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The map label for this gene is pcp [H]

Identifier: 42522450

GI number: 42522450

Start: 831144

End: 831764

Strand: Direct

Name: pcp [H]

Synonym: Bd0879

Alternate gene names: 42522450

Gene position: 831144-831764 (Clockwise)

Preceding gene: 42522449

Following gene: 42522451

Centisome position: 21.97

GC content: 51.53

Gene sequence:

>621_bases
ATGAACAATAAAAAGATTCTTCTTACGGGGTTTGAACCATTTCTGGGCGAACCCATCAATCCCAGCCAAATCCTTCTTGA
AAACATCAAGAGGGATTTGACGTTTAATGATCAGGTGCACACGCTGCTGCTGCCAGTGTCTTTTGCAAAAGCCCCAAGGC
TTGTGGCAGCGGCAATGGCGATGCAAACTTACGATGTGGTTTTGATGTTGGGACAAGCCGGTGGTCGCAAGAATATCTGC
CTTGAGCGTGTGGGTTTGAACTGGAATGAAACGGAAAGACCCGACGAAGATGGCAGCACCCCGGTGCGGGGGAGTATTTC
CCCGGAAGCACCCGCCGCGCTTTTCACTGCGGCCCCCGTTGAACAGTGGATGCAGCTTCTGAAAGAGCATCAGATCCCGG
TGGAAATTTCTCTGAGCGCGGGCGGCTATGTCTGCAACAATGTTTACTTTAGAACTTTGCAGGTGCTGGGCTCTTCACCC
GGGACTGTGGCCTGCTTTATACATGTCCCTTACCTTCCGGAGCAAGCTGAGGGTAAAGCGGAACGTCCAGCTTCAATGGA
GCTGGAGACCATGCTAAAGGCCGTTAAAACGATTCTCAGATCGATTTTAGAGGGACCCTGA

Upstream 100 bases:

>100_bases
GGAATTCCGTATCAAAGGCCATCCGCTGAATGGTACATATAGCAGTGACTTCTATATGACATGGCGAAGCCACTTCGAAT
AGGGGTAGCCACTTCGAATA

Downstream 100 bases:

>100_bases
TCATTAGGGTCCTAGACAATAATTTTTGAACCTGGTGGCAGATGCTGTCGTCTAAATATTCAAAACAGGAGGAAACCATG
AAGTTTAATCTGGTTTTGGC

Product: pyrrolidone-carboxylate peptidase

Products: NA

Alternate protein names: 5-oxoprolyl-peptidase; Pyroglutamyl-peptidase I; PGP-I; Pyrase [H]

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MNNKKILLTGFEPFLGEPINPSQILLENIKRDLTFNDQVHTLLLPVSFAKAPRLVAAAMAMQTYDVVLMLGQAGGRKNIC
LERVGLNWNETERPDEDGSTPVRGSISPEAPAALFTAAPVEQWMQLLKEHQIPVEISLSAGGYVCNNVYFRTLQVLGSSP
GTVACFIHVPYLPEQAEGKAERPASMELETMLKAVKTILRSILEGP

Sequences:

>Translated_206_residues
MNNKKILLTGFEPFLGEPINPSQILLENIKRDLTFNDQVHTLLLPVSFAKAPRLVAAAMAMQTYDVVLMLGQAGGRKNIC
LERVGLNWNETERPDEDGSTPVRGSISPEAPAALFTAAPVEQWMQLLKEHQIPVEISLSAGGYVCNNVYFRTLQVLGSSP
GTVACFIHVPYLPEQAEGKAERPASMELETMLKAVKTILRSILEGP
>Mature_206_residues
MNNKKILLTGFEPFLGEPINPSQILLENIKRDLTFNDQVHTLLLPVSFAKAPRLVAAAMAMQTYDVVLMLGQAGGRKNIC
LERVGLNWNETERPDEDGSTPVRGSISPEAPAALFTAAPVEQWMQLLKEHQIPVEISLSAGGYVCNNVYFRTLQVLGSSP
GTVACFIHVPYLPEQAEGKAERPASMELETMLKAVKTILRSILEGP

Specific function: Removes 5-oxoproline from various penultimate amino acid residues except L-proline [H]

COG id: COG2039

COG function: function code O; Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C15 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000816
- InterPro:   IPR016125 [H]

Pfam domain/function: PF01470 Peptidase_C15 [H]

EC number: =3.4.19.3 [H]

Molecular weight: Translated: 22600; Mature: 22600

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS01334 PYRASE_CYS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNKKILLTGFEPFLGEPINPSQILLENIKRDLTFNDQVHTLLLPVSFAKAPRLVAAAMA
CCCCEEEEECCCHHHCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHCHHHHHHHHH
MQTYDVVLMLGQAGGRKNICLERVGLNWNETERPDEDGSTPVRGSISPEAPAALFTAAPV
HHHHHEEEEEECCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
EQWMQLLKEHQIPVEISLSAGGYVCNNVYFRTLQVLGSSPGTVACFIHVPYLPEQAEGKA
HHHHHHHHHCCCCEEEEECCCCEEHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCC
ERPASMELETMLKAVKTILRSILEGP
CCCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNNKKILLTGFEPFLGEPINPSQILLENIKRDLTFNDQVHTLLLPVSFAKAPRLVAAAMA
CCCCEEEEECCCHHHCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHCHHHHHHHHH
MQTYDVVLMLGQAGGRKNICLERVGLNWNETERPDEDGSTPVRGSISPEAPAALFTAAPV
HHHHHEEEEEECCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
EQWMQLLKEHQIPVEISLSAGGYVCNNVYFRTLQVLGSSPGTVACFIHVPYLPEQAEGKA
HHHHHHHHHCCCCEEEEECCCCEEHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCC
ERPASMELETMLKAVKTILRSILEGP
CCCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292 [H]