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The map label for this gene is etrA [H]

Identifier: 42522055

GI number: 42522055

Start: 418833

End: 419549

Strand: Direct

Name: etrA [H]

Synonym: Bd0446

Alternate gene names: 42522055

Gene position: 418833-419549 (Clockwise)

Preceding gene: 42522049

Following gene: 42522056

Centisome position: 11.07

GC content: 44.35

Gene sequence:

>717_bases
ATGGAATCTCAGACAATACTCAACGGCGGAGTAAACTCCCTTGGTTTTATGGGTGGTCAAAACCTAAGTATTCCAAATAC
TTCAAACGTTCCCTATGAAGTCATTCATCTTAAAGAAGAGGAGATGATCTTCAAAGAAGGGGAGCCGGCGAAGGGTCTAT
ATTACGTTCAGTCGGGATGTGTTAAAGTTGTTGTAAATCGATCCCACGCGCGCGGCCGCACCACGACTAACGAATACGTG
ACGAAGCTTGTATCACCAGGAGAATACTTTGGCTACAAGGCACTTGTGAAAGGTGCTGTAACACAAAGTCATGCCAAAGC
TGTGAAATCCACGGTTCTTTGGTTGTATCCACGCGAACTTATTCAAGTGGCGATGGCACAATCCAGCCCGCTGATTAAGT
TGCTTTTGAATCAGGCCGTTAACGACCTGGAATCTTTCGAAACCATCAGTCAGCTTCACTACCTGGCATCTGTTCAGGAA
CGTATTGCTTATCAACTGGTGCTTTTGGCAGACAGATTCGGGGTTCAAACACCGAACGGTATTTCTTTGAATTTGAAACT
GACAAGAAATGAGTTCGCTCAGCTTGCCAGCACGATCAATGAGTCCTTGTCTCGTCATTTGACAGAGTTTAAAAACGAAG
GCCTTATCGACCTCAATGGTAAAGAAATCATCATTAAGAACAAAGACGGTCTGATGAGAAGATCAGGCAATTTCTAG

Upstream 100 bases:

>100_bases
AAGAGTGTTATGTCGAAATTTCAATTAGGAGGCTGTATAATACCAGTTTAGGATGACTCCAACAATTAACCCAACGAAGA
AAGCTCGGAGGTAAAAGAGT

Downstream 100 bases:

>100_bases
TCGCAACGCTATCTGCAGACGAAATTGTGAAGACCCCGGGTTGAAAACTCGGGGTTTTTTTATGCCCTAATCTATGCGAC
CATGAGTTTTAGCAAATGGG

Product: transcriptional regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MESQTILNGGVNSLGFMGGQNLSIPNTSNVPYEVIHLKEEEMIFKEGEPAKGLYYVQSGCVKVVVNRSHARGRTTTNEYV
TKLVSPGEYFGYKALVKGAVTQSHAKAVKSTVLWLYPRELIQVAMAQSSPLIKLLLNQAVNDLESFETISQLHYLASVQE
RIAYQLVLLADRFGVQTPNGISLNLKLTRNEFAQLASTINESLSRHLTEFKNEGLIDLNGKEIIIKNKDGLMRRSGNF

Sequences:

>Translated_238_residues
MESQTILNGGVNSLGFMGGQNLSIPNTSNVPYEVIHLKEEEMIFKEGEPAKGLYYVQSGCVKVVVNRSHARGRTTTNEYV
TKLVSPGEYFGYKALVKGAVTQSHAKAVKSTVLWLYPRELIQVAMAQSSPLIKLLLNQAVNDLESFETISQLHYLASVQE
RIAYQLVLLADRFGVQTPNGISLNLKLTRNEFAQLASTINESLSRHLTEFKNEGLIDLNGKEIIIKNKDGLMRRSGNF
>Mature_238_residues
MESQTILNGGVNSLGFMGGQNLSIPNTSNVPYEVIHLKEEEMIFKEGEPAKGLYYVQSGCVKVVVNRSHARGRTTTNEYV
TKLVSPGEYFGYKALVKGAVTQSHAKAVKSTVLWLYPRELIQVAMAQSSPLIKLLLNQAVNDLESFETISQLHYLASVQE
RIAYQLVLLADRFGVQTPNGISLNLKLTRNEFAQLASTINESLSRHLTEFKNEGLIDLNGKEIIIKNKDGLMRRSGNF

Specific function: Regulates anaerobic growth on fumarate, nitrite, Fe(3+), TMAO, DMSO, thiosulfate and sulfite, but not on nitrate nor Mn(4+) [H]

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 26462; Mature: 26462

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: PS50042 CNMP_BINDING_3 ; PS51063 HTH_CRP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESQTILNGGVNSLGFMGGQNLSIPNTSNVPYEVIHLKEEEMIFKEGEPAKGLYYVQSGC
CCCCEECCCCCCHHHCCCCCCCCCCCCCCCCEEEEEECHHHHHHCCCCCCCCEEEECCCE
VKVVVNRSHARGRTTTNEYVTKLVSPGEYFGYKALVKGAVTQSHAKAVKSTVLWLYPREL
EEEEEECCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
IQVAMAQSSPLIKLLLNQAVNDLESFETISQLHYLASVQERIAYQLVLLADRFGVQTPNG
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
ISLNLKLTRNEFAQLASTINESLSRHLTEFKNEGLIDLNGKEIIIKNKDGLMRRSGNF
EEEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MESQTILNGGVNSLGFMGGQNLSIPNTSNVPYEVIHLKEEEMIFKEGEPAKGLYYVQSGC
CCCCEECCCCCCHHHCCCCCCCCCCCCCCCCEEEEEECHHHHHHCCCCCCCCEEEECCCE
VKVVVNRSHARGRTTTNEYVTKLVSPGEYFGYKALVKGAVTQSHAKAVKSTVLWLYPREL
EEEEEECCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
IQVAMAQSSPLIKLLLNQAVNDLESFETISQLHYLASVQERIAYQLVLLADRFGVQTPNG
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
ISLNLKLTRNEFAQLASTINESLSRHLTEFKNEGLIDLNGKEIIIKNKDGLMRRSGNF
EEEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8253682; 12368813 [H]