT
CCEEEEEEEECCCCCCHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCC
EADKATLLGRIKTAQETAGLKDCDIVIEAATENIDLKLKIFKDLDATVKPEALLVSNTSS
CHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEEEECCCCCCCCCEEEEECCCC
ISITKIAGVTKRPTKVAGMHFMNPVPLMKLVEGIRGLQTSDETFAIVKSLAEKMDKVFVE
EEEEEECCCCCCCCHHHCHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
SVKDMPGFIVNRVLMPMINEAVYTLHEGIASVDAIDNAMKLGTNQPMGPLTLADFIGLDT
HHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
CLAIMNVLHEGLGDSKYRPCPLLVKYVEAGWLGRKTGRGFYDYSAK
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNIKTIGVVGAGQMGNGIAQVAANFGFNVIMMDVSGAALEKGIATIAGSCDRIIKKGGMT
CCEEEEEEEECCCCCCHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCC
EADKATLLGRIKTAQETAGLKDCDIVIEAATENIDLKLKIFKDLDATVKPEALLVSNTSS
CHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEEEECCCCCCCCCEEEEECCCC
ISITKIAGVTKRPTKVAGMHFMNPVPLMKLVEGIRGLQTSDETFAIVKSLAEKMDKVFVE
EEEEEECCCCCCCCHHHCHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
SVKDMPGFIVNRVLMPMINEAVYTLHEGIASVDAIDNAMKLGTNQPMGPLTLADFIGLDT
HHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
CLAIMNVLHEGLGDSKYRPCPLLVKYVEAGWLGRKTGRGFYDYSAK
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]