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The map label for this gene is cheA [H]

Identifier: 42522173

GI number: 42522173

Start: 535429

End: 537165

Strand: Direct

Name: cheA [H]

Synonym: Bd0578

Alternate gene names: 42522173

Gene position: 535429-537165 (Clockwise)

Preceding gene: 42522172

Following gene: 42522174

Centisome position: 14.15

GC content: 51.35

Gene sequence:

>1737_bases
ATGTCGGACGAAAACAAACCCCAGGACAGCCAAGAGGTGGATCTTTCTGCCTTTATCGACTTTGAACAGGTCGAAGAGGT
GTCCCGTGCGTTCTTCGAAGAGTCCAAAGAGATTCTGGAAGATCTCGACAACCTGATTCTCAAGCTGGAAAACAATCCGG
AAGATCAGGATCAGGTGAATGTGCTTTTCCGGAAAATTCACACCATCAAAGGCAGCGTCGGCGCCGTTCCCGGCGGTCAG
TTGTTGGGCTCTTTGTCACATGAATTTGAAGCCCTGCTCACCCGGATCAAACGGGAATCCCGTCCGGTCACCAAAAACTG
CATTGATCTGTTCCTGAAAAGCTCCCGCATACTGAAGGTTCTTGCGCAAAGCCTCCGCGACAAGCGCGAAGTCTATCCGG
AAGAACTCAGTGAAGCCATTGAGATTATCTCTGCCTATGGAGTCTTTGAATTCGGCGATGAATCCTCGCCGCGGGCGAAT
CGACCTGCAGCCAGTCGGGCGGTGTCTTCGTCAGACGACGAAGGCGTGTGGTTGAGTGTAAAACAGATGAACGAGCTTTT
ACGGTTGTCCGGCGAACTGCTGGTGCTTAAAAACTTTTTCCAGATGATGAATCAGACGGTGAACTTCCGGGTTCAGCCCG
AGGTCTTTGAACGCCGTCAAAGCGATTTTGCCCAGAATCTGGGGAAGATCAGTGACCAGTTCCAAAGCCAGGTGCAGAGT
GTGCGCAAGGAAAAAGCCGGAGACAGTCTTTCCGGTTTGCCGCTGCTGGTGCGTCAGGCTTCCACCGAATTGAACAAAAG
TGTTCATCTGGAATTCACGGGATCGGATCTTCTGATCGACAAGGGACTTGGGAAAGACCTCTATGAATGTCTTGTGCATC
TGGTGCGAAACTCCATCGATCACGGGATCGAGGATCAGTTTGAGCGCGCCGTGCAGGGAAAACCCACGATTGGTTTGCTG
AATCTGGAAGTGCTGGAAAAGAACGGCGCTGTGCATGTGATCTTTAAAGATGACGGCAAAGGTCTGGATCGCGAGCGCAT
TCTTCAACGCGCCATTAAAAATGCCCTGGTGACGGAAGAAGCCGCAAAGAGTCTTGCGGATGAGCAGATTTACAAATTTA
TCTTCCACGCCGGCTTCTCGACCAAAGAGAAAGTCACGACCATTTCCGGTCGTGGAGTCGGTATGGATATTGTTCTGTCC
ACGGTGGAAAGATACAAAGGGCGCATTCAGATTGACAACAATCCGGGAGCCGGTGCGACTTTCCATCTGGAAATTCCGAT
CCCCCAGCATATTATGGTCGAAAGTGCGTTGCTCTGTGCGTGGAGTCACTTCCAGCTGGCAGTGCCATTGACGTCGGTGG
CGCACATCACTTCCTGTGATGAACTGCAGGTCACCACGGTGGATCATCTGCGCTATTGCCAGTTCAGCGGCATGACGGTG
CCGCTTCTGAACTATAGTGAGATTCTGAATCTGCGCACTTCGGTCTCCGACGAGGTTGTTCGCAACTCATCGGCAGTCTT
TATTCGTATGAAAGAGGCGGTCTTTGCCCTGCTGGTGGATCGTATCGATGCGCAGACCGACCTGGTCGTAAAGTCCTTTG
GCACTATGATCGGCGAGCAAAAAGGTTTCAAGGGCATTTCCATCCTGGCAGATGAAAAAGTGACTTATATTGTGGATCCG
GAAAAAATGATGGCTTTGATGATGTTTGACCAGCAGAAGCACGAGGAGGCCGCATGA

Upstream 100 bases:

>100_bases
GTCGCTCTTCTTATTTGGGGCACTTGTAATTCAAATCTGGCCTAAATAAACCACCGTCCGTTCTAACTTAAATCCCTGAA
ATACCGATAAATTCCCTAAT

Downstream 100 bases:

>100_bases
GTGATTTCTTCGGTGATGACTTCACAGCGGAACTCAAAGCCTATTTCCTGGACAGCGTGACCAAGGAGATAGACAAGTTC
ATTGATCTGACCGATGAAAA

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 578; Mature: 577

Protein sequence:

>578_residues
MSDENKPQDSQEVDLSAFIDFEQVEEVSRAFFEESKEILEDLDNLILKLENNPEDQDQVNVLFRKIHTIKGSVGAVPGGQ
LLGSLSHEFEALLTRIKRESRPVTKNCIDLFLKSSRILKVLAQSLRDKREVYPEELSEAIEIISAYGVFEFGDESSPRAN
RPAASRAVSSSDDEGVWLSVKQMNELLRLSGELLVLKNFFQMMNQTVNFRVQPEVFERRQSDFAQNLGKISDQFQSQVQS
VRKEKAGDSLSGLPLLVRQASTELNKSVHLEFTGSDLLIDKGLGKDLYECLVHLVRNSIDHGIEDQFERAVQGKPTIGLL
NLEVLEKNGAVHVIFKDDGKGLDRERILQRAIKNALVTEEAAKSLADEQIYKFIFHAGFSTKEKVTTISGRGVGMDIVLS
TVERYKGRIQIDNNPGAGATFHLEIPIPQHIMVESALLCAWSHFQLAVPLTSVAHITSCDELQVTTVDHLRYCQFSGMTV
PLLNYSEILNLRTSVSDEVVRNSSAVFIRMKEAVFALLVDRIDAQTDLVVKSFGTMIGEQKGFKGISILADEKVTYIVDP
EKMMALMMFDQQKHEEAA

Sequences:

>Translated_578_residues
MSDENKPQDSQEVDLSAFIDFEQVEEVSRAFFEESKEILEDLDNLILKLENNPEDQDQVNVLFRKIHTIKGSVGAVPGGQ
LLGSLSHEFEALLTRIKRESRPVTKNCIDLFLKSSRILKVLAQSLRDKREVYPEELSEAIEIISAYGVFEFGDESSPRAN
RPAASRAVSSSDDEGVWLSVKQMNELLRLSGELLVLKNFFQMMNQTVNFRVQPEVFERRQSDFAQNLGKISDQFQSQVQS
VRKEKAGDSLSGLPLLVRQASTELNKSVHLEFTGSDLLIDKGLGKDLYECLVHLVRNSIDHGIEDQFERAVQGKPTIGLL
NLEVLEKNGAVHVIFKDDGKGLDRERILQRAIKNALVTEEAAKSLADEQIYKFIFHAGFSTKEKVTTISGRGVGMDIVLS
TVERYKGRIQIDNNPGAGATFHLEIPIPQHIMVESALLCAWSHFQLAVPLTSVAHITSCDELQVTTVDHLRYCQFSGMTV
PLLNYSEILNLRTSVSDEVVRNSSAVFIRMKEAVFALLVDRIDAQTDLVVKSFGTMIGEQKGFKGISILADEKVTYIVDP
EKMMALMMFDQQKHEEAA
>Mature_577_residues
SDENKPQDSQEVDLSAFIDFEQVEEVSRAFFEESKEILEDLDNLILKLENNPEDQDQVNVLFRKIHTIKGSVGAVPGGQL
LGSLSHEFEALLTRIKRESRPVTKNCIDLFLKSSRILKVLAQSLRDKREVYPEELSEAIEIISAYGVFEFGDESSPRANR
PAASRAVSSSDDEGVWLSVKQMNELLRLSGELLVLKNFFQMMNQTVNFRVQPEVFERRQSDFAQNLGKISDQFQSQVQSV
RKEKAGDSLSGLPLLVRQASTELNKSVHLEFTGSDLLIDKGLGKDLYECLVHLVRNSIDHGIEDQFERAVQGKPTIGLLN
LEVLEKNGAVHVIFKDDGKGLDRERILQRAIKNALVTEEAAKSLADEQIYKFIFHAGFSTKEKVTTISGRGVGMDIVLST
VERYKGRIQIDNNPGAGATFHLEIPIPQHIMVESALLCAWSHFQLAVPLTSVAHITSCDELQVTTVDHLRYCQFSGMTVP
LLNYSEILNLRTSVSDEVVRNSSAVFIRMKEAVFALLVDRIDAQTDLVVKSFGTMIGEQKGFKGISILADEKVTYIVDPE
KMMALMMFDQQKHEEAA

Specific function: Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY [H]

COG id: COG0643

COG function: function code NT; Chemotaxis protein histidine kinase and related kinases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HPt domain [H]

Homologues:

Organism=Escherichia coli, GI1788197, Length=441, Percent_Identity=29.0249433106576, Blast_Score=169, Evalue=4e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002545
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR004105
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR010808 [H]

Pfam domain/function: PF01584 CheW; PF02895 H-kinase_dim; PF02518 HATPase_c; PF01627 Hpt; PF07194 P2 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 64811; Mature: 64680

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS50851 CHEW ; PS50894 HPT ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDENKPQDSQEVDLSAFIDFEQVEEVSRAFFEESKEILEDLDNLILKLENNPEDQDQVN
CCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHH
VLFRKIHTIKGSVGAVPGGQLLGSLSHEFEALLTRIKRESRPVTKNCIDLFLKSSRILKV
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
LAQSLRDKREVYPEELSEAIEIISAYGVFEFGDESSPRANRPAASRAVSSSDDEGVWLSV
HHHHHHHHHHCCHHHHHHHHHHHHHHCCEECCCCCCCCCCCCHHHHCCCCCCCCCEEEEH
KQMNELLRLSGELLVLKNFFQMMNQTVNFRVQPEVFERRQSDFAQNLGKISDQFQSQVQS
HHHHHHHHHCCCHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRKEKAGDSLSGLPLLVRQASTELNKSVHLEFTGSDLLIDKGLGKDLYECLVHLVRNSID
HHHHHCCCCCCCCHHHHHHHHHHCCCEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHC
HGIEDQFERAVQGKPTIGLLNLEVLEKNGAVHVIFKDDGKGLDRERILQRAIKNALVTEE
CCHHHHHHHHHCCCCCEEEEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHH
AAKSLADEQIYKFIFHAGFSTKEKVTTISGRGVGMDIVLSTVERYKGRIQIDNNPGAGAT
HHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCEEEEECCCCCCEE
FHLEIPIPQHIMVESALLCAWSHFQLAVPLTSVAHITSCDELQVTTVDHLRYCQFSGMTV
EEEECCCCHHHHHHHHHHHHHHCCEEECCHHHHHHHCCCCCEEEEEHHHHHHHEECCCEE
PLLNYSEILNLRTSVSDEVVRNSSAVFIRMKEAVFALLVDRIDAQTDLVVKSFGTMIGEQ
ECCCHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCC
KGFKGISILADEKVTYIVDPEKMMALMMFDQQKHEEAA
CCCCCEEEEECCCEEEEECHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SDENKPQDSQEVDLSAFIDFEQVEEVSRAFFEESKEILEDLDNLILKLENNPEDQDQVN
CCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHH
VLFRKIHTIKGSVGAVPGGQLLGSLSHEFEALLTRIKRESRPVTKNCIDLFLKSSRILKV
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
LAQSLRDKREVYPEELSEAIEIISAYGVFEFGDESSPRANRPAASRAVSSSDDEGVWLSV
HHHHHHHHHHCCHHHHHHHHHHHHHHCCEECCCCCCCCCCCCHHHHCCCCCCCCCEEEEH
KQMNELLRLSGELLVLKNFFQMMNQTVNFRVQPEVFERRQSDFAQNLGKISDQFQSQVQS
HHHHHHHHHCCCHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRKEKAGDSLSGLPLLVRQASTELNKSVHLEFTGSDLLIDKGLGKDLYECLVHLVRNSID
HHHHHCCCCCCCCHHHHHHHHHHCCCEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHC
HGIEDQFERAVQGKPTIGLLNLEVLEKNGAVHVIFKDDGKGLDRERILQRAIKNALVTEE
CCHHHHHHHHHCCCCCEEEEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHH
AAKSLADEQIYKFIFHAGFSTKEKVTTISGRGVGMDIVLSTVERYKGRIQIDNNPGAGAT
HHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCEEEEECCCCCCEE
FHLEIPIPQHIMVESALLCAWSHFQLAVPLTSVAHITSCDELQVTTVDHLRYCQFSGMTV
EEEECCCCHHHHHHHHHHHHHHCCEEECCHHHHHHHCCCCCEEEEEHHHHHHHEECCCEE
PLLNYSEILNLRTSVSDEVVRNSSAVFIRMKEAVFALLVDRIDAQTDLVVKSFGTMIGEQ
ECCCHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCC
KGFKGISILADEKVTYIVDPEKMMALMMFDQQKHEEAA
CCCCCEEEEECCCEEEEECHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550470; 10360571; 9989504 [H]