Click here to switch to the map view.

The map label for this gene is fadI [H]

Identifier: 42523320

GI number: 42523320

Start: 1761615

End: 1762958

Strand: Direct

Name: fadI [H]

Synonym: Bd1835

Alternate gene names: 42523320

Gene position: 1761615-1762958 (Clockwise)

Preceding gene: 42523313

Following gene: 42523321

Centisome position: 46.57

GC content: 50.37

Gene sequence:

>1344_bases
ATGAAATCACCACGTGATGTTGTTCTTGTAGAAGGTGTTCGCACTCCCTTCGCGAAAGCAGGAACAAAACTTAAAAAAGT
ACACCCGGCAGAATTGGGTAAAGTCGCTTTGAAACAAGTTATCGCCCAGACAAATCTGGATGTGAACCTTGTGGATGAAG
TGATCATCGGGAACACCGGAAATCCTCCGGACTCTGTGAACATCTCGCGCGTGGTGGCATTGAACGCTGGTATTCCTTTG
AAAACCTCTGCATACACAGTTCACAGAAACTGCGCATCTGCACTTGAATCCATCTCCAACGGCTATGAGAAAATCAAATC
CGGAACAATGGATGTGATCCTGGCGGGCGGGACCGAAAACATGTCCCAGATGCCGACGCTGCCACCAAAAAAATTCCAGG
AAATCTACGAAAAACTTTTCGCTGCGAAAGGCCCGAAACAAGCGTTGCCATTGTTGTGGTCCCTGTTCAAAGCGGACGTG
AAGCAGATCAAAGCTTTGTTGTCCGGGAACATGCGTGATGAATACTTCCCGGTGATTTCCGTGATGATGGGTCTGACGGA
TCCTTTCGTAGGCATCAACATGGGTCAAACAGCTGAGATCCTGGCAAAAGAGTGGGGTCTGTCTCGTGAGACTCAAGATA
AATTTGCTTTGCGCTCTCACCAGCTGGCTTCCAAGGCCATGAAAGAGGGCCGCATGCGTGAAGAGATCGCTCCGGTTTAT
CTGGCTCCTGAATACAAGGAAGTGATCAGCGAAGACATCGGTCCTCGTGACACACAAACGATGGAAGCGCTGGCGAAGTT
GAAGCCGTTCTTTGATAAAGCCACAGGCTCGATCACGGCGGGGAACTCCTGTCCGATCACCGATGGTGCGGCGATGGTGT
TGATGATGTCCCGTGAAAAAGCAGAAGCTCTTGGTTATAAACCCCTGGCGACAATCCGTTCTTACGGTTTTGCAGGTCTT
GAACCTGAGCGCATGGGCTTGGGCCCGGTTTACTCCACTCCGGTGGCGTTGAAGCGTGCGGGGCTTTCCATGAAAGATAT
CGGCCTGGTGGAATTGAATGAAGCTTTCGCGGCTCAGGTTCTTTCCTGCCAAAAAGCATTTGATTCTGACAAATTCGGTC
AGGAAAAATTGGGATTGTCTTCCAAGATCGGTGAAATCCGTGATGATATTTTGAATGTCAACGGCGGAGCCATCGCACTT
GGTCACCCAGTGGGAGCAACCGGCACCCGTATCGTTCTGACTTTGGCCAAAGAAATGAAACGCAGAAACACCCAGTTTGG
TCTGGCGACTTTGTGTATCGGTGGGGGCCAAGGCGGATCCATGATCCTTGAGAACGAGGGCTAA

Upstream 100 bases:

>100_bases
CGATACTTCGGGGGGAGATCCAGAACGGCCTTTTACTATTTGGTGGAACTGCCGAAAAGACATATCATTTTAATGGTTTA
TACAACTAAGGAGACTGTTC

Downstream 100 bases:

>100_bases
AGCGAAGCTCTCGGGGCCGAAGCCCTTGGGGCAGAGCCCGGCTCTGCGCTCATAGGCTTCGGACAGTCCTCGCGGACGCC
ATCCCTTTGGGATGAGCTGC

Product: acetyl-CoA acyltransferase

Products: NA

Alternate protein names: ACSs; Acetyl-CoA acyltransferase; Acyl-CoA ligase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MKSPRDVVLVEGVRTPFAKAGTKLKKVHPAELGKVALKQVIAQTNLDVNLVDEVIIGNTGNPPDSVNISRVVALNAGIPL
KTSAYTVHRNCASALESISNGYEKIKSGTMDVILAGGTENMSQMPTLPPKKFQEIYEKLFAAKGPKQALPLLWSLFKADV
KQIKALLSGNMRDEYFPVISVMMGLTDPFVGINMGQTAEILAKEWGLSRETQDKFALRSHQLASKAMKEGRMREEIAPVY
LAPEYKEVISEDIGPRDTQTMEALAKLKPFFDKATGSITAGNSCPITDGAAMVLMMSREKAEALGYKPLATIRSYGFAGL
EPERMGLGPVYSTPVALKRAGLSMKDIGLVELNEAFAAQVLSCQKAFDSDKFGQEKLGLSSKIGEIRDDILNVNGGAIAL
GHPVGATGTRIVLTLAKEMKRRNTQFGLATLCIGGGQGGSMILENEG

Sequences:

>Translated_447_residues
MKSPRDVVLVEGVRTPFAKAGTKLKKVHPAELGKVALKQVIAQTNLDVNLVDEVIIGNTGNPPDSVNISRVVALNAGIPL
KTSAYTVHRNCASALESISNGYEKIKSGTMDVILAGGTENMSQMPTLPPKKFQEIYEKLFAAKGPKQALPLLWSLFKADV
KQIKALLSGNMRDEYFPVISVMMGLTDPFVGINMGQTAEILAKEWGLSRETQDKFALRSHQLASKAMKEGRMREEIAPVY
LAPEYKEVISEDIGPRDTQTMEALAKLKPFFDKATGSITAGNSCPITDGAAMVLMMSREKAEALGYKPLATIRSYGFAGL
EPERMGLGPVYSTPVALKRAGLSMKDIGLVELNEAFAAQVLSCQKAFDSDKFGQEKLGLSSKIGEIRDDILNVNGGAIAL
GHPVGATGTRIVLTLAKEMKRRNTQFGLATLCIGGGQGGSMILENEG
>Mature_447_residues
MKSPRDVVLVEGVRTPFAKAGTKLKKVHPAELGKVALKQVIAQTNLDVNLVDEVIIGNTGNPPDSVNISRVVALNAGIPL
KTSAYTVHRNCASALESISNGYEKIKSGTMDVILAGGTENMSQMPTLPPKKFQEIYEKLFAAKGPKQALPLLWSLFKADV
KQIKALLSGNMRDEYFPVISVMMGLTDPFVGINMGQTAEILAKEWGLSRETQDKFALRSHQLASKAMKEGRMREEIAPVY
LAPEYKEVISEDIGPRDTQTMEALAKLKPFFDKATGSITAGNSCPITDGAAMVLMMSREKAEALGYKPLATIRSYGFAGL
EPERMGLGPVYSTPVALKRAGLSMKDIGLVELNEAFAAQVLSCQKAFDSDKFGQEKLGLSSKIGEIRDDILNVNGGAIAL
GHPVGATGTRIVLTLAKEMKRRNTQFGLATLCIGGGQGGSMILENEG

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4504327, Length=441, Percent_Identity=38.7755102040816, Blast_Score=286, Evalue=3e-77,
Organism=Homo sapiens, GI167614485, Length=443, Percent_Identity=36.3431151241535, Blast_Score=247, Evalue=1e-65,
Organism=Homo sapiens, GI4501853, Length=454, Percent_Identity=35.2422907488987, Blast_Score=235, Evalue=7e-62,
Organism=Homo sapiens, GI148539872, Length=444, Percent_Identity=33.3333333333333, Blast_Score=225, Evalue=6e-59,
Organism=Homo sapiens, GI4557237, Length=441, Percent_Identity=28.7981859410431, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI194353979, Length=259, Percent_Identity=30.1158301158301, Blast_Score=98, Evalue=2e-20,
Organism=Escherichia coli, GI1788683, Length=441, Percent_Identity=36.5079365079365, Blast_Score=300, Evalue=2e-82,
Organism=Escherichia coli, GI87082165, Length=443, Percent_Identity=38.3747178329571, Blast_Score=273, Evalue=1e-74,
Organism=Escherichia coli, GI1788554, Length=443, Percent_Identity=38.8261851015801, Blast_Score=262, Evalue=3e-71,
Organism=Escherichia coli, GI1787663, Length=447, Percent_Identity=36.4653243847875, Blast_Score=247, Evalue=1e-66,
Organism=Escherichia coli, GI48994986, Length=259, Percent_Identity=47.4903474903475, Blast_Score=214, Evalue=9e-57,
Organism=Caenorhabditis elegans, GI17551802, Length=443, Percent_Identity=35.8916478555305, Blast_Score=261, Evalue=4e-70,
Organism=Caenorhabditis elegans, GI133906874, Length=441, Percent_Identity=35.6009070294785, Blast_Score=248, Evalue=4e-66,
Organism=Caenorhabditis elegans, GI17535921, Length=443, Percent_Identity=30.9255079006772, Blast_Score=188, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI25147385, Length=447, Percent_Identity=28.6353467561521, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17535917, Length=169, Percent_Identity=30.7692307692308, Blast_Score=82, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6325229, Length=453, Percent_Identity=33.3333333333333, Blast_Score=209, Evalue=5e-55,
Organism=Saccharomyces cerevisiae, GI6322031, Length=453, Percent_Identity=33.5540838852097, Blast_Score=197, Evalue=2e-51,
Organism=Drosophila melanogaster, GI17137578, Length=444, Percent_Identity=36.9369369369369, Blast_Score=270, Evalue=1e-72,
Organism=Drosophila melanogaster, GI17648125, Length=445, Percent_Identity=36.4044943820225, Blast_Score=246, Evalue=3e-65,
Organism=Drosophila melanogaster, GI24655093, Length=440, Percent_Identity=35, Blast_Score=240, Evalue=1e-63,
Organism=Drosophila melanogaster, GI24640423, Length=441, Percent_Identity=30.6122448979592, Blast_Score=189, Evalue=4e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012806
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 48090; Mature: 48090

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSPRDVVLVEGVRTPFAKAGTKLKKVHPAELGKVALKQVIAQTNLDVNLVDEVIIGNTG
CCCCCCEEEECCCCCCHHHHCCHHHHCCHHHHHHHHHHHHHHHCCCCCEEHHHHEECCCC
NPPDSVNISRVVALNAGIPLKTSAYTVHRNCASALESISNGYEKIKSGTMDVILAGGTEN
CCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCC
MSQMPTLPPKKFQEIYEKLFAAKGPKQALPLLWSLFKADVKQIKALLSGNMRDEYFPVIS
HHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
VMMGLTDPFVGINMGQTAEILAKEWGLSRETQDKFALRSHQLASKAMKEGRMREEIAPVY
HHHHCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHCCCEE
LAPEYKEVISEDIGPRDTQTMEALAKLKPFFDKATGSITAGNSCPITDGAAMVLMMSREK
ECCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCEEEEECHHH
AEALGYKPLATIRSYGFAGLEPERMGLGPVYSTPVALKRAGLSMKDIGLVELNEAFAAQV
HHHHCCCHHHHHHHCCCCCCCHHHCCCCCCCCCCHHHHHCCCCHHCCCEEEHHHHHHHHH
LSCQKAFDSDKFGQEKLGLSSKIGEIRDDILNVNGGAIALGHPVGATGTRIVLTLAKEMK
HHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHH
RRNTQFGLATLCIGGGQGGSMILENEG
HCCCCCCEEEEEEECCCCCCEEEECCC
>Mature Secondary Structure
MKSPRDVVLVEGVRTPFAKAGTKLKKVHPAELGKVALKQVIAQTNLDVNLVDEVIIGNTG
CCCCCCEEEECCCCCCHHHHCCHHHHCCHHHHHHHHHHHHHHHCCCCCEEHHHHEECCCC
NPPDSVNISRVVALNAGIPLKTSAYTVHRNCASALESISNGYEKIKSGTMDVILAGGTEN
CCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCC
MSQMPTLPPKKFQEIYEKLFAAKGPKQALPLLWSLFKADVKQIKALLSGNMRDEYFPVIS
HHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
VMMGLTDPFVGINMGQTAEILAKEWGLSRETQDKFALRSHQLASKAMKEGRMREEIAPVY
HHHHCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHCCCEE
LAPEYKEVISEDIGPRDTQTMEALAKLKPFFDKATGSITAGNSCPITDGAAMVLMMSREK
ECCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCEEEEECHHH
AEALGYKPLATIRSYGFAGLEPERMGLGPVYSTPVALKRAGLSMKDIGLVELNEAFAAQV
HHHHCCCHHHHHHHCCCCCCCHHHCCCCCCCCCCHHHHHCCCCHHCCCEEEHHHHHHHHH
LSCQKAFDSDKFGQEKLGLSSKIGEIRDDILNVNGGAIALGHPVGATGTRIVLTLAKEMK
HHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHH
RRNTQFGLATLCIGGGQGGSMILENEG
HCCCCCCEEEEEEECCCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA