BacMap

Definition	Mycobacterium avium subsp. paratuberculosis K-10, complete genome.
Accession	NC_002944
Length	4,829,781

Click here to switch to the map view.

The map label for this gene is kduD [C]

Identifier: 41410380

GI number: 41410380

Start: 4749083

End: 4749904

Strand: Direct

Name: kduD [C]

Synonym: MAP4282

Alternate gene names: 41410380

Gene position: 4749083-4749904 (Clockwise)

Preceding gene: 41410379

Following gene: 41410381

Centisome position: 98.33

GC content: 71.53

Gene sequence:

>822_bases
ATGAGCCAGTCACTTACGGACAAGGTCGCGCTGATCACCGGGGCGGCGCGCGGGCAGGGCCGCGCGCACGCGGCGCGGCT
GGCCGCCGAGGGCGCCGACATCATCGCCGTCGACCTCGCCGGGCCGCTGCCGCCGAGCGTTCCCTACGACTCGTCGACGC
CCGAGGACCTGGCCGAGACCGCGGAACTGGTGCGTGCCGCCGGACGGCGGGTCGTCACCGCACAGACCGACGTGCGCGAC
CTGGACGCCCTGACCTCCTCGGTGGACACGGCGGTGGGCGAGCTCGGCCGCCTGGACGTCATCGTGGCCAACGCCGGAAT
CTGCAGCCCCGCCCCGTGGAATCGGATCACCGCGCAGGCGTTCCGGGACACCATCGACACCAACGTCGTCGGCACCTGGA
ACACCGTGATGGCGGGGGCGCAGCACATCATCGACGGCGGCCGCGGCGGGTCGATCATCCTGATCGGCTCGGCGGCCGGC
ATCAACATGCAGTCGTTCATGGTCCACTACACCGCCAGCAAGCACGCCGTGGTGGGCATGGCCCGCGCGTTCGCCGCCGA
ACTCGGCCGCTACAACATTCGGGTCAACAGCCTCAACCCCGGGGCGGTCGCCACCCCGATGGGCACCGGCCGGATGCGCG
ACGCGCTGCGCGCGGCCGCCGACGACTACCCGCATCTGCGGGGCCTGCACAAACCGCTGCTGCCCGAGGGCATCGCGCAA
CCGGAGGACATCGCCGACGCGGTGGCCTGGCTGGCCTCCGACCAATCCAGATTGGTGACCGCCAGCCAGGTTTCGGTCGA
TCTCGGCGTCGGCTACGTGTGA

Upstream 100 bases:

>100_bases
CTTTCCGCTATCCGGCAGCGTAATCCGGCCTCGGGCTGCGGCATGCTGGAGCGCTGCACGAGGCTGGAAATCGTGCGCGA
CGGAAAGGACCCCAGCACCC

Downstream 100 bases:

>100_bases
TGCCCGCCCGCGCCCCTCGCCCCGCGCGGCCGACCAGGCACAATGGTGTGGTCAAAACCTGCGGCGGGGAGCGAGAAGGA
GCGGCATGCCCACCAGCGAA

Product: hypothetical protein

Products: @DEHY06.txt*3-Dehydro-2- Deoxy-D-Gluconate!; NADH. [C]

Alternate protein names: NA

Number of amino acids: Translated: 273; Mature: 272

Protein sequence:

>273_residues
MSQSLTDKVALITGAARGQGRAHAARLAAEGADIIAVDLAGPLPPSVPYDSSTPEDLAETAELVRAAGRRVVTAQTDVRD
LDALTSSVDTAVGELGRLDVIVANAGICSPAPWNRITAQAFRDTIDTNVVGTWNTVMAGAQHIIDGGRGGSIILIGSAAG
INMQSFMVHYTASKHAVVGMARAFAAELGRYNIRVNSLNPGAVATPMGTGRMRDALRAAADDYPHLRGLHKPLLPEGIAQ
PEDIADAVAWLASDQSRLVTASQVSVDLGVGYV

Sequences:

>Translated_273_residues
MSQSLTDKVALITGAARGQGRAHAARLAAEGADIIAVDLAGPLPPSVPYDSSTPEDLAETAELVRAAGRRVVTAQTDVRD
LDALTSSVDTAVGELGRLDVIVANAGICSPAPWNRITAQAFRDTIDTNVVGTWNTVMAGAQHIIDGGRGGSIILIGSAAG
INMQSFMVHYTASKHAVVGMARAFAAELGRYNIRVNSLNPGAVATPMGTGRMRDALRAAADDYPHLRGLHKPLLPEGIAQ
PEDIADAVAWLASDQSRLVTASQVSVDLGVGYV
>Mature_272_residues
SQSLTDKVALITGAARGQGRAHAARLAAEGADIIAVDLAGPLPPSVPYDSSTPEDLAETAELVRAAGRRVVTAQTDVRDL
DALTSSVDTAVGELGRLDVIVANAGICSPAPWNRITAQAFRDTIDTNVVGTWNTVMAGAQHIIDGGRGGSIILIGSAAGI
NMQSFMVHYTASKHAVVGMARAFAAELGRYNIRVNSLNPGAVATPMGTGRMRDALRAAADDYPHLRGLHKPLLPEGIAQP
EDIADAVAWLASDQSRLVTASQVSVDLGVGYV

Specific function: Unknown

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=279, Percent_Identity=31.5412186379928, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI10190704, Length=268, Percent_Identity=29.8507462686567, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI31542939, Length=252, Percent_Identity=30.5555555555556, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI7705925, Length=271, Percent_Identity=28.7822878228782, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI4758504, Length=242, Percent_Identity=29.3388429752066, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI4504505, Length=216, Percent_Identity=29.1666666666667, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI32483357, Length=264, Percent_Identity=26.8939393939394, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI224922801, Length=180, Percent_Identity=32.2222222222222, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI40254992, Length=267, Percent_Identity=29.2134831460674, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI19923817, Length=277, Percent_Identity=23.1046931407942, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI59889578, Length=134, Percent_Identity=32.8358208955224, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI4503301, Length=215, Percent_Identity=24.1860465116279, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI83715985, Length=198, Percent_Identity=29.7979797979798, Blast_Score=64, Evalue=1e-10,
Organism=Escherichia coli, GI1789208, Length=267, Percent_Identity=31.8352059925094, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI87082100, Length=267, Percent_Identity=29.9625468164794, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1788459, Length=263, Percent_Identity=30.4182509505703, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1787335, Length=269, Percent_Identity=29.368029739777, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI87082160, Length=270, Percent_Identity=30, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1787905, Length=266, Percent_Identity=29.3233082706767, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI2367365, Length=271, Percent_Identity=29.520295202952, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1789378, Length=262, Percent_Identity=28.6259541984733, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1790717, Length=267, Percent_Identity=28.0898876404494, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI2367175, Length=260, Percent_Identity=28.8461538461538, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1786812, Length=270, Percent_Identity=26.2962962962963, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1787526, Length=263, Percent_Identity=27.3764258555133, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17555706, Length=282, Percent_Identity=27.6595744680851, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17562910, Length=262, Percent_Identity=26.7175572519084, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17562906, Length=260, Percent_Identity=28.8461538461538, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17559104, Length=275, Percent_Identity=29.8181818181818, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI193204405, Length=257, Percent_Identity=29.5719844357977, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562908, Length=261, Percent_Identity=27.5862068965517, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17560676, Length=271, Percent_Identity=23.9852398523985, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17568967, Length=203, Percent_Identity=28.5714285714286, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI115534694, Length=267, Percent_Identity=29.9625468164794, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17562904, Length=258, Percent_Identity=27.1317829457364, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17561402, Length=267, Percent_Identity=28.4644194756554, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI25147288, Length=271, Percent_Identity=27.3062730627306, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17536025, Length=269, Percent_Identity=26.7657992565056, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17531453, Length=263, Percent_Identity=28.5171102661597, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17538182, Length=210, Percent_Identity=32.3809523809524, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17560332, Length=257, Percent_Identity=28.4046692607004, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17567345, Length=227, Percent_Identity=24.6696035242291, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17560220, Length=258, Percent_Identity=28.6821705426357, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17536651, Length=269, Percent_Identity=24.1635687732342, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17560150, Length=256, Percent_Identity=26.171875, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17544670, Length=281, Percent_Identity=24.5551601423488, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17562990, Length=255, Percent_Identity=25.8823529411765, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71994604, Length=276, Percent_Identity=25.7246376811594, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17565030, Length=262, Percent_Identity=27.4809160305344, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71994600, Length=270, Percent_Identity=24.4444444444444, Blast_Score=64, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17561272, Length=221, Percent_Identity=24.8868778280543, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=199, Percent_Identity=32.6633165829146, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324126, Length=264, Percent_Identity=25, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17737361, Length=214, Percent_Identity=32.7102803738318, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28571526, Length=270, Percent_Identity=27.4074074074074, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24639444, Length=270, Percent_Identity=29.2592592592593, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24643142, Length=271, Percent_Identity=29.8892988929889, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21357041, Length=270, Percent_Identity=27.4074074074074, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI23397609, Length=274, Percent_Identity=29.1970802919708, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI18859837, Length=209, Percent_Identity=29.1866028708134, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI281364892, Length=208, Percent_Identity=28.3653846153846, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24644339, Length=267, Percent_Identity=25.4681647940075, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI116007236, Length=258, Percent_Identity=24.8062015503876, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24663911, Length=257, Percent_Identity=26.4591439688716, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24580925, Length=210, Percent_Identity=27.6190476190476, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21355319, Length=273, Percent_Identity=23.8095238095238, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.125 [C]

Molecular weight: Translated: 28353; Mature: 28222

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQSLTDKVALITGAARGQGRAHAARLAAEGADIIAVDLAGPLPPSVPYDSSTPEDLAET
CCCCHHHHEEEEECCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHH
AELVRAAGRRVVTAQTDVRDLDALTSSVDTAVGELGRLDVIVANAGICSPAPWNRITAQA
HHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHH
FRDTIDTNVVGTWNTVMAGAQHIIDGGRGGSIILIGSAAGINMQSFMVHYTASKHAVVGM
HHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHEEEEECCCCHHHHHH
ARAFAAELGRYNIRVNSLNPGAVATPMGTGRMRDALRAAADDYPHLRGLHKPLLPEGIAQ
HHHHHHHHCCEEEEEECCCCCCEECCCCCHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCC
PEDIADAVAWLASDQSRLVTASQVSVDLGVGYV
HHHHHHHHHHHHCCCHHEEEHHHEEEECCCCCC
>Mature Secondary Structure 
SQSLTDKVALITGAARGQGRAHAARLAAEGADIIAVDLAGPLPPSVPYDSSTPEDLAET
CCCHHHHEEEEECCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHH
AELVRAAGRRVVTAQTDVRDLDALTSSVDTAVGELGRLDVIVANAGICSPAPWNRITAQA
HHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHH
FRDTIDTNVVGTWNTVMAGAQHIIDGGRGGSIILIGSAAGINMQSFMVHYTASKHAVVGM
HHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHEEEEECCCCHHHHHH
ARAFAAELGRYNIRVNSLNPGAVATPMGTGRMRDALRAAADDYPHLRGLHKPLLPEGIAQ
HHHHHHHHCCEEEEEECCCCCCEECCCCCHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCC
PEDIADAVAWLASDQSRLVTASQVSVDLGVGYV
HHHHHHHHHHHHCCCHHEEEHHHEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 15.4 {2-deoxygluconate}} [C]

Substrates: @DEOX03.txt*2-Deoxy-D-Gluconate!; NAD(+) [C]

Specific reaction: @DEOX03.txt*2-Deoxy-D-Gluconate! + NAD(+) = @DEHY06.txt*3-Dehydro-2- Deoxy-D-Gluconate! + NADH. [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA