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The map label for this gene is fumC [H]

Identifier: 42522839

GI number: 42522839

Start: 1245018

End: 1246418

Strand: Direct

Name: fumC [H]

Synonym: Bd1318

Alternate gene names: 42522839

Gene position: 1245018-1246418 (Clockwise)

Preceding gene: 42522838

Following gene: 42522840

Centisome position: 32.91

GC content: 54.32

Gene sequence:

>1401_bases
GTGATGGCAGAGGGCGGATTCAGAATCGAAAAAGACACCATGGGTGAAGTGAAAGTTCCCGCAGACAAGTTCTGGGGAGC
ACAGACCCAAAGGTCCACAGAAAACTTCCGCATCGGGGGCGATCGTTTCCCGCGCGAGATGATCCGGGCCTTGGGTGTCT
TGAAGAAGTCCGCCGCTATCACCAACGAAAAACTGGGTCTGCTTGATCCGAAAAAAGCCTCGGTCATCGTGAAAGCCGCC
GATGAAGTGATCGTCGGCAAACTCGACGCCCATTTCCCGCTGGTGGTGTGGCAGACGGGTTCAGGCACACAGACCAACAT
GAATGCCAACGAAGTTATCGCCAATCGTGCGATGGACATGATGGGCATCAAACTTCCCAGCAAGGAAGTTCATCCCAATG
ATGATGTGAACAAGGGCCAGTCTTCGAATGACACTTTCCCCACCGCCATGCACATTGCTGTGGGCGAGCAGATTCATCAT
CGCCTGATTCCGATGCTGGAAAAGCTGCACAAAGCTCTGGAAAACAAACAGAAAGAATTTAAAGACATCGTGAAAATCGG
TCGCACCCATTTGATGGATGCAACCCCCCTGACCCTGGGGCAGGAGTTTTCCGGTTACAGCACCCAGGTGAAACACTCCA
TCCAGCGCGTGAAAAACACCTTGCCGCATCTGTACGAGCTGGCATTGGGCGGGACGGCGGTGGGAACGGGTTTGAACACG
CATCCGAAATTTGCGGTTGAAGCCGCTGCGGAAATCGCTCGCGAGACGGGGATTGCCTTTGTTTCGGCTGAAAACAAGTT
TGAAGCCCTGGCGGCCCATGACGCTTTGGTGGAAGTCAGCGGGGCGCTGAACTCGGTCGCGGTGTCCCTGATGAAAATTG
CGAACGACATCCGCCTGCTGGGTTCCGGCCCGCGCTGCGGGATCGGGGAGCTTCATTTGCCCGAAAATGAACCGGGAAGC
TCCATCATGCCGGGCAAAGTGAATCCCACCCAGAGCGAGGCTATGACCATGGTCTGTGCCCAGGTGATGGGAAATCACGT
GGCCGCCACAATTGGCGGGGCGACGGGGCATTTTGAGCTGAACGTGTTTAAGCCCGTGATTGTGTTCAATGTTCTGAATT
CCGTGCGCCTGTTGGCGGACGCGGCAGAATCCTTCACCGATCACTGTGTGGTGGGCATTGAAGCCAACCGTAAACAGATT
CAGAAGCATCTGGAGCAGTCTTTGATGCTGGTGACGGCACTGAATCCTCACATTGGCTATGACAACGCAGCCAAAATTGC
CAAAACTGCCCATAAAAACGGCACAACACTGCGCGAAGAAGCCATCAATCTTGGACTGCTCTCTGGCGAAGAATTTGATA
AGATAGTAAAACCGGAAAACATGGTCGGCCCCAGCCGATAG

Upstream 100 bases:

>100_bases
CTTGGTGCGCAGCCAGACCGGCCCATGTGAACATTCAAGAACTCGTGATTTATCCCACAGATCAGGCCCATGTCGGCCAG
GTCGCTCGCAAAGGAGTGTA

Downstream 100 bases:

>100_bases
AGCGTGAGCTGAAGCTCGGCTCCAGCCAGCGGGCGCATAAGCTGAAGCTCGGCTCTAGCCGGCAGAGCTGAAGCGCCGGC
AGGCGCGCAAGCTGAAGCAG

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MMAEGGFRIEKDTMGEVKVPADKFWGAQTQRSTENFRIGGDRFPREMIRALGVLKKSAAITNEKLGLLDPKKASVIVKAA
DEVIVGKLDAHFPLVVWQTGSGTQTNMNANEVIANRAMDMMGIKLPSKEVHPNDDVNKGQSSNDTFPTAMHIAVGEQIHH
RLIPMLEKLHKALENKQKEFKDIVKIGRTHLMDATPLTLGQEFSGYSTQVKHSIQRVKNTLPHLYELALGGTAVGTGLNT
HPKFAVEAAAEIARETGIAFVSAENKFEALAAHDALVEVSGALNSVAVSLMKIANDIRLLGSGPRCGIGELHLPENEPGS
SIMPGKVNPTQSEAMTMVCAQVMGNHVAATIGGATGHFELNVFKPVIVFNVLNSVRLLADAAESFTDHCVVGIEANRKQI
QKHLEQSLMLVTALNPHIGYDNAAKIAKTAHKNGTTLREEAINLGLLSGEEFDKIVKPENMVGPSR

Sequences:

>Translated_466_residues
MMAEGGFRIEKDTMGEVKVPADKFWGAQTQRSTENFRIGGDRFPREMIRALGVLKKSAAITNEKLGLLDPKKASVIVKAA
DEVIVGKLDAHFPLVVWQTGSGTQTNMNANEVIANRAMDMMGIKLPSKEVHPNDDVNKGQSSNDTFPTAMHIAVGEQIHH
RLIPMLEKLHKALENKQKEFKDIVKIGRTHLMDATPLTLGQEFSGYSTQVKHSIQRVKNTLPHLYELALGGTAVGTGLNT
HPKFAVEAAAEIARETGIAFVSAENKFEALAAHDALVEVSGALNSVAVSLMKIANDIRLLGSGPRCGIGELHLPENEPGS
SIMPGKVNPTQSEAMTMVCAQVMGNHVAATIGGATGHFELNVFKPVIVFNVLNSVRLLADAAESFTDHCVVGIEANRKQI
QKHLEQSLMLVTALNPHIGYDNAAKIAKTAHKNGTTLREEAINLGLLSGEEFDKIVKPENMVGPSR
>Mature_466_residues
MMAEGGFRIEKDTMGEVKVPADKFWGAQTQRSTENFRIGGDRFPREMIRALGVLKKSAAITNEKLGLLDPKKASVIVKAA
DEVIVGKLDAHFPLVVWQTGSGTQTNMNANEVIANRAMDMMGIKLPSKEVHPNDDVNKGQSSNDTFPTAMHIAVGEQIHH
RLIPMLEKLHKALENKQKEFKDIVKIGRTHLMDATPLTLGQEFSGYSTQVKHSIQRVKNTLPHLYELALGGTAVGTGLNT
HPKFAVEAAAEIARETGIAFVSAENKFEALAAHDALVEVSGALNSVAVSLMKIANDIRLLGSGPRCGIGELHLPENEPGS
SIMPGKVNPTQSEAMTMVCAQVMGNHVAATIGGATGHFELNVFKPVIVFNVLNSVRLLADAAESFTDHCVVGIEANRKQI
QKHLEQSLMLVTALNPHIGYDNAAKIAKTAHKNGTTLREEAINLGLLSGEEFDKIVKPENMVGPSR

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=467, Percent_Identity=68.3083511777302, Blast_Score=641, Evalue=0.0,
Organism=Homo sapiens, GI266458395, Length=64, Percent_Identity=59.375, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1787896, Length=457, Percent_Identity=62.363238512035, Blast_Score=582, Evalue=1e-167,
Organism=Escherichia coli, GI87082375, Length=463, Percent_Identity=40.8207343412527, Blast_Score=346, Evalue=2e-96,
Organism=Caenorhabditis elegans, GI17553882, Length=461, Percent_Identity=69.41431670282, Blast_Score=650, Evalue=0.0,
Organism=Caenorhabditis elegans, GI32565146, Length=325, Percent_Identity=73.2307692307692, Blast_Score=492, Evalue=1e-139,
Organism=Saccharomyces cerevisiae, GI6324993, Length=460, Percent_Identity=66.304347826087, Blast_Score=619, Evalue=1e-178,
Organism=Drosophila melanogaster, GI24640179, Length=467, Percent_Identity=66.5952890792291, Blast_Score=636, Evalue=0.0,
Organism=Drosophila melanogaster, GI24640177, Length=467, Percent_Identity=66.3811563169165, Blast_Score=636, Evalue=0.0,
Organism=Drosophila melanogaster, GI78710009, Length=463, Percent_Identity=65.4427645788337, Blast_Score=612, Evalue=1e-175,
Organism=Drosophila melanogaster, GI24662684, Length=463, Percent_Identity=61.9870410367171, Blast_Score=590, Evalue=1e-169,
Organism=Drosophila melanogaster, GI24583245, Length=462, Percent_Identity=54.978354978355, Blast_Score=510, Evalue=1e-145,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50399; Mature: 50399

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMAEGGFRIEKDTMGEVKVPADKFWGAQTQRSTENFRIGGDRFPREMIRALGVLKKSAAI
CCCCCCCEECCCCCCCEECCHHHHCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHH
TNEKLGLLDPKKASVIVKAADEVIVGKLDAHFPLVVWQTGSGTQTNMNANEVIANRAMDM
CCCCCCCCCCCCCEEEEEECCCCEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHH
MGIKLPSKEVHPNDDVNKGQSSNDTFPTAMHIAVGEQIHHRLIPMLEKLHKALENKQKEF
HCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KDIVKIGRTHLMDATPLTLGQEFSGYSTQVKHSIQRVKNTLPHLYELALGGTAVGTGLNT
HHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
HPKFAVEAAAEIARETGIAFVSAENKFEALAAHDALVEVSGALNSVAVSLMKIANDIRLL
CCCHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
GSGPRCGIGELHLPENEPGSSIMPGKVNPTQSEAMTMVCAQVMGNHVAATIGGATGHFEL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCEEEE
NVFKPVIVFNVLNSVRLLADAAESFTDHCVVGIEANRKQIQKHLEQSLMLVTALNPHIGY
EHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHEEEEEECCCCCCC
DNAAKIAKTAHKNGTTLREEAINLGLLSGEEFDKIVKPENMVGPSR
CHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MMAEGGFRIEKDTMGEVKVPADKFWGAQTQRSTENFRIGGDRFPREMIRALGVLKKSAAI
CCCCCCCEECCCCCCCEECCHHHHCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHH
TNEKLGLLDPKKASVIVKAADEVIVGKLDAHFPLVVWQTGSGTQTNMNANEVIANRAMDM
CCCCCCCCCCCCCEEEEEECCCCEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHH
MGIKLPSKEVHPNDDVNKGQSSNDTFPTAMHIAVGEQIHHRLIPMLEKLHKALENKQKEF
HCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KDIVKIGRTHLMDATPLTLGQEFSGYSTQVKHSIQRVKNTLPHLYELALGGTAVGTGLNT
HHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
HPKFAVEAAAEIARETGIAFVSAENKFEALAAHDALVEVSGALNSVAVSLMKIANDIRLL
CCCHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
GSGPRCGIGELHLPENEPGSSIMPGKVNPTQSEAMTMVCAQVMGNHVAATIGGATGHFEL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCEEEE
NVFKPVIVFNVLNSVRLLADAAESFTDHCVVGIEANRKQIQKHLEQSLMLVTALNPHIGY
EHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHEEEEEECCCCCCC
DNAAKIAKTAHKNGTTLREEAINLGLLSGEEFDKIVKPENMVGPSR
CHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA