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The map label for this gene is cysK [H]

Identifier: 42523206

GI number: 42523206

Start: 1644141

End: 1645130

Strand: Direct

Name: cysK [H]

Synonym: Bd1710

Alternate gene names: 42523206

Gene position: 1644141-1645130 (Clockwise)

Preceding gene: 42523204

Following gene: 42523207

Centisome position: 43.46

GC content: 53.13

Gene sequence:

>990_bases
ATGAGAATATATTCTGATATCACGAAAACCATTGGTCAAACCCCCTTAATCGAAATGCAAAGAATCGGCAAAGGTTTGCC
GGGGCGTCTTCTGCTAAAGCTTGAGTTCTTTAATCCCCTGGGATCCGTCAAAGACCGCATCGGTCTGGCGATGATCGAGG
ACGCCGAGCGCTCAGGTCAGCTAAAGCCTGGGATGAAAATTATCGAACCCACAAGCGGCAACACAGGCATTGCGCTGGCT
TTTGTGGCCGCTGCCAAAGGTTATGATATCACTCTGACCATGCCAGAAACCATGTCTCAAGAGCGCCGCACGTTGCTGCT
GATGCTGGGGGCGAAAATTATTCTGACTCCGGGGCCCTTGGGTATGAAGGGGGCCATTGCCAAAGCCATGGAGCTTCTGG
AACAAACACCCAATGCCTGGATGCCTCGTCAGTTTGACAATCCGGCCAATCCGGCCATTCACAAAGAAACCACGGCTCTT
GAAATCTGGAACGACACCGATGGCAAGGTCGATATGGTCGTTAGCGGCGTCGGGACTTCCGGCACCATCACTGGTGTGGG
CACCGTGCTTAAAGCCAAAAACAAAAACATCAAAATCATCGCTGTCGAACCGGCTGAAAGCCCGGTGCTTTCCGGCGGTA
AACCCGGGCCTCACAAGATCCAGGGCCTGGGGGCAGGTTTTGTTCCCAGCGTGATGGACAGATCTGTTGTCGATGGGGTG
GAGCAGGTGTCTTCGGAAGAGTCCATAAAAGTGGCTCGGGAAGTGATCAAAAAAGAAGGCATCCCGGTGGGGATTTCCTC
GGGGGCGGCGATCAGTGCCGGTCTTCGCCAAGCGGCGAAAGAGGAAAACCGCGGTAAGAATATCGTCGTGATTATTCCAA
GCACCACCGAACGGTATCTGTCGACCTTGTTGGCCGAACAGGAACGGGCAGAGGCATTGAGTTTGCCTGTCGCTACGGTG
GATGAAAATTACCTGAGTAAAGTGAAGTAA

Upstream 100 bases:

>100_bases
ATTTCCCCTTATTAACGAAATGAAAACAAAAAACCATAAACTTCATCTTTGTCCGGTCCCGCAACGGGAGTATCATGGAA
GATACGGAGATCGGCATCTT

Downstream 100 bases:

>100_bases
AAATGGTTCCTTTTATCGTTCCGGCCAAAGAAAAAGTGCTGCTGAAAATCGGAGAGGCCCCAAAGCTTCCTCTGGCATCT
TCGCAGTTTGATATCTTTGT

Product: hypothetical protein

Products: NA

Alternate protein names: OAS sulfhydrylase; OASS; Cysteine synthase A; CSase A; O-acetylserine (thiol)-lyase A; OAS-TL A; O-acetylserine-specific cysteine synthase; Sulfide-dependent cysteine synthase [H]

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MRIYSDITKTIGQTPLIEMQRIGKGLPGRLLLKLEFFNPLGSVKDRIGLAMIEDAERSGQLKPGMKIIEPTSGNTGIALA
FVAAAKGYDITLTMPETMSQERRTLLLMLGAKIILTPGPLGMKGAIAKAMELLEQTPNAWMPRQFDNPANPAIHKETTAL
EIWNDTDGKVDMVVSGVGTSGTITGVGTVLKAKNKNIKIIAVEPAESPVLSGGKPGPHKIQGLGAGFVPSVMDRSVVDGV
EQVSSEESIKVAREVIKKEGIPVGISSGAAISAGLRQAAKEENRGKNIVVIIPSTTERYLSTLLAEQERAEALSLPVATV
DENYLSKVK

Sequences:

>Translated_329_residues
MRIYSDITKTIGQTPLIEMQRIGKGLPGRLLLKLEFFNPLGSVKDRIGLAMIEDAERSGQLKPGMKIIEPTSGNTGIALA
FVAAAKGYDITLTMPETMSQERRTLLLMLGAKIILTPGPLGMKGAIAKAMELLEQTPNAWMPRQFDNPANPAIHKETTAL
EIWNDTDGKVDMVVSGVGTSGTITGVGTVLKAKNKNIKIIAVEPAESPVLSGGKPGPHKIQGLGAGFVPSVMDRSVVDGV
EQVSSEESIKVAREVIKKEGIPVGISSGAAISAGLRQAAKEENRGKNIVVIIPSTTERYLSTLLAEQERAEALSLPVATV
DENYLSKVK
>Mature_329_residues
MRIYSDITKTIGQTPLIEMQRIGKGLPGRLLLKLEFFNPLGSVKDRIGLAMIEDAERSGQLKPGMKIIEPTSGNTGIALA
FVAAAKGYDITLTMPETMSQERRTLLLMLGAKIILTPGPLGMKGAIAKAMELLEQTPNAWMPRQFDNPANPAIHKETTAL
EIWNDTDGKVDMVVSGVGTSGTITGVGTVLKAKNKNIKIIAVEPAESPVLSGGKPGPHKIQGLGAGFVPSVMDRSVVDGV
EQVSSEESIKVAREVIKKEGIPVGISSGAAISAGLRQAAKEENRGKNIVVIIPSTTERYLSTLLAEQERAEALSLPVATV
DENYLSKVK

Specific function: Catalyzes the conversion of O-acetylserine (OAS) to cysteine through the elimination of acetate and addition of hydrogen sulfide [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=316, Percent_Identity=43.6708860759494, Blast_Score=249, Evalue=2e-66,
Organism=Homo sapiens, GI295821200, Length=316, Percent_Identity=43.6708860759494, Blast_Score=249, Evalue=2e-66,
Organism=Homo sapiens, GI4557415, Length=316, Percent_Identity=43.6708860759494, Blast_Score=249, Evalue=2e-66,
Organism=Escherichia coli, GI1788754, Length=312, Percent_Identity=54.8076923076923, Blast_Score=301, Evalue=3e-83,
Organism=Escherichia coli, GI2367138, Length=298, Percent_Identity=41.6107382550336, Blast_Score=219, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI115535073, Length=314, Percent_Identity=51.2738853503185, Blast_Score=288, Evalue=4e-78,
Organism=Caenorhabditis elegans, GI17535051, Length=314, Percent_Identity=46.1783439490446, Blast_Score=283, Evalue=7e-77,
Organism=Caenorhabditis elegans, GI17562970, Length=318, Percent_Identity=47.1698113207547, Blast_Score=283, Evalue=8e-77,
Organism=Caenorhabditis elegans, GI32566674, Length=296, Percent_Identity=48.9864864864865, Blast_Score=278, Evalue=3e-75,
Organism=Caenorhabditis elegans, GI17561720, Length=318, Percent_Identity=46.2264150943396, Blast_Score=253, Evalue=8e-68,
Organism=Caenorhabditis elegans, GI32566672, Length=229, Percent_Identity=47.5982532751092, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17534315, Length=320, Percent_Identity=39.0625, Blast_Score=191, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI25147552, Length=315, Percent_Identity=36.5079365079365, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17561716, Length=134, Percent_Identity=45.5223880597015, Blast_Score=105, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6321594, Length=320, Percent_Identity=36.25, Blast_Score=191, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6321449, Length=333, Percent_Identity=31.5315315315315, Blast_Score=116, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24643623, Length=316, Percent_Identity=39.5569620253165, Blast_Score=205, Evalue=3e-53,
Organism=Drosophila melanogaster, GI20129101, Length=316, Percent_Identity=39.5569620253165, Blast_Score=205, Evalue=3e-53,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 35044; Mature: 35044

Theoretical pI: Translated: 9.52; Mature: 9.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIYSDITKTIGQTPLIEMQRIGKGLPGRLLLKLEFFNPLGSVKDRIGLAMIEDAERSGQ
CCCHHHHHHHHCCCCCHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHCCCEEECCHHCCC
LKPGMKIIEPTSGNTGIALAFVAAAKGYDITLTMPETMSQERRTLLLMLGAKIILTPGPL
CCCCCEEEECCCCCCCEEEEEEECCCCCEEEEECCHHHHHHHHEEEEEECCEEEECCCCC
GMKGAIAKAMELLEQTPNAWMPRQFDNPANPAIHKETTALEIWNDTDGKVDMVVSGVGTS
CHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCC
GTITGVGTVLKAKNKNIKIIAVEPAESPVLSGGKPGPHKIQGLGAGFVPSVMDRSVVDGV
CEEHHHHHEEEECCCCEEEEEECCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHH
EQVSSEESIKVAREVIKKEGIPVGISSGAAISAGLRQAAKEENRGKNIVVIIPSTTERYL
HHHCCHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHCCCEEEEEECCCHHHHH
STLLAEQERAEALSLPVATVDENYLSKVK
HHHHHHHHHHHHHCCCHHCCCHHHHHHCC
>Mature Secondary Structure
MRIYSDITKTIGQTPLIEMQRIGKGLPGRLLLKLEFFNPLGSVKDRIGLAMIEDAERSGQ
CCCHHHHHHHHCCCCCHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHCCCEEECCHHCCC
LKPGMKIIEPTSGNTGIALAFVAAAKGYDITLTMPETMSQERRTLLLMLGAKIILTPGPL
CCCCCEEEECCCCCCCEEEEEEECCCCCEEEEECCHHHHHHHHEEEEEECCEEEECCCCC
GMKGAIAKAMELLEQTPNAWMPRQFDNPANPAIHKETTALEIWNDTDGKVDMVVSGVGTS
CHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCC
GTITGVGTVLKAKNKNIKIIAVEPAESPVLSGGKPGPHKIQGLGAGFVPSVMDRSVVDGV
CEEHHHHHEEEECCCCEEEEEECCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHH
EQVSSEESIKVAREVIKKEGIPVGISSGAAISAGLRQAAKEENRGKNIVVIIPSTTERYL
HHHCCHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHCCCEEEEEECCCHHHHH
STLLAEQERAEALSLPVATVDENYLSKVK
HHHHHHHHHHHHHCCCHHCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]