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The map label for this gene is yvaE [H]

Identifier: 42523246

GI number: 42523246

Start: 1693383

End: 1693820

Strand: Direct

Name: yvaE [H]

Synonym: Bd1753

Alternate gene names: 42523246

Gene position: 1693383-1693820 (Clockwise)

Preceding gene: 42523245

Following gene: 42523248

Centisome position: 44.76

GC content: 52.74

Gene sequence:

>438_bases
ATGGCATACGTGTATCTTGCAGCAGCAATTATCTTTGAGGTTTTCGGTACGATCACAATGAAGTACTCAGAGGGGTTTAC
AAAGGTGCTCCCATCCGTGCTCACGGTAGCATGTCATGGGATCTGCTTTATAAGCCTCACTGTGGCGCTTAAATATCTTC
CGGTCAGCAACGTCTATGCGATCTGGGCGGGAGTGGGAACGGCTTTGATGGCCTTCCTGGGACTGGTTATCTTCAATGAA
CCGCTGCCACTTCAAAAAGTGGTCGCCACAACATTGATTATCGCCGGTGTGGTCATCCTGAATCTGGGTGAAAGCAAAAA
AACCGAAGAGCAGGTCGCTAAGGTGGAGGCTCCGCATATTGAGCCGATTCCTTCGGCCGTGGTTGTGCCGGTTCCAGCGG
CTCCAACCGTGTCGGCGGCTCCACGCAACGCGGGTTGA

Upstream 100 bases:

>100_bases
GTCGACTGGTTCAAAAAAAGATCTCTCGGAGATTCATCCGAGACACGGGGTAAACACAATTTAATACGATAGAAAGGGTC
GAGATGCGACAGGGTGTCTT

Downstream 100 bases:

>100_bases
GGCATTTCCTCAGCAGTAAAATTCAAAACAAAAGAGAGTGGTTCAATACCACTCTCTTTTTTTATTTTCTCTAGAAAGAA
TGTACGTTCAACTTCAACTA

Product: putative multidrug efflux transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 145; Mature: 144

Protein sequence:

>145_residues
MAYVYLAAAIIFEVFGTITMKYSEGFTKVLPSVLTVACHGICFISLTVALKYLPVSNVYAIWAGVGTALMAFLGLVIFNE
PLPLQKVVATTLIIAGVVILNLGESKKTEEQVAKVEAPHIEPIPSAVVVPVPAAPTVSAAPRNAG

Sequences:

>Translated_145_residues
MAYVYLAAAIIFEVFGTITMKYSEGFTKVLPSVLTVACHGICFISLTVALKYLPVSNVYAIWAGVGTALMAFLGLVIFNE
PLPLQKVVATTLIIAGVVILNLGESKKTEEQVAKVEAPHIEPIPSAVVVPVPAAPTVSAAPRNAG
>Mature_144_residues
AYVYLAAAIIFEVFGTITMKYSEGFTKVLPSVLTVACHGICFISLTVALKYLPVSNVYAIWAGVGTALMAFLGLVIFNEP
LPLQKVVATTLIIAGVVILNLGESKKTEEQVAKVEAPHIEPIPSAVVVPVPAAPTVSAAPRNAG

Specific function: Multidrug Transporter. Confers Resistance To A Wide Range Of Toxic Compounds By Removing Them For The Cells. The Efflux Is Coupled To An Influx Of Protons. Probably Prevents The Incorporation Of Methyl VIologen Into Cells. Involved In Ethidium Bromide Ef

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family [H]

Homologues:

Organism=Escherichia coli, GI1786755, Length=100, Percent_Identity=46, Blast_Score=90, Evalue=7e-20,
Organism=Escherichia coli, GI87082378, Length=102, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000390 [H]

Pfam domain/function: PF00893 Multi_Drug_Res [H]

EC number: NA

Molecular weight: Translated: 15224; Mature: 15093

Theoretical pI: Translated: 7.40; Mature: 7.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYVYLAAAIIFEVFGTITMKYSEGFTKVLPSVLTVACHGICFISLTVALKYLPVSNVYA
CHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
IWAGVGTALMAFLGLVIFNEPLPLQKVVATTLIIAGVVILNLGESKKTEEQVAKVEAPHI
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCC
EPIPSAVVVPVPAAPTVSAAPRNAG
CCCCCEEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
AYVYLAAAIIFEVFGTITMKYSEGFTKVLPSVLTVACHGICFISLTVALKYLPVSNVYA
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
IWAGVGTALMAFLGLVIFNEPLPLQKVVATTLIIAGVVILNLGESKKTEEQVAKVEAPHI
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCC
EPIPSAVVVPVPAAPTVSAAPRNAG
CCCCCEEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]