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The map label for this gene is groEL

Identifier: 41410363

GI number: 41410363

Start: 4733338

End: 4734954

Strand: Direct

Name: groEL

Synonym: MAP4265

Alternate gene names: 41410363

Gene position: 4733338-4734954 (Clockwise)

Preceding gene: 41410362

Following gene: 41410364

Centisome position: 98.0

GC content: 70.13

Gene sequence:

>1617_bases
ATGAGCAAGATCATTGAGTACGACGAGACCGCGCGCCGCGCCATCGAGGCCGGCGTCAACACGCTTGCCGATGCGGTCCG
GGTGACGCTGGGTCCGCGGGGCCGGCATGTGGTGCTGGCCAAGGCATTCGGCGGGCCGGCCGTCACCAACGACGGCGTCA
CCGTCGCGCGGGAAATCGACCTGGAGGACCCGTTCGAGAACCTGGGCGCCCAGCTGGTGAAGTCGGTGGCGACCAAGACT
AACGACGTCGCCGGCGACGGCACCACCACCGCGACCGTGCTGGCGCAGGCGCTGGTGAAGGGCGGCCTGCGGCTGGTGGC
GGCCGGCGCCAACCCCATCGAGCTCGGCGCCGGAATCTCCAAGGCCGCCGACGCGGTGTCCGAGGCGCTGCTGGCCTCGG
CCACCCCGGTGTCCGGCAAGGACGCGATCGCCCAGGTGGCGACCGTGTCGTCGCGTGACCAGGTGCTCGGCGAGCTGGTC
GGCGAGGCGATGACCAAGGTCGGGGTCGACGGCGTGGTCAGCGTCGAAGAGTCCTCGACGCTGAACACCGAGCTGGAGTT
CACCGAGGGCGTCGGCTTCGACAAGGGCTTCCTGTCGGCCTACTTCGTCACCGACTTCGACGCCCAGCAGGCCGTGCTGG
ATGACCCGGTGATCCTGTTGCACCAGGAGAAGATCAGCTCGCTGCCCGACCTGCTGCCGATGCTGGAGAAGGTCGCCGAG
TCGGGCAAACCGCTGCTGATCATCGCCGAGGACATCGAGGGCGAGGCGCTGGCCACCCTCGTCGTCAACTCCATTCGCAA
GACGCTGAAAGCCGTTGCGGTCAAGGCGCCGTTCTTCGGCGACCGGCGCAAGGCGTTCCTGGAGGACCTGGCCATCGTGA
CCGGCGGGCAGGTGATCAACCCCGACACCGGCCTGCTGCTGCGCGAGGTCGGCACCGAGGTGCTCGGCTCGGCCCGGCGG
GTGGTGGTCAGCAAGGACGACACCATCATCGTCGACGGCGGCGGCGCCAAAGACGCCGTGGCCAACCGGATCAAGCAGCT
GCGCGCCGAGATCGAGAAGACCGACTCCGACTGGGACCGCGAGAAGCTGCAGGAGCGGCTGGCCAAGCTGGCCGGCGGCG
TGGCGGTGATCAAGGTCGGTGCGGCCACCGAGACCGCGCTCAAGGAACGCAAGGAAAGCGTCGAGGACGCGGTGGCCGCC
GCCAAGGCCGCGGTCGAGGAGGGCATCGTCGCCGGCGGCGGGTCGGCGCTGCTGCAGGCCCGCAAGGCCCTCGACGAGCT
GCGCGGATCGCTGAGCGGCGATCAGGCGCTGGGCGTCGACGTCTTCGCCGAGGCGCTGGGGGCGCCGCTGTACTGGATCG
CCAGCAACGCCGGGCTGGACGGCGCGGTGGCCGTGCACAAGGTCGCCGAGCTGCCCGCCGGCCACGGGCTCAACGCCGAG
AAGCTCAGCTACGGCGACCTGATCGCCGACGGCGTCATCGACCCGGTCAAGGTGACCCGCTCGGCGGTGCTCAACTCGGC
CTCGGTGGCGCGGATGGTGCTCACCACCGAGACGGCGGTTGTCGACAAGCCGGCCGAGGAGGCCGACGACCACGGCCACG
GACATCACCATCACTAG

Upstream 100 bases:

>100_bases
GTCTCCAAGTAACAACCGTGTCCCGCCCCGGCGATCCCCGCGTCCCCACGCGGGTGATTTCCGGGGCGGCATGCGTTACA
GCCCGGTTTGAAGGAGCCTG

Downstream 100 bases:

>100_bases
GTCTGCCGAGCAGACGCAAAAGCCCCCGACACGCCCTGCGTGCGGGGGCTTTTGCGTCTTCTCGTTCCCTACGGCGGACG
TTTAGTCTCGCGGCATGGAT

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 1; Protein Cpn60 1 [H]

Number of amino acids: Translated: 538; Mature: 537

Protein sequence:

>538_residues
MSKIIEYDETARRAIEAGVNTLADAVRVTLGPRGRHVVLAKAFGGPAVTNDGVTVAREIDLEDPFENLGAQLVKSVATKT
NDVAGDGTTTATVLAQALVKGGLRLVAAGANPIELGAGISKAADAVSEALLASATPVSGKDAIAQVATVSSRDQVLGELV
GEAMTKVGVDGVVSVEESSTLNTELEFTEGVGFDKGFLSAYFVTDFDAQQAVLDDPVILLHQEKISSLPDLLPMLEKVAE
SGKPLLIIAEDIEGEALATLVVNSIRKTLKAVAVKAPFFGDRRKAFLEDLAIVTGGQVINPDTGLLLREVGTEVLGSARR
VVVSKDDTIIVDGGGAKDAVANRIKQLRAEIEKTDSDWDREKLQERLAKLAGGVAVIKVGAATETALKERKESVEDAVAA
AKAAVEEGIVAGGGSALLQARKALDELRGSLSGDQALGVDVFAEALGAPLYWIASNAGLDGAVAVHKVAELPAGHGLNAE
KLSYGDLIADGVIDPVKVTRSAVLNSASVARMVLTTETAVVDKPAEEADDHGHGHHHH

Sequences:

>Translated_538_residues
MSKIIEYDETARRAIEAGVNTLADAVRVTLGPRGRHVVLAKAFGGPAVTNDGVTVAREIDLEDPFENLGAQLVKSVATKT
NDVAGDGTTTATVLAQALVKGGLRLVAAGANPIELGAGISKAADAVSEALLASATPVSGKDAIAQVATVSSRDQVLGELV
GEAMTKVGVDGVVSVEESSTLNTELEFTEGVGFDKGFLSAYFVTDFDAQQAVLDDPVILLHQEKISSLPDLLPMLEKVAE
SGKPLLIIAEDIEGEALATLVVNSIRKTLKAVAVKAPFFGDRRKAFLEDLAIVTGGQVINPDTGLLLREVGTEVLGSARR
VVVSKDDTIIVDGGGAKDAVANRIKQLRAEIEKTDSDWDREKLQERLAKLAGGVAVIKVGAATETALKERKESVEDAVAA
AKAAVEEGIVAGGGSALLQARKALDELRGSLSGDQALGVDVFAEALGAPLYWIASNAGLDGAVAVHKVAELPAGHGLNAE
KLSYGDLIADGVIDPVKVTRSAVLNSASVARMVLTTETAVVDKPAEEADDHGHGHHHH
>Mature_537_residues
SKIIEYDETARRAIEAGVNTLADAVRVTLGPRGRHVVLAKAFGGPAVTNDGVTVAREIDLEDPFENLGAQLVKSVATKTN
DVAGDGTTTATVLAQALVKGGLRLVAAGANPIELGAGISKAADAVSEALLASATPVSGKDAIAQVATVSSRDQVLGELVG
EAMTKVGVDGVVSVEESSTLNTELEFTEGVGFDKGFLSAYFVTDFDAQQAVLDDPVILLHQEKISSLPDLLPMLEKVAES
GKPLLIIAEDIEGEALATLVVNSIRKTLKAVAVKAPFFGDRRKAFLEDLAIVTGGQVINPDTGLLLREVGTEVLGSARRV
VVSKDDTIIVDGGGAKDAVANRIKQLRAEIEKTDSDWDREKLQERLAKLAGGVAVIKVGAATETALKERKESVEDAVAAA
KAAVEEGIVAGGGSALLQARKALDELRGSLSGDQALGVDVFAEALGAPLYWIASNAGLDGAVAVHKVAELPAGHGLNAEK
LSYGDLIADGVIDPVKVTRSAVLNSASVARMVLTTETAVVDKPAEEADDHGHGHHHH

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=530, Percent_Identity=44.5283018867925, Blast_Score=437, Evalue=1e-123,
Organism=Homo sapiens, GI31542947, Length=530, Percent_Identity=44.5283018867925, Blast_Score=437, Evalue=1e-123,
Organism=Homo sapiens, GI38455427, Length=549, Percent_Identity=22.2222222222222, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI24307939, Length=552, Percent_Identity=21.9202898550725, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI5453607, Length=547, Percent_Identity=23.217550274223, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI302058290, Length=455, Percent_Identity=24.6153846153846, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI5453603, Length=208, Percent_Identity=30.2884615384615, Blast_Score=66, Evalue=9e-11,
Organism=Escherichia coli, GI1790586, Length=530, Percent_Identity=53.9622641509434, Blast_Score=536, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI17555558, Length=530, Percent_Identity=42.6415094339623, Blast_Score=424, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI193210679, Length=212, Percent_Identity=40.5660377358491, Blast_Score=158, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI17532603, Length=529, Percent_Identity=22.4952741020794, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17564182, Length=529, Percent_Identity=22.6843100189036, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI25144674, Length=535, Percent_Identity=24.6728971962617, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI25147750, Length=207, Percent_Identity=29.951690821256, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323288, Length=525, Percent_Identity=45.9047619047619, Blast_Score=449, Evalue=1e-127,
Organism=Saccharomyces cerevisiae, GI6322524, Length=103, Percent_Identity=36.8932038834951, Blast_Score=67, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6320058, Length=182, Percent_Identity=24.7252747252747, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24641193, Length=530, Percent_Identity=46.6037735849057, Blast_Score=462, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24641191, Length=530, Percent_Identity=46.6037735849057, Blast_Score=462, Evalue=1e-130,
Organism=Drosophila melanogaster, GI45550936, Length=528, Percent_Identity=44.3181818181818, Blast_Score=441, Evalue=1e-124,
Organism=Drosophila melanogaster, GI45550132, Length=528, Percent_Identity=44.3181818181818, Blast_Score=441, Evalue=1e-124,
Organism=Drosophila melanogaster, GI45550935, Length=528, Percent_Identity=44.3181818181818, Blast_Score=441, Evalue=1e-124,
Organism=Drosophila melanogaster, GI17864606, Length=524, Percent_Identity=39.8854961832061, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24584129, Length=528, Percent_Identity=33.3333333333333, Blast_Score=268, Evalue=6e-72,
Organism=Drosophila melanogaster, GI19921262, Length=528, Percent_Identity=33.3333333333333, Blast_Score=268, Evalue=6e-72,
Organism=Drosophila melanogaster, GI17647245, Length=539, Percent_Identity=23.3766233766234, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24652903, Length=539, Percent_Identity=23.3766233766234, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24645179, Length=527, Percent_Identity=22.011385199241, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24583944, Length=159, Percent_Identity=26.4150943396226, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 55794; Mature: 55663

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKIIEYDETARRAIEAGVNTLADAVRVTLGPRGRHVVLAKAFGGPAVTNDGVTVAREID
CCCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEEECCCCCCCCCCCEEEEECC
LEDPFENLGAQLVKSVATKTNDVAGDGTTTATVLAQALVKGGLRLVAAGANPIELGAGIS
CCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCEEEEECCCCCHHHCCCHH
KAADAVSEALLASATPVSGKDAIAQVATVSSRDQVLGELVGEAMTKVGVDGVVSVEESST
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCEEEECCCCC
LNTELEFTEGVGFDKGFLSAYFVTDFDAQQAVLDDPVILLHQEKISSLPDLLPMLEKVAE
CCCEEEECCCCCCCCHHHEEEEEECCCCHHHHHCCCEEEEEHHHHHCCHHHHHHHHHHHH
SGKPLLIIAEDIEGEALATLVVNSIRKTLKAVAVKAPFFGDRRKAFLEDLAIVTGGQVIN
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEC
PDTGLLLREVGTEVLGSARRVVVSKDDTIIVDGGGAKDAVANRIKQLRAEIEKTDSDWDR
CCCHHHHHHHHHHHHCCCCEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCH
EKLQERLAKLAGGVAVIKVGAATETALKERKESVEDAVAAAKAAVEEGIVAGGGSALLQA
HHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
RKALDELRGSLSGDQALGVDVFAEALGAPLYWIASNAGLDGAVAVHKVAELPAGHGLNAE
HHHHHHHHCCCCCCCCCCHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCCC
KLSYGDLIADGVIDPVKVTRSAVLNSASVARMVLTTETAVVDKPAEEADDHGHGHHHH
CCCCCHHHHCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCC
>Mature Secondary Structure 
SKIIEYDETARRAIEAGVNTLADAVRVTLGPRGRHVVLAKAFGGPAVTNDGVTVAREID
CCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEEECCCCCCCCCCCEEEEECC
LEDPFENLGAQLVKSVATKTNDVAGDGTTTATVLAQALVKGGLRLVAAGANPIELGAGIS
CCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCEEEEECCCCCHHHCCCHH
KAADAVSEALLASATPVSGKDAIAQVATVSSRDQVLGELVGEAMTKVGVDGVVSVEESST
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCEEEECCCCC
LNTELEFTEGVGFDKGFLSAYFVTDFDAQQAVLDDPVILLHQEKISSLPDLLPMLEKVAE
CCCEEEECCCCCCCCHHHEEEEEECCCCHHHHHCCCEEEEEHHHHHCCHHHHHHHHHHHH
SGKPLLIIAEDIEGEALATLVVNSIRKTLKAVAVKAPFFGDRRKAFLEDLAIVTGGQVIN
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEC
PDTGLLLREVGTEVLGSARRVVVSKDDTIIVDGGGAKDAVANRIKQLRAEIEKTDSDWDR
CCCHHHHHHHHHHHHCCCCEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCH
EKLQERLAKLAGGVAVIKVGAATETALKERKESVEDAVAAAKAAVEEGIVAGGGSALLQA
HHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
RKALDELRGSLSGDQALGVDVFAEALGAPLYWIASNAGLDGAVAVHKVAELPAGHGLNAE
HHHHHHHHCCCCCCCCCCHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCCC
KLSYGDLIADGVIDPVKVTRSAVLNSASVARMVLTTETAVVDKPAEEADDHGHGHHHH
CCCCCHHHHCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA