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The map label for this gene is cbh [H]

Identifier: 42522252

GI number: 42522252

Start: 615748

End: 616809

Strand: Direct

Name: cbh [H]

Synonym: Bd0665

Alternate gene names: 42522252

Gene position: 615748-616809 (Clockwise)

Preceding gene: 42522251

Following gene: 42522253

Centisome position: 16.28

GC content: 52.82

Gene sequence:

>1062_bases
ATGAAGGTGTTATCCGTTTTTTTAAGTCTGCTCTTGGCAGTTCCCGCCTATCCGTGCACCCGCATTTTGTGGGACGGGAA
AAACCAGGATGTTATTGTGGGTCGTAATATGGATTGGTCCGAGGACACTGGCTCGAACATGTGGTTGTTCCCGCGGGGGA
TGGAGCGTGATGGGATGGCCTCCAAGAATTCTGCTAAGTGGACGTCCAAGTATGGCAGTGTGATTCTGTCGATGTACGAT
GTGGGGACTGCGGATGGGGTGAATGAAAAGGGACTGACGGCAAATTTGTTGTATCTGTCGGAAAGCCATTTCGGGACGCG
GGATGAAAAGGTGCCGGGGATGTCAGTCAGTATGTGGGCGCAGTATTTTCTGGATAACTTTGCCACAGTGTCTGAAGCGG
TTTCTTCAATGGAAAAGTCTCCCATCCAGGTTTTGATGGCCAGCGTGCCCACGGCCCACGGAGTGCGGCAGGGGACCGTG
CATCTGGCCTTGTCAGACAAAACCGGGGACTCGGTCGTGATGGAGTATATCGATGGCAAAGCCAAATTCTATCACGGCAA
AGAGTATCGTTTTATGACGAACTCGCCTCCCTTCGACCAGCAGCTGAAATCCATGAAGCAGTATCAGGGATTTGGCGGCA
GTAAAAAACTTCCAGGGACCACCGAGGCGGCCGACCGATTTGTGCGTGCGGCTTACTACACCCAGCACCTGCCGGACCCC
AAGGACTATCGGGAGGCGGTGGCGGGCGTCCTGAGTGTGTTGCGAAATGTATCGCAGCCTTTTGGCACACCCGATCCGGC
TCGCCCTTATATTTCGACCACCCGCTGGCGGACCGTGGCGGATCTGACCCGGGGACTTTATTTTTATGAAAGTACTTTGA
GTCCCTATCTTGTCTGGGTTGAGCTGCCAAAGCTTGACTTCAAAAAGGGCACAGCGGTGAAGAAGATCAATCTGGTCAAA
AACTATGAGCTGATTGGCGACGTCACGGGCAAGTTCAAAACCACACCGGTTTTCCAATTCCTGAAGCCTGACGATCAGGG
ATTGTTGAAGGCGCAGAATTAA

Upstream 100 bases:

>100_bases
GTCATGAATATCAGTTCAATCTGGATACGGCGGCCGGTCAGGAAGCCTTGCAACGATCTGTTGAATTTATGCAAAACCAA
TTAAAAAAGGAGACGTCTTT

Downstream 100 bases:

>100_bases
GTCCGTTTTGACTTTGCACGGCCCCACTTGCTAGGCTCTAGGCAGCCTGTGGGGCTGAGGTTTCAATGAATCTATTGTTT
CGACTTTTGCATGTCCTGCT

Product: choloylglycine hydrolase

Products: NA

Alternate protein names: Bile salt hydrolase; Conjugated bile acid hydrolase; CBAH [H]

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MKVLSVFLSLLLAVPAYPCTRILWDGKNQDVIVGRNMDWSEDTGSNMWLFPRGMERDGMASKNSAKWTSKYGSVILSMYD
VGTADGVNEKGLTANLLYLSESHFGTRDEKVPGMSVSMWAQYFLDNFATVSEAVSSMEKSPIQVLMASVPTAHGVRQGTV
HLALSDKTGDSVVMEYIDGKAKFYHGKEYRFMTNSPPFDQQLKSMKQYQGFGGSKKLPGTTEAADRFVRAAYYTQHLPDP
KDYREAVAGVLSVLRNVSQPFGTPDPARPYISTTRWRTVADLTRGLYFYESTLSPYLVWVELPKLDFKKGTAVKKINLVK
NYELIGDVTGKFKTTPVFQFLKPDDQGLLKAQN

Sequences:

>Translated_353_residues
MKVLSVFLSLLLAVPAYPCTRILWDGKNQDVIVGRNMDWSEDTGSNMWLFPRGMERDGMASKNSAKWTSKYGSVILSMYD
VGTADGVNEKGLTANLLYLSESHFGTRDEKVPGMSVSMWAQYFLDNFATVSEAVSSMEKSPIQVLMASVPTAHGVRQGTV
HLALSDKTGDSVVMEYIDGKAKFYHGKEYRFMTNSPPFDQQLKSMKQYQGFGGSKKLPGTTEAADRFVRAAYYTQHLPDP
KDYREAVAGVLSVLRNVSQPFGTPDPARPYISTTRWRTVADLTRGLYFYESTLSPYLVWVELPKLDFKKGTAVKKINLVK
NYELIGDVTGKFKTTPVFQFLKPDDQGLLKAQN
>Mature_353_residues
MKVLSVFLSLLLAVPAYPCTRILWDGKNQDVIVGRNMDWSEDTGSNMWLFPRGMERDGMASKNSAKWTSKYGSVILSMYD
VGTADGVNEKGLTANLLYLSESHFGTRDEKVPGMSVSMWAQYFLDNFATVSEAVSSMEKSPIQVLMASVPTAHGVRQGTV
HLALSDKTGDSVVMEYIDGKAKFYHGKEYRFMTNSPPFDQQLKSMKQYQGFGGSKKLPGTTEAADRFVRAAYYTQHLPDP
KDYREAVAGVLSVLRNVSQPFGTPDPARPYISTTRWRTVADLTRGLYFYESTLSPYLVWVELPKLDFKKGTAVKKINLVK
NYELIGDVTGKFKTTPVFQFLKPDDQGLLKAQN

Specific function: The enzyme catalyzes the degradation of conjugated bile acids in the mammalian gut [H]

COG id: COG3049

COG function: function code M; Penicillin V acylase and related amidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C59 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003199 [H]

Pfam domain/function: PF02275 CBAH [H]

EC number: =3.5.1.24 [H]

Molecular weight: Translated: 39509; Mature: 39509

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLSVFLSLLLAVPAYPCTRILWDGKNQDVIVGRNMDWSEDTGSNMWLFPRGMERDGMA
CHHHHHHHHHHHHCCCCCCCEEEECCCCCCEEEECCCCCCCCCCCCEEEECCCCCCCCCC
SKNSAKWTSKYGSVILSMYDVGTADGVNEKGLTANLLYLSESHFGTRDEKVPGMSVSMWA
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHH
QYFLDNFATVSEAVSSMEKSPIQVLMASVPTAHGVRQGTVHLALSDKTGDSVVMEYIDGK
HHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCEEEEEEECCCCCHHHHHHHCCC
AKFYHGKEYRFMTNSPPFDQQLKSMKQYQGFGGSKKLPGTTEAADRFVRAAYYTQHLPDP
EEEEECCEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCH
KDYREAVAGVLSVLRNVSQPFGTPDPARPYISTTRWRTVADLTRGLYFYESTLSPYLVWV
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHEECCCCCEEEEE
ELPKLDFKKGTAVKKINLVKNYELIGDVTGKFKTTPVFQFLKPDDQGLLKAQN
ECCCCCCCCCCCEEEEHHHHCHHHEECCCCCEECCCHHEEECCCCCCCCCCCC
>Mature Secondary Structure
MKVLSVFLSLLLAVPAYPCTRILWDGKNQDVIVGRNMDWSEDTGSNMWLFPRGMERDGMA
CHHHHHHHHHHHHCCCCCCCEEEECCCCCCEEEECCCCCCCCCCCCEEEECCCCCCCCCC
SKNSAKWTSKYGSVILSMYDVGTADGVNEKGLTANLLYLSESHFGTRDEKVPGMSVSMWA
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHH
QYFLDNFATVSEAVSSMEKSPIQVLMASVPTAHGVRQGTVHLALSDKTGDSVVMEYIDGK
HHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCEEEEEEECCCCCHHHHHHHCCC
AKFYHGKEYRFMTNSPPFDQQLKSMKQYQGFGGSKKLPGTTEAADRFVRAAYYTQHLPDP
EEEEECCEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCH
KDYREAVAGVLSVLRNVSQPFGTPDPARPYISTTRWRTVADLTRGLYFYESTLSPYLVWV
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHEECCCCCEEEEE
ELPKLDFKKGTAVKKINLVKNYELIGDVTGKFKTTPVFQFLKPDDQGLLKAQN
ECCCCCCCCCCCEEEEHHHHCHHHEECCCCCEECCCHHEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7618863; 11792842 [H]